LC GC EuropePub Date : 2023-09-29DOI: 10.4995/lc.2023.19752
Covadonga Blasco Veganzones
{"title":"Le Corbusier et la ballena : habitar la cubierta de Ronchamp","authors":"Covadonga Blasco Veganzones","doi":"10.4995/lc.2023.19752","DOIUrl":"https://doi.org/10.4995/lc.2023.19752","url":null,"abstract":"En 1957, Le Corbusier publicó junto al editor Gerd Hatje un monográfico sobre la capilla de Ronchamp en el que aparecían algunas de las primeras fotografías del interior de la cubierta del edificio. Sesenta y cinco años después, este artículo recoge imágenes inéditas de ese mismo espacio tomadas durante una visita a la cubierta realizada durante el período de ejecución del plan de rehabilitación de Notre-Dame du Haut llevado a cabo entre los años 2022 y 2024. Con el fin de analizar el vacío comprendido entre las dos láminas de hormigón que conforman la cubierta, así como la relación que establece dicho vacío tanto con los espacios interiores de la capilla como con el paisaje exterior, la reflexión teórica que acompaña a las imágenes aportadas se sirve de la metáfora como herramienta para su desarrollo, permitiendo así que el lenguaje preserve la naturaleza sugestiva de este espacio oculto. Siguiendo esta premisa, los elementos arquitectónicos reconocibles en la cubierta de la capilla —trampillas, huecos de ventilación, chimeneas, vigas o pasos de mantenimiento— se transforman en los órganos de la anatomía de una ballena. La exploración de estos elementos desvela la forma en la que en el envés oculto de Ronchamp también reside la obra de arte.","PeriodicalId":49915,"journal":{"name":"LC GC Europe","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135198936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
LC GC EuropePub Date : 2023-09-29DOI: 10.4995/lc.2023.20250
Juan Calatrava Escobar
{"title":"Pascal Aumasson, Yves Brand’Honneur. Savina, Le Corbusier. De l’art celtique à la sculpture moderne","authors":"Juan Calatrava Escobar","doi":"10.4995/lc.2023.20250","DOIUrl":"https://doi.org/10.4995/lc.2023.20250","url":null,"abstract":"Reseña del libro mencionado en el título.","PeriodicalId":49915,"journal":{"name":"LC GC Europe","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135199877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
LC GC EuropePub Date : 2023-09-01DOI: 10.56530/lcgc.eu.hj6872i9
{"title":"What Goes Around Comes Around?","authors":"","doi":"10.56530/lcgc.eu.hj6872i9","DOIUrl":"https://doi.org/10.56530/lcgc.eu.hj6872i9","url":null,"abstract":"“Questions of Quality” is 30 years old! What, if anything, has changed in chromatography laboratories over that time? What, if anything, remains the same?","PeriodicalId":49915,"journal":{"name":"LC GC Europe","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135349017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
LC GC EuropePub Date : 2023-09-01DOI: 10.56530/lcgc.eu.vg7476d5
Jennifer K. Field, Melvin R. Euerby, Patrik Petersson, Stuart N. Berry, James Hogbin, Veronica Paget, Earl McKoy, Raymond Wong
{"title":"Anomalous Retention Prediction Using Modelling Software in Gradient Reversed-Phase Liquid Chromatography: Why it Can Occur and How to Prevent It","authors":"Jennifer K. Field, Melvin R. Euerby, Patrik Petersson, Stuart N. Berry, James Hogbin, Veronica Paget, Earl McKoy, Raymond Wong","doi":"10.56530/lcgc.eu.vg7476d5","DOIUrl":"https://doi.org/10.56530/lcgc.eu.vg7476d5","url":null,"abstract":"This article presents the benefits of screening column and mobile phase combinations that generate differing chromatographic selectivities in reversed-phase gradient ultrahigh-pressure liquid chromatographic (UHPLC) method development strategies. Photodiode array (PDA) and mass spectrophotometric (MS) detection was necessary to facilitate peak tracking or identification of components in the sample mixture to build retention models. Retention time prediction accuracies of < 0.3% were obtained from a two-dimensional gradient time vs. temperature model when the initial gradient conditions were maintained. However, anomalous retention predictions were observed when higher %B initial gradient conditions were employed. Polar analytes in the sample mixture that started to migrate down the column in the dwell volume of the UHPLC system produced inaccurate retention time predictions if an inappropriate dwell volume was used in the retention model. An iterative dwell volume estimation was demonstrated to generate more accurate retention time predictions than when a practically determined dwell volume was used. However, to obtain good predictions the analyst should endeavour to use initial chromatographic conditions that promote focusing of all analytes on top of the column (that is, retention factor > 10).","PeriodicalId":49915,"journal":{"name":"LC GC Europe","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135349000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessing How Chemical Exposures Affect Human Health.","authors":"Erin S Baker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Measuring chemical exposure is extremely challenging due to the range and number of anthropogenic molecules encountered in our daily lives, as well as their complex transformations throughout the body. To broadly characterize how chemical exposures influence human health, a combination of genomic, transcriptomic, proteomic, endogenous metabolomic, and xenobiotic measurements must be performed. However, while genomic, transcriptomic, and proteomic analyses have rapidly progressed over the last two decades, advancements in instrumentation and computations for nontargeted xenobiotic and endogenous small molecule measurements are still greatly needed.</p>","PeriodicalId":49915,"journal":{"name":"LC GC Europe","volume":"36 Suppl","pages":"7-10"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
LC GC EuropePub Date : 2023-05-01DOI: 10.56530/lcgc.eu.qq7969g7
Benjamin P Libert, Samuel W Foster, Elisabeth P Gates, Matthew Morse, Greg Ward, Milton L Lee, James P Grinias
{"title":"Exploring Biopharmaceutical Analysis with Compact Capillary Liquid Chromatography Instrumentation.","authors":"Benjamin P Libert, Samuel W Foster, Elisabeth P Gates, Matthew Morse, Greg Ward, Milton L Lee, James P Grinias","doi":"10.56530/lcgc.eu.qq7969g7","DOIUrl":"10.56530/lcgc.eu.qq7969g7","url":null,"abstract":"<p><p>A recent trend in the design of liquid chromatography (LC) instrumentation is the move towards miniaturized and portable systems. These smaller platforms provide wider flexibility in operation, with the opportunity for conducting analysis directly at the point of sample collection rather than transporting the sample to a centralized laboratory facility. For the manufacturing of pharmaceutical and biopharmaceutical products, these platforms can be implemented for process monitoring and product characterization directly in manufacturing environments. This article describes a portable, miniaturized LC instrument coupled to a mass spectrometer (MS) for characterization of a biopharmaceutical monoclonal antibody (mAb).</p>","PeriodicalId":49915,"journal":{"name":"LC GC Europe","volume":"36 Suppl 5","pages":"24-27"},"PeriodicalIF":1.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9918470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"HISTORY OF CHROMATOGRAPHY Hamish Small: Experimenter Extraordinaire.","authors":"André M Striegel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hamish Small spoke to André Striegel about the secrets of his success in separation science, including the development of ion chromatography, and the value of vague thoughts in scientific progress.</p>","PeriodicalId":49915,"journal":{"name":"LC GC Europe","volume":"33 ","pages":"776-781"},"PeriodicalIF":1.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605081/pdf/nihms-1526113.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37391006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New Developments in the Field of Monoliths for Chromatography.","authors":"Frantisek Svec","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49915,"journal":{"name":"LC GC Europe","volume":"23 5","pages":"689854"},"PeriodicalIF":1.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227114/pdf/nihms221982.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30302222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}