利用紧凑型毛细管液相色谱仪探索生物制药分析。

IF 0.8 4区化学 Q4 CHEMISTRY, ANALYTICAL

LC GC Europe Pub Date : 2023-05-01 DOI:10.56530/lcgc.eu.qq7969g7

Benjamin P Libert, Samuel W Foster, Elisabeth P Gates, Matthew Morse, Greg Ward, Milton L Lee, James P Grinias

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引用次数: 0

摘要

液相色谱 (LC) 仪器设计的最新趋势是向小型化和便携式系统发展。这些小型平台提供了更大的操作灵活性，可直接在样品采集点进行分析，而无需将样品运送到集中的实验室设施。对于制药和生物制药产品的生产，这些平台可以直接在生产环境中进行过程监控和产品表征。本文介绍了一种用于生物制药单克隆抗体 (mAb) 表征的与质谱仪 (MS) 相连接的便携式微型液相色谱仪。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Exploring Biopharmaceutical Analysis with Compact Capillary Liquid Chromatography Instrumentation.

A recent trend in the design of liquid chromatography (LC) instrumentation is the move towards miniaturized and portable systems. These smaller platforms provide wider flexibility in operation, with the opportunity for conducting analysis directly at the point of sample collection rather than transporting the sample to a centralized laboratory facility. For the manufacturing of pharmaceutical and biopharmaceutical products, these platforms can be implemented for process monitoring and product characterization directly in manufacturing environments. This article describes a portable, miniaturized LC instrument coupled to a mass spectrometer (MS) for characterization of a biopharmaceutical monoclonal antibody (mAb).

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来源期刊

LC GC Europe 化学-分析化学

CiteScore

0.37

自引率

60.00%

发文量

审稿时长

3 months

期刊介绍： Because LCGC is directed to experienced researchers and applications personnel in the field of chromatography, avoid describing details or techniques that are common knowledge among such specialists.