Libyan Journal of Medicine最新文献

{"title":"Effects of vitamin C and D on the mRNA expression of angiotensin converting enzyme 2 receptor, cathepsin L, and transmembrane serine protease in the mouse lungs.","authors":"Meshref A Alruwaili,&nbsp;Yazun Jarrar","doi":"10.1080/19932820.2022.2054111","DOIUrl":"https://doi.org/10.1080/19932820.2022.2054111","url":null,"abstract":"<p><p>Vitamins (Vit) C and D are widely used as immunogenic supplements among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. The SAR-CoV-2 virus enters into the pulmonary endothelial cells through attachment to angiotensin converting enzyme 2 receptor (Ace2) and the proteolytic activity of Cathepsin L (Ctsl) and transmembrane serine protease 2 (Tmprss2) enzymes. This study aimed to determine the influence of Vit C and D on the mRNA expression of <i>Ace2, Tmprss2</i>, and <i>Ctsl</i> genes in the mouse lungs. Vitamins C and D were administrated to different groups of mice through intra-peritoneal route in doses equivalent to human for 30 days. Then, the mRNA expression of SARS-CoV-2 entry gene was analyzed using qRT-PCR. It is found that Vit D, but not C, upregulated significantly (<i>P</i> < 0.05) the mRNA expression of <i>Ace2</i> by more than six folds, while downregulated the expression of <i>Ctsl</i> and <i>Tmprss2</i> genes by 2.8 and 2.2 folds, respectively. It can be concluded from this study that Vit D alters the mRNA expression of <i>Ace2, Tmprss</i>, and <i>Ctsl</i> genes in the mouse lungs. This finding can help us in understanding, at least in part, the molecular influence of Vit D on genes involved in the entry of SARS-CoV-2 into the cells.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fc/19/ZLJM_17_2054111.PMC8942545.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40309493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a structured health education on prevention of HIV risky behaviours among adolescents in Nigeria - a pragmatic randomized controlled trial.","authors":"Ijeoma O Maduakolam,&nbsp;Ngozi P Ogbonnaya,&nbsp;Ifeoma F Ndubuisi,&nbsp;Echezona N D Ekechukwu,&nbsp;Ijeoma L Okoronkwo,&nbsp;Obinna Onwujekwe","doi":"10.1080/19932820.2022.2128414","DOIUrl":"https://doi.org/10.1080/19932820.2022.2128414","url":null,"abstract":"<p><p>Infection with HIV/AIDS continues to be a major public health concern around the world, particularly in low- and middle-income nations. To assess the effectiveness of structured health education on the prevention of HIV/AIDS risky behaviours among adolescents in secondary school. A pretest-posttest-control group randomized controlled trial where a sample of 647 adolescents was drawn from the population of 2,890 secondary school students and was block-randomized into the intervention (n = 400) and control (n = 224) groups. Data were collected using a content-validated (CVI = 4.2/5) and reliable (k = 0.791) self-developed structured questionnaire. Data were analyzed using descriptive statistics and with inferential statistics of independent and paired t-tests at α = 0.05. Pre-intervention risky behaviours in both groups were below average though lower in the intervention than in the control group. Pre-intervention risky behaviour was significantly higher among males than females in the rural school (p < 0.001) and in both schools together (p < 0.001). Health education significantly affected risky behaviour with the intervention group being associated with lesser risky behaviour than the control group. There was no significant difference in the post-intervention risky behaviour between males and females in the rural (0.285), urban (0.179) and both schools together (p = 0.956). Post-intervention reduced risky behaviours more significantly in the intervention than in the control groups. HIV/AIDS health education should be part of schools' curriculum, guidance and counsellor teachers should be trained as HIV counsellors.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0c/cf/ZLJM_17_2128414.PMC9543117.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40386157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General practitioners should provide the cardiorespiratory rehabilitation' 'minimum advice' for long COVID-19 patients.","authors":"Wafa Benzarti, Emna Toulgui, Christian Prefaut, Karim Chamari, Helmi Ben Saad","doi":"10.1080/19932820.2021.2009101","DOIUrl":"10.1080/19932820.2021.2009101","url":null,"abstract":"","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cc/70/ZLJM_17_2009101.PMC8635671.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39673774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient safety in medical education: Tunisian students' attitudes.","authors":"Olfa Ezzi,&nbsp;Mohamed Mahjoub,&nbsp;Nihel Omri,&nbsp;Asma Ammar,&nbsp;Dorra Loghmari,&nbsp;Souhir Chelly,&nbsp;Abir Mtira,&nbsp;Sana Rhimi,&nbsp;Mansour Njah","doi":"10.1080/19932820.2022.2122159","DOIUrl":"https://doi.org/10.1080/19932820.2022.2122159","url":null,"abstract":"<p><p>Health care delivery continues to be unsafe despite major patient safety (PS) improvement efforts over the past decade. Medical school education plays an important role in promoting this culture during initial training. To determine undergraduate medical students' attitudes toward PS at a Tunisian medical school. We carried out a cross-sectional study among undergraduate medical students at Ibn Al Jazzar Medical School in Sousse, Tunisia, using a self-administered questionnaire inspired from the valid tool: Attitudes to Patient Safety Questionnaire (APSQ III). A total of 178 medical students responded to the questionnaire. Medical students tend to have an overall positive perceptions of PS culture with a global mean score 5.33 ± 0.5. Among the individual domains 'Working hours as a cause of error' earned the highest score (6.38 ± 1.0) followed in order by 'Team functioning' (6.24 ± 0.8), 'Error inevitability' (5.91 ± 1.0) and 'Patient involvement in reducing error' (5.50 ± 1.0). The lowest score was for 'Professional incompetence as a cause of error' (4.01 ± 1.0). A PS domain's mean scores comparison based on socio-demographic variables: gender, age, academic year and on PS training revealed a statistically significant difference (p < 0.05) for five PS key dimensions: ' Error reporting confidence ', ' Working hours as a cause of error ', ' Professional incompetence as a cause of error ', ' Team functioning ' and 'PS training received'. Tunisian medical students showed positive attitude towards PS. Nevermore, intensive in terms of frequency and duration sessions, based on various teaching methods may be needed to fulfill students' educational needs.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/af/ZLJM_17_2122159.PMC9481112.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33462490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parents' concerns and attitudes towards school reopening during COVID-19 pandemic: a cross-sectional survey-Tripoli, Libya, 2021.","authors":"Mwada Jallul, Nada Elgriw, Farag I Eltaib, Samira M Al Dwigen, Asma Elfallah, Hajer M Elgheriani, Wafeya S Atwear, Mohamed Burid Milad, Inas M Alhudiri, Adam Elzagheid","doi":"10.1080/19932820.2022.2087847","DOIUrl":"10.1080/19932820.2022.2087847","url":null,"abstract":"<p><p>The issue of school reopening has raised several concerns; therefore, the parent's opinion is essential to consider. This study aimed to evaluate the parent's attitudes and concerns toward school reopening in the COVID-19 era. A cross-sectional survey was performed using in-person self-administered questionnaires, the data was collected in the period between January and April 2021 covering parents' concerns and attitudes toward school reopening. A total of 402 parents participated in the survey. Analysis showed that 56.7% of parents have agreed with school reopening, but 54% have raised some legitimate concerns. Importantly, there was a strong correlation between parents' opinions towards school reopening and their level of education, and their concerns about their children's safety if the school was reopened. Despite parents' concerns, it does seem that slightly over half were in favour of school reopening and would send their children to school only if the schools did apply strict precautions and restriction measures. Sharing parents' views toward school reopening with school leaders and decision-makers is important to assess the feasibility and effectiveness of return to schools and to improve existing prevention programs.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/8f/ZLJM_17_2087847.PMC9262368.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40473369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptoms at disease onset predict prognosis in COVID-19 disease.","authors":"Aiyuan Zhou,&nbsp;Qing Song,&nbsp;Yating Peng,&nbsp;Xin Liao,&nbsp;Peng Huang,&nbsp;Wenlong Liu,&nbsp;Zhi Xiang,&nbsp;Qimi Liu,&nbsp;Mingyan Jiang,&nbsp;Xudong Xiang,&nbsp;Dingding Deng,&nbsp;Ping Chen","doi":"10.1080/19932820.2021.2010338","DOIUrl":"https://doi.org/10.1080/19932820.2021.2010338","url":null,"abstract":"<p><p>The main clinical manifestations of coronavirus disease 2019 (COVID-19) onset are respiratory symptoms, including cough, sputum, and dyspnea. However, a significant proportion of patients initially manifested non-respiratory symptoms, such as fever, myalgia, and diarrhea. Here, we compared the different characteristics and outcomes between the patients with respiratory symptoms and non-respiratory symptoms at illness onset. The patients admitted to the respiratory departments from eight hospitals in Hunan and Guangxi Province with nucleic acid-positive severe acute respiratory syndrome coronavirus (SARS-CoV-2) were recruited. Epidemiological information, clinical manifestations, laboratory findings, and radiological characteristics, treatment regimens, and outcomes data were recorded and analyzed. The median age of the recruited 541 subjects was 43 years (IQR, 33-55). Of the 541 subjects, 404 (74.5%) subjects had initial symptom that were respiratory, while 137 (25.5%) subjects had non-respiratory symptoms. Respiratory COVID-19 subjects had more secondary bacterial infections (8.7% vs 0.0%, <i>P</i> < 0.001), needed the intensive care unit more (9.7% vs 2.2%, <i>P</i> = 0.005), non-invasive ventilation more (7.2% vs 1.5%, <i>P</i> = 0.004), developed ARDS more (11.4% vs 2.2%, <i>P</i> = 0.001) and needed longer time to recover (18.5 vs 16.7 days, <i>P</i> = 0.003) compared to predominately non-respiratory COVID-19 subjects. The multivariate model showed that age (OR = 1.04, <i>P</i> = 0.01), dyspnea (OR = 4.91, <i>P</i> < 0.001) and secondary bacterial infection (OR = 19.8, <i>P</i> < 0.001) were independently associated with development of ARDS among COVID-19 patients. We identify COVID-19 subjects with dyspnea at disease onset who have a worse prognosis. We also demonstrate age and secondary bacterial infections to be independently associated with ARDS development in subjects with COVID-19.<b>ABBREVIATIONS</b>: COVID-19: Coronavirus disease 2019; ARDS: acute respiratory distress syndrome; IQR: interquartile range; ICU: intensive care unit; CDC: Chinese Center for Disease Control and Prevention.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fb/92/ZLJM_17_2010338.PMC8725726.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9835282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of perinatal depression among working pregnant women: a hospital-based cross-sectional study.","authors":"Abdallah Jihed,&nbsp;Mohamed Ben Rejeb,&nbsp;Houyem Said Laatiri,&nbsp;Chekib Zedini,&nbsp;Manel Mallouli,&nbsp;Ali Mtiraoui","doi":"10.1080/19932820.2022.2114182","DOIUrl":"https://doi.org/10.1080/19932820.2022.2114182","url":null,"abstract":"<p><p>Perinatal depression is a major public health problem having serious negative impacts on personal, family, and child developmental outcomes. This study aimed to determine the prevalence of major depressive disorder (MDD) and its associated factors in working pregnant women. This descriptive, cross-sectional study was performed on 389 working pregnant women enrolled from four Tunisian public maternity hospitals. Data collection tools were the sociodemographic, obstetric, family relationships, and work environment questionnaire, and the Center for Epidemiologic Studies Depression Scale (CES-D). The mean score of depression was 27.39 ± 6.97 and 76.1% of women had major depressive symptoms using cutoff points on the CES-D ≥ 23. Family income, diagnosis with a chronic illness, history of depression, and employment categories were associated with major depressive symptoms. In multivariate analyses, family income and work posture were significantly associated with MDD. These results suggest an increased burden of MDD during pregnancy in Tunisian women. Prevention, early detection, and interventions are needed to reduce the prevalence of perinatal depression.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bc/f4/ZLJM_17_2114182.PMC9415599.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40438037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical prognosis after idiopathic macular hole surgery: machine learning based-predection.","authors":"Hsouna Zgolli,&nbsp;Hamad H K El Zarrug,&nbsp;Moufid Meddeb,&nbsp;Sonya Mabrouk,&nbsp;Nawres Khlifa","doi":"10.1080/19932820.2022.2034334","DOIUrl":"https://doi.org/10.1080/19932820.2022.2034334","url":null,"abstract":"<p><p>To develop a machine learning (ML) model for the prediction of the idiopathic macular hole (MH) status at 9 months after vitrectomy and inverted flap internal limiting membrane (ILM) peeling surgery. This single center was conducted at Department A, Institute Hedi Raies of Ophthalmology, Tunis, Tunisia. The study included 114 patients. In total, 120 eyes underwent optical coherence tomography (OCT) and inverted flap ILM peeling for surgery. Then 510 B scan of macular OCT was acquired 9 months after surgery. MH diameter, basal MH diameter (b), nasal and temporal arm lengths and macular hole angle were measured. Indices including hole form factor, MH index, diameter hole index (DHI) and tractional hole, MH area index and MH volume index were calculated. Receiver operating characteristic (ROC) curves and cut‑off values were derived for each indices predicting closure or not of the MH. The area under the receiver operating characteristic curve (AUC) and kappa value were calculated to evaluate performance of the medical decision support system (MDSS) in predicting the MH closure. From the ROC curve analysis, it was derived that MH indices like MH diameter, diameter hole index (DHI), MH index, and hole formation factor were capable of successfully predicting MH closure while basal diameter, DHI and MH area index predicted none closure MH. The MDSS achieved an AUC of 0.984 with a kappa value of 0.934. Based on the preoperative OCT parameters, our ML model achieved remarkable accuracy in predicting MH outcomes after pars plana vitrectomy and inverted flap ILM peeling. Therefore, MDSS may help optimize surgical planning for full thickness macular hole patients in the future.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fa/e0/ZLJM_17_2034334.PMC8865103.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39644183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health status in individuals with Down syndrome.","authors":"Roba Elrefadi,&nbsp;Hawwa Beaayou,&nbsp;Khadiga Herwis,&nbsp;Ahmed Musrati","doi":"10.1080/19932820.2022.2116794","DOIUrl":"https://doi.org/10.1080/19932820.2022.2116794","url":null,"abstract":"<p><p>Down syndrome (DS) is a neurodevelopmental disorder of known genetic cause, with a wide array of oral and systemic manifestations. The aim of the present study is to determine the level of oral hygiene status and practice of a group of individuals with DS in Benghazi/Libya. In this cross-sectional study 124 individuals were recruited from The Rehabilitation Centre of Special Needs in the city of Benghazi, Libya. Questionnaires were distributed among the attendees, covering oral health aspects and diet habits. Oral examination was conducted to evaluate oral health status among individuals with DS. The data were analysed descriptively and inferentially (including Chi-square test and Fisher's exact test) using the Statistical Package for Social Science version 20 (SPSS). Most of DS individuals brush their teeth once daily (62%), spending less than one minute in brushing (44%). For diet habits, more than half (55%) eat sweet snacks between meals. For the dental status, 47% of the subject had zero DMFT, followed by score 2 in 21%. The highest percentage in Oral hygiene Index (OHI) was scored 1 by 46% of participants. The zero CPITN score was seen in 54.5%. Our results have shown a weaker tendency of DS towards oral hygiene. This should strengthen our goal of guiding and encouraging parents of individuals with DS to be more cautious in providing help and supervision of their individuals' practice of oral health care.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8a/26/ZLJM_17_2116794.PMC9448436.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33447467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variant-specific RT-qPCR for rapid screening of B.1.617 mutations in SARS-CoV-2.","authors":"Mwada Jallul, Khaled Ibrahim, Ahmed Zaghdani, Mohamed Musbah Abdusalam, Samira M Al Dwigen, Wafya S Atwair, Mohamed Elbasir, Inas Alhudiri, Salah Edin El Meshri, Adam Elzagheid","doi":"10.1080/19932820.2022.2121252","DOIUrl":"10.1080/19932820.2022.2121252","url":null,"abstract":"<p><p>The continuous emergence of new SARS-CoV-2 variants required rapid and reliable diagnostic methods for early detection and monitoring of the spread of the virus, especially in low-resource countries where whole genome sequencing is not available. We aimed to evaluate and compare the performance of two different RT-qPCR screening assays for the detection of B.1.617 lineage mutations. A total of 85 SARS-CoV-2 positive samples were collected between 9^th August and 10 September 2021 and screened by two mutation-specific RT-qPCR assays for simultaneous detection of B.1.617.1 and B.1.617.2 lineage mutations. VIASURE Variant II PCR assay identified 2 Delta variant-specific mutations (L452R, and P681 R) in 80% of tested samples, while the PKamp™ Variant Detect™ assay was only able to detect one Delta variant specific mutation (L452R) in 75% of tested samples. This is the first report to show the Delta variant as the cause of the third wave in Libya. The use of multiplex RT-qPCR assays has allowed the identification of new variants for rapid screening. However, RT-qPCR results should be confirmed by whole genome sequencing of SARS-COV-2.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8e/a6/ZLJM_17_2121252.PMC9467536.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40351830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}