Prognostic value of glucose transporter proteins-1 (GLUT1) in breast carcinoma.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-12-01 Epub Date: 2023-11-21 DOI:10.1080/19932820.2023.2283953

Mehenaz Hanbazazh, Abdulhadi Samman, Saad Samargandy, Jaudah Al-Maghrabi

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Abstract

Several studies have reported increased glucose transporters (GLUT) expression in different cancer types, including breast cancer. The primary purpose of this study is to examine GLUT1 immunoexpression in breast cancer patients in Saudi Arabia and to determine its significance. The study examined the association between GLUT1 immunophenotype and the clinicopathological characteristics in breast cancer. GLUT1 expression was analyzed in retrospectively collected tissue samples (n = 578) from breast cancer patients using immunohistochemistry. A total of 311 (54%) of the cases expressed GLUT1 cytoplasmic immunohistochemical staining. In univariate analysis, we found a significant association between GLUT1 expression and high-grade tumors (p < 0.0001). Positive estrogen and progesterone receptor results predicted lower GLUT1 immunoexpression (p < 0.0001 for both). Vascular invasion showed a significant association with GLUT1 immunoexpression (p = 0.045). Our findings support that GLUT1 immunohistochemistry can be used as a marker to determine the grade and hormonal receptor status in breast cancer.

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葡萄糖转运蛋白1 (GLUT1)在乳腺癌中的预后价值。

一些研究报道了葡萄糖转运蛋白(GLUT)在不同类型的癌症(包括乳腺癌)中的表达增加。本研究的主要目的是检测GLUT1免疫在沙特阿拉伯乳腺癌患者中的表达，并确定其意义。本研究探讨了GLUT1免疫表型与乳腺癌临床病理特征之间的关系。应用免疫组织化学方法对回顾性收集的578例乳腺癌患者组织样本中GLUT1的表达进行分析。共有311例(54%)患者表达GLUT1细胞质免疫组化染色。在单因素分析中，我们发现GLUT1表达与高级别肿瘤之间存在显著关联(p < 0.0001)。雌激素和孕激素受体阳性预测GLUT1免疫表达降低(两者p < 0.0001)。血管侵袭与GLUT1免疫表达显著相关(p = 0.045)。我们的研究结果支持GLUT1免疫组化可以作为乳腺癌分级和激素受体状态的标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.