Libyan Journal of Medicine最新文献

{"title":"Teaching empathy in Balint groups.","authors":"Mirjana Stojanović-Tasić, Milan Latas, Emilija Novaković, Marija Milić, Mirjana Virijević, Kristina Rakić, Nenad Milošević, Jovana Milošević, Jelena Aritonović Pribaković, Suzana Adžić, Romana Petrović, Milica Popović Radovanović, Mary Vukša, Danijela Ilić, Milica Bogdanović, Biljana Trajković, Andrija Milović","doi":"10.1080/19932820.2026.2651993","DOIUrl":"10.1080/19932820.2026.2651993","url":null,"abstract":"<p><p>The aim of this study was to examine whether participation in Balint groups is associated with higher levels of empathy among physicians. This study was carried out with a sample of 210 physicians working in primary health centers in Belgrade. Among them, 70 doctors had completed Balint training lasting at least one year, while the remaining 140 doctors had never participated in such training (the non-Balint group). Empathy levels among doctors were assessed using the Interpersonal Reactivity Index (IRI), an evaluation scale developed by Davis that consists of four subscales: perspective taking, fantasy, empathic concern, and personal distress. We found that physicians who completed Balint training had significantly higher scores on the perspective taking, fantasy, and empathic concern subscales compared to those who did not complete the training (<i>p </i>< 0.001). Regarding the personal distress subscale, there was no statistically significant difference between the two groups of physicians (<i>p</i>= 0.530). In the multivariate logistic regression models, participation in the Balint group emerged as the only significant predictor for the perspective taking and empathic concern subscales (<i>p </i>< 0.001), while for the fantasy subscale, both participation in the Balint group and being a medical specialist were identified as significant predictors. Participation in Balint groups is significantly associated with higher levels of empathy among physicians.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":"21 1","pages":"2651993"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, risk factors, management strategies and consequences of work-related musculoskeletal disorders among dental students and professionals in Makkah, Saudi Arabia: a cross-sectional study.","authors":"Afnan Anas Nassar, Khalid Talal Aboalshamat, Salma Saleh Albaqaawi, Rania Abdullah Alosaimi, Aseel Ahmed Almalki, Abrar Yousef Baitalmal","doi":"10.1080/19932820.2026.2651992","DOIUrl":"10.1080/19932820.2026.2651992","url":null,"abstract":"<p><p>Work-related musculoskeletal disorders (WRMSDs) refer to injuries or conditions that affect the muscles, tendons, nerves, and other components of the musculoskeletal system, often resulting from repetitive movements, sustained static postures, or prolonged periods of sitting and standing. Dental professionals and students are particularly susceptible due to the physically demanding nature of clinical practice. These disorders can adversely affect professional performance, productivity, and overall quality of life. The present study aimed to determine the prevalence, associated risk factors, and potential consequences of WRMSDs among dental students and professionals at Umm Al-Qura University, Makkah, Saudi Arabia. A cross-sectional survey was conducted among dental students and professionals at Umm Al-Qura University. Data were collected using a self-administered, structured online questionnaire designed to assess the prevalence of WRMSDs, associated risk factors, and management strategies. Statistical analysis was performed using IBM SPSS Statistics software, with the level of significance set at <i>p</i> < 0.05. Among the respondents, 67.8% were under 25 years of age, and 59.8% were female. More than half (55.6%) reported experiencing WRMSD symptoms in at least one body region during the past year, with 36.8% indicating chronic pain. The most commonly affected areas were the neck (56.9%), and lower back (52.3%). The leading contributing factors were inappropriate posture (44.8%) and prolonged sitting (29.7%). The most affected quality-of-life domains included increased stress and anxiety (33.1%), sleep disturbances (30.0%), and reduced academic or occupational performance (25.0%). Despite the high prevalence, 77% of participants did not seek professional care. The most frequently reported pain management strategies were the use of analgesics (31.4%) and engagement in physical activity (29.3%). This study demonstrates a high burden of WRMSDs among dental students and professionals, with symptoms primarily affecting the neck and lower back. Incorporating ergonomic training and structured occupational health programs into dental education and clinical practice may reduce long-term functional impairment and improve overall well-being.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":"21 1","pages":"2651992"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13034702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate post-denudation intracytoplasmic sperm injection is associated with higher fertilization and early cleavage-stage embryo yield: a prospective sibling-oocyte cohort from Libyan ICSI cycles.","authors":"Najwa A Mahmoud, Muetaz M Feetouri, Mohamed K Elkawafi, Omar S Alqabbasi, Mahmoud A Aloriby, Tarek S Bader, Yousef M Hasen, Ali M Milad, Mosaab S Abdulkarim, Farag A Bleiblo","doi":"10.1080/19932820.2026.2666920","DOIUrl":"10.1080/19932820.2026.2666920","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Intracytoplasmic sperm injection (ICSI) has become an integral practice in assisted reproduction technology (ART), but the optimal time interval between oocyte denudation (DN) and ICSI is still not well defined. Libya remains underrepresented in global fertility estimates, and prospective paired data on DN-to-ICSI timing from Libyan IVF practice are limited. We aimed to investigate whether performing ICSI immediately after DN, compared with an intended four-hour delay, affects pregnancy outcomes and early embryology yield. This prospective cohort study was conducted at the Fertility and Reproductive Medicine Center, Beirut Hospital, Benghazi and included 88 Libyan ICSI cycles. After enzymatic-mechanical DN using hyaluronidase, mature metaphase II (MII) oocytes were injected with selected sperm. Within each cycle, sibling MII oocytes were allocated in a 1:1 ratio to immediate ICSI or delayed ICSI after an intended interval of about four hours, using a computer-generated within-cycle allocation sequence. For clinical comparison, cycles were allocated by pre-generated permuted-block randomization to transfer blastocysts under one timing condition (44 cycles/arm). The primary outcome was normal fertilization (two pronuclei); secondary outcomes included cleavage (Day 3), blastulation and blastocyst quality (Day 5/6; Gardner-Schoolcraft), biochemical pregnancy and clinical pregnancy. Immediate DN-ICSI was significantly associated with higher fertilization rates than delayed injection (80.07% ± 17.09% vs 70.80% ± 17.37%; mean difference: 9.26, 95% CI 4.40-14.12; &lt;i&gt;p&lt;/i&gt; = 0.0003) and a higher cleavage rate (76.89% ± 17.03% vs 67.97% ± 18.47%; mean difference 8.93 points, 95% CI 3.59-14.26; &lt;i&gt;p&lt;/i&gt; = 0.0013). Biochemical pregnancy (40.9% vs 54.5%; &lt;i&gt;p&lt;/i&gt; = 0.200) and clinical pregnancy (29.5% vs 27.3%; &lt;i&gt;p&lt;/i&gt; = 0.813) did not differ significantly. These results suggest that a shorter DN-to-ICSI interval may improve fertilization and early embryo development, with no observed differences in blastulation or early pregnancy outcomes. Larger multicenter studies with cumulative live births are required to determine clinical relevance.Intracytoplasmic sperm injection (ICSI) has become an integral practice in assisted reproduction technology (ART), but the optimal time interval between oocyte denudation (DN) and ICSI is still not well defined. Libya remains underrepresented in global fertility estimates, and prospective paired data on DN-to-ICSI timing from Libyan IVF practice are limited. We aimed to investigate whether performing ICSI immediately after DN, compared with an intended four-hour delay, affects pregnancy outcomes and early embryology yield. This prospective cohort study was conducted at the Fertility and Reproductive Medicine Center, Beirut Hospital, Benghazi and included 88 Libyan ICSI cycles. After enzymatic-mechanical DN using hyaluronidase, mature metaphase II (MII) oocytes were injected with selected sperm. Within each cycle, sibl","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":"21 1","pages":"2666920"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unregulated use of <i>Artemisia</i> in cancer patients in Libya: an emerging ethical and public health concern.","authors":"Inas Alhudiri, Fawzi Ebrahim, Adam Elzagheid","doi":"10.1080/19932820.2025.2611580","DOIUrl":"10.1080/19932820.2025.2611580","url":null,"abstract":"<p><p>A concerning trend has recently emerged in Libya where cancer patients are seeking unproven herbal remedies derived from local Artemisia species driven by circulating claims on social media. These unregulated traditional medicines can interact with standard cancer treatments such as chemotherapy and radiation therapy. Scientific evidence suggests that <i>Artemisia</i> compounds can alter drug metabolism through enzymatic pathways (notably the CYP450 system), potentially neutralizing treatment efficacy or exacerbating systemic toxicity. This letter evaluates the toxicological profile of <i>Artemisia</i> and proposes an ethical framework for patient protection and public health intervention in Libya.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":"21 1","pages":"2611580"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12805842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective concordance of multidetector CT angiography and digital subtraction angiography in assessing bronchial artery morphology for hemoptysis embolization outcomes.","authors":"Somayeh Haji Ahmadi, Naeimeh Kardanpour, Mohammadreza Elhaie, Mohammad Saleh Jafarpisheh, Peyman Hashemi, Seyyed-Ali Alaei","doi":"10.1080/19932820.2026.2630407","DOIUrl":"10.1080/19932820.2026.2630407","url":null,"abstract":"<p><p>Hemoptysis, often life-threatening in its massive form, is predominantly caused by bronchial artery pathology. Bronchial artery embolization (BAE) is the established first-line intervention, yet the relationship between bronchial artery morphology and embolization outcomes remains insufficiently defined. This prospective pilot study aimed to assess the association between bronchial artery anatomical features and short-term outcomes following BAE, and to evaluate concordance between computed tomography (CT) angiography and digital subtraction angiography (DSA) in detecting hypertrophy and tortuosity. Twenty-eight patients with hemoptysis requiring BAE were prospectively enrolled in a cohort study. Baseline multidetector CT angiography characterized bronchial artery origin, diameter, hypertrophy, tortuosity, and systemic collaterals. All patients underwent DSA-guided BAE. Treatment success was defined as cessation of hemoptysis within 48 hours, with recurrence assessed at 30 days. Inter-modality agreement was measured using Cohen's kappa. Immediate success was achieved in 92.9% of cases, with recurrence observed in 14.3% at 30 days. No statistically significant associations were found between artery morphology and outcomes. Descriptive trends suggested higher recurrence in patients with systemic collaterals and smaller left bronchial artery diameters (<2 mm). Moderate agreement was observed between CT and DSA for hypertrophy detection (Kappa = 0.563 for right bronchial artery, 0.500 for left), while substantial agreement was found for tortuosity (Kappa = 0.710 and 0.774, respectively). CT angiography demonstrated moderate concordance with DSA for hypertrophy detection (Kappa = 0.563 for right bronchial artery, 0.500 for left), while substantial agreement was found for tortuosity (Kappa = 0.710 and 0.774, respectively). Bronchial artery morphology was not significantly predictive of short-term BAE outcomes, though systemic collaterals and small vessel diameters may contribute to recurrence risk. While moderate agreement limits CTA as a sole tool, it aids in identifying targets efficiently. Larger, multicenter studies are warranted to refine risk stratification and optimize hemoptysis management.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":"21 1","pages":"2630407"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12903930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of research quantity, quality, and impact in MENA research centers.","authors":"Amin Bredan","doi":"10.1080/19932820.2026.2626625","DOIUrl":"10.1080/19932820.2026.2626625","url":null,"abstract":"<p><p>Research performance in the Middle East and North Africa (MENA) is often assessed using national aggregates that mask substantial institutional variation. Evidence on how output, quality, and excellence relate to economic resources and institutional capacity across the region remains limited. Data from the SCImago Research Centers Rankings were used to analyze 321 non-university, non-health research centers across 22 MENA countries. Indicators included research output, Quality, Excellence, collaboration, innovation, and Institutional Citation Impact per researcher (ICI/T). Analyses were conducted at both country and institutional levels using descriptive statistics, correlation analysis, and clustering. The analysis reveals extreme heterogeneity within and across countries. National income is strongly associated with research Excellence but shows a much weaker relationship with baseline Quality. ICI/T is strongly associated with Excellence and displays reduced variance at higher values, indicating increasing stability of elite performance. Clustering identifies multiple tiers of research systems that cut across income categories. A small group of countries exhibits disproportionately high Excellence relative to weak institutional impact, consistent with structural decoupling. International collaboration supports Quality but does not predict Excellence, while regional and industry collaboration remain limited. Economic resources accelerate elite research performance but do not guarantee high baseline quality. Long-term research performance in the MENA region depends primarily on institutional alignment, governance, and sustained capacity building rather than output expansion alone.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":"21 1","pages":"2626625"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and impact of hyponatremia in chronic obstructive pulmonary disease. A systematic review and meta-analysis.","authors":"Purnima Adhikari, Raju Rana, Rohini Punja, Prakashini Koteshwar, Rahul Magazine, Mohan K Manu, Santa Kumar Das, Sharma Paudel, Chandni Gupta","doi":"10.1080/19932820.2026.2642904","DOIUrl":"10.1080/19932820.2026.2642904","url":null,"abstract":"<p><p>Hyponatremia has been found to be associated with chronic obstructive pulmonary disease (COPD) and acute exacerbations of chronic obstructive pulmonary disease (AECOPD). However, there is a lack of systematic evidence on the prevalence and impact of hyponatremia in COPD and AECOPD patients. We performed a systematic search on three major databases for articles published on or before 31 July 2025. We included all the studies reporting the prevalence or number of hyponatremia cases in COPD patients (stable and exacerbation) aged 18 years and above. Pooled prevalence was calculated by a random effects model using RStudio. The Joanna Briggs Institute (JBI) tool was used for quality evaluation of the included studies. In this systematic review and meta-analysis, we included 11 studies out of 284 studies retrieved in the initial search. Of these 11 studies, three were COPD studies, and eight were AECOPD studies. The pooled prevalence of hyponatremia among COPD patients was 14% (95% CI: 4%-28%), with significant heterogeneity (<i>I</i>² = 98.3%, <i>p </i>< 0.0001). The pooled prevalence of hyponatremia in AECOPD patients was 19% (95% CI: 9%-32%), with significant heterogeneity (<i>I</i>² = 98.8%, <i>p </i>< 0.0001). Most of the studies showed that hyponatremia was not associated with mortality as an outcome of AECOPD. This study found a high prevalence of hyponatremia in both COPD and AECOPD patients; however, substantial heterogeneity (<i>I</i>² > 98%) necessitates cautious interpretation of pooled estimates. Future studies with standardized diagnostic criteria and larger sample sizes are needed to establish more precise prevalence rates.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":"21 1","pages":"2642904"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-targeted pyrazole scaffolds: synthesis, mechanistic insights, and therapeutic potential in anticancer, antioxidant, and anti-inflammatory applications.","authors":"Suhailah S Aljameel, Mohamed E Eissa, Zinab Alatawi, Hanadi A Alahmadi, Mohammad E Azab, Tarek A Yousef, Sayed K Ramadan, Hasan A Aljohi, Eida S Al-Farraj, Eman Abdullah Bahattab, Ahmed Ghareeb, Eman A E El-Helw","doi":"10.1080/19932820.2026.2642992","DOIUrl":"10.1080/19932820.2026.2642992","url":null,"abstract":"<p><p>Pyrazole derivatives are a class of heterocyclic compounds known to have broad pharmacological effects. This study aimed to synthesize and characterize a new series of pyrazole derivatives and investigate their effects on a series of <i>in vitro</i> assays. Five synthesized compounds were confirmed structurally using standard spectroscopic techniques, and their cytotoxic activity was evaluated against HeLa cells using MTT assay and morphological examination of viability. DNA damage and fragmentation were analyzed using a comet assay, agarose gel electrophoresis, and diphenylamine reaction. Antioxidant properties were evaluated with radical scavenging assays, and anti-inflammatory potential was assessed with <i>in vitro</i> inhibition assays (COX-1/2). Pyrazolethione <b>5</b> showed antiproliferative effects at all concentrations, with preserved cell confluence at ≤62.5 µg/mL. It also demonstrates DPPH scavenging activity similar to that of ascorbic acid in a dose-dependent manner, reaching a maximum activity of 85.9% with an IC₅₀ of 48.77. In addition, it demonstrated antioxidant activity, although significantly lower than that of gallic acid, with a maximum scavenging percentage of 83.9% at 1000 μg/mL and an IC₅₀ of 54.97 μg/mL. In the comet assay, the treatment significantly increased DNA fragmentation to 26.2% ± 0.88% from 12.8% ± 0.77% in the control cells (<i>p </i>< 0.01), representing a two-fold induction of apoptosis. The test compound inhibited COX-1 in a dose-dependent manner (86.29% inhibition at 1000 µg/mL), producing an IC₅₀ value of 29.14 ± 0.97 µg/mL, while it produced moderate inhibition of COX-2, 82.03% inhibition at 1000 µg/mL, and had an IC₅₀ value of 51.49 ± 2.13 µg/mL. According to flow cytometry analysis, untreated HeLa cells were mainly in G1 (54.56%) and G0 (34.86%), with fewer cells in S (9.63%), and G2-M (0.94%). In pyrazolethione-treated HeLa cells, G0 accumulation (73.57%) and fewer proliferative phases (S 3.10% and G2-M 2.78%) indicated substantial alteration to the cell cycle. Pyrazolethione <b>5</b> demonstrates a favorable safety profile, with minimal cytotoxicity at lower concentrations, and impressive antioxidant and anti-inflammatory activities. The DPPH and gallic acid-like radical scavenging activities, moderate COX-1 and COX-2 inhibition, and DNA fragmentation suggest multiple bioactivities. Furthermore, the compound significantly altered cell cycle progression in HeLa cells, leading to G0/G1 arrest and reduced proliferation. Taken together, the data indicate pyrazolethione <b>5</b> is a potential lead compound for further development/investigation as an anticancer and anti-inflammatory agent with low toxicity.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":"21 1","pages":"2642992"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of EMMPRIN as a biomarker in nonodontogenic carcinomas: a histological study.","authors":"Ben Amer M Antisar, Omar M Enas, Elsheikh M Sahar, Musrati S Ahmed","doi":"10.1080/19932820.2025.2598896","DOIUrl":"10.1080/19932820.2025.2598896","url":null,"abstract":"<p><p>EMMPRIN is a widely distributed cell surface glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It induces the production of extracellular matrix metalloproteinases (MMPs) and plays an important role in angiogenesis via stimulation of vascular endothelial growth factor (VEGF). The aim of the present work was to assess and compare the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in different oral nonodontogenic carcinomas. Fifty-four diagnosed cases of oral nonodontogenic carcinomas were selected, and biopsies were taken from the tumor tissue, fixed, processed, and cut into sections to be stained with hematoxylin and eosin (H&E) for routine histopathological examination. Immunohistochemistry was performed for EMMPRIN. All cases showed positive EMMPRIN expression with different intensities. The results were recorded and statistically analyzed using student <i>t</i>-test, Pearson correlation, test and ANOVA test. This study concluded that elevated EMMPRIN expression is correlated with tumor proliferation, angiogenesis, metastasis, and invasion.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":"21 1","pages":"2598896"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12777829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145846895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of risk factors of breast cancer among women in Dodoma, Tanzania: a community-based cross-sectional study.","authors":"James J Yahaya, Angelina A Joho","doi":"10.1080/19932820.2026.2625359","DOIUrl":"10.1080/19932820.2026.2625359","url":null,"abstract":"<p><p>Assessment of risk factors of breast cancer in the general population provides insightful information towards prevention of breast cancer. This study aimed to assess the risk factors of breast cancer among women in a community from a resource-limited setting in sub-Saharan Africa. This descriptive community-based cross-sectional study was conducted in Dodoma, Tanzania, from July to December 2020. The study included women aged between 18 and 70 years. The data were analyzed using SPSS program version 25.0. Independent <i>t</i>-test was used to compare the mean age of the participants for the availability of risk factors of breast cancer. A two-tailed <i>p</i> < 0.05 was considered significant. A total of 354 women were analyzed, and the median age was 27.0 (23.0-35.3) years. Only 11.8% (<i>n</i> = 18) of all the participants did not have any of the risk factors examined. Not engaging in physical activity was the most frequent risk factor which accounted for 68.2% (<i>n</i> = 242) of all the participants. There were more 60.7% (<i>n</i> = 215) of the study participants with a low mean age (22.9 ± 3.5) who had more than 5 risk factors compared to 39.3% (<i>n</i> = 139) of the participants with a high mean age (25.3 ± 9.4) who had more than 5 risk factors, with no statistically significant difference (95% CI = 0.91-2.22, <i>p</i> = 0.31). There is a large proportion of women younger than 40 years in the population of Tanzanian women with many risk factors of breast cancer. This may contribute to the currently observed increase in the incidence of breast cancer in Tanzania for women aged less than 40 years. Therefore, there is an urgency for targeted awareness and screening for breast cancer among younger women in Tanzania so as to increase early detection and diagnosis.</p>","PeriodicalId":49910,"journal":{"name":"Libyan Journal of Medicine","volume":"21 1","pages":"2625359"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}