Lifetime Data Analysis最新文献

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A flexible time-varying coefficient rate model for panel count data. 面板计数数据的灵活时变系数率模型。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2024-10-01 Epub Date: 2024-05-28 DOI: 10.1007/s10985-024-09630-1
Dayu Sun, Yuanyuan Guo, Yang Li, Jianguo Sun, Wanzhu Tu
{"title":"A flexible time-varying coefficient rate model for panel count data.","authors":"Dayu Sun, Yuanyuan Guo, Yang Li, Jianguo Sun, Wanzhu Tu","doi":"10.1007/s10985-024-09630-1","DOIUrl":"10.1007/s10985-024-09630-1","url":null,"abstract":"<p><p>Panel count regression is often required in recurrent event studies, where the interest is to model the event rate. Existing rate models are unable to handle time-varying covariate effects due to theoretical and computational difficulties. Mean models provide a viable alternative but are subject to the constraints of the monotonicity assumption, which tends to be violated when covariates fluctuate over time. In this paper, we present a new semiparametric rate model for panel count data along with related theoretical results. For model fitting, we present an efficient EM algorithm with three different methods for variance estimation. The algorithm allows us to sidestep the challenges of numerical integration and difficulties with the iterative convex minorant algorithm. We showed that the estimators are consistent and asymptotically normally distributed. Simulation studies confirmed an excellent finite sample performance. To illustrate, we analyzed data from a real clinical study of behavioral risk factors for sexually transmitted infections.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":"721-741"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Call for papers for a special issue on survival analysis in artificial intelligence. 人工智能生存分析特刊征稿启事。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2024-10-01 Epub Date: 2024-10-16 DOI: 10.1007/s10985-024-09636-9
Xingqiu Zhao
{"title":"Call for papers for a special issue on survival analysis in artificial intelligence.","authors":"Xingqiu Zhao","doi":"10.1007/s10985-024-09636-9","DOIUrl":"10.1007/s10985-024-09636-9","url":null,"abstract":"","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":"853-854"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatiotemporal multilevel joint modeling of longitudinal and survival outcomes in end-stage kidney disease. 对终末期肾病的纵向和生存结果进行时空多层次联合建模。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2024-10-01 Epub Date: 2024-10-04 DOI: 10.1007/s10985-024-09635-w
Esra Kürüm, Danh V Nguyen, Qi Qian, Sudipto Banerjee, Connie M Rhee, Damla Şentürk
{"title":"Spatiotemporal multilevel joint modeling of longitudinal and survival outcomes in end-stage kidney disease.","authors":"Esra Kürüm, Danh V Nguyen, Qi Qian, Sudipto Banerjee, Connie M Rhee, Damla Şentürk","doi":"10.1007/s10985-024-09635-w","DOIUrl":"10.1007/s10985-024-09635-w","url":null,"abstract":"<p><p>Individuals with end-stage kidney disease (ESKD) on dialysis experience high mortality and excessive burden of hospitalizations over time relative to comparable Medicare patient cohorts without kidney failure. A key interest in this population is to understand the time-dynamic effects of multilevel risk factors that contribute to the correlated outcomes of longitudinal hospitalization and mortality. For this we utilize multilevel data from the United States Renal Data System (USRDS), a national database that includes nearly all patients with ESKD, where repeated measurements/hospitalizations over time are nested in patients and patients are nested within (health service) regions across the contiguous U.S. We develop a novel spatiotemporal multilevel joint model (STM-JM) that accounts for the aforementioned hierarchical structure of the data while considering the spatiotemporal variations in both outcomes across regions. The proposed STM-JM includes time-varying effects of multilevel (patient- and region-level) risk factors on hospitalization trajectories and mortality and incorporates spatial correlations across the spatial regions via a multivariate conditional autoregressive correlation structure. Efficient estimation and inference are performed via a Bayesian framework, where multilevel varying coefficient functions are targeted via thin-plate splines. The finite sample performance of the proposed method is assessed through simulation studies. An application of the proposed method to the USRDS data highlights significant time-varying effects of patient- and region-level risk factors on hospitalization and mortality and identifies specific time periods on dialysis and spatial locations across the U.S. with elevated hospitalization and mortality risks.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":"827-852"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unifying mortality forecasting model: an investigation of the COM–Poisson distribution in the GAS model for improved projections 统一死亡率预测模型:为改进预测而对 GAS 模型中 COM-Poisson 分布的研究
IF 1.3 3区 数学
Lifetime Data Analysis Pub Date : 2024-09-13 DOI: 10.1007/s10985-024-09634-x
Suryo Adi Rakhmawan, Tahir Mahmood, Nasir Abbas, Muhammad Riaz
{"title":"Unifying mortality forecasting model: an investigation of the COM–Poisson distribution in the GAS model for improved projections","authors":"Suryo Adi Rakhmawan, Tahir Mahmood, Nasir Abbas, Muhammad Riaz","doi":"10.1007/s10985-024-09634-x","DOIUrl":"https://doi.org/10.1007/s10985-024-09634-x","url":null,"abstract":"<p>Forecasting mortality rates is crucial for evaluating life insurance company solvency, especially amid disruptions caused by phenomena like COVID-19. The Lee–Carter model is commonly employed in mortality modelling; however, extensions that can encompass count data with diverse distributions, such as the Generalized Autoregressive Score (GAS) model utilizing the COM–Poisson distribution, exhibit potential for enhancing time-to-event forecasting accuracy. Using mortality data from 29 countries, this research evaluates various distributions and determines that the COM–Poisson model surpasses the Poisson, binomial, and negative binomial distributions in forecasting mortality rates. The one-step forecasting capability of the GAS model offers distinct advantages, while the COM–Poisson distribution demonstrates enhanced flexibility and versatility by accommodating various distributions, including Poisson and negative binomial. Ultimately, the study determines that the COM–Poisson GAS model is an effective instrument for examining time series data on mortality rates, particularly when facing time-varying parameters and non-conventional data distributions.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":"60 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142220139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Special issue dedicated to Mitchell H. Gail, M.D. Ph.D. 米切尔-盖尔医学博士特刊
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2024-07-01 Epub Date: 2024-06-24 DOI: 10.1007/s10985-024-09631-0
Mei-Ling Ting Lee
{"title":"Special issue dedicated to Mitchell H. Gail, M.D. Ph.D.","authors":"Mei-Ling Ting Lee","doi":"10.1007/s10985-024-09631-0","DOIUrl":"10.1007/s10985-024-09631-0","url":null,"abstract":"","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":"529-530"},"PeriodicalIF":1.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A constrained maximum likelihood approach to developing well-calibrated models for predicting binary outcomes. 开发校准良好的二元结果预测模型的受限最大似然法。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2024-07-01 Epub Date: 2024-05-08 DOI: 10.1007/s10985-024-09628-9
Yaqi Cao, Weidong Ma, Ge Zhao, Anne Marie McCarthy, Jinbo Chen
{"title":"A constrained maximum likelihood approach to developing well-calibrated models for predicting binary outcomes.","authors":"Yaqi Cao, Weidong Ma, Ge Zhao, Anne Marie McCarthy, Jinbo Chen","doi":"10.1007/s10985-024-09628-9","DOIUrl":"10.1007/s10985-024-09628-9","url":null,"abstract":"<p><p>The added value of candidate predictors for risk modeling is routinely evaluated by comparing the performance of models with or without including candidate predictors. Such comparison is most meaningful when the estimated risk by the two models are both unbiased in the target population. Very often data for candidate predictors are sourced from nonrepresentative convenience samples. Updating the base model using the study data without acknowledging the discrepancy between the underlying distribution of the study data and that in the target population can lead to biased risk estimates and therefore an unfair evaluation of candidate predictors. To address this issue assuming access to a well-calibrated base model, we propose a semiparametric method for model fitting that enforces good calibration. The central idea is to calibrate the fitted model against the base model by enforcing suitable constraints in maximizing the likelihood function. This approach enables unbiased assessment of model improvement offered by candidate predictors without requiring a representative sample from the target population, thus overcoming a significant practical challenge. We study theoretical properties for model parameter estimates, and demonstrate improvement in model calibration via extensive simulation studies. Finally, we apply the proposed method to data extracted from Penn Medicine Biobank to inform the added value of breast density for breast cancer risk assessment in the Caucasian woman population.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":"624-648"},"PeriodicalIF":1.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140877759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Competing risks and multivariate outcomes in epidemiological and clinical trial research. 流行病学和临床试验研究中的竞争风险和多变量结果。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2024-07-01 Epub Date: 2024-05-06 DOI: 10.1007/s10985-024-09629-8
R L Prentice
{"title":"Competing risks and multivariate outcomes in epidemiological and clinical trial research.","authors":"R L Prentice","doi":"10.1007/s10985-024-09629-8","DOIUrl":"10.1007/s10985-024-09629-8","url":null,"abstract":"<p><p>Data analysis methods for the study of treatments or exposures in relation to a clinical outcome in the presence of competing risks have a long history, often with inference targets that are hypothetical, thereby requiring strong assumptions for identifiability with available data. Here data analysis methods are considered that are based on single and higher dimensional marginal hazard rates, quantities that are identifiable under standard independent censoring assumptions. These lead naturally to joint survival function estimators for outcomes of interest, including competing risk outcomes, and provide the basis for addressing a variety of data analysis questions. These methods will be illustrated using simulations and Women's Health Initiative cohort and clinical trial data sets, and additional research needs will be described.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":"531-548"},"PeriodicalIF":1.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Bayesian quantile joint modeling of multivariate longitudinal and time-to-event data. 多变量纵向和时间到事件数据的贝叶斯量化联合建模。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2024-07-01 Epub Date: 2024-03-01 DOI: 10.1007/s10985-024-09622-1
Damitri Kundu, Shekhar Krishnan, Manash Pratim Gogoi, Kiranmoy Das
{"title":"A Bayesian quantile joint modeling of multivariate longitudinal and time-to-event data.","authors":"Damitri Kundu, Shekhar Krishnan, Manash Pratim Gogoi, Kiranmoy Das","doi":"10.1007/s10985-024-09622-1","DOIUrl":"10.1007/s10985-024-09622-1","url":null,"abstract":"<p><p>Linear mixed models are traditionally used for jointly modeling (multivariate) longitudinal outcomes and event-time(s). However, when the outcomes are non-Gaussian a quantile regression model is more appropriate. In addition, in the presence of some time-varying covariates, it might be of interest to see how the effects of different covariates vary from one quantile level (of outcomes) to the other, and consequently how the event-time changes across different quantiles. For such analyses linear quantile mixed models can be used, and an efficient computational algorithm can be developed. We analyze a dataset from the Acute Lymphocytic Leukemia (ALL) maintenance study conducted by Tata Medical Center, Kolkata. In this study, the patients suffering from ALL were treated with two standard drugs (6MP and MTx) for the first two years, and three biomarkers (e.g. lymphocyte count, neutrophil count and platelet count) were longitudinally measured. After treatment the patients were followed nearly for the next three years, and the relapse-time (if any) for each patient was recorded. For this dataset we develop a Bayesian quantile joint model for the three longitudinal biomarkers and time-to-relapse. We consider an Asymmetric Laplace Distribution (ALD) for each outcome, and exploit the mixture representation of the ALD for developing a Gibbs sampler algorithm to estimate the regression coefficients. Our proposed model allows different quantile levels for different biomarkers, but still simultaneously estimates the regression coefficients corresponding to a particular quantile combination. We infer that a higher lymphocyte count accelerates the chance of a relapse while a higher neutrophil count and a higher platelet count (jointly) reduce it. Also, we infer that across (almost) all quantiles 6MP reduces the lymphocyte count, while MTx increases the neutrophil count. Simulation studies are performed to assess the effectiveness of the proposed approach.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":"680-699"},"PeriodicalIF":1.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measurement error models with zero inflation and multiple sources of zeros, with applications to hard zeros. 零膨胀和多源零的测量误差模型,以及对硬零的应用。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.1007/s10985-024-09627-w
Anindya Bhadra, Rubin Wei, Ruth Keogh, Victor Kipnis, Douglas Midthune, Dennis W Buckman, Ya Su, Ananya Roy Chowdhury, Raymond J Carroll
{"title":"Measurement error models with zero inflation and multiple sources of zeros, with applications to hard zeros.","authors":"Anindya Bhadra, Rubin Wei, Ruth Keogh, Victor Kipnis, Douglas Midthune, Dennis W Buckman, Ya Su, Ananya Roy Chowdhury, Raymond J Carroll","doi":"10.1007/s10985-024-09627-w","DOIUrl":"10.1007/s10985-024-09627-w","url":null,"abstract":"<p><p>We consider measurement error models for two variables observed repeatedly and subject to measurement error. One variable is continuous, while the other variable is a mixture of continuous and zero measurements. This second variable has two sources of zeros. The first source is episodic zeros, wherein some of the measurements for an individual may be zero and others positive. The second source is hard zeros, i.e., some individuals will always report zero. An example is the consumption of alcohol from alcoholic beverages: some individuals consume alcoholic beverages episodically, while others never consume alcoholic beverages. However, with a small number of repeat measurements from individuals, it is not possible to determine those who are episodic zeros and those who are hard zeros. We develop a new measurement error model for this problem, and use Bayesian methods to fit it. Simulations and data analyses are used to illustrate our methods. Extensions to parametric models and survival analysis are discussed briefly.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":"600-623"},"PeriodicalIF":1.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the role of Volterra integral equations in self-consistent, product-limit, inverse probability of censoring weighted, and redistribution-to-the-right estimators for the survival function. 论 Volterra 积分方程在生存函数的自洽、乘积限制、反删减概率加权和向右再分布估计器中的作用。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2024-07-01 Epub Date: 2024-03-21 DOI: 10.1007/s10985-024-09623-0
Robert L Strawderman, Benjamin R Baer
{"title":"On the role of Volterra integral equations in self-consistent, product-limit, inverse probability of censoring weighted, and redistribution-to-the-right estimators for the survival function.","authors":"Robert L Strawderman, Benjamin R Baer","doi":"10.1007/s10985-024-09623-0","DOIUrl":"10.1007/s10985-024-09623-0","url":null,"abstract":"<p><p>This paper reconsiders several results of historical and current importance to nonparametric estimation of the survival distribution for failure in the presence of right-censored observation times, demonstrating in particular how Volterra integral equations help inter-connect the resulting estimators. The paper begins by considering Efron's self-consistency equation, introduced in a seminal 1967 Berkeley symposium paper. Novel insights provided in the current work include the observations that (i) the self-consistency equation leads directly to an anticipating Volterra integral equation whose solution is given by a product-limit estimator for the censoring survival function; (ii) a definition used in this argument immediately establishes the familiar product-limit estimator for the failure survival function; (iii) the usual Volterra integral equation for the product-limit estimator of the failure survival function leads to an immediate and simple proof that it can be represented as an inverse probability of censoring weighted estimator; (iv) a simple identity characterizes the relationship between natural inverse probability of censoring weighted estimators for the survival and distribution functions of failure; (v) the resulting inverse probability of censoring weighted estimators, attributed to a highly influential 1992 paper of Robins and Rotnitzky, were implicitly introduced in Efron's 1967 paper in its development of the redistribution-to-the-right algorithm. All results developed herein allow for ties between failure and/or censored observations.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":"649-666"},"PeriodicalIF":1.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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