Lifetime Data Analysis最新文献

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Shape-constrained estimation for current duration data in cross-sectional studies. 横断面研究中当前持续时间数据的形状约束估计。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2025-06-14 DOI: 10.1007/s10985-025-09658-x
Chi Wing Chu, Hok Kan Ling
{"title":"Shape-constrained estimation for current duration data in cross-sectional studies.","authors":"Chi Wing Chu, Hok Kan Ling","doi":"10.1007/s10985-025-09658-x","DOIUrl":"https://doi.org/10.1007/s10985-025-09658-x","url":null,"abstract":"<p><p>We study shape-constrained nonparametric estimation of the underlying survival function in a cross-sectional study without follow-up. Assuming the rate of initiation event is stationary over time, the observed current duration becomes a length-biased and multiplicatively censored counterpart of the underlying failure time of interest. We focus on two shape constraints for the underlying survival function, namely, log-concavity and convexity. The log-concavity constraint is versatile as it allows for log-concave densities, bi-log-concave distributions, increasing densities, and multi-modal densities. We establish the consistency and pointwise asymptotic distribution of the shape-constrained estimators. Specifically, the proposed estimator under log-concavity is consistent and tuning-parameter-free, thus circumventing the well-known inconsistency issue of the Grenander estimator at 0, where correction methods typically involve tuning parameters.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and analysis of individually randomized group-treatment trials with time to event outcomes. 随机分组治疗试验的设计和分析。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2025-06-03 DOI: 10.1007/s10985-025-09657-y
Sin-Ho Jung
{"title":"Design and analysis of individually randomized group-treatment trials with time to event outcomes.","authors":"Sin-Ho Jung","doi":"10.1007/s10985-025-09657-y","DOIUrl":"https://doi.org/10.1007/s10985-025-09657-y","url":null,"abstract":"<p><p>In a typical individually randomized group-treatment (IRGT) trial, subjects are randomized between a control arm and an experimental arm. While the subjects randomized to the control arm are treated individually, those in the experimental arm are assigned to one of clusters for group treatment. By sharing some common frailties, the outcomes of subjects in the same groups tend to be dependent, whereas those in the control arm are independent. In this paper, we consider IRGT trials with time to event outcomes. We modify the two-sample log-rank test to compare the survival data from TRGT trials, and derive its sample size formula. The proposed sample size formula requires specification of marginal survival distributions for the two arms, bivariate survival distribution and cluster size distribution for the experimental arm, and accrual period or accrual rate together with additional follow-up period. In a sample size calculation, either the cluster sizes are given and the number of clusters is calculated or the number of clusters is given at the time of study open and the required accrual period to determine the cluster sizes is calculated. Simulations and a real data example show that the proposed test statistic controls the type I error rate and the formula provides accurately powered sample sizes. Also proposed are optimal designs minimizing the total sample size or the total cost when the cost per subject is different between two treatment arms.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating network structures in recurrent event data with discrete observation times. 研究具有离散观测时间的循环事件数据中的网络结构。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2025-05-23 DOI: 10.1007/s10985-025-09656-z
Yufeng Xia, Yangkuo Li, Xiaobing Zhao, Xuan Xu
{"title":"Investigating network structures in recurrent event data with discrete observation times.","authors":"Yufeng Xia, Yangkuo Li, Xiaobing Zhao, Xuan Xu","doi":"10.1007/s10985-025-09656-z","DOIUrl":"https://doi.org/10.1007/s10985-025-09656-z","url":null,"abstract":"<p><p>To investigate pairwise interactions arising from recurrent event processes in a longitudinal network, the framework of the stochastic block model is followed, where every node belongs to a latent group and interactions between node pairs from two specified groups follow a conditional nonhomogeneous Poisson process. Our focus lies on discrete observation times, which are commonly encountered in reality for cost-saving purposes. The variational EM algorithm and variational maximum likelihood estimation are applied for statistical inference. A specific method based on the defined distribution function F and self-consistency algorithm for recurrent events is used when estimating the intensity functions of edges. Numerical simulations illustrate the performance of our proposed estimation procedure in uncovering the underlying structure in the longitudinal networks with recurrent event processes. The dataset of interactions between French schoolchildren for influenza monitoring is analyzed.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regression analysis of a graphical proportional hazards model for informatively left-truncated current status data. 信息左截断当前状态数据的图形比例风险模型的回归分析。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2025-05-10 DOI: 10.1007/s10985-025-09655-0
Mengyue Zhang, Shishu Zhao, Shuying Wang, Xiaolin Xu
{"title":"Regression analysis of a graphical proportional hazards model for informatively left-truncated current status data.","authors":"Mengyue Zhang, Shishu Zhao, Shuying Wang, Xiaolin Xu","doi":"10.1007/s10985-025-09655-0","DOIUrl":"https://doi.org/10.1007/s10985-025-09655-0","url":null,"abstract":"<p><p>In survival analysis, researchers commonly focus on variable selection issues in real-world data, particularly when complex network structures exist among covariates. Additionally, due to factors such as data collection costs and delayed entry, real-world data often exhibit censoring and truncation phenomena.This paper addresses left-truncated current status data by employing a copula-based approach to model the relationship between censoring time and failure time. Based on this, we investigate the problem of variable selection in the context of complex network structures among covariates. To this end, we integrate Markov Random Field (MRF) with the Proportional Hazards (PH) model, and extend the latter to more flexibly characterize the correlation structure among covariates. For solving the constructed model, we propose a penalized optimization method and utilize spline functions to estimate the baseline hazard function. Through numerical simulation experiments and case studies of clinical trial data, we comprehensively evaluate the effectiveness and performance of the proposed model and its parameter inference strategy. This evaluation not only demonstrates the robustness of the proposed model in handling complex disease data but also further verifies the high precision and reliability of the parameter estimation method.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrative analysis of high-dimensional RCT and RWD subject to censoring and hidden confounding. 高维RCT与RWD的综合分析。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2025-04-29 DOI: 10.1007/s10985-025-09654-1
Xin Ye, Shu Yang, Xiaofei Wang, Yanyan Liu
{"title":"Integrative analysis of high-dimensional RCT and RWD subject to censoring and hidden confounding.","authors":"Xin Ye, Shu Yang, Xiaofei Wang, Yanyan Liu","doi":"10.1007/s10985-025-09654-1","DOIUrl":"https://doi.org/10.1007/s10985-025-09654-1","url":null,"abstract":"<p><p>In this study, we focus on estimating the heterogeneous treatment effect (HTE) for survival outcome. The outcome is subject to censoring and the number of covariates is high-dimensional. We utilize data from both the randomized controlled trial (RCT), considered as the gold standard, and real-world data (RWD), possibly affected by hidden confounding factors. To achieve a more efficient HTE estimate, such integrative analysis requires great insight into the data generation mechanism, particularly the accurate characterization of unmeasured confounding effects/bias. With this aim, we propose a penalized-regression-based integrative approach that allows for the simultaneous estimation of parameters, selection of variables, and identification of the existence of unmeasured confounding effects. The consistency, asymptotic normality, and efficiency gains are rigorously established for the proposed estimate. Finally, we apply the proposed method to estimate the HTE of lobar/sublobar resection on the survival of lung cancer patients. The RCT is a multicenter non-inferiority randomized phase 3 trial, and the RWD comes from a clinical oncology cancer registry in the United States. The analysis reveals that the unmeasured confounding exists and the integrative approach does enhance the efficiency for the HTE estimation.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantile regression under dependent censoring with unknown association. 关联未知的相关审查下的分位数回归。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2025-04-01 Epub Date: 2025-03-16 DOI: 10.1007/s10985-025-09647-0
Myrthe D'Haen, Ingrid Van Keilegom, Anneleen Verhasselt
{"title":"Quantile regression under dependent censoring with unknown association.","authors":"Myrthe D'Haen, Ingrid Van Keilegom, Anneleen Verhasselt","doi":"10.1007/s10985-025-09647-0","DOIUrl":"10.1007/s10985-025-09647-0","url":null,"abstract":"<p><p>The study of survival data often requires taking proper care of the censoring mechanism that prohibits complete observation of the data. Under right censoring, only the first occurring event is observed: either the event of interest, or a competing event like withdrawal of a subject from the study. The corresponding identifiability difficulties led many authors to imposing (conditional) independence or a fully known dependence between survival and censoring times, both of which are not always realistic. However, recent results in survival literature showed that parametric copula models allow identification of all model parameters, including the association parameter, under appropriately chosen marginal distributions. The present paper is the first one to apply such models in a quantile regression context, hence benefiting from its well-known advantages in terms of e.g. robustness and richer inference results. The parametric copula is supplemented with a likewise parametric, yet flexible, enriched asymmetric Laplace distribution for the survival times conditional on the covariates. Its asymmetric Laplace basis provides its close connection to quantiles, while the extension with Laguerre orthogonal polynomials ensures sufficient flexibility for increasing polynomial degrees. The distributional flavour of the quantile regression presented, comes with advantages of both theoretical and computational nature. All model parameters are proven to be identifiable, consistent, and asymptotically normal. Finally, performance of the model and of the proposed estimation procedure is assessed through extensive simulation studies as well as an application on liver transplant data.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":"253-299"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lifetime analysis with monotonic degradation: a boosted first hitting time model based on a homogeneous gamma process. 具有单调退化的寿命分析:一种基于均匀伽马过程的改进的首次撞击时间模型。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2025-04-01 Epub Date: 2025-04-05 DOI: 10.1007/s10985-025-09648-z
Clara Bertinelli Salucci, Azzeddine Bakdi, Ingrid Kristine Glad, Bo Henry Lindqvist, Erik Vanem, Riccardo De Bin
{"title":"Lifetime analysis with monotonic degradation: a boosted first hitting time model based on a homogeneous gamma process.","authors":"Clara Bertinelli Salucci, Azzeddine Bakdi, Ingrid Kristine Glad, Bo Henry Lindqvist, Erik Vanem, Riccardo De Bin","doi":"10.1007/s10985-025-09648-z","DOIUrl":"10.1007/s10985-025-09648-z","url":null,"abstract":"<p><p>In the context of time-to-event analysis, First hitting time methods consider the event occurrence as the ending point of some evolving process. The characteristics of the process are of great relevance for the analysis, which makes this class of models interesting and particularly suitable for applications where something about the degradation path is known. In cases where the degradation can only worsen, a monotonic process is the most suitable choice. This paper proposes a boosting algorithm for first hitting time models based on an underlying homogeneous gamma process to account for the monotonicity of the degradation trend. The predictive power and versatility of the algorithm are shown with real data examples from both engineering and biomedical applications, as well as with simulated examples.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":"300-339"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total time on test-based goodness-of-fit statistics for the reciprocal property in fatigue-life models. 疲劳寿命模型中互反特性的基于试验的拟合优度统计的总时间。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2025-04-01 Epub Date: 2025-04-26 DOI: 10.1007/s10985-025-09653-2
Cecilia Castro, Marta Azevedo, Víctor Leiva, Luís Meira-Machado
{"title":"Total time on test-based goodness-of-fit statistics for the reciprocal property in fatigue-life models.","authors":"Cecilia Castro, Marta Azevedo, Víctor Leiva, Luís Meira-Machado","doi":"10.1007/s10985-025-09653-2","DOIUrl":"https://doi.org/10.1007/s10985-025-09653-2","url":null,"abstract":"<p><p>We propose a new goodness-of-fit procedure designed to verify the reciprocal property that characterizes the fatigue-life or Birnbaum-Saunders (BS) distribution. Under this property, scaling a random variable that takes positive values by its median results in the same distribution as its reciprocal, a feature frequently encountered in reliability and survival studies. Our procedure employs total time on test (TTT) curves to compare the behavior of the observed data and its reciprocal counterpart, capturing both local and global discrepancies through supremum- and area-based statistics. We establish the theoretical validity of these statistics under mild assumptions, showing that they deliver accurate inference for moderate to large samples. Simulation evidence indicates that our TTT-based procedures are sensitive to subtle departures from log-symmetry, particularly when the distribution underlying the data has heavier or lighter tails than the assumed one. Illustrative real data examples further reveal how overlooking deviations from the reciprocal property can distort reliability estimates and predictions of failure times, showing the practical importance of the new goodness-of-fit procedure. Overall, our findings strengthen the BS framework and provide robust tools for model validation and selection when log-symmetric modeling assumptions are in place.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":"31 2","pages":"422-441"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A pairwise pseudo-likelihood approach for regression analysis of doubly truncated data. 双截断数据回归分析的两两伪似然方法。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2025-04-01 Epub Date: 2025-03-31 DOI: 10.1007/s10985-025-09649-y
Cunjin Zhao, Peijie Wang, Jianguo Sun
{"title":"A pairwise pseudo-likelihood approach for regression analysis of doubly truncated data.","authors":"Cunjin Zhao, Peijie Wang, Jianguo Sun","doi":"10.1007/s10985-025-09649-y","DOIUrl":"10.1007/s10985-025-09649-y","url":null,"abstract":"<p><p>Double truncation commonly occurs in astronomy, epidemiology and economics. Compared to one-sided truncation, double truncation, which combines both left and right truncation, is more challenging to handle and the methods for analyzing doubly truncated data are limited. For the situation, a common approach is to perform conditional analysis conditional on truncation times, which is simple but may not be efficient. Corresponding to this, we propose a pairwise pseudo-likelihood approach that aims to recover some information missed in the conditional methods and can yield more efficient estimation. The resulting estimator is shown to be consistent and asymptotically normal. An extensive simulation study indicates that the proposed procedure works well in practice and is indeed more efficient than the conditional approach. The proposed methodology applied to an AIDS study.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":"340-363"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Goodness-of-fit testing in the presence of cured data: IPCW approach. 存在固化数据的拟合优度检验:IPCW方法。
IF 1.2 3区 数学
Lifetime Data Analysis Pub Date : 2025-04-01 Epub Date: 2025-03-04 DOI: 10.1007/s10985-025-09646-1
Marija Cuparić, Bojana Milošević
{"title":"Goodness-of-fit testing in the presence of cured data: IPCW approach.","authors":"Marija Cuparić, Bojana Milošević","doi":"10.1007/s10985-025-09646-1","DOIUrl":"10.1007/s10985-025-09646-1","url":null,"abstract":"<p><p>Here we revisit a goodness-of-fit testing problem for randomly right-censored data in the presence of cured subjects, i.e. the population consists of two parts: the cured or non-susceptible group, who will never experience the event of interest versus those who will undergo the event of interest when followed up sufficiently long. We consider the modifications of proposed characterization-based goodness-of-fit tests for the exponential distribution constructed via the inverse probability of censoring weighted U- or V-approach. We present their asymptotic properties and extend our discussion to encompass suitable generalizations applicable to a variety of tests formulated using the same methodology. A comparative power study of these proposed tests against a recent CvM-based competitor and the modifications of the most prominent competitors identified in prior studies that did not consider the presence of cured subjects, demonstrates good finite sample performance. Novel tests are illustrated on a real dataset related to leukemia relapse.</p>","PeriodicalId":49908,"journal":{"name":"Lifetime Data Analysis","volume":" ","pages":"233-252"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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