Medical Dosimetry最新文献

{"title":"A study on clinical evaluation of generalized equivalent uniform dose (gEUD) photon optimizer based VMAT planning on the halcyon platform for head and neck cancer","authors":"Venugopal Sundaram MSc, MCMPI, DIMPCB ,&nbsp;David Khanna MSc, PhD ,&nbsp;Mohandass Palanisamy MSc, PhD ,&nbsp;Prabhu R MSc ,&nbsp;Rekha Arya MD ,&nbsp;Nilotpal Chakravarty MD ,&nbsp;Balaji K MSc ,&nbsp;Sweta Soni DNB","doi":"10.1016/j.meddos.2025.10.004","DOIUrl":"10.1016/j.meddos.2025.10.004","url":null,"abstract":"<div><h3>Aim</h3><div>This study investigates the clinical performance and efficacy of generalized Equivalent Uniform Dose (gEUD) objectives in Volumetric Modulated Arc Therapy (VMAT) planning for Head and Neck Cancer (HNC) using the Halcyon LINAC Photon Optimizer (PO) engine.</div></div><div><h3>Materials and Methods</h3><div>50 HNC patients previously treated with Dose Volume (DV) based Halcyon VMAT plans were retrospectively selected. gEUD based plans were generated by re-planning the DV plans using gEUD objectives for organs at risk (OARs) and a combination of gEUD and DV objectives for PTVs, while maintaining consistent beam geometry and other optimization parameters. Target coverage (D95%, D98%, Dmean, D2%, V105%, CI, HI), OAR doses (mean and maximum), and treatment delivery parameters (MU, MF, BOT, PD gamma pass rate) were compared between the 2 planning strategies. A 2-tailed paired Student's t-test was used for statistical analysis, and box-and-whisker plots were generated.</div></div><div><h3>Results</h3><div>The gEUD based planning achieved comparable PTV coverage and homogeneity to DV based planning. Critically, gEUD optimization significantly reduced mean parotid doses (<em>p</em> &lt; 0.05). Substantial reductions in spinal cord and mandible doses were also observed with gEUD planning (<em>p</em> &lt; 0.001). While small increases in brain dose were noted with gEUD, they remained below clinical tolerance limits. No significant differences were found in treatment delivery parameters or PD QA pass rates.</div></div><div><h3>Conclusion</h3><div>The gEUD based VMAT planning for HNC using the Halcyon LINAC demonstrates significant OAR sparing, particularly for parotids, spinal cord, and mandible, without compromising target coverage or delivery efficiency. These findings support the clinical implementation of gEUD optimization for HNC to potentially reduce treatment-related toxicity and improve the therapeutic window.</div></div>","PeriodicalId":49837,"journal":{"name":"Medical Dosimetry","volume":"51 2","pages":"Pages 159-168"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinically interpretable machine-learning model for predicting heart mean dose using simple BEV-based metrics","authors":"Sathiyaraj Palanivel Ph.D.","doi":"10.1016/j.meddos.2026.01.008","DOIUrl":"10.1016/j.meddos.2026.01.008","url":null,"abstract":"<div><div>Radiation-induced cardiac toxicity remains a major concern in left-sided breast cancer radiotherapy, with mean heart dose (MHD) serving as a key predictor of long-term cardiac morbidity. This study aimed to develop a clinically interpretable machine-learning model to predict MHD using simple beam’s-eye-view (BEV)–based heart-projection metrics. A retrospective cohort of 127 patients treated with postoperative left breast or chest wall radiotherapy including supraclavicular nodal irradiation was analyzed. Heart projections in the lateral and vertical directions were measured from medial and lateral tangential fields, defined as medial tangential horizontal (MTH), lateral tangential horizontal (LTH), medial tangential vertical (MTV), and lateral tangential vertical (LTV). Outliers were removed using interquartile range criteria. A multivariable linear regression model was developed using 5-fold cross-validation to predict MHD. In addition, a logistic regression classifier was trained to categorize patients suitable for three-dimensional conformal radiotherapy (MHD ≤ 4 Gy) versus inverse planning (MHD &gt; 4 Gy). Model performance was evaluated using R², root mean squared error (RMSE), mean absolute error (MAE), Pearson correlation coefficient, accuracy, and area under the receiver operating characteristic curve (AUC). The linear regression model demonstrated strong predictive performance during cross-validation (R² = 0.69, RMSE = 0.61 Gy, MAE = 0.47 Gy), with a significant correlation between predicted and measured MHD (<em>r</em> = 0.83, <em>p</em> &lt; 0.001). Independent validation further improved performance (R² = 0.76, RMSE = 0.69 Gy, MAE = 0.56 Gy; <em>r</em> = 0.90, <em>p</em> &lt; 0.001). The logistic regression classifier achieved an overall accuracy of 88% with excellent discrimination (AUC = 0.95). Simple beam’s-eye-view (BEV)-based heart-projection metrics can reliably predict MHD, enabling rapid preplanning assessment and supporting early selection of cardiac-sparing radiotherapy techniques.</div></div>","PeriodicalId":49837,"journal":{"name":"Medical Dosimetry","volume":"51 3","pages":"Pages 272-277"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of set-up position changes during the online adaptive radiotherapy","authors":"Öznur Şenkesen Ph.D,&nbsp;Emine Burçin Ispir Ph.D,&nbsp;İrem Aydın MSc","doi":"10.1016/j.meddos.2026.01.009","DOIUrl":"10.1016/j.meddos.2026.01.009","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to assess intrafractional positional shifts occurring during cone-beam computed tomography (CBCT)-based online adaptive radiotherapy (oART) using the Varian Ethos system. Specifically, we quantified these positional deviations and examined their relevance for planning target volume (PTV) margin definition in the absence of pretreatment verification imaging.</div></div><div><h3>Materials and Methods</h3><div>A retrospective analysis was performed on 28 patients who underwent oART, covering a total of 627 fractions. For each fraction, an initial CBCT was used for adaptive planning, followed by a second CBCT immediately before treatment to assess intrafractional motion. Shifts between the two CBCTs were measured in the anterior‒posterior (AP), superior‒inferior (SI), and medial‒lateral (ML) directions. The means ± standard deviations and ranges are reported. Additionally, CBCT acquisition intervals, total treatment times, and monitor unit (MU) differences between the reference and adaptive plans were evaluated.</div></div><div><h3>Results</h3><div>We found mean positional shifts of 0.11 ± 0.09 cm (AP), 0.07 ± 0.14 cm (SI), and 0.06 ± 0.09 cm (ML). We calculated PTV margins with all position corrections, ranging from 2.5 to 3.9 mm depending on the region and direction. CBCT intervals ranged from 11.4 to 17.5 minutes, and total treatment time from 14 to 45 minutes, depending on site. No strong correlation was observed between treatment time and the magnitude of positional shifts, although weak but statistically significant correlations were observed <strong>for</strong> prostate (AP) and rectum (ML). MU differences between the reference and adaptive plans reached statistical significance for prostate, endometrial, and bladder treatments.</div></div><div><h3>Conclusions</h3><div>Intrafractional positional changes during oART are clinically relevant and may compromise geometric accuracy when not accounted for. In the absence of pretreatment imaging, individualized PTV margins based on treatment site and direction should be considered. Incorporating secondary CBCT or adopting site-specific margin strategies is recommended, particularly for pelvic treatments.</div></div>","PeriodicalId":49837,"journal":{"name":"Medical Dosimetry","volume":"51 3","pages":"Pages 278-285"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case study comparing VMAT treatment techniques to reduce dose to femoral heads for postmenopausal women during pelvic radiotherapy","authors":"Jayne Vandervelde M.S., R.T.(T),&nbsp;Melissa Hodges M.S., R.T.(T),&nbsp;Nishele Lenards Ph.D., C.M.D., RT(R)(T), FAAMD,&nbsp;Ashley Hunzeker M.S., CMD,&nbsp;Matt Tobler C.M.D., FAAMD","doi":"10.1016/j.meddos.2026.03.009","DOIUrl":"10.1016/j.meddos.2026.03.009","url":null,"abstract":"<div><div>Volumetric modulated arc therapy (VMAT) is a common radiation treatment technique that delivers radiation to the planning target volume (PTV) while sparing the organs at risk (OAR). One limitation of VMAT on Varian linear accelerators is the limited distance the multileaf collimators (MLCs) can travel across the x-axis of the treatment field. The researchers in this case study sought to evaluate whether a split-field technique offers improved sparing of OAR, particularly dose to the femoral heads, in postmenopausal women undergoing treatment for the endometrium and pelvic lymph nodes. In the following retrospective study, 3 patients with endometrial cancer were selected. Two plans were generated for each patient, 1 split-field and 1 full-field. The full-field plan covered the full width of the PTV in both arcs. The split-field plan was created by reducing the X1 jaw to 2.0 cm on the clockwise arc, and the X2 jaw was reduced to 2.0 cm on the counterclockwise arc. PTV coverage along with OAR doses, was evaluated for all plans. All 3 patients showed lower doses to the femoral heads in the split-field plan. Doses to the rectum, bladder, and small bowel were also lower in the split-field plan. Differences in the dose were sometimes very small between the 2 techniques. Overall, the split-field technique demonstrated improved dose reduction over the full-field technique, but more research with a larger sample size is required to confirm the split-field technique.</div></div>","PeriodicalId":49837,"journal":{"name":"Medical Dosimetry","volume":"51 3","pages":"Pages 370-374"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Establishing a knowledge-based planning model for left-sided breast cancer patients receiving hypofractionated postmastectomy and regional nodal irradiation.”","authors":"Jiayi Chen","doi":"10.1016/j.meddos.2026.03.005","DOIUrl":"10.1016/j.meddos.2026.03.005","url":null,"abstract":"","PeriodicalId":49837,"journal":{"name":"Medical Dosimetry","volume":"51 3","pages":"Page 348"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved scalp sparing using 10 MV photons in glioblastoma radiotherapy combined with adjuvant tumor treating fields: A dosimetric comparison","authors":"Hongqiang You,&nbsp;Jiajun Zheng,&nbsp;Xiaosuo He","doi":"10.1016/j.meddos.2026.03.003","DOIUrl":"10.1016/j.meddos.2026.03.003","url":null,"abstract":"<div><div>This study investigates whether 10 MV photons offer superior scalp-sparing effects compared to 6 MV in glioblastoma (GBM) radiotherapy for patients undergoing radiotherapy combined with adjuvant Tumor Treating Fields (TTFields). A retrospective dosimetric analysis was conducted using 6-MV GBM radiotherapy plans from 29 patients who had undergone radiotherapy combined with adjuvant TTFields. The 10 MV plans were meticulously designed to replicate the same field geometry, optimization objectives, and optimization parameters as the 6 MV plans. Both 6 MV and 10 MV plans were compared for planning target volume (PTV) coverage (evaluated using <em>D</em>_98% and <em>D</em>_2%), organ-at-risk (OAR) sparing (assessed via <em>D</em>_max for brainstem, the optic nerves, and optic chiasm), and scalp sparing (measured by <em>D</em>_10cc, <em>D</em>_20cc, and <em>D</em>_mean), the conformity index (CI), and the gradient index (GI). Statistical comparisons were performed using paired t-tests. Results showed no significant differences in target coverage, OAR sparing, CI, and GI between the two modalities (<em>p</em> &gt; 0.05). For 6 MV photons, the Scalp <em>D</em>_10cc, <em>D</em>_20cc, and <em>D</em>_mean were 36.65 ± 7.39 Gy, 31.90 ± 7.32 Gy, and 20.57 ± 5.74 Gy, respectively. In comparison, these values decreased to 34.49 ± 7.53 Gy, 29.76 ± 7.49 Gy, and 19.55 ± 5.62 Gy for 10 MV photons, with all differences reaching statistical significance (<em>p</em> &lt; 0.05). The 10 MV photons exhibited a notable reduction in scalp dose while achieving equivalent target coverage and sparing of OARs. These results underscore the potential of 10 MV photons to enhance GBM radiotherapy combined with adjuvant TTFields by minimizing superficial tissue toxicity and improving compliance to subsequent TTFields.</div></div>","PeriodicalId":49837,"journal":{"name":"Medical Dosimetry","volume":"51 3","pages":"Pages 333-338"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluence-corrected pencil beam algorithm for carbon ion therapy patient quality assurance in solid phantoms","authors":"Yunzhou Xia PhD,&nbsp;Kai Wang BSc,&nbsp;Qinqin Cheng MSc,&nbsp;Xiuzhen Deng MSc,&nbsp;Hongfei Li MSc","doi":"10.1016/j.meddos.2026.02.003","DOIUrl":"10.1016/j.meddos.2026.02.003","url":null,"abstract":"<div><div>Solid phantoms streamline carbon ion therapy quality assurance (QA), but introduce dose deviations as treatment planning system’s (TPS) pencil beam algorithms (PBA) calculate dose in water. This study develops a fluence-corrected PBA, enabling accurate patient-specific QA directly in solid phantoms at Heavy Ion Medical Machine (HIMM) centers. Beam modeling was done in TOPAS Monte Carlo simluation platform to match the integrated depth doses (IDD) and phase space parameters to the clinical commissioning data. Depth-dose data in PTW RW3 slab phantom and in water were simulated, from which energy- and depth-dependent fluence correction (FC) factors (FCFs) were derived. The FCFs were validated experimentally and incorporated into the PBA. 4 types of QA workflows were compared for 2 patient plans at varying equivalent depths: 1) phantom CT without FC-PBA 2) phantom CT with FC 3) virtual CT with stopping power ratio overwritten to 1 with FC, and 4) virtual CT overwritten with phantom SPR with FC. A simplified depth-dependent correction table was fitted from measurement. The simulated FCFs increased with energy and depth from about 0.4% at 2 centimeters to 5% at 25 centimeters, which agreed with the measurement within <span><math><mo>±</mo></math></span>0.5%. At depths <span><math><mo>&lt;</mo></math></span> 100 mm, the gamma pass rates were similar for all 4 workflows. For depths <span><math><mo>&gt;</mo></math></span> 100 mm, the gamma pass rates increased from (81, 77, 69)% for workflow 1 to (99, 99, 97)% on average for workflows 2-4, under 3 mm/3%, 2 mm/3% and 2 mm/2% criteria, respectively. Workflow 2 and 4 gave similar results with mean difference 0.1(<span><math><mo>±</mo></math></span>0.6)%. The simplified table gave 0.0231% FC per millimeter of RW3 thickness, which agreed to the simulation within 1%. Carbon ion therapy QA in the RW3 requires FCFs particularly for <span><math><mo>&gt;</mo></math></span> 100 mm depths. Under <span><math><mo>≥</mo></math></span> 2% pass rate criteria, either the fluence-corrected PBA or the simplified table could be adopted on a virtual phantom to support easier QA workflow.</div></div>","PeriodicalId":49837,"journal":{"name":"Medical Dosimetry","volume":"51 3","pages":"Pages 310-317"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination and use of patient curvature correction factors by measurement in electron monitor unit calculations","authors":"Neil Richmond MSc,&nbsp;Katie Chester MSc,&nbsp;Liam Walker PhD","doi":"10.1016/j.meddos.2026.03.007","DOIUrl":"10.1016/j.meddos.2026.03.007","url":null,"abstract":"<div><div>In our department, monitor units (MU) for electron treatments are calculated using a Monte Carlo algorithm in the RayStation treatment planning system and independently checked using RadCalc software. An audit found that 22 of 50 independent checks failed the ± 5% local tolerance level. One of the causes for the discrepancy was thought to be that the RadCalc calculation takes no account of the patient surface curvature. Three-dimensional printed moulds were used to create wax “domes” and “bowls” with curvatures ranging from +0.33 cm⁻¹ to −0.13 cm⁻¹. The dose per MU delivered at d_max^, under the wax phantoms, to a calibrated NACP type chamber was determined by measurement. The fields were delivered using 6 to 18 MeV electrons from a Varian TrueBeam linac. The measured data shows that the dose varies linearly, for a given electron energy, with the curvature of the wax mould. This information was used to create a set of curvature correction factors to be applied to the 50 independent MU checks. When the appropriate correction factor was applied to the RadCalc MU only 3 of the 50 calculations were beyond the tolerance level, improving agreement and reducing the number of out of tolerance results.</div></div>","PeriodicalId":49837,"journal":{"name":"Medical Dosimetry","volume":"51 3","pages":"Pages 350-354"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of gyroscopic and robotic radiosurgery platforms for uveal melanoma treatment","authors":"Hüseyin Kivanc MSc ,&nbsp;Yagiz Yedekci PhD ,&nbsp;Gozde Yazici MD ,&nbsp;İrem Koç MD ,&nbsp;Hayyam Kıratlı MD ,&nbsp;Halil Murat Aydin PhD","doi":"10.1016/j.meddos.2025.11.003","DOIUrl":"10.1016/j.meddos.2025.11.003","url":null,"abstract":"<div><div>To perform a comprehensive dosimetric comparison between the ZAP-X gyroscopic radiosurgery system and the CyberKnife (CK) robotic platform for the treatment of uveal melanoma (UM), with a focus on target coverage, organ at risk (OAR) sparing, plan quality metrics and treatment delivery efficiency. A total of 45 uveal melanoma patients previously treated with the CK system were retrospectively analyzed. For each patient, treatment plans were generated for both the ZAP-X and CK platforms using identical contouring datasets, shell structures, optimization parameters and dose calculation algorithms. Dosimetric parameters related to target coverage and OARs were compared, along with conformity index (CI), new conformity index (nCI), homogeneity index (HI), gradient indices (GI50% and GI25%), monitor units (MU) and estimated treatment times. Both systems achieved adequate target coverage with no significant difference in PTV D98% values. ZAP-X demonstrated significantly higher D_max, lower CI and nCI, and steeper dose gradients (GI50%, GI25%) compared to CK (<em>p</em> &lt; 0.001 <em>for all</em>), indicating better conformity and dose fall-off. ZAP-X also delivered significantly lower doses to several OARs (<em>p</em> &lt; 0.05 <em>for all</em>), including the optic nerves, contralateral eye, lenses, vitreous humor, lacrimal gland and brain. Although ZAP-X required more MUs per fraction, it achieved shorter treatment times. ZAP-X offers superior dose conformity, sharper dose gradients, and improved OAR sparing for uveal melanoma treatment without increasing treatment duration. While further clinical validation is required, these results support the potential of ZAP-X as a promising stereotactic radiosurgery platform for ocular tumors.</div></div>","PeriodicalId":49837,"journal":{"name":"Medical Dosimetry","volume":"51 2","pages":"Pages 181-188"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Directed Journal Reading (DJR) Program","authors":"","doi":"10.1016/j.meddos.2026.03.012","DOIUrl":"10.1016/j.meddos.2026.03.012","url":null,"abstract":"","PeriodicalId":49837,"journal":{"name":"Medical Dosimetry","volume":"51 2","pages":"Page 249"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}