Molecular Aspects of Medicine最新文献_第9页

Muscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets 肌肉老化和肌肉疏松症：病理、病因和最有希望的治疗目标。

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-12-01 Epub Date: 2024-09-22 DOI: 10.1016/j.mam.2024.101319

Mercedes Grima-Terrén , Silvia Campanario , Ignacio Ramírez-Pardo , Andrés Cisneros , Xiaotong Hong , Eusebio Perdiguero , Antonio L. Serrano , Joan Isern , Pura Muñoz-Cánoves

{"title":"Muscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets","authors":"Mercedes Grima-Terrén , Silvia Campanario , Ignacio Ramírez-Pardo , Andrés Cisneros , Xiaotong Hong , Eusebio Perdiguero , Antonio L. Serrano , Joan Isern , Pura Muñoz-Cánoves","doi":"10.1016/j.mam.2024.101319","DOIUrl":"10.1016/j.mam.2024.101319","url":null,"abstract":"<div><div>Sarcopenia is a progressive muscle wasting disorder that severely impacts the quality of life of elderly individuals. Although the natural aging process primarily causes sarcopenia, it can develop in response to other conditions. Because muscle function is influenced by numerous changes that occur with age, the etiology of sarcopenia remains unclear. However, recent characterizations of the aging muscle transcriptional landscape, signaling pathway disruptions, fiber and extracellular matrix compositions, systemic metabolomic and inflammatory responses, mitochondrial function, and neurological inputs offer insights and hope for future treatments. This review will discuss age-related changes in healthy muscle and our current understanding of how this can deteriorate into sarcopenia. As our elderly population continues to grow, we must understand sarcopenia and find treatments that allow individuals to maintain independence and dignity throughout an extended lifespan.</div></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"100 ","pages":"Article 101319"},"PeriodicalIF":8.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles transport RNA between cells: Unraveling their dual role in diagnostics and therapeutics 细胞外囊泡在细胞间运输 RNA：揭示细胞外囊泡在诊断和治疗中的双重作用

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-10-01 Epub Date: 2024-08-01 DOI: 10.1016/j.mam.2024.101302

Zahra Payandeh , Benyapa Tangruksa , Jane Synnergren , Sepideh Heydarkhan-Hagvall , Joel Z. Nordin , Samir EL. Andaloussi , Jan Borén , John Wiseman , Mohammad Bohlooly-Y , Lennart Lindfors , Hadi Valadi

{"title":"Extracellular vesicles transport RNA between cells: Unraveling their dual role in diagnostics and therapeutics","authors":"Zahra Payandeh , Benyapa Tangruksa , Jane Synnergren , Sepideh Heydarkhan-Hagvall , Joel Z. Nordin , Samir EL. Andaloussi , Jan Borén , John Wiseman , Mohammad Bohlooly-Y , Lennart Lindfors , Hadi Valadi","doi":"10.1016/j.mam.2024.101302","DOIUrl":"10.1016/j.mam.2024.101302","url":null,"abstract":"<div><p>Modern methods of molecular diagnostics and therapy have revolutionized the field of medicine in recent years by providing more precise and effective tools for detecting and treating diseases. This progress includes a growing exploration of the body's secreted vesicles, known as extracellular vesicles (EVs), for both diagnostic and therapeutic purposes. EVs are a heterogeneous population of lipid bilayer vesicles secreted by almost every cell type studied so far. They are detected in body fluids and conditioned culture media from living cells. EVs play a crucial role in communication between cells and organs, both locally and over long distances. They are recognized for their ability to transport endogenous RNA and proteins between cells, including messenger RNA (mRNA), microRNA (miRNA), misfolded neurodegenerative proteins, and several other biomolecules. This review explores the dual utilization of EVs, serving not only for diagnostic purposes but also as a platform for delivering therapeutic molecules to cells and tissues. Through an exploration of their composition, biogenesis, and selective cargo packaging, we elucidate the intricate mechanisms behind RNA transport between cells via EVs, highlighting their potential use for both diagnostic and therapeutic applications. Finally, it addresses challenges and outlines prospective directions for the clinical utilization of EVs.</p></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"99 ","pages":"Article 101302"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S009829972400061X/pdfft?md5=73ba7a20be41091963375739f9ec2675&pid=1-s2.0-S009829972400061X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141873363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatitis C virus chronicity and oncogenic potential: Vaccine development progress 丙型肝炎病毒的慢性化和致癌潜力：疫苗开发进展

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI: 10.1016/j.mam.2024.101305

Yuki Haga , Sydney Coates , Ranjit Ray

{"title":"Hepatitis C virus chronicity and oncogenic potential: Vaccine development progress","authors":"Yuki Haga , Sydney Coates , Ranjit Ray","doi":"10.1016/j.mam.2024.101305","DOIUrl":"10.1016/j.mam.2024.101305","url":null,"abstract":"<div><p>Hepatitis C virus (HCV) infection is a major health problem worldwide. It can cause liver cirrhosis and hepatocellular carcinoma (HCC), making it a cause of morbidity from liver disease. Thus, there is an urgent need for a prophylactic HCV vaccine. Fortunately, modern medicine has transformed the therapy for HCV infection through development of direct-acting antiviral agents (DAAs), achieving high rates of sustained virologic response and giving significant relief from HCC and associated mortality, but unfortunately it fails to eradicate the risk of HCC, especially in HCV-cleared patients with already advanced liver disease. Additionally, DAA-cured patients do not develop sufficient antiviral immunity and are susceptible to reinfection. A comprehensive strategy to control HCV infection must include a vaccine development approach in which the host can develop humoral and cellular immunity to eradicate HCV successfully; however, this remains a challenge as HCV has developed systems to evade immune attacks from its host. This review highlights the current understanding of HCV's effect on liver disease and cancer progression, the nature of immune responses from cell populations interacting with HCV, and the current strategies for vaccine development. The information in this review will advance prophylactic intervention strategies for HCV infection, with the end goal being to prevent chronicity and subsequent liver disease leading to HCC.</p></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"99 ","pages":"Article 101305"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling multifaceted roles of myeloid innate immune cells in the pathogenesis of psoriasis 揭示髓系先天性免疫细胞在银屑病发病机制中的多方面作用

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-10-01 Epub Date: 2024-08-26 DOI: 10.1016/j.mam.2024.101306

Sohyeon Park , Jinsun Jang , Hee Joo Kim , YunJae Jung

{"title":"Unveiling multifaceted roles of myeloid innate immune cells in the pathogenesis of psoriasis","authors":"Sohyeon Park , Jinsun Jang , Hee Joo Kim , YunJae Jung","doi":"10.1016/j.mam.2024.101306","DOIUrl":"10.1016/j.mam.2024.101306","url":null,"abstract":"<div><p>Psoriasis is a chronic inflammatory skin disease occurring worldwide. Initially viewed as a keratinocyte disorder, psoriasis is now recognized to involve a complex interplay between genetic predisposition, environmental triggers, and a dysregulated immune system, with a significant role of CD4<sup>+</sup> T cells producing IL-17. Recent genetic studies have identified susceptibility loci that underscore the importance of innate immune responses, particularly the roles of myeloid cells, such as dendritic cells, macrophages, and neutrophils. These cells initiate and sustain inflammation through cytokine production triggered by external stimuli. They influence keratinocyte behavior and interact with adaptive immune cells. Recent techniques have further revealed the heterogeneity of myeloid cells in psoriatic lesions, highlighting the contributions of less-studied subsets, such as eosinophils and mast cells. This review examines the multifaceted roles of myeloid innate immune cells in psoriasis, emphasizing their functional diversity in promoting psoriatic inflammation. It also describes current treatment targeting myeloid innate immune cells and explores potential new therapeutic strategies based on the functional characteristics of these subsets. Future research should focus on the detailed characterization of myeloid subsets and their interactions to develop targeted treatments that address the complex immune landscape of psoriasis.</p></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"99 ","pages":"Article 101306"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0098299724000657/pdfft?md5=a8fe469b309b5f4b85a33cab9291835f&pid=1-s2.0-S0098299724000657-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142077002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular mechanisms of cancer cachexia. Role of exercise training 癌症恶病质的分子机制。运动训练的作用

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-10-01 Epub Date: 2024-07-25 DOI: 10.1016/j.mam.2024.101293

Eva Tamayo-Torres , Amanda Garrido , Rafael de Cabo , Julián Carretero , María Carmen Gómez-Cabrera

{"title":"Molecular mechanisms of cancer cachexia. Role of exercise training","authors":"Eva Tamayo-Torres , Amanda Garrido , Rafael de Cabo , Julián Carretero , María Carmen Gómez-Cabrera","doi":"10.1016/j.mam.2024.101293","DOIUrl":"10.1016/j.mam.2024.101293","url":null,"abstract":"<div><p>Cancer-associated cachexia represents a multifactorial syndrome mainly characterized by muscle mass loss, which causes both a decrease in quality of life and anti-cancer therapy failure, among other consequences. The definition and diagnostic criteria of cachexia have changed and improved over time, including three different stages (pre-cachexia, cachexia, and refractory cachexia) and objective diagnostic markers. This metabolic wasting syndrome is characterized by a negative protein balance, and anti-cancer drugs like chemotherapy or immunotherapy exacerbate it through relatively unknown mechanisms. Due to its complexity, cachexia management involves a multidisciplinary strategy including not only nutritional and pharmacological interventions. Physical exercise has been proposed as a strategy to counteract the effects of cachexia on skeletal muscle, as it influences the mechanisms involved in the disease such as protein turnover, inflammation, oxidative stress, and mitochondrial dysfunction. This review will summarize the experimental and clinical evidence of the impact of physical exercise on cancer-associated cachexia.</p></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"99 ","pages":"Article 101293"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0098299724000529/pdfft?md5=043b63cf65d41888f643301387e1613b&pid=1-s2.0-S0098299724000529-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes and male fertility disorders 糖尿病与男性生育障碍

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-10-01 Epub Date: 2024-07-30 DOI: 10.1016/j.mam.2024.101303

Andrea Graziani , Raffaele Scafa , Giuseppe Grande , Alberto Ferlin

{"title":"Diabetes and male fertility disorders","authors":"Andrea Graziani , Raffaele Scafa , Giuseppe Grande , Alberto Ferlin","doi":"10.1016/j.mam.2024.101303","DOIUrl":"10.1016/j.mam.2024.101303","url":null,"abstract":"<div><p>Couple infertility is a common condition, defined as being unable to conceive after 12 months of regular unprotected sexual intercourse. Male Factor Infertility (MFI) is responsible, alone or in combination with female factors, for about half of the overall cases of couple infertility. MFI is gradually increasing in prevalence, with a notable decline in semen parameters over the last decades. The aetiologies behind the finding of decreasing sperm counts are difficult to pinpoint but might be due in part to increasing rates of overweight and obesity in men of childbearing age. Diabetes mellitus (DM) is a common and chronic metabolic disease, whose prevalence is also gradually increasing, rising up to 10% of the population. The International Diabetes Federation estimates that there are currently more than 500 million people living with DM worldwide, the vast majority of whom suffering from type 2 DM (T2DM). There is growing awareness of the relationship between unhealthy lifestyle, in particular unhealthy diet, and MFI. Starting from all these premises, the aim of this narrative review is to describe the current evidence on the link between DM and MFI, both in terms of DM as a cause of/a risk factor for MFI and of MFI as a possible predictive marker for T2DM. Finally, we will discuss the risk of DM as a consequence of the therapy of MFI or assisted reproductive techniques.</p></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"99 ","pages":"Article 101303"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0098299724000621/pdfft?md5=7fc25e028243290f17b294fca4dbb1aa&pid=1-s2.0-S0098299724000621-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the role of endocrine disrupting chemicals in testicular germ cell cancer: Insights into molecular mechanisms 了解干扰内分泌的化学物质在睾丸生殖细胞癌中的作用：洞察分子机制

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-10-01 Epub Date: 2024-08-29 DOI: 10.1016/j.mam.2024.101307

Won-Ki Pang, Ekaterina Kuznetsova, Hélène Holota, Angélique De Haze, Claude Beaudoin, David H. Volle

{"title":"Understanding the role of endocrine disrupting chemicals in testicular germ cell cancer: Insights into molecular mechanisms","authors":"Won-Ki Pang, Ekaterina Kuznetsova, Hélène Holota, Angélique De Haze, Claude Beaudoin, David H. Volle","doi":"10.1016/j.mam.2024.101307","DOIUrl":"10.1016/j.mam.2024.101307","url":null,"abstract":"<div><p>This comprehensive review examines the complex interplay between endocrine disrupting chemicals (EDCs) and the development of testicular germ cell tumors (TGCTs). Despite the high cure rates of TGCTs, challenges in diagnosis and treatment remain, necessitating a deeper understanding of the etiology of the disease. Here, we emphasize current knowledge on the role of EDCs as potential risk factors for TGCTs, focusing on pesticides and perfluorinated and polyfluoroalkyl substances (PFAs/PFCs). Evidence suggests that EDCs disrupt endocrine pathways and induce epigenetic changes that contribute to the development of TGCTs. However, the direct link between EDCs and TGCTs remains elusive and requires further investigation of the molecular mechanisms. We also highlighted the importance of studying nuclear receptors as potential targets for understanding TGCT etiology. In addition, recent evidence implicates PFAs/PFCs in TGCT incidence, highlighting the need for further research into their impact on human health. Overall, this review provides valuable insights into the potential role of EDCs in TGCT development and suggests avenues for future research, while also highlighting how understanding their influence may pave the way for novel therapeutic approaches to improve disease management.</p></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"99 ","pages":"Article 101307"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142097214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frailty and biological age. Which best describes our aging and longevity? 虚弱和生理年龄。哪一种最能说明我们的衰老和长寿？

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1016/j.mam.2024.101291

Judith Félix , Irene Martínez de Toda , Estefanía Díaz-Del Cerro , Mónica González-Sánchez , Mónica De la Fuente

引用次数: 0

Vaccines for breast cancer prevention: Are we there yet? 预防乳腺癌的疫苗：我们成功了吗？

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-08-01 Epub Date: 2024-07-10 DOI: 10.1016/j.mam.2024.101292

Shaveta Vinayak , Denise L. Cecil , Mary L. Disis

引用次数: 0

Modern methods of molecular diagnostics 现代分子诊断方法。

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-08-01 Epub Date: 2024-05-21 DOI: 10.1016/j.mam.2024.101278

引用次数: 0