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Case report: pre-symptomatic clinical and metabolic profile in posterior cortical atrophy and dementia with Lewy bodies. 病例报告:后皮质萎缩和路易体痴呆症的症状前临床和代谢概况。
IF 0.6 4区 医学
Neurocase Pub Date : 2024-02-01 Epub Date: 2024-05-17 DOI: 10.1080/13554794.2024.2348223
Dror Shir, Nick Corriveau-Lecavalier, Jonathan Graff-Radford, Mary M Machulda, David S Knopman, Ronald C Petersen, Aivi T Nguyen, Dennis W Dickson, David T Jones
{"title":"Case report: pre-symptomatic clinical and metabolic profile in posterior cortical atrophy and dementia with Lewy bodies.","authors":"Dror Shir, Nick Corriveau-Lecavalier, Jonathan Graff-Radford, Mary M Machulda, David S Knopman, Ronald C Petersen, Aivi T Nguyen, Dennis W Dickson, David T Jones","doi":"10.1080/13554794.2024.2348223","DOIUrl":"10.1080/13554794.2024.2348223","url":null,"abstract":"<p><p>A research participant was monitored over nearly two decades at Mayo Clinic, undergoing annual neurologic assessments, neuropsychological tests, and multimodal imaging. Initially, he was cognitively normal but developed symptoms consistent with Posterior Cortical Atrophy (PCA) during the study. Early tests indicated mild, yet normal-range declines in language and visuospatial skills. FDG-PET scans revealed increased metabolism in posterior brain regions long before symptoms appeared. Advanced analysis using a novel in-house machine-learning tool predicted concurrent Alzheimer's disease and dementia with Lewy bodies. Autopsy confirmed a mixed neurodegenerative condition with significant Alzheimer's pathology and dense neocortical Lewy bodies. This case underscores the value of longitudinal imaging in predicting complex neurodegenerative diseases, offering vital insights into the early neurocognitive changes associated with PCA and dementia with Lewy bodies.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"1-7"},"PeriodicalIF":0.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11243756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frontal allographic agraphia in a patient with behavioral variant frontotemporal dementia. 一名行为变异型额颞叶痴呆症患者的额叶异形书写障碍。
IF 0.6 4区 医学
Neurocase Pub Date : 2024-02-01 Epub Date: 2024-05-16 DOI: 10.1080/13554794.2024.2353936
Yasuhisa Sakurai, Masashi Hamada, Hiroshi Takuma
{"title":"Frontal allographic agraphia in a patient with behavioral variant frontotemporal dementia.","authors":"Yasuhisa Sakurai, Masashi Hamada, Hiroshi Takuma","doi":"10.1080/13554794.2024.2353936","DOIUrl":"10.1080/13554794.2024.2353936","url":null,"abstract":"<p><p>We report a patient with behavioral variant frontotemporal dementia who developed agraphia, irritability, perseverative and stereotyped behavior, and dietary changes. MRI revealed bilateral frontal convexity atrophy. Neuropsychological examination showed fluent aphasia with perseverative allographic agraphia, mild semantic impairment, and dysexecutive syndrome. Allographic agraphia featured unidirectional conversion from <i>hiragana</i> (cursive form of Japanese phonograms) and <i>kanji</i> (Japanese morphograms) to <i>katakana</i> (square form of Japanese phonograms), as opposed to mutual (bidirectional) conversion between <i>hiragana</i> and <i>katakana</i> in parieto-occipital gyri lesions. Furthermore, all letters of the word were converted and this whole-word conversion may be characteristic of perseverative behavior in frontotemporal dementia.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"32-38"},"PeriodicalIF":0.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Symptomatic progression of frontotemporal dementia with the TARDBP I383V variant. TARDBP I383V变异型额颞叶痴呆症的症状进展。
IF 0.6 4区 医学
Neurocase Pub Date : 2024-02-01 Epub Date: 2024-05-17 DOI: 10.1080/13554794.2024.2354540
Peter S Pressman, Danelle J Carter, Eliana Marisa Ramos, Joie Molden, Kaitlin Smith, Francesca Dino, Corey McMillan, David Irwin, Katya Rascovsky, Nupur Ghoshal, Marguerite Knudtson, Rosa Rademakers, Daniel Geschwind, Tania Gendron, Leonard Petrucelli, Hilary Heuer, Bradley F Boeve, Sami Barmada, Adam Boxer, Maria Luisa Gorno Tempini, Howard J Rosen
{"title":"Symptomatic progression of frontotemporal dementia with the <i>TARDBP</i> I383V variant.","authors":"Peter S Pressman, Danelle J Carter, Eliana Marisa Ramos, Joie Molden, Kaitlin Smith, Francesca Dino, Corey McMillan, David Irwin, Katya Rascovsky, Nupur Ghoshal, Marguerite Knudtson, Rosa Rademakers, Daniel Geschwind, Tania Gendron, Leonard Petrucelli, Hilary Heuer, Bradley F Boeve, Sami Barmada, Adam Boxer, Maria Luisa Gorno Tempini, Howard J Rosen","doi":"10.1080/13554794.2024.2354540","DOIUrl":"10.1080/13554794.2024.2354540","url":null,"abstract":"<p><p>We present a longitudinal description of a man with the <i>TARDBP</i> I383V variant of frontotemporal dementia (FTD). His progressive changes in behavior and language resulted in a diagnosis of the right temporal variant of FTD, also called the semantic behavioral variant (sbvFTD). We also present data from a small series of patients with the <i>TARDBP</i> I383V variant who were enrolled in a nationwide FTD research collaboration (ALLFTD). These data support slowly progressive loss of semantic function. While semantic dementia is infrequently considered genetic, the <i>TARDBP</i> I383V variant seems to be an exception. Longitudinal analyses in larger samples are warranted.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"39-47"},"PeriodicalIF":0.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Akinetic mutism and gait disturbance in a patient with delayed post-hypoxic leukoencephalopathy. 一名迟发性缺氧后白质脑病患者的动觉缄默症和步态障碍。
IF 0.6 4区 医学
Neurocase Pub Date : 2024-02-01 Epub Date: 2024-05-09 DOI: 10.1080/13554794.2024.2353125
Sung Ho Jang, Hyeok Gyu Kwon
{"title":"Akinetic mutism and gait disturbance in a patient with delayed post-hypoxic leukoencephalopathy.","authors":"Sung Ho Jang, Hyeok Gyu Kwon","doi":"10.1080/13554794.2024.2353125","DOIUrl":"10.1080/13554794.2024.2353125","url":null,"abstract":"<p><p>We report on a patient with delayed post-hypoxic leukoencephalopathy (DPHL) who showed akinetic mutism and gait disturbance, neural injuries that were demonstrated on diffusion tensor tractography (DTT). A patient was exposed to carbon monoxide (CO) and rapidly recovered; however, two weeks after onset, he began to show cognitive impairment and gait disturbance. At six weeks after CO exposure, he showed akinetic mutism and gait inability. DTT at 6-weeks post-exposure showed discontinuations in neural connectivities of the caudate nucleus to the medial prefrontal and orbitofrontal cortex in both hemispheres. In addition, the corticoreticulospinal tract revealed severe thinning in both hemispheres.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"29-31"},"PeriodicalIF":0.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated bilateral fornix anterior columns infarction with acute amnesia and fiber tracts damage, a case report. 孤立性双侧穹窿前柱梗死伴急性健忘症和纤维束损伤,病例报告。
IF 0.6 4区 医学
Neurocase Pub Date : 2023-12-01 Epub Date: 2024-05-03 DOI: 10.1080/13554794.2024.2348762
Wen-Ting Yang, Fu-Qiang Tang
{"title":"Isolated bilateral fornix anterior columns infarction with acute amnesia and fiber tracts damage, a case report.","authors":"Wen-Ting Yang, Fu-Qiang Tang","doi":"10.1080/13554794.2024.2348762","DOIUrl":"10.1080/13554794.2024.2348762","url":null,"abstract":"<p><p>Isolated fornix anterior column infarction has rarely been described and is difficult to assess accurately using conventional magnetic resonance imaging (MRI). We report the case of a 75-year-old female who experienced acute anterograde amnesia. MRI performed within 24 h after amnesia onset showed an isolated infarction of the bilateral anterior columns of the fornix on diffusion-weighted imaging (DWI). Her symptoms persisted for up to 50 days, and diffusion tensor imaging (DTI) showed disruption of the fiber tracts of the fornix. when acute amnesia syndrome onset, fornix anterior column infarction should be considered, and optimized DWI and DTI methods are needed to study the fornix in vivo in future research.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"186-190"},"PeriodicalIF":0.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delayed recovery from ataxic dementia following liposuction. 抽脂手术后共济失调性痴呆症的延迟恢复。
IF 0.6 4区 医学
Neurocase Pub Date : 2023-12-01 Epub Date: 2024-05-04 DOI: 10.1080/13554794.2024.2346982
Ana Clara de Oliveira, Marcos Benchimol, Ilana Benchimol, Leila Chimelli, Ricardo de Oliveira-Souza
{"title":"Delayed recovery from ataxic dementia following liposuction.","authors":"Ana Clara de Oliveira, Marcos Benchimol, Ilana Benchimol, Leila Chimelli, Ricardo de Oliveira-Souza","doi":"10.1080/13554794.2024.2346982","DOIUrl":"10.1080/13554794.2024.2346982","url":null,"abstract":"<p><p>A 19-year-old student developed hypoventilation and cyanosis at the end of a cosmetic liposuction procedure. She was awake, but severely abulic, disoriented, and unable to stand and walk due to severe locomotor ataxia. Neuropsychological evaluation showed psychomotor slowness, and deficits in memory encoding and retrieval, and on executive, and visuospatial and visuoperceptual tests; oral comprehension and constructional praxis were spared. ¹H-MRS showed a reduction of NAA. A year later, her cognitive and neurological exam, and NAA returned to normal, and she resumed her normal life. The severity of the acute manifestations of hypoxic encephalopathy not always entail a poor prognosis.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"174-179"},"PeriodicalIF":0.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors that can influence neurocognitive performance: a case study in a controlled environment. 影响神经认知表现的因素:受控环境中的案例研究。
IF 0.6 4区 医学
Neurocase Pub Date : 2023-12-01 Epub Date: 2024-04-27 DOI: 10.1080/13554794.2024.2348228
Tiffany Grezmak, Kamini Krishnan
{"title":"Factors that can influence neurocognitive performance: a case study in a controlled environment.","authors":"Tiffany Grezmak, Kamini Krishnan","doi":"10.1080/13554794.2024.2348228","DOIUrl":"10.1080/13554794.2024.2348228","url":null,"abstract":"<p><p>This is a case study of a patient in her 50s who presents with severe malnutrition, alcohol dependence, and untreated Bipolar Affective Disorder. She was hospitalized multiple times and placed in a group home 1 year after symptom onset. Cognitive and functional improvements are observed over a 6-year period, as demonstrated by 3 comprehensive neuropsychological evaluations. Residing in a monitored and structured environment for 6 years, with stability in psychiatric medications, monitored nutrition and abstinence from alcohol are attributed to this improvement. This study provides unique evidence of the impact of balanced nutrition and improvements in psychiatric symptoms on cognition.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"180-185"},"PeriodicalIF":0.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of a visual search task in a virtual reality space with a moving background on spatial cognition and standing balance in patients with left hemiparetic stroke. 移动背景虚拟现实空间中的视觉搜索任务对左侧偏瘫脑卒中患者空间认知和站立平衡的影响
IF 0.6 4区 医学
Neurocase Pub Date : 2023-12-01 Epub Date: 2024-05-12 DOI: 10.1080/13554794.2024.2346980
Kazushige Iwakawa, Hiroka Ohshita, Naoya Nozaki, Motoyasu Takenaka, Yuki Ikeda, Fuminari Kaneko, Kazu Amimoto
{"title":"Effects of a visual search task in a virtual reality space with a moving background on spatial cognition and standing balance in patients with left hemiparetic stroke.","authors":"Kazushige Iwakawa, Hiroka Ohshita, Naoya Nozaki, Motoyasu Takenaka, Yuki Ikeda, Fuminari Kaneko, Kazu Amimoto","doi":"10.1080/13554794.2024.2346980","DOIUrl":"10.1080/13554794.2024.2346980","url":null,"abstract":"<p><p>We examined effects of a visual search task (VST) in virtual reality (VR) with a moving background on spatial cognition and standing balance in left hemiparetic strokes. The VST with background deviation was allocated to Case A. In Case B, the VST without the deviation was performed. As a results, in Case A, the reaction time of VST was shortened in the paretic space and ability of weight-shift to the paretic side was improved. In conclusion, the VST in the VR with a spatial manipulation may improve spatial cognition and standing balance in left hemiparetic strokes.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"167-173"},"PeriodicalIF":0.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Young-onset dementia with Lewy Bodies presenting with apathy and alexithymia. 幼年路易体痴呆症表现为冷漠和无情感。
IF 0.6 4区 医学
Neurocase Pub Date : 2023-12-01 Epub Date: 2024-05-16 DOI: 10.1080/13554794.2024.2354545
Stefania Kaninia, Rosaleen A McCarthy, Zia Saad, George P Pengas
{"title":"Young-onset dementia with Lewy Bodies presenting with apathy and alexithymia.","authors":"Stefania Kaninia, Rosaleen A McCarthy, Zia Saad, George P Pengas","doi":"10.1080/13554794.2024.2354545","DOIUrl":"10.1080/13554794.2024.2354545","url":null,"abstract":"<p><p>A diagnosis of young-onset dementia can pose a significant challenge for the clinician. We present a young patient with a very unusual presentation of Dementia with Lewy Bodies. The lack of motor symptoms and his marked apathy delayed his diagnosis. His symptoms were thought to be due to depression based on normal structural imaging and the psychiatric nature of his presentation. An extensive work-up was performed. Evidence of a structural neurodegenerative process was provided by the HMPAO-SPECT. Cardiac MIBG confirmed the diagnosis.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"191-194"},"PeriodicalIF":0.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A neuropsychiatric case of delayed post-hypoxic leukoencephalopathy from opioid intoxication resulting in Anton-Babinski syndrome and quadriplegia. 一例因阿片类药物中毒导致安东-巴宾斯基综合征和四肢瘫痪的迟发性缺氧后白质脑病神经精神病例。
IF 0.6 4区 医学
Neurocase Pub Date : 2023-10-01 Epub Date: 2024-05-07 DOI: 10.1080/13554794.2024.2350103
Roberto A Cardona Quiñones, Saidy A Salem Hernández, Sayuri Sekimitsu, Joalex Antongiorgi Torres, Oleg Yerstein, Laura T Safar
{"title":"A neuropsychiatric case of delayed post-hypoxic leukoencephalopathy from opioid intoxication resulting in Anton-Babinski syndrome and quadriplegia.","authors":"Roberto A Cardona Quiñones, Saidy A Salem Hernández, Sayuri Sekimitsu, Joalex Antongiorgi Torres, Oleg Yerstein, Laura T Safar","doi":"10.1080/13554794.2024.2350103","DOIUrl":"10.1080/13554794.2024.2350103","url":null,"abstract":"<p><p>This is the case of a 26-year-old male who developed Anton Babinski syndrome (ABS), quadriplegia, and delayed post-hypoxic leukoencephalopathy (DPHL) after an opioid overdose. He exhibited cortical blindness, visual anosognosia, and confabulation upon awakening. Several days later, he experienced acute psychosis and agitation. T2-FSE MRI revealed extensive supratentorial leukoencephalopathy involving both cerebral hemispheres, extending to the posterior corpus callosum due to cerebral anoxia. This case report will discuss different types of encephalopathy from opioid abuse, ABS, visual anosognosia, and confabulation's pathogenic mechanisms. It underscores the necessity of researching substance-induced neuropsychiatric disorders and their pathogenic mechanisms for effective treatments.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"160-166"},"PeriodicalIF":0.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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