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Young-onset dementia with Lewy Bodies presenting with apathy and alexithymia. 幼年路易体痴呆症表现为冷漠和无情感。
IF 0.6 4区 医学
Neurocase Pub Date : 2023-12-01 Epub Date: 2024-05-16 DOI: 10.1080/13554794.2024.2354545
Stefania Kaninia, Rosaleen A McCarthy, Zia Saad, George P Pengas
{"title":"Young-onset dementia with Lewy Bodies presenting with apathy and alexithymia.","authors":"Stefania Kaninia, Rosaleen A McCarthy, Zia Saad, George P Pengas","doi":"10.1080/13554794.2024.2354545","DOIUrl":"10.1080/13554794.2024.2354545","url":null,"abstract":"<p><p>A diagnosis of young-onset dementia can pose a significant challenge for the clinician. We present a young patient with a very unusual presentation of Dementia with Lewy Bodies. The lack of motor symptoms and his marked apathy delayed his diagnosis. His symptoms were thought to be due to depression based on normal structural imaging and the psychiatric nature of his presentation. An extensive work-up was performed. Evidence of a structural neurodegenerative process was provided by the HMPAO-SPECT. Cardiac MIBG confirmed the diagnosis.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"191-194"},"PeriodicalIF":0.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A neuropsychiatric case of delayed post-hypoxic leukoencephalopathy from opioid intoxication resulting in Anton-Babinski syndrome and quadriplegia. 一例因阿片类药物中毒导致安东-巴宾斯基综合征和四肢瘫痪的迟发性缺氧后白质脑病神经精神病例。
IF 0.6 4区 医学
Neurocase Pub Date : 2023-10-01 Epub Date: 2024-05-07 DOI: 10.1080/13554794.2024.2350103
Roberto A Cardona Quiñones, Saidy A Salem Hernández, Sayuri Sekimitsu, Joalex Antongiorgi Torres, Oleg Yerstein, Laura T Safar
{"title":"A neuropsychiatric case of delayed post-hypoxic leukoencephalopathy from opioid intoxication resulting in Anton-Babinski syndrome and quadriplegia.","authors":"Roberto A Cardona Quiñones, Saidy A Salem Hernández, Sayuri Sekimitsu, Joalex Antongiorgi Torres, Oleg Yerstein, Laura T Safar","doi":"10.1080/13554794.2024.2350103","DOIUrl":"10.1080/13554794.2024.2350103","url":null,"abstract":"<p><p>This is the case of a 26-year-old male who developed Anton Babinski syndrome (ABS), quadriplegia, and delayed post-hypoxic leukoencephalopathy (DPHL) after an opioid overdose. He exhibited cortical blindness, visual anosognosia, and confabulation upon awakening. Several days later, he experienced acute psychosis and agitation. T2-FSE MRI revealed extensive supratentorial leukoencephalopathy involving both cerebral hemispheres, extending to the posterior corpus callosum due to cerebral anoxia. This case report will discuss different types of encephalopathy from opioid abuse, ABS, visual anosognosia, and confabulation's pathogenic mechanisms. It underscores the necessity of researching substance-induced neuropsychiatric disorders and their pathogenic mechanisms for effective treatments.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"160-166"},"PeriodicalIF":0.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing malingering and personality styles in dissociative identity disorder: a case study. 评估分离性身份识别障碍中的装疯卖傻和人格风格：一项个案研究。
IF 0.6 4区 医学
Neurocase Pub Date : 2023-10-01 Epub Date: 2024-05-04 DOI: 10.1080/13554794.2024.2348218
Renzo C Lanfranco, Juan Carlos Martínez-Aguayo, Marcelo Arancibia
{"title":"Assessing malingering and personality styles in dissociative identity disorder: a case study.","authors":"Renzo C Lanfranco, Juan Carlos Martínez-Aguayo, Marcelo Arancibia","doi":"10.1080/13554794.2024.2348218","DOIUrl":"10.1080/13554794.2024.2348218","url":null,"abstract":"<p><p>Dissociative Identity Disorder (DID), formerly Multiple Personality Disorder, involves two or more distinct identities controlling behaviour, stemming from trauma-related dissociation. Understanding DID's cognitive, neural, and psychometric aspects remains a challenge, especially in distinguishing genuine cases from malingering. We present a case of a DID patient with nine identities, evaluated to rule out malingering. Using the Millon Index of Personality Styles, we assessed the primary and two alternate identities, revealing marked differences. High consistency scores support validity. We suggest employing personality inventories beyond symptomatology to characterise dissociative identities' consistency and adaptation styles, aiding in malingering assessments in future studies.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"141-150"},"PeriodicalIF":0.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Facilitated lexical processing accuracy and reaction times following repetitive Transcranial Magnetic Stimulation in dementia of the Alzheimer type: a case study. 重复经颅磁刺激对阿尔茨海默型痴呆症患者词汇处理准确性和反应时间的促进作用：一项病例研究。
IF 0.6 4区 医学
Neurocase Pub Date : 2023-10-01 Epub Date: 2024-05-03 DOI: 10.1080/13554794.2024.2348222
Georgia Roumpea, Jurij Bon, Katarina Marjanovič, Zvezdan Pirtošek, Christina Manouilidou
{"title":"Facilitated lexical processing accuracy and reaction times following repetitive Transcranial Magnetic Stimulation in dementia of the Alzheimer type: a case study.","authors":"Georgia Roumpea, Jurij Bon, Katarina Marjanovič, Zvezdan Pirtošek, Christina Manouilidou","doi":"10.1080/13554794.2024.2348222","DOIUrl":"10.1080/13554794.2024.2348222","url":null,"abstract":"<p><p>We investigated the potential effects of high-frequency (10 Hz) repetitive Transcranial Magnetic Stimulation (rTMS) of the bilateral Dorsolateral Prefrontal Cortex (DLPFC) (30-sessions; 2-sessions/day) on improving lexical processing in one participant with mild - Alzheimer's disease (hereafter dementia of the Alzheimer type-DAT). Increased accuracy and faster reaction times (RTs) were reported in a lexical-decision task (LDT) up to 2-months post-intervention. The current findings indicate that high-frequency stimulation of the DLPFC might be a potential therapeutic tool to improve lexical processing in mild-DAT.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"151-159"},"PeriodicalIF":0.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regional cerebral blood flow in a patient with asystole episodes associated with anti-NMDA receptor encephalitis. 与抗 NMDA 受体脑炎相关的一名晕厥发作患者的区域脑血流。
IF 0.6 4区 医学
Neurocase Pub Date : 2023-08-01 Epub Date: 2024-04-27 DOI: 10.1080/13554794.2024.2348221
Gaku Aboshi, Takaki Akahane, Keisuke Noto, Ryota Kobayashi, Masakazu Akiho, Akihito Suzuki
{"title":"Regional cerebral blood flow in a patient with asystole episodes associated with anti-NMDA receptor encephalitis.","authors":"Gaku Aboshi, Takaki Akahane, Keisuke Noto, Ryota Kobayashi, Masakazu Akiho, Akihito Suzuki","doi":"10.1080/13554794.2024.2348221","DOIUrl":"10.1080/13554794.2024.2348221","url":null,"abstract":"<p><p>Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a rare and severe autoimmune encephalitis that displays neuropsychiatric symptoms and autonomic instability, e.g., hypoventilation and cardiac arrhythmia. Severe arrhythmia including asystole associated with this encephalitis is rare. Several causes have been suggested. Nevertheless, no report of the literature has described examination by functional brain imaging of a patient with asystole during anti-NMDA receptor encephalitis. This case is that of a 34-year-old woman diagnosed as having anti-NMDA receptor encephalitis. She repeatedly showed 10-20 s asystole episodes necessitating a temporary transvenous pacemaker. After resection of the bilateral ovarian cystic tumor, her symptoms improved. Regional cerebral blood flow (rCBF) was evaluated using single-photon emission computed tomography. The rCBF was increased in the amygdala, hypothalamus, anterior cingulate, hippocampus, and anterior temporal lobes, but decreased in the dorsolateral frontal lobes, parietal lobes, and occipital lobes. Findings in this case suggest that altered rCBF in the patient with asystole episodes associated with anti-NMDA receptor encephalitis was observed in several brain lesions. The rCBF increases in the central autonomic networks, i.e., the amygdala, hypothalamus, and anterior cingulate, might be associated with dysregulation of sympathetic and parasympathetic nervous systems leading to asystole.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"113-116"},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lissencephaly: presentation of a clinical case of LIS 1 with a diagnosis confirmed by MLPA method and indications for rehabilitation treatment in childhood. 无脑畸形：介绍一例通过 MLPA 方法确诊的 LIS 1 临床病例，以及儿童康复治疗的适应症。
IF 0.6 4区 医学
Neurocase Pub Date : 2023-08-01 Epub Date: 2024-05-03 DOI: 10.1080/13554794.2024.2346985
Rita Abrunzo
{"title":"Lissencephaly: presentation of a clinical case of LIS 1 with a diagnosis confirmed by MLPA method and indications for rehabilitation treatment in childhood.","authors":"Rita Abrunzo","doi":"10.1080/13554794.2024.2346985","DOIUrl":"10.1080/13554794.2024.2346985","url":null,"abstract":"<p><p>Lissencephaly is a very rare clinical condition that affects the formation of the brain and causes severe psychomotor retardation, convulsions and muscular spasticity or hypotonia, often also associated with respiratory problems, facial dysmorphisms, abnormalities of the fingers and toes and difficulty swallowing resulting in reduced life expectancy. The clinical case described in the following article demonstrates the diagnostic process and rehabilitation treatment of a patient through a narrative review of the scientific literature and the presentation of this condition in order to provide indications to guide rehabilitation treatment in childhood.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"103-112"},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of Pitt-Hopkins syndrome: psychopharmacological approach for anxiety, insomnia, and agitation. 一例皮特-霍普金斯综合征：焦虑、失眠和躁动的精神药物治疗方法。
IF 0.6 4区 医学
Neurocase Pub Date : 2023-08-01 Epub Date: 2024-05-03 DOI: 10.1080/13554794.2024.2348230
Cemre Istanbullu, Binay Kayan Ocakoglu, Gul Karacetin
{"title":"A case of Pitt-Hopkins syndrome: psychopharmacological approach for anxiety, insomnia, and agitation.","authors":"Cemre Istanbullu, Binay Kayan Ocakoglu, Gul Karacetin","doi":"10.1080/13554794.2024.2348230","DOIUrl":"10.1080/13554794.2024.2348230","url":null,"abstract":"<p><p>Pitt-Hopkins syndrome (PTHS) is a rare genetic disorder resulting from TCF4 gene mutations which is characterized by dysmorphic facial features, psychomotor delay, intellectual disability, breathing anomalies, and seizures. Psychiatric conditions are occasionally seen. We present the case report of a seven-year-old PTHS patient with anxiety, insomnia, and agitation. We discuss the psychopharmacological intervention options for this patient. The present case study reports on a 7-year-old female with PTHS, autism spectrum disorder (ASD), and intellectual disability. She had insomnia, crying spells and agitation complaints. For anxiety symptoms and agitation, risperidone, fluoxetine, and clonazepam treatment were given by the neurologist which caused behavioral disinhibition, paroxysmal agitation and no benefit. After admission to our hospital, aripiprazole and hydroxyzine were prescribed for anxiety and ASD-related irritability. She showed a minimal improvement but hyperventilation attacks were still ongoing. Hydroxyzine was stopped, and quetiapine was given to eliminate sleep disturbance. Her sleep period went up to eleven hours. For the anxiety symptoms, escitalopram was prescribed. She showed improvements in sleep, diminished hyperactivity and decreased frequency of abnormal breathing spells. Also, enhancement of social communication skills like increased eye contact and response to her name was observed. Patients with genetic syndromes may have various psychiatric complaints. Psychopharmacological interventions should be administered carefully for the side effects.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"117-120"},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neglecting the bottom space: an object-based disorder? A two-case observational study. 忽视底部空间：基于物体的失调？两例观察研究。
IF 0.8 4区 医学
Neurocase Pub Date : 2023-08-01 Epub Date: 2024-02-26 DOI: 10.1080/13554794.2024.2315860
Jennifer Martin, Patrik Vuilleumier, Frédéric Assal, Roberta Ronchi
{"title":"Neglecting the bottom space: an object-based disorder? A two-case observational study.","authors":"Jennifer Martin, Patrik Vuilleumier, Frédéric Assal, Roberta Ronchi","doi":"10.1080/13554794.2024.2315860","DOIUrl":"10.1080/13554794.2024.2315860","url":null,"abstract":"<p><p>Altitudinal neglect is an atypical form of spatial neglect where brain-damaged patients neglect the lower, or sometimes the upper, part of the space. Our understanding of this phenomena is limited, with unknown occurrence across different reference frames, such as distance (peripersonal vs. extrapersonal) and system of reference (egocentric vs. allocentric). Two patients with acute bilateral (P1) or right hemispheric (P2) stroke, with signs of bottom altitudinal neglect, underwent an extensive evaluation of neglect within 10 days post-stroke. Assessments involved altitudinal neglect and unilateral spatial neglect (USN) in peripersonal space, exploring egocentric and allocentric signs and in extrapersonal space. Compared to a control group of 15 healthy age-matched subjects, patients showed allocentric and egocentric left USN in peripersonal space, and mostly allocentric signs of altitudinal neglect. No signs of neglect were evidenced in extrapersonal space. Altitudinal neglect could thus present as an allocentric form of spatial neglect, suggesting that allocentric representations may not only affect the deployment of attentional resources along horizontal dimensions but also operate along vertical dimensions. Future studies should deepen our understanding of altitudinal neglect, eventually leading to further unravel spatial processes that control attention, their corresponding brain mechanisms, and implications for patients' rehabilitation and functional outcome.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"121-131"},"PeriodicalIF":0.8,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139974229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cortical blindness after percutaneous vertebroplasty: a case report and comprehensive review of the literature. 经皮椎体成形术后的皮质盲：病例报告和文献综述。
IF 0.6 4区 医学
Neurocase Pub Date : 2023-08-01 Epub Date: 2024-04-30 DOI: 10.1080/13554794.2024.2346984
Chunnan Shi, Zhijie Wang, Meiying Lin, Zhiqin Chen, Peiyang Xu, Yi Li, Jinshan Zhang
{"title":"Cortical blindness after percutaneous vertebroplasty: a case report and comprehensive review of the literature.","authors":"Chunnan Shi, Zhijie Wang, Meiying Lin, Zhiqin Chen, Peiyang Xu, Yi Li, Jinshan Zhang","doi":"10.1080/13554794.2024.2346984","DOIUrl":"10.1080/13554794.2024.2346984","url":null,"abstract":"<p><strong>Objective: </strong>Many complications but cortical blindness after percutaneous vertebroplasty has been rarely reported. Here, we describe a case who developed cortical blindness after percutaneous vertebroplasty. We also reviewed the literature to find the possible causes of this complication and its treatment.</p><p><strong>Methods: </strong>Case report and literature review.</p><p><strong>Results: </strong>A 71-year-old woman experienced cortical blindness after percutaneous vertebroplast. She developed dizziness, nausea, sweating, blood pressure changes, and vision loss during the procedure. MRI confirmed bilateral cerebral infarctions. The patient recovered with conservative treatment.</p><p><strong>Conclusions: </strong>Percutaneous vertebroplasty, though helpful, carries a rare risk of cortical blindness. Surgeon awareness is crucial for informing patients of this potential complication.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"99-102"},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of deep transcranial magnetic stimulation on Alzheimer's disease: a case report examining cognitive functioning, memory, and QEEG. 深部经颅磁刺激对阿尔茨海默病的影响：一份研究认知功能、记忆和 QEEG 的病例报告。
IF 0.6 4区 医学
Neurocase Pub Date : 2023-06-01 Epub Date: 2024-04-27 DOI: 10.1080/13554794.2024.2346987
Nathaniel A Shanok, Sabrina Muzac, Brittany Derbin, Enis Cabeza, Raul Rodriguez
{"title":"The effects of deep transcranial magnetic stimulation on Alzheimer's disease: a case report examining cognitive functioning, memory, and QEEG.","authors":"Nathaniel A Shanok, Sabrina Muzac, Brittany Derbin, Enis Cabeza, Raul Rodriguez","doi":"10.1080/13554794.2024.2346987","DOIUrl":"10.1080/13554794.2024.2346987","url":null,"abstract":"<p><p>Numerous treatment options are being studied for Alzheimer's disease (AD) given the rising prevalence of this condition worldwide. Transcranial Magnetic Stimulation (TMS) is a promising option for regulating specific neurological abnormalities pertaining to this condition. This case presents a patient with AD and co-occurring major depressive disorder that received 36 sessions of Deep TMS to the frontal and temporal lobes. This patient experienced improved general cognitive functioning and memory, remission from depression, and reduced slow-frequency theta activity in frontal and temporal sites. Following 7 months of weekly maintenance, additional improvements occurred. This report suggests that Deep TMS may be effective in mitigating AD symptoms, and maintenance sessions are advisable.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"81-86"},"PeriodicalIF":0.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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