Neurocase最新文献_第3页

An advancement of intraoperative language mapping in awake craniotomy. 清醒开颅术中语言定位的研究进展。

IF 0.5 4区医学

Neurocase Pub Date : 2026-04-01 Epub Date: 2026-05-05 DOI: 10.1080/13554794.2026.2666421

Rhiannon MacKenzie-Phelan, Francis McGlone, Samantha Brooks, Daniel Roberts

{"title":"An advancement of intraoperative language mapping in awake craniotomy.","authors":"Rhiannon MacKenzie-Phelan, Francis McGlone, Samantha Brooks, Daniel Roberts","doi":"10.1080/13554794.2026.2666421","DOIUrl":"10.1080/13554794.2026.2666421","url":null,"abstract":"Direct electrical stimulation (DES) during awake craniotomy is the gold-standard for language mapping; however, conventional tasks (e.g. counting, object naming, reading) provide limited sensitivity to grammatical and sentence-level processes. The present study introduces the first intraoperative application of the English Verb and Noun Test for Perioperative testing (VAN-POP), a sentence-based paradigm designed to probe object and action naming with finite verbs in past and present tense. VAN-POP was administered to four UK English-speaking patients undergoing awake craniotomy for WHO grade II-III gliomas involving frontal, temporal, or parietal regions. Language-positive sites were identified in three patients, and real-time monitoring revealed language disruptions in three patients. DES elicited action naming disruptions in two patients. Middle and inferior frontal stimulation induced tense errors and verbal-visual paraphasias, whilst angular gyrus stimulation induced speech arrest. During resection, three patients exhibited action naming disruptions, including semantic and morphosyntactic errors, anomia, and delays. Postoperatively, no patients showed clinically significant deficits requiring speech and language therapy. These findings demonstrate that VAN-POP is feasible for intraoperative use and increases sensitivity to grammar-related cortical sites beyond conventional mapping approaches. Incorporating finite verb production within DES protocols may improve delineation of language networks, supporting better preservation of function.","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"80-97"},"PeriodicalIF":0.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial Neurocase. 编辑编号。

IF 0.8 4区医学

Neurocase Pub Date : 2026-02-01 Epub Date: 2026-03-08 DOI: 10.1080/13554794.2026.2635887

Marc W Haut

引用次数: 0

A novel mutation in colony-stimulating factor 1 receptor (CSF1R) causing CSF1R-related disorder (CSF1R-RD). 集落刺激因子1受体（CSF1R）突变导致CSF1R相关疾病（CSF1R- rd）

IF 0.5 4区医学

Neurocase Pub Date : 2026-02-01 Epub Date: 2026-02-04 DOI: 10.1080/13554794.2026.2613957

Anup N Sonti, Elizabeth Joe, Jillian V Berry, Michelle McDonnell, Seyed Ahmad Sajjadi, Nasim Sheik-Bahaei, Lilyana Amezcua, Danielle Feigenbaum, Mark F Lew, Matthew Blurton-Jones, Elizabeth Head, John M Ringman

引用次数: 0

Beyond motor impairment: investigating cognitive aspects of hereditary spastic paraplegia in a Greek case series. 超越运动障碍：在希腊病例系列中调查遗传性痉挛性截瘫的认知方面。

IF 0.5 4区医学

Neurocase Pub Date : 2026-02-01 Epub Date: 2026-03-02 DOI: 10.1080/13554794.2026.2635354

Alex Malioukis, Dimitrios Kasselimis, Georgia Angelopoulou, Dimitrios Tsolakopoulos, Zoi Nikitopoulou, Georgia Karadima, Georgios Koutsis, Constantin Potagas

{"title":"Beyond motor impairment: investigating cognitive aspects of hereditary spastic paraplegia in a Greek case series.","authors":"Alex Malioukis, Dimitrios Kasselimis, Georgia Angelopoulou, Dimitrios Tsolakopoulos, Zoi Nikitopoulou, Georgia Karadima, Georgios Koutsis, Constantin Potagas","doi":"10.1080/13554794.2026.2635354","DOIUrl":"10.1080/13554794.2026.2635354","url":null,"abstract":"Hereditary spastic paraplegia (HSP) is a heterogeneous group of inherited disorders primarily characterized by progressive spasticity and lower extremity weakness. Traditionally associated with corticospinal tract dysfunction, HSP was long presumed to leave cognitive function largely unaffected. However, growing evidence increasingly recognizes cognitive impairment as a relevant feature of the condition. The primary aim of this study is to broaden the understanding of the cognitive profile in HSP, by examining cognitive impairments in a Greek cohort. A detailed neuropsychological assessment was conducted in 10 HSP patients and 30 healthy controls, including measures of executive function, memory, attention, processing speed, visual scanning, and social cognition. Our findings revealed widespread cognitive impairment, with prominent deficits in processing speed, attention, visual scanning, and social cognition, supporting reduced cognitive resilience in HSP. On a neuroanatomic level, the observed cognitive decline in HSP may indicate localized dysfunction within the frontal area of the brain among affected patients. We futher hypothesize that genetically distinct HSP subtypes converge on shared cellular disruptions that may compromise frontotemporal networks, thereby producing similar cognitive phenotypes.","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"51-63"},"PeriodicalIF":0.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147345541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delayed-onset parkinsonism after carbon monoxide poisoning: neuropsychological perspectives from a case report. 一氧化碳中毒后迟发性帕金森氏症：一例病例报告的神经心理学观点。

IF 0.8 4区医学

Neurocase Pub Date : 2026-02-01 Epub Date: 2025-12-29 DOI: 10.1080/13554794.2025.2610945

Michelle Ingiardi, Elisa Pini, Veronica Laini, Beatrice Feder, Eugenio Magni, Nazzareno Fagoni, Fulvio Pepe

引用次数: 0

Familial young-onset Parkinson's disease associated with SNCA gene duplication: a case series of three sisters from Turkey. 与SNCA基因重复相关的家族性早发帕金森病：土耳其三姐妹的病例系列

IF 0.5 4区医学

Neurocase Pub Date : 2026-02-01 Epub Date: 2026-02-25 DOI: 10.1080/13554794.2026.2620678

Pervin Işeri, Enes Demiryurek

{"title":"Familial young-onset Parkinson's disease associated with SNCA gene duplication: a case series of three sisters from Turkey.","authors":"Pervin Işeri, Enes Demiryurek","doi":"10.1080/13554794.2026.2620678","DOIUrl":"10.1080/13554794.2026.2620678","url":null,"abstract":"SNCA gene duplications are a rare cause of autosomal dominant Parkinson's disease (PD), linked to early onset and cognitive or behavioral symptoms. Data from Turkey remain limited. To describe the clinical, cognitive, behavioral, and genetic features of three Turkish sisters with familial PD due to SNCA duplication. This retrospective case series includes three sisters with PD. Clinical history, neurological examinations, Unified Parkinson's Disease Rating Scale (UPDRS-III) scores, treatment history, and neuropsychological findings were recorded. Genetic testing was conducted using whole exome sequencing. One sister underwent subthalamic nucleus deep brain stimulation (STN-DBS), and outcomes were followed over time. All patients presented with early-onset PD and classic motor symptoms, including bradykinesia and rigidity. Non-motor features such as REM sleep behavior disorder, orthostatic hypotension, urinary incontinence, and hallucinations were common. Two developed impulse control disorders, including hypersexuality and compulsive behaviors. Cognitive decline occurred in two, with MoCA scores of 24 and 22, and neuropsychological testing revealed frontal and temporolimbic dysfunction. The sister treated with DBS showed initial improvement but later motor and cognitive progression. This first detailed Turkish familial series highlights the broad symptom spectrum of SNCA duplication PD and underscores the need for genetic and neuropsychiatric assessment in familial cases.","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"40-50"},"PeriodicalIF":0.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147286038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixed primary progressive aphasia and alcohol use disorder: a case of detailed clinical phenotyping outperforming molecular imaging. 混合性原发性进行性失语和酒精使用障碍：1例详细临床表型优于分子影像学。

IF 0.5 4区医学

Neurocase Pub Date : 2026-02-01 Epub Date: 2026-02-18 DOI: 10.1080/13554794.2026.2623906

Obiora Okoye, Cristiano Schaffer Aguzzoli, Petronilla Battista, Claudia Ramos, Karen Meenan, Maison Abu Raya, Buddhika Ratnasiri, Julio C Rojas, Jessica de Leon, Bruce Miller, Maria Luisa Gorno-Tempini, Renaud La Joie, Salvatore Spina

{"title":"Mixed primary progressive aphasia and alcohol use disorder: a case of detailed clinical phenotyping outperforming molecular imaging.","authors":"Obiora Okoye, Cristiano Schaffer Aguzzoli, Petronilla Battista, Claudia Ramos, Karen Meenan, Maison Abu Raya, Buddhika Ratnasiri, Julio C Rojas, Jessica de Leon, Bruce Miller, Maria Luisa Gorno-Tempini, Renaud La Joie, Salvatore Spina","doi":"10.1080/13554794.2026.2623906","DOIUrl":"10.1080/13554794.2026.2623906","url":null,"abstract":"Primary progressive aphasia (PPA) refers to a group of clinically and pathologically heterogeneous syndromes characterized by progressive and relatively selective impairment in speech and language as the main cognitive domain in the early disease stage. The main clinical variants of PPA based on current diagnostic criteria include logopenic variant PPA (lvPPA), nonfluent variant PPA (nfvPPA), and semantic variant PPA (svPPA). Identification of speech/language and non-language abilities and in vivo biomarkers (such as neuroimaging, genetic, and biofluid studies) facilitates the correct classification of the main variants. PPA variants clinical presentation may overlap leading to a diagnosis of mixed or unclassified PPA. We report the case of a trilingual patient with a 10-year history of word-finding difficulties initially attributed to chronic alcohol abuse. Her clinical presentation was evocative of lvPPA with features of svPPA, while her neuropsychological testing and MRI data were suggestive of a diagnosis of svPPA. While β-amyloid PET brain imaging was negative, postmortem immunohistochemical analysis of the brain showed unequivocal evidence of Alzheimer's disease. We describe this case of complex PPA for which clinical data outperformed imaging biomarkers in predicting the underlying neuropathology and discuss chronic alcohol abuse as a potential risk factor for neurodegeneration.","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"29-39"},"PeriodicalIF":0.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13180464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual form agnosia of line drawings and alexia and agraphia of Kanji after right fusiform gyrus and occipitotemporal lobe infarction. 右侧梭状回和枕颞叶梗死后的线形失认和汉字失读失写。

IF 0.8 4区医学

Neurocase Pub Date : 2026-02-01 Epub Date: 2025-11-23 DOI: 10.1080/13554794.2025.2587128

Yoshiko Kurosaki, Masakuni Nomura, Ryusaku Hashimoto

引用次数: 0

Management of MOGAD in an immunosuppressed HIV-positive patient: the first case presenting with alexia without agraphia. 免疫抑制hiv阳性患者MOGAD的处理：第一例无失写症的失读症。

IF 0.8 4区医学

Neurocase Pub Date : 2025-12-01 Epub Date: 2025-11-05 DOI: 10.1080/13554794.2025.2585052

Özlem Totuk, Çiğdem Akalan, Serkan Demir

{"title":"Management of MOGAD in an immunosuppressed HIV-positive patient: the first case presenting with alexia without agraphia.","authors":"Özlem Totuk, Çiğdem Akalan, Serkan Demir","doi":"10.1080/13554794.2025.2585052","DOIUrl":"10.1080/13554794.2025.2585052","url":null,"abstract":"Myelin oligodendrocyte glycoprotein antibody-associated disease (MOG AD) is a rare autoimmune demyelinating condition typically presenting with optic neuritis, transverse myelitis, or encephalitis. Its occurrence in immunocompromised individuals, particularly those with human immunodeficiency virus (HIV), is rare and presents unique diagnostic and therapeutic challenges. We report the case of a 70-year-old HIV-positive man who developed alexia without agraphia following treatment for opportunistic infections, including Pneumocystis jirovecii pneumonia and cytomegalovirus. Brain MRI revealed a non-enhancing hyperintense lesion in the medial left occipital lobe extending into the splenium of the corpus callosum. MOG-IgG was positive at a titer of 1:30, while aquaporin-4 antibodies and paraneoplastic panels were negative. Neuropsychological assessment confirmed selective impairment in visual word recognition with preserved writing ability, consistent with alexia without agraphia. The patient was treated with intravenous immunoglobulin (IVIG) without corticosteroids due to immunosuppressive concerns and demonstrated approximately 40% improvement in visual word recognition accuracy. At six months follow-up, no relapse was observed, and reading ability remained stable. This case represents the first reported instance of MOGAD presenting with alexia without agraphia in an HIV-positive individual, underscoring the importance of considering autoimmune demyelination in immunosuppressed patients with focal neurological deficits.","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"254-259"},"PeriodicalIF":0.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple ischemic strokes in a patient treated with Lecanemab: a case report. 利卡耐单抗治疗患者多发性缺血性中风1例

IF 0.8 4区医学

Neurocase Pub Date : 2025-12-01 Epub Date: 2025-10-16 DOI: 10.1080/13554794.2025.2566151

Hajar Alammar, Mamadou Diallo, Daniel A Llano

引用次数: 0