{"title":"Exploring Seizure Risks in Cerebral Venous Sinus Thrombosis Based on Thrombosis Site.","authors":"Ali Amini Harandi, Helia Jafari Khaljiri, Nafiseh Jahangiri Zarkani, Hossein Pakdaman, Nika Khalili","doi":"10.1097/NRL.0000000000000625","DOIUrl":"https://doi.org/10.1097/NRL.0000000000000625","url":null,"abstract":"<p><strong>Objectives: </strong>Cerebral venous sinus thrombosis (CVST) often leads to seizures, potentially worsening prognosis. This study aimed to assess the relationship between specific occlusion sites and seizure occurrence.</p><p><strong>Methods: </strong>We retrospectively analyzed 154 patients diagnosed with CVST in 3 major hospitals in Tehran. Medical records detailing sinus involvement, seizure occurrence, and baseline characteristics were reviewed. Statistical analyses included the χ2 or the Fisher exact tests, followed by binomial logistic regression to identify independent predictors. Model performance was evaluated using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>The study included 102 women (66.2%) and 52 men (33.8%), with a mean age of 36.4±10.8 years. A total of 35 patients (22.7%) experienced seizures, predominantly generalized tonic-clonic (85.7%). Superior sagittal sinus (SSS) involvement was strongly associated with seizures (odds ratio=3.056, P=0.006), while left transverse sinus involvement showed a marginally significant inverse relationship in univariate analysis (P=0.027), which became nonsignificant in the multivariate model (P=0.056). Trolard vein thrombosis was rare but associated with a high seizure rate (3/4 cases). The ROC for the final model showed moderate predictive ability (AUC=0.676).</p><p><strong>Conclusion: </strong>SSS thrombosis significantly predicted seizures in Iranian CVST patients. Although rare, trolard vein involvement may carry a substantial seizure risk. These findings underscore the importance of precise imaging and individualized treatment plans for high-risk CVST patients. By illuminating the role of SSS and trolard vein, this study highlights the need for prospective trials to refine clinical decision-making.</p>","PeriodicalId":49758,"journal":{"name":"Neurologist","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurologistPub Date : 2025-04-03DOI: 10.1097/NRL.0000000000000613
Surabhi Garg, Tuqa Asedi, Elyse Sandra Vetter, Hussein Alsadi, Rachel Alexis Dukes, Chelsey Marie Schartz, Mohammed Q Al-Sabbagh, Sibi Thirunavukkarasu, Prasanna Eswaradass
{"title":"Does Fasting Triglyceride Level Influence Core Infarct Volume in Acute Stroke?","authors":"Surabhi Garg, Tuqa Asedi, Elyse Sandra Vetter, Hussein Alsadi, Rachel Alexis Dukes, Chelsey Marie Schartz, Mohammed Q Al-Sabbagh, Sibi Thirunavukkarasu, Prasanna Eswaradass","doi":"10.1097/NRL.0000000000000613","DOIUrl":"https://doi.org/10.1097/NRL.0000000000000613","url":null,"abstract":"<p><strong>Objective: </strong>Our study explores the relationship between fasting triglyceride levels and initial infarct volume in acute ischemic stroke (AIS) patients.</p><p><strong>Methods: </strong>We performed a retrospective chart review and cross-sectional analysis of AIS patients admitted to a tertiary care center in Kansas from 2010 to 2023. Inclusion criteria were AIS patients who (1) underwent CTA and CTP within 24 hours of stroke onset, and (2) had fasting triglyceride levels measured within 24 hours of admission. Infarct volume was calculated using RAPID software (iSchemaView Inc.). Statistical analyses were conducted using STATA (Release 16), with T tests, ANOVA, χ2 tests, and multivariable linear regression applied as appropriate.</p><p><strong>Results: </strong>We included 178 patients, 52% (n=92) of whom were male, and 31% were aged 61 to 70 years. Mean TG levels were 116.91±70.23 mg/dL, and mean infarct volume was 41.64±53.35 mL. Linear regression showed a significant positive association between TG levels and infarct volume (P<0.01, β=0.17, 95% CI: 0.06-0.28), with a 0.17 mL increase in infarct volume per unit increase in TG levels. Patients with Embolic stroke of undetermined source (ESUS) had larger infarct volumes compared with those with large artery atherosclerosis (P<0.05) and the highest mean TG levels (135.61 mg/dL).</p><p><strong>Conclusion: </strong>Hypertriglyceridemia was positively associated with larger infarct volumes, particularly in ESUS patients, who had the highest TG levels and larger infarct sizes. These findings suggest that elevated TG may predict worse stroke outcomes and could be a potential therapeutic target for stroke prevention.</p>","PeriodicalId":49758,"journal":{"name":"Neurologist","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurologistPub Date : 2025-04-02DOI: 10.1097/NRL.0000000000000621
Hinpetch Daungsupawong, Viroj Wiwanitkit
{"title":"Artificial Intelligence-powered Virtual Assistant for Emergency Triage in Neurology.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1097/NRL.0000000000000621","DOIUrl":"https://doi.org/10.1097/NRL.0000000000000621","url":null,"abstract":"","PeriodicalId":49758,"journal":{"name":"Neurologist","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurologistPub Date : 2025-03-31DOI: 10.1097/NRL.0000000000000596
Waseem Wahood, Bilal Bucak, Carlee I Oakley, Zafer Keser
{"title":"Are Noncancerous Gynecologic Conditions or Pregnancy Risk Factors for Ischemic Stroke in Cervical Artery Dissection?","authors":"Waseem Wahood, Bilal Bucak, Carlee I Oakley, Zafer Keser","doi":"10.1097/NRL.0000000000000596","DOIUrl":"https://doi.org/10.1097/NRL.0000000000000596","url":null,"abstract":"<p><strong>Objective: </strong>Cervical artery dissection (CeAD) was previously thought to be more common in men, but recent epidemiology studies show a disproportionate increase in the incidence of CeAD in women. In addition to sex-based differences in clinical presentation, there are unique biological risk factors for CeAD in women. Identifying risk factors for ischemic stroke in CeAD is crucial in individualizing treatment options. Herein, we utilized an inpatient cohort to investigate whether noncancerous gynecologic conditions or pregnancy are risk factors for ischemic stroke in CeAD.</p><p><strong>Methods: </strong>The National Inpatient Sample was queried from 2016 to 2020 for patients diagnosed with CeAD using the International Classification of Diseases, 10th edition, correction of the mean codes. Diagnoses of pregnancy/puerperium and noncancerous gynecologic conditions were identified. Among CeAD admissions, acute ischemic stroke (AIS) was also identified. Hierarchical, multivariable regression, adjusted for patient demographics and medical comorbidities, was conducted to assess factors associated with AIS.</p><p><strong>Results: </strong>A total of 34,925 women with CeAD were identified. Of these women, 2.1% were pregnant or up to six weeks postpartum, 1.3% had a noncancerous gynecologic condition, and 0.09% had both active pregnancy/puerperium and a noncancerous gynecologic condition. Noncancerous gynecologic conditions (odds ratio = 1.86, P = 0.012) were found to be an independent risk factor for AIS in CeAD but not active pregnancy/puerperium (odds ratio = 0.84, P = 0.34).</p><p><strong>Conclusion: </strong>In this national inpatient sample of female patients with CeAD, the presence of noncancerous gynecologic conditions is associated with an increased risk of AIS. Further studies are needed to validate this observation and help guide the best antithrombotic treatment decisions in this patient population.</p>","PeriodicalId":49758,"journal":{"name":"Neurologist","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurologistPub Date : 2025-03-25DOI: 10.1097/NRL.0000000000000619
Jie Li, Xiaoying Miao, Yan Chen, Jianke Gu, Yan Zeng, Qinhui Zhu, Huiqi Yao
{"title":"Incidence and Risk Factors of Urinary Retention in Acute Ischemic Stroke Patients: A Retrospective Study.","authors":"Jie Li, Xiaoying Miao, Yan Chen, Jianke Gu, Yan Zeng, Qinhui Zhu, Huiqi Yao","doi":"10.1097/NRL.0000000000000619","DOIUrl":"https://doi.org/10.1097/NRL.0000000000000619","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the incidence and risk factors of urinary retention in acute ischemic stroke (AIS) patients.</p><p><strong>Materials and methods: </strong>A total of 993 patients diagnosed with AIS were analyzed retrospectively. According to the incidence of urinary retention, these patients were divided into the urinary retention group and the nonurinary retention group. The incidence of urinary retention after AIS was analyzed. Univariate analysis and binary logistic regression analysis were performed to screen the independent risk factors for urinary retention after AIS.</p><p><strong>Results: </strong>The incidence of urinary retention in AIS patients was 10.98% (109/993). According to the results of the univariate analysis, age (P<0.01), sex (P=0.020), National Institutes of Health Stroke Scale (NIHSS) <10 (P<0.01), Barthel Index (BI) <40 (P<0.01), multiple cerebral infarction (P=0.002), manual muscle test (MMT) (P<0.01), urinary tract infection (UTI) (P<0.01), and benign prostate hyperplasia (BPH) (P<0.01) were significantly correlated with urinary retention incidence. The binary logistic regression analysis revealed that female (OR: 1.954, 95% CI: 1.065-3.587), BI <40 (OR: 24.067, 95% CI: 11.652-49.713), UTI (OR: 8.214, 95% CI: 3.714-18.169), and BPH (OR: 11.342, 95% CI: 5.460-12.560) were independent risk factors for urinary retention after AIS.</p><p><strong>Conclusions: </strong>The incidence of urinary retention in AIS patients was 10.98%. BI <40, UTI, and BPH were identified as risk factors for poststroke urinary retention. In addition, being female constituted another risk factor for urinary retention, requiring further study.</p>","PeriodicalId":49758,"journal":{"name":"Neurologist","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurologistPub Date : 2025-03-19DOI: 10.1097/NRL.0000000000000622
Guangtao Bai, Liang Jiang, Qi Li, Peiju Qiu
{"title":"Study on Intermittent Theta Burst Stimulation Improves Expression Function and Mechanism in Patients With Aphasia After Stroke.","authors":"Guangtao Bai, Liang Jiang, Qi Li, Peiju Qiu","doi":"10.1097/NRL.0000000000000622","DOIUrl":"https://doi.org/10.1097/NRL.0000000000000622","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effects of Intermittent Theta Burst Stimulation (iTBS) on the posterior inferior frontal gyrus of the left hemisphere on the expression function of patients with aphasia after stroke, and to explore the specific mechanism of fractional amplitude of low-frequency fluctuation (fALFF) analysis and degree centrality (DC) analysis of resting-state functional MRI.</p><p><strong>Methods: </strong>According to the inclusion and exclusion criteria, 40 patients with poststroke aphasia were randomized into a treatment group (iTBS group) and a control group (S-iTBS group). Patients in the iTBS group received iTBS +speech training, and patients in the S-iTBS group received sham iTBS + speech training. The Western aphasia test (Chinese version) was used to assess spontaneous language, naming, retelling, and aphasia quotient before and after treatment; resting-state fMRI scans were performed before and after treatment, and the scanned image data were analyzed to explore specific activated or suppressed brain regions.</p><p><strong>Results: </strong>Compared with before and after treatment, the scores of spontaneous language, naming, retelling, and aphasia quotient of the patients in iTBS group improved significantly, and the spontaneous language, naming, retelling, and aphasia quotient of the patients in S-iTBS group also improved. After the treatment, the scores of naming, retelling and aphasia quotient of the patients in the iTBS group improved significantly compared with that of the patients in the S-iTBS group. The resting-state fMRI results of the 2 groups before and after treatment were fALFF analysis found that the fALFF value increased in multiple brain regions in the left frontal and temporal lobes of the patients in iTBS group. Meanwhile, DC analysis also found increased DC values in multiple frontotemporal brain regions of the left hemisphere of patients in the iTBS group, indicating that the improved activation of the above brain regions of the patients in the iTBS group was significantly compared with that of the patients in the S-iTBS group.</p><p><strong>Conclusions: </strong>iTBS combined with conventional speech training significantly improved the expression function of patients with aphasia after stroke. After iTBS action on the left hemisphere, increased activation of multiple brain regions in the left hemisphere may be one of the important mechanisms by which iTBS improves expression function in poststroke aphasia patients.</p>","PeriodicalId":49758,"journal":{"name":"Neurologist","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurologistPub Date : 2025-03-19DOI: 10.1097/NRL.0000000000000616
Jiaxuan Li, Xinhui Jia, Xinyi Chen, Jie Hu, Xun He, Yueyu Zhang, Yi Tang, Juncang Wu
{"title":"Extracorporeal Counterpulsation Therapy Enhances Neurological Outcomes in Patients Experiencing Acute Ischemic Stroke.","authors":"Jiaxuan Li, Xinhui Jia, Xinyi Chen, Jie Hu, Xun He, Yueyu Zhang, Yi Tang, Juncang Wu","doi":"10.1097/NRL.0000000000000616","DOIUrl":"https://doi.org/10.1097/NRL.0000000000000616","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to assess the effects of extracorporeal counterpulsation therapy (ECP) on the short-term outcomes of patients with acute ischemic stroke in the mid-stroke phase.</p><p><strong>Methods: </strong>A total of 171 patients with acute ischemic stroke from the Department of Neurology at our hospital were selected and randomly assigned to 2 groups: 84 patients in the ECP group and 87 patients in the control group. Both groups received standard medication and rehabilitation. In addition, extracorporeal counterpulsation was incorporated into the treatment for the ECP group. At the conclusion of the treatment and after 90 days, both groups were evaluated based on the NIHSS and MRS scores.</p><p><strong>Results: </strong>No statistically significant differences were detected between the NIHSS and MRS scores of the 2 groups before and following treatment (P>0.05). However, on the 90th day, the NIHSS and MRS scores of the ECP group were significantly lower than those of the comparison group (P<0.05). The difference in the proportion of patients with NIHSS scores ≤1 between the 2 groups was 20.8%, whereas the absolute difference in MRS scores was 14.1%.</p><p><strong>Conclusion: </strong>Extracorporeal counter therapy effectively enhances neurological function in patients with ischemic stroke, thereby improving their ability to perform activities of daily living and overall prognosis.</p>","PeriodicalId":49758,"journal":{"name":"Neurologist","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurologistPub Date : 2025-03-19DOI: 10.1097/NRL.0000000000000611
Seul Bi Kim, Seung Min Kim, Byoung-Soo Shin, Hyun Goo Kang
{"title":"Unilateral Weakness Caused By Spinal Cord Infarction in a Renal Transplant Recipient.","authors":"Seul Bi Kim, Seung Min Kim, Byoung-Soo Shin, Hyun Goo Kang","doi":"10.1097/NRL.0000000000000611","DOIUrl":"https://doi.org/10.1097/NRL.0000000000000611","url":null,"abstract":"<p><strong>Introduction: </strong>Spinal cord infarction has various clinical presentations, depending on the vascular territory involved at the spinal cord level. The most common symptom is bilateral weakness. However, unilateral hemiparesis can occur if the sulcal artery is involved. Stroke is the most common and serious cerebrovascular complication associated with kidney transplantation. Clinically asymptomatic renal transplant recipients may experience increased intima-media thickening, which is significantly associated with an increased prevalence of cerebrovascular diseases.</p><p><strong>Case report: </strong>Herein, we report the case of a 64-year-old adult male with a history of kidney transplantation who presented with sudden-onset right-sided hemiparesis. The patient presented with right shoulder pain, right fingertip paresthesia, and recent dysuria, necessitating catheterization. T2-weighted magnetic resonance imaging at the C2-C3 level revealed hyperintensity corresponding to the right sulcal artery. Diffusion-weighted imaging revealed hyperintensities corresponding to T2 signal abnormalities, with a decreased apparent diffusion coefficient. The patient was diagnosed with cervical spinal cord infarction involving the right sulcal artery at the C2-C3 level. Subsequently, pulsed intravenous methylprednisolone and dual antiplatelet treatment (aspirin and clopidogrel) were administered. The patient showed a rapid and marked improvement in neurological function within 3 days.</p><p><strong>Conclusion: </strong>The patient in this case report initially presented with unilateral hemiparesis. The symptoms mimicked those of stroke, making accurate diagnosis challenging. This case highlights the need to consider spinal cord infarction in the differential diagnosis of patients presenting with unilateral hemiparesis. In addition, our findings suggest that spinal cord infarction may be a long-term complication in kidney transplant recipients.</p>","PeriodicalId":49758,"journal":{"name":"Neurologist","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nomogram Model for Predicting the Functional Outcomes in Patients With Minor Ischemic Stroke Based on Clinical Characteristics and Small Vessel Disease Burden.","authors":"Ruqian He, Xiaona Xu, Xiachan Chen, Haoye Cai, Xuerong Huang, Hao Shu","doi":"10.1097/NRL.0000000000000614","DOIUrl":"https://doi.org/10.1097/NRL.0000000000000614","url":null,"abstract":"<p><strong>Objectives: </strong>Our purpose is to assess the role of total small vessel disease (SVD) burden affecting the clinical outcome and develop and validate a prognostic nomogram for minor ischemic stroke (MIS) patients.</p><p><strong>Methods: </strong>Between January 2018 and April 2023, 454 MIS patients were enrolled. The functional outcome was the modified Rankin scale (mRS) score at 90 days. The least absolute shrinkage and selection operator (LASSO) regression and multivariate logistic regression model were used to identify prognostic predictors, and then a nomogram was drawn.</p><p><strong>Results: </strong>Our nomogram comprising of systolic blood pressure (SBP), baseline National Institutes of Health Stroke Scale score (NIHSS), total SVD burden scores, coronary heart disease, disabling stroke, progressive stroke, alteplase treatment, and infarction location demonstrated a good discriminative power in both the training set (AUC=0.870; 95% CI: 0.827-0.912) and the internal validation set (AUC=0.876; 95% CI: 0.817-0.935). The calibration curve and DCA in our result showed the model's high degree of calibration and clinical value. The DeLong test was used to compare the AUCs between the nomogram and non-SVD burden score model in the training (P=0.028) and internal validation sets (P=0.013), indicating that our nomogram performs significantly better than the non-SVD burden score model.</p><p><strong>Conclusions: </strong>The SVD burden is an important prognosis factor. Furthermore, the proposed nomogram has good discrimination, calibration, and clinical benefits and is better than the non-SVD burden score model in predicting the outcomes for MIS patients.</p>","PeriodicalId":49758,"journal":{"name":"Neurologist","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurologistPub Date : 2025-03-13DOI: 10.1097/NRL.0000000000000612
Igor Bueno Garrido, Brenda Lima do Espírito Santo, Vinicius Viana Abreu Montanaro
{"title":"Thalamic Infarctions: A Case Study of Inferolateral and Posterior Choroidal Branch Involvement in a Patient Without Classic Vascular Risk Factors.","authors":"Igor Bueno Garrido, Brenda Lima do Espírito Santo, Vinicius Viana Abreu Montanaro","doi":"10.1097/NRL.0000000000000612","DOIUrl":"https://doi.org/10.1097/NRL.0000000000000612","url":null,"abstract":"<p><strong>Introduction: </strong>Thalamic infarctions represent a rare subset of ischemic strokes, characterized by a diverse array of clinical manifestations and significant diagnostic challenges. These infarctions can lead to a wide range of neurological deficits, depending on the specific vascular territory involved. Infarctions within the posterior circulation territory of P2, particularly those affecting the inferolateral and posterior choroidal arteries, are associated with distinct neurological symptoms, including contralateral sensory loss, hemiparesis, hemiataxia, thalamic hand, and various sensory and motor disturbances.</p><p><strong>Case report: </strong>We present the case of a 47-year-old woman with a unilateral thalamic infarction involving occlusion of the P2 branch of the posterior cerebral artery. The infarction, caused by a paradoxical embolism secondary to a high-grade patent foramen ovale (PFO) with an interatrial septal aneurysm, occurred in the absence of classic vascular risk factors. The patient exhibited a clinical syndrome consistent with ischemic lesions in the inferolateral and posterior choroidal arteries, manifesting as right-sided hemiparesthesia, hemiataxia with neuropathic pain, thalamic hand, dystonia, and tremor in the upper right limb.</p><p><strong>Conclusion: </strong>Early and precise clinical identification of thalamic infarctions, especially in rare cases involving multiple vascular territories, is essential for improving patient care and outcomes. Recognizing the spectrum of potential symptoms facilitates effective symptom management, minimizes the risk of secondary complications, and optimize neurological rehabilitation.</p>","PeriodicalId":49758,"journal":{"name":"Neurologist","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}