Perfusion-Uk最新文献

{"title":"Endobronchial valves for severe air leak in critically ill children with necrotizing pneumonia requiring extracorporeal membrane oxygenation.","authors":"Alex J Katz, Bhavesh M Patel, Vanessa M Mazandi, Lauren M C Grant, Aoife Corcoran, Pelton Phinizy, Antoinette Wannes Daou, Garrett Keim, Paula M Magee, Myron Allukian, Todd J Kilbaugh, Sin Tran, Adam S Himebauch, Joseph Piccione, Kumaran Senthil","doi":"10.1177/02676591251365419","DOIUrl":"10.1177/02676591251365419","url":null,"abstract":"<p><p>IntroductionAir leak is a common complication of necrotizing pneumonia in critically ill children. Severe air leaks impact effective oxygenation and ventilation, oftentimes necessitating multiple thoracostomy tubes and extracorporeal support. Endobronchial valves (EBV) are a minimally invasive intervention to control air leak that may expedite de-escalation of care for critically ill children with necrotizing pneumonia.MethodsA retrospective case series was conducted on patients at the Children's Hospital of Philadelphia who were hospitalized in the pediatric intensive care unit, required extracorporeal membrane oxygenation (ECMO), and underwent placement of one or more EBVs for air leak from July 2023 through August 2024.ResultsSix patients, median age 12 years (range 18 months to 18 years), were hospitalized for necrotizing pneumonia complicated by severe air leak and required ECMO. The most common etiology was a viral infection with bacterial co-infection. The median number of EBVs placed per patient was five. The median total time on ECMO was 10 days, with a median duration of 3.5 days after valve placement. The median duration of antibiotic therapy was 47 days (range 24 to 126 days). One patient had a contralateral pneumothorax after valve placement, and another died due to progression of multiorgan failure that began before EBV placement. The five surviving patients were discharged from the hospital, weaned from all respiratory support, and their valves were removed without complication.ConclusionEndobronchial valves are a feasible intervention for severe air leak in critically ill children with necrotizing pneumonia and may expedite liberation from ECMO.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"455-461"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal support for cardiorespiratory failure from paradoxical coronary and pulmonary embolism: A case report of mechanical support, revascularization, embolectomy, and shunt closure.","authors":"Casey Carr, George Chrysant, Jordan Phillips, Robert S Schoaps, Obaid Ashraf, Laura V Swant, Joseph M Brewer","doi":"10.1177/02676591261424686","DOIUrl":"https://doi.org/10.1177/02676591261424686","url":null,"abstract":"<p><p>Paradoxical coronary embolism (PCE) is an uncommon cause of acute myocardial infarction (AMI), typically occurring when venous thromboemboli cross a right-to-left shunt in the setting of elevated right-sided pressures. We report a case of mixed obstructive and cardiogenic shock caused by simultaneous pulmonary embolism (PE) and PCE. A previously healthy 43-year-old woman developed profound hypoxemia and inferior ST-segment elevation 3 days after knee surgery. Coronary angiography revealed distal right coronary artery occlusion, successfully treated with aspiration thrombectomy and percutaneous coronary intervention. Persistent hypoxemia, right ventricular injury, and hemodynamic collapse prompted initiation of venoarterial extracorporeal membrane oxygenation (VA ECMO). Subsequent imaging identified extensive bilateral PE and a patent foramen ovale with significant right-to-left shunting. Catheter-based pulmonary embolectomy improved cardiopulmonary function, followed by percutaneous PFO closure. She recovered fully and was discharged home neurologically intact. This case highlights the importance of early recognition, appropriate ECMO configuration, and comprehensive management of PCE with concurrent PE.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":"41 1_suppl","pages":"185S-187S"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The HEART-UA survey: Healthcare extracorporeal assessment and resource tracking in Ukraine during the war.","authors":"Stepan Maruniak, Oleh Loskutov, Sergii Sudakevych, Borys Todurov, Justyna Swol","doi":"10.1177/02676591251415337","DOIUrl":"https://doi.org/10.1177/02676591251415337","url":null,"abstract":"<p><p>IntroductionThe HEART-UA (Healthcare Extracorporeal Assessment and Resource Tracking in Ukraine) survey represents the first nationwide evaluation of extracorporeal life support (ECLS) and renal replacement therapy (RRT) availability in Ukraine. The study aimed to systematically characterize national ECLS and RRT capacity, assess temporal changes before and during the conflict, and identify major operational limitations affecting access to extracorporeal organ support.MethodsA structured cross-sectional survey was conducted among Ukrainian hospitals providing ECLS and/or RRT. Data collection included institutional characteristics, ECMO device availability, case volumes in 2021 and 2023, staffing models, barriers to ECLS provision, and the availability of CRRT and intermittent hemodialysis. Responses were clustered at the institutional level, and duplicates were merged. Categorical variables were compared between the pre-war and wartime periods using Fisher's exact or chi-squared tests where appropriate.ResultsTwenty-two institutional responses were analyzed, including 15 ECLS centers, 16 CRRT centers, and 19 IHD-capable institutions. Geographical distribution showed regional clustering of ECLS resources. No statistically significant expansion in ECMO device availability or procedural volumes was observed between 2021 and 2023. The predominant barriers to ECLS provision included shortages of consumables (60%), insufficient trained personnel (53%), and inadequate numbers of ECMO devices (47%). CRRT availability was higher, but most centers reported major limitations due to shortages of consumable circuits, machine availability, and infrastructural instability. Humanitarian aid related to extracorporeal support was received by only 27% of institutions and was irregular, fragmented, and insufficient to meet national needs.ConclusionsThe HEART-UA survey demonstrates that Ukraine's capacity to provide extracorporeal organ support has remained critically constrained during the war. Device availability, trained personnel, and consumable supply chains are still major limiting factors. Although many centers continue to provide lifesaving ECLS, CRRT, and IHD despite extreme operational challenges, the overall system is highly dependent on inconsistent humanitarian aid.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":"41 1_suppl","pages":"51S-59S"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-guided tools in adult ECMO: Current advancements, emerging Trends and future directions.","authors":"Benjamin Friedrichson, Andrew Stephens, Monika Tukacs, Justyna Swol, Thomas Jasny","doi":"10.1177/02676591261428030","DOIUrl":"10.1177/02676591261428030","url":null,"abstract":"<p><p>IntroductionExtracorporeal membrane oxygenation (ECMO) provides life support for patients with refractory cardiac or respiratory failure. The complexity of ECMO management and associated mortality necessitates high-accuracy clinical decision-making systems. Artificial intelligence (AI) has emerged as a potential approach to address challenges in ECMO management, from patient selection to real-time assessment and outcome prediction.ObjectiveTo synthesize the current evidence of AI application in adult ECMO, addressing predictive modelling for patient outcomes, real-time decision support systems, and complication prevention, as well as the evolving regulatory challenges governing medical AI deployment in critical care settings.MethodsA narrative literature review was conducted across PubMed/MEDLINE, Embase, Cochrane Library, IEEE Xplore, and preprint servers (arXiv/medRxiv). The search strategy combined ECMO-relevant terms (\"V-A ECMO\", \"V-V ECMO\") with AI terminologies (\"artificial intelligence\", \"machine learning\", \"deep learning\", \"digital twin\"). Studies were included if they focused on adult cohorts (age ≥18 years) and were published in English between 2018 and 2025.ResultsThe review found several AI algorithms under development for different stages of ECMO therapy. AI algorithms have been developed to assist in the initiation, prognostication, complication detection, real-time control, and weaning of ECMO. However, none have been clinically translated thus far.ConclusionWhile AI for precision ECMO management is promising, several prerequisites remain unmet, including the integration of high-frequency device data, prospective external multicenter validation, and the development of robust regulatory frameworks. Securing these advances will bridge the gap between algorithm development and the clinical arena.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":"41 1_suppl","pages":"16S-25S"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13149997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends and risk factors for bleeding and thrombosis in pediatric ECMO: A multicenter cohort study.","authors":"Kevin J Doré, Carlton M Kelly, Timothy T Cornell, Lindsey K Rasmussen, Shelby Burk, Laura L Loftis, Christine Allen, Melania M Bembea, Brian M Boville, Jamie Furlong-Dillard, Santosh Kaipa, Bridget Norton, Heather Viamonte, Linda Wallenkamp, Ahmed Said, Marie E Steiner, Matthew P Malone, Aaron Kline, Daniel Tawfik","doi":"10.1177/02676591251365417","DOIUrl":"10.1177/02676591251365417","url":null,"abstract":"<p><p>IntroductionBleeding and thrombosis are major causes of morbidity and mortality in pediatric extracorporeal membrane oxygenation (ECMO), yet their evolving, time-dependent risks remain poorly defined. This study evaluated clinical predictors of bleeding and thrombotic events using time-to-event analysis.MethodsA retrospective cohort study was conducted using the Pediatric ECMO Outcomes Registry (PEDECOR) from October 2011 to September 2024. Patients aged ≤18 years undergoing their first ECMO run were included. Two time-varying Cox proportional hazards models assessed associations between prior complications and time to first bleed or thrombosis, adjusting for clinical and ECMO-related variables.ResultsAmong 1444 patients, median age was 0.4 years (IQR: 0.0-4.4), and 53.6% were male. Bleeding occurred in 65% and thrombosis in 28%. Time to first bleeding events had a median of 2 days (IQR: 0-4) while time to first thrombosis had a median of 3 days (IQR: 2-6). Prior thrombosis was associated with lower early bleeding risk (HR: 0.39, 95% CI: 0.25-0.62, <i>p</i> < 0.001), which reversed over time (interaction HR: 1.44, 95% CI: 1.08-1.92, <i>p</i> = 0.013; crossover at 12.4 days). Similarly, prior bleeding was associated with reduced early thrombosis risk (HR: 0.49, 95% CI: 0.34-0.71, <i>p</i> < 0.001), but reversed over time (interaction HR: 1.63, 95% CI: 1.26-2.11, <i>p</i> < 0.001; crossover at 4.3 days). Central cannulation, cardiac surgery, and non-pulmonary indications were associated with bleeding; sepsis was associated with thrombosis. Anticoagulant type and sex were not significant.ConclusionsBleeding and thrombosis are common and time-dependent in pediatric ECMO. These findings support dynamic anticoagulation strategies tailored to evolving risk.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"401-413"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could AI and should AI influence ECLS.","authors":"Prakash P Punjabi","doi":"10.1177/02676591251395591","DOIUrl":"10.1177/02676591251395591","url":null,"abstract":"","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"367-369"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145402597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calculation of blood loss in cardiac surgery: How should we monitor?","authors":"Yerlan Orazymbetov, Serik Aitaliyev, Povilas Jakuška, Audronė Veikutienė, Tadas Lenkutis, Rassul Zhumagaliyev, Aušra Saudargienė, Rimantas Benetis","doi":"10.1177/02676591251370110","DOIUrl":"10.1177/02676591251370110","url":null,"abstract":"<p><p>BackgroundThe bleeding in cardiac surgery remains a significant clinical problem. There is no \"gold standard\" method to quantify blood loss. Traditional measurement of drainage volume often underestimates or overestimates, as it does not consider the type of fluid. We hypothesized that blood loss could be more accurately calculated using the Hb/kg index in terms of haemoglobin (Hb) mass loss per kilogram of the patient's body mass. This study aimed to ObjectiveTo develop a novel approach for calculating actual blood loss using the Hb/kg index.MethodsThis single-center prospective study included 195 patients who underwent cardiac surgery between October 2023 and November 2024. The Hb/kg index was calculated based on intraoperative Hb loss, Hb loss via chest tubes, packed red blood cell transfusions and patient weight. Eighty-six additional clinical predictors were analyzed using conventional statistics and machine learning algorithms. Predictors with statistically significant Spearman correlations were included for further analysis.ResultsLasso regression achieved the best overall performance in predicting Hb/kg index. It yielded the lowest mean squared error (0.08 ± 0.04), mean absolute percentage error (0.18 ± 0.10), with the highest correlation (0.92 ± 0.06) and R² score (0.82 ± 0.13). BMI showed a significant negative relationship (-0.018, <i>p</i> < 0.001). Postoperative Hb and haematocrit values had negative correlation (-0.69, <i>p</i> < 0.001 and -0.07, <i>p</i> < 0.015), while initial Hb was positively correlated (0.85, <i>p</i> < 0.001).ConclusionsThis method provides a more reliable and clinically relevant tool to calculate actual blood loss and allows for a more precise assessment and treatment.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"470-477"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary approach to prolonged in-hospital cardiac arrest (IHCA) managed by ECPR and emergent valve-in-valve transcatheter aortic valve implantation.","authors":"Fung Ming Brian Lau, Sin Kwan Tammy Ma, Cheung Chi Simon Lam, Tze Hui Yeoh, Wai Kit Chan, Chun Wai Ngai, Ching Wai Sin, Pauline Yeung Ng","doi":"10.1177/02676591251415340","DOIUrl":"https://doi.org/10.1177/02676591251415340","url":null,"abstract":"<p><p>IntroductionExtracorporeal Cardiopulmonary Resuscitation (ECPR) is a lifesaving intervention for in-hospital (IHCA) and out-of-hospital cardiac arrest (OHCA). However, severe aortic regurgitation (AR) has traditionally been considered an absolute contraindication for veno-arterial extracorporeal membrane oxygenation (V-A ECMO).Case reportA 63-year-old man with aortic regurgitation experienced IHCA with 50 min of low-flow time. The patient received ECPR and emergent valve-in-valve (ViV) transcatheter aortic valve implantation (TAVI) through a rapid multidisciplinary approach. Despite transient focal neurological symptoms in the early post-resuscitation period, the patient steadily recovered and was discharged with a favourable Cerebral Performance Category (CPC) of 2.DiscussionThis case challenges the absolute contraindication of severe aortic regurgitation for veno-arterial extracorporeal membrane oxygenation (V-A ECMO) and ECPR candidacy, demonstrating that a multidisciplinary approach with planned venting strategies and rapid definitive intervention can lead to satisfactory patient outcomes.ConclusionSevere aortic regurgitation may not absolutely preclude candidacy for peripheral V-A ECMO. A pre-emptive approach integrating detailed venting strategies with emergent transcatheter interventions expands the salvageable population with valvular heart disease.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":"41 1_suppl","pages":"161S-165S"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence guided tools in pediatric extracorporeal membrane oxygenation: Implications for clinical practice.","authors":"Mirjana Cvetkovic","doi":"10.1177/02676591261427672","DOIUrl":"https://doi.org/10.1177/02676591261427672","url":null,"abstract":"<p><p>IntroductionPediatric extracorporeal membrane oxygenation (ECMO) is a highly complex therapy characterised by rapidly evolving physiology, high complication rates, and substantial cognitive demands on multidisciplinary teams. Management requires continuous integration of physiologic, laboratory, ventilatory, and circuit-derived data to support time-critical decisions related to gas exchange, haemodynamics, anticoagulation, transfusion, circuit surveillance, and weaning. Despite technological advances and growing international standardisation, morbidity and mortality continue to be driven by neurologic injury, bleeding and thrombosis, and clinical factors influencing successful liberation from ECMO support.AimTo review contemporary artificial intelligence (AI) and machine learning (ML) applications relevant to pediatric ECMO and evaluate their potential role as clinically aligned decision-support tools for clinicians and ECMO practice.MethodsA narrative review of English-language literature (2020-2026) was conducted using PubMed, MEDLINE, and Scopus to identify AI/ML studies, systematic reviews, and guideline documents addressing pediatric ECMO outcomes, complication prediction, circuit surveillance, and weaning or decannulation support, as well as methodological and governance frameworks relevant to clinical implementation.ResultsMost ECMO-AI applications employ supervised learning or deep learning approaches integrating demographic, clinical, laboratory, and ECMO device time-series data. Recent studies demonstrate emerging promise for neurologic risk prediction, bleeding and transfusion risk forecasting, circuit anomaly detection, and dynamic assessment of weaning readiness. Progress has included registry-based analyses, externally validated pediatric models, and time-series frameworks aligned with clinical workflows. However, heterogeneity in data quality, outcome definitions, and validation strategies remains substantial.ConclusionAI-guided tools in pediatric ECMO are transitioning from early feasibility studies toward more mature, clinically aligned decision-support applications. With rigorous validation, transparent reporting, and strong governance, AI has the potential to enhance situational awareness and consistency of care while preserving the central role of expert multidisciplinary judgement.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":"41 1_suppl","pages":"26S-38S"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is pulse pressure a mediator in the relationship between hyperoxemia and acute brain injury in veno-arterial extracorporeal membrane oxygenation (VA-ECMO) patients? An ELSO registry study.","authors":"Leon Fan, Winnie L Liu, Shi Nan Feng, Yaman B Ahmed, Matteo Di Nardo, Melissa A Vogelsong, Aniket S Rali, Akram M Zaaqoq, Daniel Brodie, Glenn J R Whitman, Sung-Min Cho","doi":"10.1177/02676591261427660","DOIUrl":"https://doi.org/10.1177/02676591261427660","url":null,"abstract":"<p><p>IntroductionHyperoxemia is associated with increased mortality and acute brain injury (ABI) in patients receiving veno-arterial extracorporeal membrane oxygenation (VA-ECMO), though the role of native cardiac function in this relationship is unclear. Pulse pressure (PP) can reflect the proximal shift of dual circulation between ECMO and native heart function. We aimed to investigate the relationship between PP, hyperoxemia, and ABI.MethodsWe included adults (≥18 years) receiving peripheral VA-ECMO for cardiogenic shock from the ELSO Registry (2013-2024).ResultsABI occurred in 1012/8486 (11.9%) patients. In multivariable logistic regression adjusting for demographic and clinical covariates, severe hyperoxemia (PaO₂ ≥ 300 mmHg) remained independently associated with ABI (aOR: 1.40, 95% CI: 1.04-1.86). Low pulse pressure (PP) was more frequent among ABI patients, but PP was not independently associated with ABI after adjustment (aOR: 1.01, 95% CI: 0.81-1.25). PaO₂ and PP were inversely related. In mediation analysis PP accounted for 8.2% of the total effect of hyperoxemia on ABI overall (14% in the non-LV-vented cohort).ConclusionSevere hyperoxemia during ECMO was associated with increased ABI risk. Low PP was not. PP mediated the relationship between hyperoxemia and ABI. Reduced cardiac function may drive proximal dual circulation shift, predisposing patients to hyperoxemia and ABI. Hyperoxemia appears modifiable, and improved PP may reduce ABI.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":"41 1_suppl","pages":"126S-136S"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}