Perfusion-Uk最新文献_第3页

Brain injury plasma biomarkers in patients on veno-arterial extracorporeal membrane oxygenation: A pilot prospective observational study. 静脉-动脉体外膜氧合患者的脑损伤血浆生物标志物：一项试点前瞻性观察研究。

IF 1.1 4区医学

Perfusion-Uk Pub Date : 2025-04-01 Epub Date: 2024-05-17 DOI: 10.1177/02676591241256006

Syed Ameen Ahmad, Shrey Kapoor, Siam Muquit, Aaron Gusdon, Shivalika Khanduja, Wendy Ziai, Allen D Everett, Glenn Whitman, Sung-Min Cho, On Behalf Of Herald Investigators

{"title":"Brain injury plasma biomarkers in patients on veno-arterial extracorporeal membrane oxygenation: A pilot prospective observational study.","authors":"Syed Ameen Ahmad, Shrey Kapoor, Siam Muquit, Aaron Gusdon, Shivalika Khanduja, Wendy Ziai, Allen D Everett, Glenn Whitman, Sung-Min Cho, On Behalf Of Herald Investigators","doi":"10.1177/02676591241256006","DOIUrl":"10.1177/02676591241256006","url":null,"abstract":"IntroductionEarly diagnosis of acute brain injury (ABI) is critical for patients on veno-arterial extracorporeal membrane oxygenation (V-A ECMO) to guide anticoagulation strategy; however, neurological assessment in ECMO is often limited by patient sedation.MethodsIn this pilot study of adults from June 2018 to May 2019, plasma samples of glial fibrillary acidic protein (GFAP), neurofilament light chain (NFL), and tubulin associated unit (Tau) were collected daily after V-A ECMO cannulation and measured using a multiplex platform. Primary outcomes were occurrence of ABI, assessed clinically, and neurologic outcome, assessed by modified Rankin Scale (mRS).ResultsOf 20 consented patients (median age = 48.5°years; 55% female), 8 (40%) had ABI and 15 (75%) had unfavorable neurologic outcome at discharge. 10 (50%) patients were centrally cannulated. Median duration on ECMO was 4.5°days (IQR: 2.5-9.5). Peak GFAP, NFL, and Tau levels were higher in patients with ABI vs. without (AUC = 0.77; 0.85; 0.57, respectively) and in patients with unfavorable vs. favorable neurologic outcomes (AUC = 0.64; 0.59; 0.73, respectively). GFAP elevated first, NFL elevated to the highest degree, and Tau showed limited change regardless of ABI.ConclusionFurther studies are warranted to determine how plasma biomarkers may facilitate early detection of ABIs in V-A ECMO to assist timely clinical decision-making.","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"657-667"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can a low prime volume arterial filter be used as an alternative for a venous bubble trap in minimal extracorporeal circulation? An in vitro investigation. 在最小体外循环中，低原液容量动脉过滤器能否替代静脉气泡捕捉器？一项体外研究。

IF 1.1 4区医学

Perfusion-Uk Pub Date : 2025-04-01 Epub Date: 2024-05-20 DOI: 10.1177/02676591241256532

Marco Stehouwer, Kristina Legg, Roel de Vroege

{"title":"Can a low prime volume arterial filter be used as an alternative for a venous bubble trap in minimal extracorporeal circulation? An in vitro investigation.","authors":"Marco Stehouwer, Kristina Legg, Roel de Vroege","doi":"10.1177/02676591241256532","DOIUrl":"10.1177/02676591241256532","url":null,"abstract":"BackgroundDuring cardiac surgery the use of a minimal extracorporeal circulation (MiECC) system may reduce the adverse effects for the patient. This is probably caused by reduced inflammation and hemodilution. For the use of a MiECC circuit, a venous bubble trap (VBT) is warranted for safety reasons. The aim of this study was to assess if an arterial filter with a small prime volume has the same (or better) air removal capacities as a VBT in a MiECC circuit and subsequentially may be used as an alternative.MethodsIn an in vitro study, air removal properties were compared between the arterial filter and three VBT's on the market, VBT160 (Getinge), VBT 8 (LivaNova and VARD (Medtronic). In a MiECC circuit, the filter devices were placed in a venous position and challenged with massive and micro air. Gaseous microemboli (GME) were measured with a bubble counter proximal and distal of the VBT device.ResultsMore than 99.9 % of the air was removed after a bolus air challenge by all VBT's. Both the VARD and the AF100 showed better GME removal properties (not significant for the AF100) compared to the other devices. All filters showed GME generation after a challenge with massive air. Compared to the other filters, only the VARD showed no passing of larger bubbles when a volume of 50 mL of air was present in the filter.ConclusionsThe AF100 seems to be a safe and low prime alternative for use in a MiECC system as a venous air trap. A word of caution, placement of the AF100 arterial filter in the venous line is off label use.","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"686-692"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracorporeal life support after surgical repair for acute type a aortic dissection: A systematic review and meta-analysis. 急性主动脉夹层手术修复后的体外生命支持：系统回顾和荟萃分析。

IF 1.1 4区医学

Perfusion-Uk Pub Date : 2025-04-01 Epub Date: 2024-05-10 DOI: 10.1177/02676591241253464

Michel Pompeu Sá, Xander Jacquemyn, Nicholas Hess, James A Brown, Tulio Caldonazo, Hristo Kirov, Torsten Doenst, Derek Serna-Gallegos, David Kaczorowski, Ibrahim Sultan

{"title":"Extracorporeal life support after surgical repair for acute type a aortic dissection: A systematic review and meta-analysis.","authors":"Michel Pompeu Sá, Xander Jacquemyn, Nicholas Hess, James A Brown, Tulio Caldonazo, Hristo Kirov, Torsten Doenst, Derek Serna-Gallegos, David Kaczorowski, Ibrahim Sultan","doi":"10.1177/02676591241253464","DOIUrl":"10.1177/02676591241253464","url":null,"abstract":"BackgroundThe use of extracorporeal life support (ECLS) in patients after surgical repair for acute type A aortic dissection (ATAAD) has not been well documented.MethodsWe performed a systematic review and meta-analysis to assess the outcomes of ECLS after surgery for ATAAD with data published by October 2023 in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) and the Meta-analysis of Observational Studies in Epidemiology (MOOSE) reporting guidelines. The protocol was registered in PROSPERO (CRD42023479955).ResultsTwelve observational studies met our eligibility criteria, including 280 patients. Mean age was 55.0 years and women represented 25.3% of the overall population. Although the mean preoperative left ventricle ejection fraction was 59.8%, 60.8% of patients developed left ventricle failure and 34.0% developed biventricular failure. Coronary involvement and malperfusion were found in 37.1% and 25.6%, respectively. Concomitant coronary bypass surgery was performed in 38.5% of patients. Regarding ECLS, retrograde flow (femoral) was present in 39.9% and central cannulation was present in 35.4%. In-hospital mortality was 62.8% and pooled estimate of successful weaning was 50.8%. Neurological complications, bleeding and renal failure were found in 25.9%, 38.7%, and 65.5%, respectively.ConclusionECLS after surgical repair for ATAAD remains associated with high rates of in-hospital death and complications, but it still represents a chance of survival in critical situations. ECLS remains a salvage attempt and surgeons should not try to avoid ECLS at all costs after repairing an ATAAD case.","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"631-639"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140908733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Haemodynamic monitoring in veno-venous ecmo. 静脉-静脉 ecmo 的血流动力学监测。

IF 1.1 4区医学

Perfusion-Uk Pub Date : 2025-04-01 Epub Date: 2024-05-29 DOI: 10.1177/02676591241258882

Francesco Alessandri, Giovanni Giordano

引用次数: 0

Corrigendum to "Perfusion education and training in Europe anno 2023". 2023 年欧洲灌注教育和培训 "的更正。

IF 1.1 4区医学

Perfusion-Uk Pub Date : 2025-04-01 Epub Date: 2024-05-13 DOI: 10.1177/02676591241249325

引用次数: 0

Atrial fibrillation inpatient management patterns and clinical outcomes during the conflict in Syria: An observational cohort study. 叙利亚冲突期间心房颤动住院病人的管理模式和临床结果：一项观察性队列研究。

IF 1.1 4区医学

Perfusion-Uk Pub Date : 2025-04-01 Epub Date: 2024-06-03 DOI: 10.1177/02676591241259140

Ibrahim Antoun, Majed Aljabal, Alkassem Alkhayer, Yaman Mahfoud, Alamer Alkhayer, Peter Simon, Ahmed Kotb, Joseph Barker, Akash Mavilakandy, Muhammad Usman Naseer, Riyaz Somani, G André Ng, Mustafa Zakkar

{"title":"Atrial fibrillation inpatient management patterns and clinical outcomes during the conflict in Syria: An observational cohort study.","authors":"Ibrahim Antoun, Majed Aljabal, Alkassem Alkhayer, Yaman Mahfoud, Alamer Alkhayer, Peter Simon, Ahmed Kotb, Joseph Barker, Akash Mavilakandy, Muhammad Usman Naseer, Riyaz Somani, G André Ng, Mustafa Zakkar","doi":"10.1177/02676591241259140","DOIUrl":"10.1177/02676591241259140","url":null,"abstract":"BackgroundAtrial fibrillation (AF) is the most common sustained arrhythmia worldwide. However, there is no data on AF inpatient management strategies and clinical outcomes in Syria.ObjectivesThe study aims were to review the inpatient management of patients with AF and assess cardiovascular (CV) mortality in a tertiary cardiology centre in Latakia, Syria.MethodsA single-centre retrospective observational cohort study was conducted at Tishreen's University Hospital, Latakia, Syria, from June 2021 to June 2023. Patients ≥16 years of age presenting and being treated for AF as the primary diagnosis with or without a thromboembolic event were included. Medical records were examined for patients' demographics, laboratory results, treatment plans and inpatient details. Studied outcomes include inpatient all-cause and CV mortality, ischemic and bleeding events, and conversion to sinus rhythm (SR).ResultsThe study included 596 patients. The median age was 58, and 61% were males. 121 patients (20.3%) were known to have AF. A rhythm control strategy was pursued in 39% of patients. Ischemic and bleeding events occurred in 62 (11%) and 12 (2%), respectively. CV and all-cause mortality occurred in 28 (4.7%) and 31 patients (5%), respectively. The presence of valvular heart disease (VHD) (adjusted odds ratio (aOR) = 9.1, 95% confidence interval (CI): 1.7 to 55.1, p < .001), thyroid disease (aOR: 9.7, 95% CI = 1.2 to 91.6, p < .001) and chronic obstructive pulmonary disease (COPD) (aOR: 82, 95% CI: 12.7 to 71, p < .001) were independent risk factors of increased CV inpatient mortality.ConclusionSyrian inpatients admitted with AF in Latakia are relatively younger than those in other countries. Active thyroid disease, COPD and VHD were independent risk factors of inpatient CV mortality with AF.","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"711-719"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141236194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracorporeal membrane oxygenation after lung transplant: An ELSO registry analysis.

IF 1.1 4区医学

Perfusion-Uk Pub Date : 2025-03-28 DOI: 10.1177/02676591251331158

Yota Suzuki, Ravi Radhakrishnan, Rui-Min D Mao, John Ryan, Alexander Wisniewski, Philip Carrott, Ernest G Chan, William Lynch, Gabriel Loor, Subhasis Chatterjee, Masashi Furukawa, Pablo G Sanchez

{"title":"Extracorporeal membrane oxygenation after lung transplant: An ELSO registry analysis.","authors":"Yota Suzuki, Ravi Radhakrishnan, Rui-Min D Mao, John Ryan, Alexander Wisniewski, Philip Carrott, Ernest G Chan, William Lynch, Gabriel Loor, Subhasis Chatterjee, Masashi Furukawa, Pablo G Sanchez","doi":"10.1177/02676591251331158","DOIUrl":"https://doi.org/10.1177/02676591251331158","url":null,"abstract":"BackgroundThe use of extracorporeal membrane oxygenation (ECMO) has expanded and is now widely applied to perioperative care in lung transplant. Respiratory failure after lung transplant is a clinical challenge where ECMO plays a critical role.MethodsThe Extracorporeal Life Support Organization registry was queried for patients 18 years and older who were treated with ECMO after lung transplant in 2010-2022. ECMO runs for more than 24 hours after lung transplant were included regardless of the timing of initiation. Univariable analyses were performed to compare procedural and patient characteristics across ECMO eras. Multivariable logistic regression was performed to identify predictors of surviving to discharge.ResultsOne-thousand nine-hundred and sixty-six patients met the inclusion criteria, and 1422 patients (72.3%) survived to discharge. The number of ECMO runs steadily increased throughout the study period, with a trend of improving survival. Higher annual center volume (Odds Ratio[OR]: 0.97, p < 0.001), longer ECMO duration (OR 1.01/day, p < 0.001), veno-arterial mode (OR 2.28, p < 0.001), initiation of ECMO >72 hours after transplant (OR 3.93, p < 0.001), and ventilator duration >5 days (1.55, p = 0.035) were associated with higher probability of survival to discharge.ConclusionsECMO after lung transplant has expanded over the last 12 years along with improved survival. The data suggest a potential benefit of early ECMO initiation in this patient population. High ECMO volume was associated with better outcomes, and expertise in ECMO is considered essential in lung transplant centers.","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"2676591251331158"},"PeriodicalIF":1.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perfusion education: Existence of perfusion doctorate programmes.

IF 1.1 4区医学

Perfusion-Uk Pub Date : 2025-03-28 DOI: 10.1177/02676591251331164

Bişar Amaç, Mesut Engin

引用次数: 0

Long-term outcomes after pediatric cardiac surgery: A 20-year single-institution study.

IF 1.1 4区医学

Perfusion-Uk Pub Date : 2025-03-25 DOI: 10.1177/02676591251328926

Luis Eduardo Silva Delgado, Erika Thalia Vasquez Cueva, Katherine Silva Delgado, Jorge Luis Maguiña Quispe, Eduardo Silva

{"title":"Long-term outcomes after pediatric cardiac surgery: A 20-year single-institution study.","authors":"Luis Eduardo Silva Delgado, Erika Thalia Vasquez Cueva, Katherine Silva Delgado, Jorge Luis Maguiña Quispe, Eduardo Silva","doi":"10.1177/02676591251328926","DOIUrl":"https://doi.org/10.1177/02676591251328926","url":null,"abstract":"PurposeThis study evaluated the long-term outcomes and factors associated with survival in patients undergoing cardiac surgery with cardiopulmonary bypass at a children's cardiac center.MethodsA retrospective cohort study was conducted between 2001 and 2020 Outcomes included early or late survival and associated risk factors for survival.ResultsSurvival had a mean of 16.78 years (95% CI 16.50-17.06). The survival rates at 1, 5, 10, and 19 years were 91, 88, and 88%, respectively. Cox regression analysis indicated that age HR = 0.39, 95% CI [0.26-0.59], the RACHS-1 scale HR = 9.92, 95% CI [3.67-26.79], open chest HR = 1, 90, 95% CI [1.20-3.00], cardiac arrest HR = 3.91, 95% CI [2.40-6.36] and peritoneal dialysis HR = 6.71, 95% CI [4, 33-10.38], were independently associated with worse survival.Conclusionslong-term survival of children who undergo cardiac surgery at our single center was satisfactory. Age, higher RACHS score, delayed sternal closure, cardiac arrest, and peritoneal dialysis were strong predictors of adverse outcomes affecting early and long-term survival of pediatric cardiac surgery.","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"2676591251328926"},"PeriodicalIF":1.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Level of sedation in patients with COVID-19 supported with ECMO: Comment.

IF 1.1 4区医学

Perfusion-Uk Pub Date : 2025-03-23 DOI: 10.1177/02676591251329549

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0