Perfusion-UkPub Date : 2025-01-01Epub Date: 2024-01-03DOI: 10.1177/02676591231226159
Yan Zhang, Hui Xiong, Bo Wang, Ming Luo, Ting Liu, Zhen Qin, Jin-Ge Fan, Rong-Hua Zhou
{"title":"Carbon dioxide production index (VCO<sub>2</sub>i) predicts hyperlactatemia during cardiopulmonary bypass in pediatric carDiac surGery (pGDP- VCO<sub>2</sub>i): Study protocol for a nested case-control trial.","authors":"Yan Zhang, Hui Xiong, Bo Wang, Ming Luo, Ting Liu, Zhen Qin, Jin-Ge Fan, Rong-Hua Zhou","doi":"10.1177/02676591231226159","DOIUrl":"10.1177/02676591231226159","url":null,"abstract":"<p><strong>Background: </strong>Hyperlactatemia (HL) during cardiopulmonary bypass (CPB) is relatively frequent in infants and associates with increased morbidity and mortality. Studies on adults have shown that carbon dioxide production index (VCO<sub>2</sub>i) during CPB is linked to the occurrence of HL, with 'critical thresholds' for VCO<sub>2</sub>i reported to be 60 mL/min/m<sup>2</sup>. However, considering infants have a higher metabolic rate and lower tolerance to hypoxia, the critical threshold of VCO<sub>2</sub>i in infants cannot be replied to the existing adults' standards. The objective of this study is to investigate the association of VCO<sub>2</sub>i during CPB and HL, and explore the critical VCO<sub>2</sub>i threshold during CPB in infants.</p><p><strong>Methods: </strong>VCO<sub>2</sub>i predicts hyperlactatemia during cardiopulmonary bypass in pediatric cardiac surgery (pGDP-VCO<sub>2</sub>i) is a nested case-control study. A cohort of consecutive pediatric patients of less than 3 years of age, undergoing congenital cardiac surgeries between May 2021 and December 2023 in West China Hospital will be enrolled. The VCO<sub>2</sub>i levels of each patient will be recorded every 5 min during CPB. The primary outcome is the rate of HL. The infants will be divided into two groups based on the presence or not of HL. Pre- and intraoperative factors will be tested for independent association with HL. Then, we will make an analysis, and the critical value of VCO<sub>2</sub>i will be obtained. The postoperative outcome of patients with or without HL will be compared.</p><p><strong>Discussion: </strong>This will be the first trial to investigate the association of VCO<sub>2</sub>i during CPB and HL, and explore the critical VCO<sub>2</sub>i threshold during CPB in pediatrics. The results of this study are expected to lay a foundation for clinical application of goal-directed perfusion (GDP) management strategy, and optimize the perfusion strategy and improve the prognosis of pediatric patients undergoing cardiac surgery.</p><p><strong>Trial registration: </strong>Chictr.org.cn, ChiCTR2100044296 on 16 March 2021.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"157-163"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Perfusion-UkPub Date : 2025-01-01Epub Date: 2024-01-25DOI: 10.1177/02676591241230610
Raffaele Silvano, Pietro Giorgio Malvindi, Francesca Mazzocca, Stefania Genova, Emanuele Di Campli, Francesca Paterna, Jacopo M D'Este, Jacopo Alfonsi, Paolo Berretta, Christopher Munch, Marco Di Eusanio
{"title":"Vacuum assisted and gravitational venous drainage in aortic valve surgery: A propensity-match study.","authors":"Raffaele Silvano, Pietro Giorgio Malvindi, Francesca Mazzocca, Stefania Genova, Emanuele Di Campli, Francesca Paterna, Jacopo M D'Este, Jacopo Alfonsi, Paolo Berretta, Christopher Munch, Marco Di Eusanio","doi":"10.1177/02676591241230610","DOIUrl":"10.1177/02676591241230610","url":null,"abstract":"<p><strong>Introduction: </strong>Vacuum assisted venous drainage (VAVD) is widely adopted in minimally invasive cardiac surgery. VAVD enables the advantage of using smaller cannulae in a reduced surgical field while allowing satisfactory drainage and pump flow. The production of gaseous micro-emboli is a recognized risk associated with VAVD, however no difference in clinical endpoints have been reported between patients operated on with gravity venous drainage (GVD) or with VAVD. Due to the paucity of data on selected surgical populations, we sought to evaluate the early outcomes of patients undergoing isolated aortic valve replacement using VAVD or GVD.</p><p><strong>Methods: </strong>Data on 521 patients between 09/2016 and 09/2022 were retrieved from our internal database. Patients were divided into two groups according to use VAVD or GVD. A propensity match analysis was performed to account for difference between the two groups.</p><p><strong>Results: </strong>The propensity match provided two well balanced cohorts with 129 patients each. A minimally invasive access was used in 97% of the cases in VAVD group vs 98% in GVD group (<i>p</i> = .68). Mean cardiopulmonary by-pass (CPB) time was 71 vs 73 min (<i>p</i> = .74), respectively. There was no difference in lactates peak (<i>p</i> = .19) and urine output during CPB (<i>p</i> = .74). We registered two in-hospital deaths in VAVD cohort (1.6%) vs. no mortality in GVD group (<i>p</i> = .5). Postoperative cerebral stroke occurred in 1 patient in GVD cohort vs. 0 in VAVD (<i>p</i> = 1). Severe postoperative acute kidney injury complicated the course in 16 patients in GVD group and in 5 patients who had VAVD (<i>p</i> = .012). VAVD was associated with a higher number of patients with elevated postoperative AST (<i>p</i> = .07) and Troponin I (<i>p</i> = .01) values.</p><p><strong>Conclusions: </strong>The use of VAVD during isolated aortic valve replacement was not associated with increased risks of postoperative complications and in-hospital mortality with results that were at least similar to those registered in a matched cohort of patients operated on with GVD.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"221-228"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139565191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Perfusion-UkPub Date : 2025-01-01Epub Date: 2024-02-23DOI: 10.1177/02676591241226464
Yuriy Stukov, Mark S Bleiweis, Laura Wilson, Giles J Peek, Keith March, Elaine M Richards, Edward D Staples, Jeffrey P Jacobs
{"title":"Comparison of different porcine models simulating myocardial cold ischemia of pediatric donor hearts.","authors":"Yuriy Stukov, Mark S Bleiweis, Laura Wilson, Giles J Peek, Keith March, Elaine M Richards, Edward D Staples, Jeffrey P Jacobs","doi":"10.1177/02676591241226464","DOIUrl":"10.1177/02676591241226464","url":null,"abstract":"<p><strong>Background: </strong>Our team previously identified a stem cell-derived cardioprotective additive that can be added to standard cardioplegia to extend myocardial viability during prolonged myocardial cold ischemic time (CIT) in rodent models. The purpose of this study was to utilize a porcine model to compare <i>in-vivo</i> versus <i>ex-vivo</i> porcine simulation of CIT that accompanies cardiac transplantation in humans, in order to determine an optimal method for translation of our studies to larger animals.</p><p><strong>Methods: </strong>Eight 39-55 kg Yorkshire X pigs were randomly assigned to either <i>in-vivo</i> or <i>ex-vivo</i> simulation. After administration of general anesthesia and endotracheal intubation, baseline measurement of left ventricular performance was obtained via transesophageal echocardiography (TEE). After midline sternotomy and heparin administration, the aorta was cross-clamped and two liters of HTK-Custodiol were introduced via the aortic root. The <i>in-vivo</i> method utilized cold ischemic heart storage in the chest cavity while supporting the experimental animal with cardiopulmonary bypass (CPB). The <i>ex-vivo</i> method involved standard cardiac procurement, cold ischemic storage outside of the body, and subsequent cardiac reperfusion utilizing cardiac reanimation in a Langendorff heart perfusion mode. After CIT, measurements of post-ischemic left ventricular performance were obtained via echocardiography. Results are presented as: Mean ± Standard Deviation (Median, Minimum-Maximum).</p><p><strong>Results: </strong>Weight (kilograms) was similar in the <i>in-vivo</i> group and the <i>ex-vivo</i> group: 44 ± 1.8 (44, 42-46) versus 44 ± 5.1 (43.5, 39-51), respectively. Cold ischemic time (minutes) was longer in the <i>ex-vivo</i> group: 360 ± 0 (360, 360-360) versus 141 ± 26.7 (149, 102-163). Temperature (degrees Celsius) was colder in the <i>ex-vivo</i> group: 8 ± 0 (8, 8-8) versus 16.5 ± 4.2 (16, 12-16).In the <i>in-vivo</i> group, baseline ejection fraction and ejection fraction after CIT were: 48.25% ± 14.95% (48.5%, 33%-63%) and 41.25% ± 22.32% (41.5%, 20%-62%), respectively. In the <i>ex-vivo</i> group, baseline ejection fraction and ejection fraction after CIT were: 56.4% ± 5.9% (57%, 50%-67%) and 60.4% ± 7.7% (61.5%, 51.9%-67%), respectively.</p><p><strong>Conclusion: </strong>The <i>ex-vivo</i> technique is suitable to evaluate cardioplegia additives that may substantially extend myocardial tolerance to cold ischemia.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"192-201"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139933852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Perfusion-UkPub Date : 2025-01-01Epub Date: 2023-12-12DOI: 10.1177/02676591231221708
Noy Meshulami, Raghav Murthy, Maisy Meyer, Andrew D Meyer, Shubhi Kaushik
{"title":"Bivalirudin anticoagulation for cardiopulmonary bypass during cardiac surgery.","authors":"Noy Meshulami, Raghav Murthy, Maisy Meyer, Andrew D Meyer, Shubhi Kaushik","doi":"10.1177/02676591231221708","DOIUrl":"10.1177/02676591231221708","url":null,"abstract":"<p><strong>Introduction: </strong>Heparin is the primary anticoagulant for cardiopulmonary bypass (CPB) support during cardiac surgery. While widely used, ∼2% of cardiac surgery patients develop heparin-induced thrombocytopenia (HIT) and 4-26% develop heparin resistance. Bivalirudin is an alternative anticoagulant mainly used for percutaneous coronary interventions. Given the challenges associated with heparin anticoagulation, we conducted a review to explore the use of bivalirudin for CPB surgery.</p><p><strong>Methods: </strong>PubMed and Embase scoping review included 2 randomized controlled trials, a retrospective comparison study, 3 pilot studies, and 30 case reports. To provide a contemporary series, we searched for articles published from 2010 to 2023. Our review included studies from both adult and pediatric populations.</p><p><strong>Results: </strong>While data is limited, bivalirudin seems to supply similar effectiveness and safety as heparin for CPB anticoagulation. Across the three comparative studies, the heparin cohorts had a 0-9% mortality rate and 0-27% rate of major bleeding/reoperation compared to a 0-3% mortality and 0-6% major bleeding/reoperation rate for the bivalirudin cohorts. Bivalirudin was successfully used as an anticoagulant in a wide range of CPB surgeries (e.g., heart transplants, ventricular assisted device placements, and valve repairs). Successful patient outcomes were reported with bivalirudin infusion of ∼2 mg/kg/hour, activated clotting time monitoring (target >400 s or 2.5× baseline), use of cardiotomy suctions, minimization of stagnant blood, and post-bypass modified ultrafiltration.</p><p><strong>Conclusion: </strong>Bivalirudin is a safe and effective anticoagulant for CPB, especially for patients with HIT or heparin resistance. Further comparative research is called for to optimize bivalirudin utilization for CPB during cardiac surgery.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"7-19"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138799803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Perfusion-UkPub Date : 2025-01-01Epub Date: 2024-01-17DOI: 10.1177/02676591241228173
Danni Fu, Byung Joon Park, Gaurav Rao, John Makaryus
{"title":"Severe COVID-19 post pregnancy complicated by acute thromboemboli resulting in ST-elevation myocardial infarction - A case report.","authors":"Danni Fu, Byung Joon Park, Gaurav Rao, John Makaryus","doi":"10.1177/02676591241228173","DOIUrl":"10.1177/02676591241228173","url":null,"abstract":"<p><p><i>Introduction:</i> It has been shown that pregnancy can cause alterations in the severity of COVID-19 infection. We demonstrate an immediate post-partum patient diagnosed with severe COVID-19 and subsequently developed acute thrombosis of coronary artery.<i>Case Summary:</i> 35-year-old female unvaccinated for COVID-19 presented in labor and delivered on the same day. Several hours later, she was found to be in respiratory distress and tested positive for COVID-19. On day 7, computerized tomography (CT) of chest revealed bilateral pneumonia and pneumomediastinum. On day 8, she developed chest pain with electrocardiogram (EKG) showing inferior STelevations with troponin I of 0.6 ng/mL. She was intubated for airway protection and emergent diagnostic angiogram revealed thrombus occlusion of the third right posterolateral segment that resulted in thrombolysis in myocardial infarction (TIMI) 0 flow without evidence of underlying atherosclerotic disease in the remaining vessels. Intracoronary IIb/IIIa inhibitor was administered. Arterial blood gas in the lab revealed profound hypoxia despite being on 100% inspired oxygen. Multidisciplinary decision was made to cannulate patient for venovenous extracorporeal membrane oxygenation (ECMO) to treat severe COVID-19 pneumonia. She was finally decannulated from ECMO on day 65. After prolonged hospital stay, she eventually recovered and was discharged to rehabilitation.<i>Conclusions:</i> The center for disease control (CDC) surveillance has reported that pregnant patients with COVID-19 are more likely to require invasive ventilation and ECMO, and die given the immunological changes during pregnancy. Hypercoagulable state caused by combination of pregnancy and COVID-19 resulting in coronary thrombosis is rarely described in literature, our case demonstrated the paucity of this phenomenon.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"251-255"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Perfusion-UkPub Date : 2025-01-01Epub Date: 2024-01-22DOI: 10.1177/02676591241228975
Alice V Vinogradsky, Stephanie N Nguyen, Abhishek Mathur, Koji Takeda
{"title":"Liberal use of veno-arterial extracorporeal membrane oxygenation in combined sequential heart-liver transplantation.","authors":"Alice V Vinogradsky, Stephanie N Nguyen, Abhishek Mathur, Koji Takeda","doi":"10.1177/02676591241228975","DOIUrl":"10.1177/02676591241228975","url":null,"abstract":"<p><p>Combined heart-liver transplantation (CHLT) is a rarely though increasingly performed procedure with evolving indications. Despite CHLT being performed at only a handful of centers, the use of intraoperative mechanical circulatory support to optimize hemodynamics and facilitate dual-organ transplantation varies widely. At our center, we liberally utilize veno-arterial extracorporeal membrane oxygenation (V-A ECMO) when a veno-venous shunt is anticipated to be insufficient in mitigating the hemodynamic perturbations associated with liver reperfusion. In this series, we describe our experience with V-A ECMO in sequential (heart-first) CHLT and demonstrate highly favorable outcomes with this strategy.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"256-260"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139522146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Perfusion-UkPub Date : 2025-01-01Epub Date: 2024-09-03DOI: 10.1177/02676591241282589
Justyna Swol
{"title":"Do not ask if ECMO, but when - More unanswered questions.","authors":"Justyna Swol","doi":"10.1177/02676591241282589","DOIUrl":"10.1177/02676591241282589","url":null,"abstract":"","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"5-6"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Perfusion-UkPub Date : 2025-01-01Epub Date: 2023-12-05DOI: 10.1177/02676591231220832
Juan I Chico, Vanesa Gomez, Santiago Freita, María D Rivas, David Mosquera, Eva M Menor, Miguel A Piñon
{"title":"Successful implementation of prophylactic veno-venoarterial extracorporeal membrane oxygenation in high-risk trauma surgery: A case report.","authors":"Juan I Chico, Vanesa Gomez, Santiago Freita, María D Rivas, David Mosquera, Eva M Menor, Miguel A Piñon","doi":"10.1177/02676591231220832","DOIUrl":"10.1177/02676591231220832","url":null,"abstract":"<p><strong>Introduction: </strong>Extracorporeal Membrane Oxygenation (ECMO) is increasingly utilized in trauma care, yet its elective use during high-risk surgeries remains unreported.</p><p><strong>Case report: </strong>We report a successful instance of prophylactic ECMO support via a Veno-Venoarterial (V-VA) configuration during high-risk surgery in a patient with extensive trauma, including severe thoracic damage and a highly unstable thoracic spine fracture. V-VA ECMO prevented complications such as hemodynamic and respiratory collapse associated with chest compression during the surgical procedure, as the patient should be in a prone position.</p><p><strong>Discussion: </strong>The potential of ECMO as prophylactic support in high-risk surgery amongst trauma patients underscores a novel application of this technology. Complex configurations must be evaluated to avoid associated ECMO complications.</p><p><strong>Conclusion: </strong>Our case highlights the potential of prophylactic ECMO hybrid modes, indicating their safe application during high-risk procedures in select trauma patients.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"243-246"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Perfusion-UkPub Date : 2025-01-01Epub Date: 2023-12-29DOI: 10.1177/02676591231224645
Shouliang Jiang, Ping Yan, Zhongyang Ma, Juan Liang, Yong Hu, Jun Tang
{"title":"Outcomes of COVID-19 patients undergoing extracorporeal membrane oxygenation: A systematic review and meta-Analysis.","authors":"Shouliang Jiang, Ping Yan, Zhongyang Ma, Juan Liang, Yong Hu, Jun Tang","doi":"10.1177/02676591231224645","DOIUrl":"10.1177/02676591231224645","url":null,"abstract":"<p><strong>Background: </strong>The Coronavirus Disease 2019 (COVID-19) pandemic has been ongoing for over 3 years, during which numerous clinical and experimental studies have been conducted. The objective of this systematic review and meta-analysis was to assess the survival probability and complications of COVID-19 patients receiving extracorporeal membrane oxygenation (ECMO).</p><p><strong>Methods: </strong>We searched the databases by using Population-Intervention-Comparison-Outcome-Study Design (PICOS). We conducted a search of the PubMed, Web of Science, and EMBASE databases to retrieve studies published until December 10, 2022. A random-effects meta-analysis, subgroup analysis, and assessed the studies using the Newcastle-Ottawa Scale score. The results were presented as pooled morbidity with 95% confidence intervals.</p><p><strong>Results: </strong>The study was conducted on 19 studies that enrolled a total of 1494 patients, and the results showed a pooled survival probability of 66.0%. The pooled morbidity for intracranial hemorrhage was 8.7%, intracranial thrombosis 7.0%, pneumothorax 9.0%, pulmonary embolism 11.0%, pulmonary hemorrhage 9.0%, heart failure 14.0%, liver failure 13.0%, renal injury 44.0%, gastrointestinal hemorrhage 6.0%, gastrointestinal ischemia 6.0% and venous thrombosis 31.0%.</p><p><strong>Conclusion: </strong>This systematic review and meta-analysis of observational studies focused on the survival probability and complications of COVID-19 patients undergoing ECMO, which are significant in evaluating the use of ECMO in COVID-19 patients and provide a basis for further research.</p><p><strong>Trial registration: </strong>Our study was registered on PROSPERO with registration number CRD42022382555.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"36-48"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139075711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Perfusion-UkPub Date : 2025-01-01Epub Date: 2023-12-11DOI: 10.1177/02676591231222136
Matthijs Gerritse, Thomas J van Brakel, Joris van Houte, Marloes van Hoeven, Eddy Overdevest, Mohamed Soliman-Hamad
{"title":"Optimal antegrade cerebral perfusion flow in patients undergoing surgery for acute type A aortic dissection: A retrospective single-center analysis.","authors":"Matthijs Gerritse, Thomas J van Brakel, Joris van Houte, Marloes van Hoeven, Eddy Overdevest, Mohamed Soliman-Hamad","doi":"10.1177/02676591231222136","DOIUrl":"10.1177/02676591231222136","url":null,"abstract":"<p><strong>Background: </strong>Systemic hypothermia with bilateral antegrade selective cerebral perfusion (ASCP) is the preferred cerebral protective strategy for type A aortic dissection surgery. The optimal ASCP flow rate remains uncertain and the target flow cannot always be reached due to pressure limitations. The aim of this study was to assess the correlation between ASCP flow and regional cerebral oxygen saturation (rSO2).</p><p><strong>Methods: </strong>A retrospective analysis was performed on 140 patients with acute type A aortic dissection who underwent surgery with moderate hypothermic circulatory arrest and bilateral ASCP between 2015 and 2021. Pearson correlation analysis was performed between ASCP flow and rSO2.</p><p><strong>Results: </strong>The median circulatory arrest duration was 46.5 (IQR:37.0-61.0) minutes. There was no significant correlation between ASCP flow and rSO2 for both the right (r = -.02, <i>p</i> = .851), and the left hemisphere (r = - .04, <i>p</i> = .618). The rSO2 values for ten patients who received > 10 mL/kg/min flow did not differ significantly from 130 patients who received 10 mL/kg/min or less for both the left hemisphere (<i>p</i> = .135), and the right hemisphere (<i>p</i> = .318). The ASCP flow was 5.1 (IQR:5.0- 6.5) mL/kg/min in five patients with, and 7.2 (IQR:5.8-8.3) mL/kg/min in 135 patients without a watershed infarction (<i>p</i> = .098).</p><p><strong>Conclusions: </strong>There was no correlation between ASCP flow rate and rSO2 in patients with acute type A aortic dissection. Furthermore, ASCP flow below 10 mL/kg/min was not associated with a reduction in rSO2. Definitive associations between ASCP flow and neurological outcome after type A aortic dissection surgery need further investigation.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"125-131"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}