Revista De Investigacion Clinica-Clinical and Translational Investigation最新文献_第7页

Tumor-Promoting Effects of Microrna-421/4-Aminobutyrate Aminotransferase Axis in Hepatocellular Carcinoma. Microrna-421/4氨基丁酸氨基转移酶轴在肝癌中的促瘤作用。

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2023-01-01 DOI: 10.24875/RIC.23000073

Yuanguang Liu, Ran Cheng, Yijie Wu, Chunmei Liu, Yang Liu, Qing Chang, Jun Yin

{"title":"Tumor-Promoting Effects of Microrna-421/4-Aminobutyrate Aminotransferase Axis in Hepatocellular Carcinoma.","authors":"Yuanguang Liu, Ran Cheng, Yijie Wu, Chunmei Liu, Yang Liu, Qing Chang, Jun Yin","doi":"10.24875/RIC.23000073","DOIUrl":"10.24875/RIC.23000073","url":null,"abstract":"Background: MicroRNA-421 (miR-421) has been implicated in hepatocellular carcinoma (HCC), but its potential mechanism in HCC remains unclear.Objectives: The study aimed to study the potential mechanism of miR-421 in HCC which is necessary.Methods: The downstream target genes of miR-421 were screened in HCC tissues and cells using miDIP, Targetscan, and starBase databases. Differential analysis, survival analysis, and Pearson correlation analysis were performed between miR-421 and its downstream target genes. Quantitative reverse transcription polymerase chain reaction and western blot were used to assay RNA and protein levels of 4-aminobutyrate aminotransferase (ABAT) and epithelial-mesenchymal transition (EMT)-related proteins. Cell-based assays, including CCK-8, wound healing, transwell, flow cytometry, and metabolic measurements, were implemented to assess proliferation, migration, invasion, cell cycle, and apoptosis of HCC cells with different treatments. Dual-luciferase assay was utilized to detect the targeting relationship between miR-421 and ABAT.Results: miR-421 level was elevated in HCC tissues and cells, and low miR-421 expression hindered phenotype progression of HCC cells. ABAT was identified as a direct target of miR-421 in HCC cells, and miR-421 could inhibit ABAT expression. Rescue assay revealed that miR-421 promoted HCC cell tumorigenesis progress and affected cell metabolic remodeling through down-regulating ABAT.Conclusion: The miR-421/ABAT regulatory axis promoted HCC cell tumorigenesis progress, highlighting its potential as a therapeutic target for HCC.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"75 5","pages":"233-248"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type 2 Diabetes Mellitus and Nonvalvular Atrial Fibrillation in Mexico: National Registries Raise a Red Flag. 2型糖尿病和非瓣膜性心房颤动在墨西哥:国家登记机构提出了一个危险信号。

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2023-01-01 DOI: 10.24875/RIC.23000056

Manlio F Márquez-Murillo, Eduardo Brenner-Muslera, Diana L Rodríguez-Carrillo, César A Chua-López, Margarita Torres-Tamayo

{"title":"Type 2 Diabetes Mellitus and Nonvalvular Atrial Fibrillation in Mexico: National Registries Raise a Red Flag.","authors":"Manlio F Márquez-Murillo, Eduardo Brenner-Muslera, Diana L Rodríguez-Carrillo, César A Chua-López, Margarita Torres-Tamayo","doi":"10.24875/RIC.23000056","DOIUrl":"https://doi.org/10.24875/RIC.23000056","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases worldwide and is highly prevalent in Mexico, as 10.2% of the adult population harbors this condition. T2DM is usually associated with cardiovascular comorbidities, including arrhythmias. Metabolic impairment is one of the mechanisms that contribute to tissue remodeling that affects atrial structure, and concomitant, the cardiac conduction system, both could result in atrial fibrillation (AF). AF is estimated to affect more than a half million Mexicans, and its incidence is expected to keep rising. According to national registries, T2DM is present in 28.4% of Mexican patients with AF and the coexistence of both diseases is associated with a higher risk of stroke. In clinical practice, the CHA2DS2-VASc risk score is useful for stroke risk stratification in patients with AF to facilitate the adequate use of anticoagulation therapy. T2DM is among the items of the CHA2DS2-VASc score because it correlates with an intrinsic prothrombotic state. In this narrative review, we present information that highlights the need for optimal glucose control and adequate anticoagulation in subjects with T2DM and AF.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"75 4","pages":"179-186"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10055250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New-onset Geriatric Epilepsy in a Latin American Country: A Multi-centric Study from Mexico. 拉丁美洲国家新发老年癫痫:一项来自墨西哥的多中心研究

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2023-01-01 DOI: 10.24875/RIC.23000057

Roberto A Suástegui Román, Ángel Lee, Laura E Hernández Vanegas, Gerónimo Pacheco-Aispuro, Brigham Bowles, Christopher Mader, Elizabeth Aveleyra Ojeda

{"title":"New-onset Geriatric Epilepsy in a Latin American Country: A Multi-centric Study from Mexico.","authors":"Roberto A Suástegui Román, Ángel Lee, Laura E Hernández Vanegas, Gerónimo Pacheco-Aispuro, Brigham Bowles, Christopher Mader, Elizabeth Aveleyra Ojeda","doi":"10.24875/RIC.23000057","DOIUrl":"https://doi.org/10.24875/RIC.23000057","url":null,"abstract":"Background: In Latin America, epilepsy in the elderly is a neglected issue that has never been studied. The epidemiological transition has significantly altered the demographics of epilepsy, and therefore, we would like to draw attention to this topic. Objective: We require local real-world evidence, as the literature often depicts a different scenario, including pharmacological management. Methods: From 2007 to 2018, we recruited all patients with new-onset geriatric epilepsy (first seizure after the age of 60) tracked from ten Mexican hospitals, adding them to patients with similar characteristics from a previously published study. The diagnosis was confirmed in all patients by a certified neurologist, and they were also studied using a conventional electroencephalogram and imaging workup. Results: A diagnosis of new-onset geriatric epilepsy (Elderly patients was established in 100 cases. No specific cause was found in 26% of patients, while 42% had a stroke and 10% had neurocysticercosis (NCC). Monotherapy was the choice in 83 patients, and phenytoin was the most used drug (50%), followed by carbamazepine (25%). Conclusion: NCC remains a frequent cause of new-onset geriatric epilepsy. This distribution is not seen in the literature, mainly representing patients from wealthy economies. In our setting, financial constraints influence the choice of the drug, and newer antiepileptic drugs should be made more affordable to this population with economic and physical frailty.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"75 4","pages":"203-211"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10109358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Hemodialysis in the Last Decade in Latin America. 过去十年拉丁美洲血液透析的进展。

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2023-01-01 DOI: 10.24875/RIC.23000224

María C González-Bedat, Guillermo Rosa-Diez, Ricardo Correa-Rotter

{"title":"Advances in Hemodialysis in the Last Decade in Latin America.","authors":"María C González-Bedat, Guillermo Rosa-Diez, Ricardo Correa-Rotter","doi":"10.24875/RIC.23000224","DOIUrl":"10.24875/RIC.23000224","url":null,"abstract":"Unassigned: Kidney replacement therapy (KRT) initiated in Latin America towards the second half of the 20th century, starting with dialytic therapies and, shortly thereafter, with kidney transplant. By the end of 2021, close to half a million Latin Americans were under KRT, with an overall unadjusted prevalence of 872 per million persons (pmp), yet with significant heterogeneity between nations. By treatment modality, 68% of prevalent patients were treated with hemodialysis (HD), 9% with peritoneal dialysis (PD), and 23% were living with a functioning kidney graft (LFG). In the last decade, HD is the KRT that has had the largest growth, and it also has incorporated newer and better technologies. Nevertheless, Latin America shows heterogeneity between countries, and as a region we are far from achieving full accessibility to all in need of KRT. While there has been growth and improvement in existing renal dialysis registries, and several countries that did not previously have these registries have implemented them, there are still some nations with limited or absent registry implementation. The number of nephrologists in the region is heterogeneous, with only four countries having an appropriate group of specialists. The remaining nations have an important need to expand nephrology training programs. SLANH is a major regional player in addressing these topics and supporting the expansion of appropriate nephrology programs to improve inequalities and patient care. (Rev Invest Clin. 2023;75(6):300-8).","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"75 6","pages":"300-308"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

At-risk Pregnant Woman with Sticky Platelet Syndrome, Previous Recurrent Preeclampsia, and Current Proteinuria - A Rare Experience. 有黏性血小板综合征、既往复发性子痫前期和当前蛋白尿的高危孕妇-罕见的经历。

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2023-01-01 DOI: 10.24875/RIC.22000307

Lucia Stančiaková, Miroslava Dobrotová, Jela Ivanková, Ingrid Škorňová, Tomáš Bolek, Monika Brunclíková, Matej Samoš, Ján Danko, Mária Škereňová, Peter Kubisz, Ján Staško

引用次数: 0

Preface: Special Issue on Challenges and New Findings on Misused Psychoactive Drugs. 前言:关于滥用精神药物的挑战和新发现的特刊。

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2023-01-01 DOI: 10.24875/RIC.230001221

Silvia L Cruz

引用次数: 0

Meta-analysis to Implement Alpha-Synuclein in Extracellular Vesicles as a Potential Biomarker for Parkinsons Disease. 细胞外囊泡α -突触核蛋白作为帕金森病潜在生物标志物的meta分析

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2023-01-01 DOI: 10.24875/RIC.23000017

Víctor H Juárez-Vaquera, Marcos F Rosetti-Sciutto, Valeria Morales-Ruiz, Laura V Adalid-Peralta

引用次数: 0

The Predictive Value of R Wave Peak Time to Detect Thrombus Burden in St-segment Elevation Myocardial Infarction: A Retrospective Cohort Study in a Tertiary Medical Center. R波峰值时间对st段抬高型心肌梗死血栓负荷的预测价值:一项三级医疗中心的回顾性队列研究

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2023-01-01 DOI: 10.24875/RIC.23000102

Zehra Güven-Çetin, Bekir Demirtaş, Ahmet Balun, Hülya Çiçekçioğlu, Kerem Özbek, Mustafa Çetin

{"title":"The Predictive Value of R Wave Peak Time to Detect Thrombus Burden in St-segment Elevation Myocardial Infarction: A Retrospective Cohort Study in a Tertiary Medical Center.","authors":"Zehra Güven-Çetin, Bekir Demirtaş, Ahmet Balun, Hülya Çiçekçioğlu, Kerem Özbek, Mustafa Çetin","doi":"10.24875/RIC.23000102","DOIUrl":"https://doi.org/10.24875/RIC.23000102","url":null,"abstract":"Unassigned: Background: Patients with higher thrombus burden have higher procedural complications and more long-term adverse cardiac events. Detecting patients with high thrombus burden (HTB) before coronary intervention could help avoid procedural complications. Objective: The research aimed to analyze the R wave peak time (RWPT) on the electrocardiogram to predict thrombus burden before coronary angiography in patients with acute ST-segment elevation myocardial infarction (STEMI). Materials and Methods: A total of 159 patients with STEMI were included in the study conducted at a tertiary medical center. The thrombolysis in myocardial infarction (TIMI) thrombus scale was applied to assess the thrombus burden. TIMI thrombus grades 0, 1, 2, and 3 were accepted as low; 4 and 5 had HTB. RWPT was measured from the beginning of the QRS complex to the R-peak from the leads pointing to the infarct-related artery. Results: Patients were divided into two groups according to their angiographically defined thrombus burden as low and high. The low thrombus burden group (LTB) comprised fifty-four patients, whereas the HTB group comprised 105 patients. In the LTB group, RWPT was 47.96 ± 9.17 ms, and in the HTB group was 53.58 ± 8.92 ms; it was significantly longer (p < 0.01). Receiver operating characteristic analysis showed that a cut-off value of preprocedural RWPT of > 46.5 ms predicted the occurrence of HTB with a sensitivity and specificity of 87.62% and 51.85%, respectively (AUC 0.682, 95% CI 0.590-0.774, p < 0.001). Conclusion: The present study evaluated the relationship between the RWPT and thrombus burden in STEMI patients. Based on the results, RWPT is an independent predictor of HTB.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"75 4","pages":"212-220"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10107073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author's reply to sars-cov-2 reinfection rate in vaccinated hospital workers: correspondence. 提交人对接种疫苗的医院工作人员sars-cov-2再感染率的答复:函件。

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2022-12-16 DOI: 10.24875/RIC.22000251

Eric Ochoa-Hein, Patricia E Leal-Morán, Karen A Nava-Guzmán, Abril T Vargas-Fernández, José F Vargas-Fernández, Fabricio Díaz-Rodríguez, Joel Armando Rayas-Bernal, Ricardo González-González, Pavel Vázquez-González, Martha A Huertas-Jiménez, Sandra Rajme-López, Pilar Ramos-Cervantes, Violeta Ibarra-González, Luis A García-Andrade, Fernando Ledesma-Barrientos, Alfredo Ponce-de-León, José Sifuentes-Osornio, Arturo Galindo-Fraga

引用次数: 0

What did we learn about coronavirus disease-19-associated acute kidney injury during the pandemic? 在大流行期间，我们对冠状病毒病-19相关的急性肾损伤学到了什么?

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2022-12-16 DOI: 10.24875/RIC.22000146

Noemí Del Toro-Cisneros, Adrián E Caballero-Islas, Juan C Ramírez-Sandoval, Juan M Mejía-Vilet, Mauricio Arvizu-Hernández, Gustavo Casas-Aparicio, Jonathan Chávez-Íñiguez, Lilia M Rizo-Topete, Olynka Vega-Vega

{"title":"What did we learn about coronavirus disease-19-associated acute kidney injury during the pandemic?","authors":"Noemí Del Toro-Cisneros, Adrián E Caballero-Islas, Juan C Ramírez-Sandoval, Juan M Mejía-Vilet, Mauricio Arvizu-Hernández, Gustavo Casas-Aparicio, Jonathan Chávez-Íñiguez, Lilia M Rizo-Topete, Olynka Vega-Vega","doi":"10.24875/RIC.22000146","DOIUrl":"https://doi.org/10.24875/RIC.22000146","url":null,"abstract":"Initial reports suggested that kidney involvement after coronavirus disease 19 (COVID-19) infection was uncommon, but this premise appears to be incorrect. Acute kidney injury can occur through various mechanisms and complicate the course of up to 25% of patients with COVID-19 hospitalized in our Institution, and of over 50% of those on invasive mechanical ventilation. Mechanisms of injury include direct kidney injury and predominantly tubular, although glomerular injury has been reported, and resulting from severe hypoxic respiratory failure, secondary infection, and exposure to nephrotoxic drugs. The mainstay of treatment remains the prevention of progressive kidney damage and, in some cases, the use of renal replacement therapy. Although the use of blood purification techniques has been proposed as a potential treatment, results to date have not been conclusive. In this manuscript, the mechanisms of kidney injury by COVID-19, risk factors, and the mainstays of treatment are reviewed.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"74 6","pages":"302-313"},"PeriodicalIF":1.4,"publicationDate":"2022-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10776519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0