Revista De Investigacion Clinica-Clinical and Translational Investigation最新文献

{"title":"Routine systematic prostate biopsies not replaced by magnetic resonance imaging-targeted biopsy.","authors":"David Gómez-Ortiz,&nbsp;Adrián M Garza-Gangemi,&nbsp;Mariano Oropeza-Aguilar,&nbsp;Sergio Rangel-Suárez,&nbsp;Verónica Espinosa-Cruz,&nbsp;Antonio C Villegas-Hernández,&nbsp;Ricardo Martínez-Martínez,&nbsp;Ricardo A Castillejos-Molina","doi":"10.24875/RIC.22000084","DOIUrl":"https://doi.org/10.24875/RIC.22000084","url":null,"abstract":"<p><strong>Background: </strong>Multiparametric magnetic resonance imaging improves the performance of prostate cancer (PCa) diagnostics through a better selection of patients.</p><p><strong>Objectives: </strong>The aim of the study was to study the detection rate (DR) of systematic and targeted cognitive biopsies in a cohort with the previous negative systematic biopsies. A secondary objective was to describe the value of prostate-specific antigen density (PSAd) in the detection of clinically significant PCa (CSPCa).</p><p><strong>Methods: </strong>We designed a prospective, single-center, and comparative study to determine the DR of systematic and targeted cognitive biopsies. The clinical and pathological characteristics of each patient were described.</p><p><strong>Results: </strong>A total of 111 patients with Prostate Imaging Reporting and Data System lesions > 3 were included in the study. PCa was detected in 41.4% (46 of 111 patients); 42 (91.3%) were detected by systematic biopsy and 30 (65.2%) by targeted biopsy. CSPCa was detected in 26 (23.4%), 23 (88.5%) by systematic biopsy, and 21 (76.9%) by targeted biopsy. PSAd > 0.15 was directly associated with CSPCa.</p><p><strong>Conclusion: </strong>The detection of PCa by systematic biopsy in this series was higher than 80%; hence, its routine use should not be replaced by targeted biopsy, since it continues to be the cornerstone of the diagnosis in patients with prior negative biopsies.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":" ","pages":"212-218"},"PeriodicalIF":1.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40552003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guillain-Barré syndrome amid the coronavirus disease 2019 era.","authors":"Rujittika Mungmunpuntipantip,&nbsp;Viroj Wiwanitkti","doi":"10.24875/RIC.22000081","DOIUrl":"https://doi.org/10.24875/RIC.22000081","url":null,"abstract":"","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"74 3","pages":"172"},"PeriodicalIF":1.4,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10507690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of uric acid/albumin ratio for the prediction of new-onset atrial fibrillation in patients with ST-Elevation myocardial infarction.","authors":"Murat Selçuk,&nbsp;Tufan Çınar,&nbsp;Faysal Şaylık,&nbsp;Tayyar Akbulut,&nbsp;Suha Asal,&nbsp;Vedat Çiçek,&nbsp;Mert İlker Hayıroğlu,&nbsp;İbrahim Halil Tanboğa","doi":"10.24875/RIC.22000072","DOIUrl":"https://doi.org/10.24875/RIC.22000072","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of studies supporting the association between the uric acid/albumin ratio (UAR) and the development of new-onset atrial fibrillation (NOAF) in ST-elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (pPCI).</p><p><strong>Objective: </strong>The objective of the study was to assess the efficacy of the UAR for predicting the occurrence of NOAF in STEMI patients undergoing pPCI.</p><p><strong>Methods: </strong>We recruited 1484 consecutive STEMI patients in this retrospective and cross-sectional investigation. The population sample was classified based on the development of NOAF during hospitalization. NOAF was defined as an atrial fibrillation (AF) observed during hospitalization in patients without a history of AF or atrial flutter. The UAR was computed by dividing the serum uric acid (UA) level by serum albumin level.</p><p><strong>Results: </strong>After pPCI, 119 STEMI patients (8%) were diagnosed with NOAF. NOAF patients had higher serum UAR levels than individuals who did not have NOAF. According to the multivariable logistic regression model, the UAR was an independent predictor for NOAF in STEMI patients (OR: 6.951, 95% CI: 2.978-16.28, p < 0.001). The area under curve (AUC) value of the UAR in a receiver operating characteristics (ROC) evaluation was 0.758, which was greater than those of its components (albumin [AUC: 0.633] and UA [AUC: 0.647]) and C-reactive protein (AUC: 0.714). The optimal UAR value in predicting NOAF in STEMI patients was greater than 1.39, with a sensitivity of 69% and a specificity of 74.5%.</p><p><strong>Conclusion: </strong>To the best of our knowledge, this is the first study indicating that the UAR was an independent predictor of NOAF development in STEMI patients.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":" ","pages":"156-164"},"PeriodicalIF":1.4,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40478587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-Cov-2 and Anti-COVID Vaccines Trigger Guillain-Barré Syndrome.","authors":"Josef Finsterer","doi":"10.24875/RIC.22000082","DOIUrl":"https://doi.org/10.24875/RIC.22000082","url":null,"abstract":"","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"74 3","pages":"173"},"PeriodicalIF":1.4,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10450963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammasome genes polymorphisms and susceptibility to gout. Is there a link?","authors":"Denise Clavijo-Cornejo,&nbsp;Alberto López-Reyes,&nbsp;Esteban Cruz-Arenas,&nbsp;Leonor Jacobo-Albavera,&nbsp;Daniel Rivera-Tlaltzicapa,&nbsp;Adriana Francisco-Balderas,&nbsp;Mayra Domínguez-Pérez,&nbsp;Pablo Romero-Morelos,&nbsp;Janitzia Vázquez-Mellado,&nbsp;Luis H Silveira,&nbsp;Carlos Pineda,&nbsp;Gabriela Martínez-Nava,&nbsp;Marwin Gutierrez","doi":"10.24875/RIC.21000603","DOIUrl":"https://doi.org/10.24875/RIC.21000603","url":null,"abstract":"<p><strong>Background: </strong>The inflammatory response in gout disease is induced by the activation of NLR family pyrin domain-containing 3 (NLPR3) signaling pathway mediated by IL-1β release.</p><p><strong>Objective: </strong>The objective of the study was to determine the association between single nucleotide polymorphisms (SNPs) within NLRP3 inflammasome genes and gout susceptibility.</p><p><strong>Methods: </strong>Mexican patients with gout from the National Rehabilitation Institute and General Hospital of Mexico were enrolled. A healthy control group was also included. We analyzed the frequency and allelic distribution of eight SNPs from seven different genes within the NLRP3 inflammasome signaling pathway: TLR4 rs2149356, CD14 rs2569190, NLRP3 rs3806268, NLRP3 rs10754558, CARD8 rs2043211, IL-1β rs1143623, P2RX7 rs3751142, and PPARGC1B rs45520937 SNPs.</p><p><strong>Results: </strong>We found that the SNP rs45520937 of PPARGC1B was associated with the risk of developing gout when it was analyzed using the dominant model (Odds ratio [OR] = 2.30; 95% confidence interval [CI]: 1.09-4.86; p = 0.030), and it is proposed that the adaptor molecule CD14 rs2569190 polymorphism could be associated with a lower risk of gout under an additive model (OR= 0.41;95% CI: 0.16-1.05; p = 0.064). No significant associations were identified for the remaining SNPs.</p><p><strong>Conclusion: </strong>Our findings suggest that the PPARGC1B rs45520937 SNP is associated with gout susceptibility.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":" ","pages":"147-155"},"PeriodicalIF":1.4,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40311401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma and COVID-19 among healthcare workers from a Mexican Hospital: is there an association?","authors":"J. Morales-Romero, P. Paredes-Casillas, J. E. López-Contreras, K. J. Arellano-Arteaga, M. Bedolla-Barajas","doi":"10.24875/RIC.22000017","DOIUrl":"https://doi.org/10.24875/RIC.22000017","url":null,"abstract":"Background\u0000Asthma does not appear to be a risk factor for developing COVID-19.\u0000\u0000\u0000Objective\u0000The objective of the study was to analyze the role of asthma as a factor associated with COVID-19 among healthcare workers (HW).\u0000\u0000\u0000Methods\u0000A crosssectional study was conducted in HW from a Mexican hospital. Data were obtained through an epidemiological survey that included age, sex, and history of COVID-19. Multivariate logistic regression analysis was performed to identify factors associated with COVID-19.\u0000\u0000\u0000Results\u0000In total, 2295 HW were included (63.1% women; mean age 39.1 years); and 1550 (67.5%) were medical personnel. The prevalence of asthma in HW with COVID-19 was 8.3%; for the group without COVID-19, the prevalence was 5.3% (p = 0.011). The multivariate analyses suggested that asthma was associated with COVID-19 (OR 1.59, p = 0.007).\u0000\u0000\u0000Conclusion\u0000Our study suggests that asthma could be a factor associated with COVID-19 in HW.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"31 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81856920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION BETWEEN APOE-ε4 CARRIER STATUS AND QUALITATIVE NEUROIMAGING CHARACTERISTICS IN OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT.","authors":"A. Mimenza-Alvarado, M. J. Suing-Ortega, Teresa Tusié-Luna, T. Juárez-Cedillo, J. Ávila-Funes, S. Aguilar-Navarro","doi":"10.24875/ric.21000550","DOIUrl":"https://doi.org/10.24875/ric.21000550","url":null,"abstract":"BACKGROUND\u0000The pathogenesis of mild cognitive impairment (MCI) is multifactorial and includes the presence of genetic variants such as the ε4 allele of the apolipoprotein E gene (APOE-ε4). Association between the APOE-ε4 carrier status and deleterious structural and functional changes on magnetic resonance imaging (MRI) has been previously described in individuals with Alzheimer's disease. However, the central nervous system changes may possibly develop in earlier stages of cognitive impairment, as reflected in MCI.\u0000\u0000\u0000OBJECTIVE\u0000The objective of the study was to determine the association between APOE-ε4 carrier status and qualitative changes on MRI (medial temporal and parietal atrophy), as well as the detection of white matter hyperintensities (WMH) in older adults with MCI, in the memory clinic of a tertiary care hospital in Mexico City.\u0000\u0000\u0000METHODS\u0000A cross-sectional study of 72 adults aged 60 years or above who underwent an exhaustive clinical, neuroimaging, and neuropsychological evaluation. Multivariate logistic regression models were constructed to determine the association between APOE-ε4 carrier status and qualitative/quantitative changes on MRI.\u0000\u0000\u0000RESULTS\u0000Mean age was 75.2 years (± 7.2) and 64% were female. Twenty-one participants were cognitively normal and 51 had MCI. Almost 56% were APOE-ε4 carriers and were associated with medial-temporal atrophy according to the Scheltens scale (odds ratio [OR]: 20.0, 95% confidence intervals [CI]: 3.03-131.7), parietal atrophy according to the Koedam's score (OR: 6.3; 95% CI 1.03-39.53), and WMH according to the Fazekas scale (OR: 11.7, 95% CI: 1.26-108.2), even after adjusting for age, educational level, and cardiovascular risk factors.\u0000\u0000\u0000CONCLUSION\u0000The APOE-ε4 carrier status was associated with medial temporal and parietal atrophy, as well as WMH. Our findings support the hypothesis suggesting the contribution of this genotype to neurodegeneration and cerebral vascular pathology.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"55 2 1","pages":"113-120"},"PeriodicalIF":1.4,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90675455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guillain-Barré Syndrome in Mexico: An Updated Review Amid the Coronavirus Disease 2019 ERA.","authors":"J. Galnares-Olalde, J. C. López-Hernández, M. García‐Grimshaw, S. Valdés-Ferrer, M. E. Briseño-Godínez, Adib J. de-Saráchaga, M. A. Alegría-Loyola, Anna L. Bazán-Rodríguez, Eunice Martínez-Jiménez, E. S. Vargas-Cañas","doi":"10.24875/RIC.22000006","DOIUrl":"https://doi.org/10.24875/RIC.22000006","url":null,"abstract":"Guillain-Barré syndrome (GBS) is the most frequent cause of acute flaccid paralysis and if not diagnosed and treated timely, a significant cause of long-term disability. Incidence in Latin America ranges from 0.71 to 7.63 cases/100,000 person-years. Historically, GBS has been linked to infections (mainly gastrointestinal by Campylobacter jejuni) and vaccines (including those against severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]); however, a trigger cannot be detected in most cases. Regarding SARS-CoV-2, epidemiological studies have found no association with its development. Acute motor axonal neuropathy is the most common electrophysiological variant in Mexico and Asian countries. Intravenous immunoglobulin or plasma exchanges are still the treatment cornerstones. Mortality in Mexico can be as high as 12%. Avances in understanding the drivers of nerve injury in GBS that may provide the basis for developing targeted therapies have been made during the past decade; despite them, accurate criteria for selecting patients requiring acute treatment, prognostic biomarkers, and novel therapies are still needed. The newly-developed vaccines against SARS-CoV-2 have raised concerns regarding the potential risk for developing GBS. In the midst of coronavirus disease 2019 and vaccination campaigns against SARS-CoV-2, this review discusses the epidemiology, clinical presentation, management, and outcomes of GBS in Mexico.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"16 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73700479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epistasis Between Two Gene Variants of Leptin and Vascular Endothelial Growth Factor Genes in the Development of Primary Knee Osteoarthritis.","authors":"Matvey Sosa-Arellano,&nbsp;Norma C González-Huerta,&nbsp;Eugenio Morales-Hernández,&nbsp;Carolina Duarte-Salazar,&nbsp;Antonio Miranda-Duarte","doi":"10.24875/RIC.21000493","DOIUrl":"https://doi.org/10.24875/RIC.21000493","url":null,"abstract":"<p><strong>Background: </strong>The association of leptin (<i>LEP</i>) and vascular endothelial growth factor A (<i>VEGFA</i>) genes with the susceptibility to knee osteoarthritis (OA) has been analyzed; however, the epistasis between them has not been investigated.</p><p><strong>Objective: </strong>The objective of the study was to analyze the association of <i>LEP</i> and <i>VEGFA</i> variants and their interaction with primary knee OA in a Mexican Mestizo population.</p><p><strong>Methods: </strong>A case-control study was developed. Cases were ≥40 years, BMI ≤27 kg/m², with primary knee OA and radiologic Grade ≥2. Controls were participants with no knee OA and a radiologic Grade < 2. The rs2167270 of <i>LEP</i> and rs2010963 of <i>VEGFA</i> were genotyped. Genotypic association was tested under codominant, dominant, and recessive models. Uni- and multi-variate analyses were developed through non-conditional logistic regression. The multifactor dimensionality reduction algorithm was developed to detect epistasis.</p><p><strong>Results: </strong>Participants comprised 103 cases and 179 controls. Allelic and genotypic distributions did not show differences between the groups. Notwithstanding, a statistically significant interaction was observed between the <i>LEP</i> and <i>VEGFA</i> genes (p = 0.02) with a testing accuracy of 0.5199 and cross-validation consistency of 10/10. This interaction model confers an increased risk to knee OA (OR [95% CI] = 1.8 [1.1-2.9]).</p><p><strong>Conclusion: </strong>Interaction between <i>LEP</i> and <i>VEGFA</i> is related with genetic susceptibility to developing primary knee OA.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"74 2","pages":"081-089"},"PeriodicalIF":1.4,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39785153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Result Turnaround Time of RT-PCR for SARS-CoV-2 is the Main Cause of COVID-19 Diagnostic Delay: A Country-Wide Observational Study of Mexico and Colombia.","authors":"Isaac Núñez,&nbsp;Pablo F Belaunzarán-Zamudio,&nbsp;Yanink Caro-Vega","doi":"10.24875/RIC.21000542","DOIUrl":"https://doi.org/10.24875/RIC.21000542","url":null,"abstract":"<p><strong>Background: </strong>Delay in COVID-19 diagnosis due to late real-time reverse transcription-polymerase chain reaction reporting has been described to be an important cause of suboptimal COVID-19 surveillance and outbreak containment.</p><p><strong>Objective: </strong>The objective of the study was to determine the duration of diagnostic delay due to test turnaround time and its association with marginalization status.</p><p><strong>Methods: </strong>In this observational study using national open data of Mexico and Colombia, we quantified the delay in COVID-19 diagnosis that occurred in both countries. We considered two periods that contributed to the delay in diagnosis: the time from symptom onset until testing <i>(delay-one)</i> and test turnaround time <i>(delay-two)</i>. Marginalization status was determined according to country-specific scores.</p><p><strong>Results: </strong>Among 3,696,773 patients from Mexico and Colombia, <i>delay-two</i> was generally longer than <i>delay-one</i>. Median <i>delay-one</i> was 3 days and delay-two 7 days in Colombia, while in Mexico, they were 3 days and 4 days, respectively. In Colombia, worse marginalization status prolonged <i>delaytwo</i>. In Mexico, a lower number and percentage of rapid tests were performed in areas with worse marginalization.</p><p><strong>Conclusion: </strong>Diagnostic delay was mostly due to test turnaround time. Marginalization status was an important barrier to diagnostic test access.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"74 2","pages":"071-080"},"PeriodicalIF":1.4,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39941009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}