Revista De Investigacion Clinica-Clinical and Translational Investigation最新文献

{"title":"Inflammasome genes polymorphisms and susceptibility to gout. Is there a link?","authors":"Denise Clavijo-Cornejo,&nbsp;Alberto López-Reyes,&nbsp;Esteban Cruz-Arenas,&nbsp;Leonor Jacobo-Albavera,&nbsp;Daniel Rivera-Tlaltzicapa,&nbsp;Adriana Francisco-Balderas,&nbsp;Mayra Domínguez-Pérez,&nbsp;Pablo Romero-Morelos,&nbsp;Janitzia Vázquez-Mellado,&nbsp;Luis H Silveira,&nbsp;Carlos Pineda,&nbsp;Gabriela Martínez-Nava,&nbsp;Marwin Gutierrez","doi":"10.24875/RIC.21000603","DOIUrl":"https://doi.org/10.24875/RIC.21000603","url":null,"abstract":"<p><strong>Background: </strong>The inflammatory response in gout disease is induced by the activation of NLR family pyrin domain-containing 3 (NLPR3) signaling pathway mediated by IL-1β release.</p><p><strong>Objective: </strong>The objective of the study was to determine the association between single nucleotide polymorphisms (SNPs) within NLRP3 inflammasome genes and gout susceptibility.</p><p><strong>Methods: </strong>Mexican patients with gout from the National Rehabilitation Institute and General Hospital of Mexico were enrolled. A healthy control group was also included. We analyzed the frequency and allelic distribution of eight SNPs from seven different genes within the NLRP3 inflammasome signaling pathway: TLR4 rs2149356, CD14 rs2569190, NLRP3 rs3806268, NLRP3 rs10754558, CARD8 rs2043211, IL-1β rs1143623, P2RX7 rs3751142, and PPARGC1B rs45520937 SNPs.</p><p><strong>Results: </strong>We found that the SNP rs45520937 of PPARGC1B was associated with the risk of developing gout when it was analyzed using the dominant model (Odds ratio [OR] = 2.30; 95% confidence interval [CI]: 1.09-4.86; p = 0.030), and it is proposed that the adaptor molecule CD14 rs2569190 polymorphism could be associated with a lower risk of gout under an additive model (OR= 0.41;95% CI: 0.16-1.05; p = 0.064). No significant associations were identified for the remaining SNPs.</p><p><strong>Conclusion: </strong>Our findings suggest that the PPARGC1B rs45520937 SNP is associated with gout susceptibility.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":" ","pages":"147-155"},"PeriodicalIF":1.4,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40311401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma and COVID-19 among healthcare workers from a Mexican Hospital: is there an association?","authors":"J. Morales-Romero, P. Paredes-Casillas, J. E. López-Contreras, K. J. Arellano-Arteaga, M. Bedolla-Barajas","doi":"10.24875/RIC.22000017","DOIUrl":"https://doi.org/10.24875/RIC.22000017","url":null,"abstract":"Background\u0000Asthma does not appear to be a risk factor for developing COVID-19.\u0000\u0000\u0000Objective\u0000The objective of the study was to analyze the role of asthma as a factor associated with COVID-19 among healthcare workers (HW).\u0000\u0000\u0000Methods\u0000A crosssectional study was conducted in HW from a Mexican hospital. Data were obtained through an epidemiological survey that included age, sex, and history of COVID-19. Multivariate logistic regression analysis was performed to identify factors associated with COVID-19.\u0000\u0000\u0000Results\u0000In total, 2295 HW were included (63.1% women; mean age 39.1 years); and 1550 (67.5%) were medical personnel. The prevalence of asthma in HW with COVID-19 was 8.3%; for the group without COVID-19, the prevalence was 5.3% (p = 0.011). The multivariate analyses suggested that asthma was associated with COVID-19 (OR 1.59, p = 0.007).\u0000\u0000\u0000Conclusion\u0000Our study suggests that asthma could be a factor associated with COVID-19 in HW.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"31 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81856920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION BETWEEN APOE-ε4 CARRIER STATUS AND QUALITATIVE NEUROIMAGING CHARACTERISTICS IN OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT.","authors":"A. Mimenza-Alvarado, M. J. Suing-Ortega, Teresa Tusié-Luna, T. Juárez-Cedillo, J. Ávila-Funes, S. Aguilar-Navarro","doi":"10.24875/ric.21000550","DOIUrl":"https://doi.org/10.24875/ric.21000550","url":null,"abstract":"BACKGROUND\u0000The pathogenesis of mild cognitive impairment (MCI) is multifactorial and includes the presence of genetic variants such as the ε4 allele of the apolipoprotein E gene (APOE-ε4). Association between the APOE-ε4 carrier status and deleterious structural and functional changes on magnetic resonance imaging (MRI) has been previously described in individuals with Alzheimer's disease. However, the central nervous system changes may possibly develop in earlier stages of cognitive impairment, as reflected in MCI.\u0000\u0000\u0000OBJECTIVE\u0000The objective of the study was to determine the association between APOE-ε4 carrier status and qualitative changes on MRI (medial temporal and parietal atrophy), as well as the detection of white matter hyperintensities (WMH) in older adults with MCI, in the memory clinic of a tertiary care hospital in Mexico City.\u0000\u0000\u0000METHODS\u0000A cross-sectional study of 72 adults aged 60 years or above who underwent an exhaustive clinical, neuroimaging, and neuropsychological evaluation. Multivariate logistic regression models were constructed to determine the association between APOE-ε4 carrier status and qualitative/quantitative changes on MRI.\u0000\u0000\u0000RESULTS\u0000Mean age was 75.2 years (± 7.2) and 64% were female. Twenty-one participants were cognitively normal and 51 had MCI. Almost 56% were APOE-ε4 carriers and were associated with medial-temporal atrophy according to the Scheltens scale (odds ratio [OR]: 20.0, 95% confidence intervals [CI]: 3.03-131.7), parietal atrophy according to the Koedam's score (OR: 6.3; 95% CI 1.03-39.53), and WMH according to the Fazekas scale (OR: 11.7, 95% CI: 1.26-108.2), even after adjusting for age, educational level, and cardiovascular risk factors.\u0000\u0000\u0000CONCLUSION\u0000The APOE-ε4 carrier status was associated with medial temporal and parietal atrophy, as well as WMH. Our findings support the hypothesis suggesting the contribution of this genotype to neurodegeneration and cerebral vascular pathology.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"55 2 1","pages":"113-120"},"PeriodicalIF":1.4,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90675455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guillain-Barré Syndrome in Mexico: An Updated Review Amid the Coronavirus Disease 2019 ERA.","authors":"J. Galnares-Olalde, J. C. López-Hernández, M. García‐Grimshaw, S. Valdés-Ferrer, M. E. Briseño-Godínez, Adib J. de-Saráchaga, M. A. Alegría-Loyola, Anna L. Bazán-Rodríguez, Eunice Martínez-Jiménez, E. S. Vargas-Cañas","doi":"10.24875/RIC.22000006","DOIUrl":"https://doi.org/10.24875/RIC.22000006","url":null,"abstract":"Guillain-Barré syndrome (GBS) is the most frequent cause of acute flaccid paralysis and if not diagnosed and treated timely, a significant cause of long-term disability. Incidence in Latin America ranges from 0.71 to 7.63 cases/100,000 person-years. Historically, GBS has been linked to infections (mainly gastrointestinal by Campylobacter jejuni) and vaccines (including those against severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]); however, a trigger cannot be detected in most cases. Regarding SARS-CoV-2, epidemiological studies have found no association with its development. Acute motor axonal neuropathy is the most common electrophysiological variant in Mexico and Asian countries. Intravenous immunoglobulin or plasma exchanges are still the treatment cornerstones. Mortality in Mexico can be as high as 12%. Avances in understanding the drivers of nerve injury in GBS that may provide the basis for developing targeted therapies have been made during the past decade; despite them, accurate criteria for selecting patients requiring acute treatment, prognostic biomarkers, and novel therapies are still needed. The newly-developed vaccines against SARS-CoV-2 have raised concerns regarding the potential risk for developing GBS. In the midst of coronavirus disease 2019 and vaccination campaigns against SARS-CoV-2, this review discusses the epidemiology, clinical presentation, management, and outcomes of GBS in Mexico.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"16 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73700479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epistasis Between Two Gene Variants of Leptin and Vascular Endothelial Growth Factor Genes in the Development of Primary Knee Osteoarthritis.","authors":"Matvey Sosa-Arellano,&nbsp;Norma C González-Huerta,&nbsp;Eugenio Morales-Hernández,&nbsp;Carolina Duarte-Salazar,&nbsp;Antonio Miranda-Duarte","doi":"10.24875/RIC.21000493","DOIUrl":"https://doi.org/10.24875/RIC.21000493","url":null,"abstract":"<p><strong>Background: </strong>The association of leptin (<i>LEP</i>) and vascular endothelial growth factor A (<i>VEGFA</i>) genes with the susceptibility to knee osteoarthritis (OA) has been analyzed; however, the epistasis between them has not been investigated.</p><p><strong>Objective: </strong>The objective of the study was to analyze the association of <i>LEP</i> and <i>VEGFA</i> variants and their interaction with primary knee OA in a Mexican Mestizo population.</p><p><strong>Methods: </strong>A case-control study was developed. Cases were ≥40 years, BMI ≤27 kg/m², with primary knee OA and radiologic Grade ≥2. Controls were participants with no knee OA and a radiologic Grade < 2. The rs2167270 of <i>LEP</i> and rs2010963 of <i>VEGFA</i> were genotyped. Genotypic association was tested under codominant, dominant, and recessive models. Uni- and multi-variate analyses were developed through non-conditional logistic regression. The multifactor dimensionality reduction algorithm was developed to detect epistasis.</p><p><strong>Results: </strong>Participants comprised 103 cases and 179 controls. Allelic and genotypic distributions did not show differences between the groups. Notwithstanding, a statistically significant interaction was observed between the <i>LEP</i> and <i>VEGFA</i> genes (p = 0.02) with a testing accuracy of 0.5199 and cross-validation consistency of 10/10. This interaction model confers an increased risk to knee OA (OR [95% CI] = 1.8 [1.1-2.9]).</p><p><strong>Conclusion: </strong>Interaction between <i>LEP</i> and <i>VEGFA</i> is related with genetic susceptibility to developing primary knee OA.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"74 2","pages":"081-089"},"PeriodicalIF":1.4,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39785153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Result Turnaround Time of RT-PCR for SARS-CoV-2 is the Main Cause of COVID-19 Diagnostic Delay: A Country-Wide Observational Study of Mexico and Colombia.","authors":"Isaac Núñez,&nbsp;Pablo F Belaunzarán-Zamudio,&nbsp;Yanink Caro-Vega","doi":"10.24875/RIC.21000542","DOIUrl":"https://doi.org/10.24875/RIC.21000542","url":null,"abstract":"<p><strong>Background: </strong>Delay in COVID-19 diagnosis due to late real-time reverse transcription-polymerase chain reaction reporting has been described to be an important cause of suboptimal COVID-19 surveillance and outbreak containment.</p><p><strong>Objective: </strong>The objective of the study was to determine the duration of diagnostic delay due to test turnaround time and its association with marginalization status.</p><p><strong>Methods: </strong>In this observational study using national open data of Mexico and Colombia, we quantified the delay in COVID-19 diagnosis that occurred in both countries. We considered two periods that contributed to the delay in diagnosis: the time from symptom onset until testing <i>(delay-one)</i> and test turnaround time <i>(delay-two)</i>. Marginalization status was determined according to country-specific scores.</p><p><strong>Results: </strong>Among 3,696,773 patients from Mexico and Colombia, <i>delay-two</i> was generally longer than <i>delay-one</i>. Median <i>delay-one</i> was 3 days and delay-two 7 days in Colombia, while in Mexico, they were 3 days and 4 days, respectively. In Colombia, worse marginalization status prolonged <i>delaytwo</i>. In Mexico, a lower number and percentage of rapid tests were performed in areas with worse marginalization.</p><p><strong>Conclusion: </strong>Diagnostic delay was mostly due to test turnaround time. Marginalization status was an important barrier to diagnostic test access.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"74 2","pages":"071-080"},"PeriodicalIF":1.4,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39941009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Development of Acute Kidney Injury After Liver Transplantation.","authors":"Rodrigo Catalán,&nbsp;José V Jiménez-Ceja,&nbsp;Rodolfo Rincón-Pedrero,&nbsp;Antonio Olivas-Martínez,&nbsp;Armando J Martínez-Rueda,&nbsp;Silvana Bazúa-Valenti,&nbsp;Diego L Carrillo-Pérez,&nbsp;Leoneli I Grajeda-Medina,&nbsp;Ignacio García-Juárez,&nbsp;Mario Vilatobá,&nbsp;Juan A Ortega-Trejo,&nbsp;Rosalba Pérez-Villalva,&nbsp;Norma A Bobadilla,&nbsp;Erika Moreno,&nbsp;Gerardo Gamba","doi":"10.24875/RIC.21000496","DOIUrl":"https://doi.org/10.24875/RIC.21000496","url":null,"abstract":"<p><strong>Background: </strong>Early post-liver transplant (LT) acute kidney injury (AKI) has been associated with worse short-term and long-term outcomes, but the incidence and risk factors in our population are unknown.</p><p><strong>Methods: </strong>We designed a prospective, singlecenter, longitudinal cohort study to determine the incidence of AKI during the immediate postoperative period of LT, and to identify the risk factors associated with AKI after LT. Pre-operative and intraoperative variables were analyzed to determine if there was any correlation with the development of post-operative AKI.</p><p><strong>Results: </strong>Eighty-six patients were included in the final analysis; from them, 45 (52%) developed AKI in the following 30 days after LT. The presence of hepatic encephalopathy prior to LT was the factor most strongly associated with the development of AKI (Relative Risk 3.67, 95% Confidence Interval 1.08-8.95). Other factors associated with AKI development were male gender and a higher serum lactate during surgery.</p><p><strong>Conclusion: </strong>AKI was a frequent complication that significantly worsened the prognosis of LT recipients and was associated with an increased 30-day mortality rate. The presence of hepatic encephalopathy strongly predicted the development of severe AKI.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"74 2","pages":"090-096"},"PeriodicalIF":1.4,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39941012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride-Rich Lipoproteins: Their Role in Atherosclerosis.","authors":"Yulino Castillo-Núñez,&nbsp;Enrique Morales-Villegas,&nbsp;Carlos A Aguilar-Salinas","doi":"10.24875/RIC.21000416","DOIUrl":"https://doi.org/10.24875/RIC.21000416","url":null,"abstract":"<p><p>The term \"triglyceride-rich lipoproteins\" (TRLs) includes chylomicrons and their remnants, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL). In this manuscript, the mechanisms by which atherogenic TRLs contribute to the formation of atheroma plaques are reviewed. Cholesterol from TRLs that can be retained in the subendothelial space (i.e., remnants, DLs, and small VLDLs) contributes to the genesis of atherosclerosis. Triglycerides of atherogenic TRLs induce inflammation of the arterial wall. Mechanisms that explain the involvement of TRLs in atherosclerosis are the generation of pro-atherogenic changes in high-density lipoproteins and low-density lipoproteins, accumulation of TRLs in plasma, and their passage to the subendothelial space where they cause endothelial dysfunction and inflammation of the vascular wall. Furthermore, plasma accumulation of TRLs causes hyperviscosity and a procoagulant state. Finally, this manuscript summarizes the controversial aspects of the clinical approach and the treatment of cases with dyslipidemia explained by atherogenic TRLs.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"74 2","pages":"061-070"},"PeriodicalIF":1.4,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39609127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Admission Monocyte/HDL Ratio Predicts Adverse Cardiac Remodeling After St-Elevation Myocardial Infarction.","authors":"Ferhat Eyyupkoca,&nbsp;Onur Yildirim,&nbsp;Serkan Sivri,&nbsp;Mehmet Ali-Felekoglu,&nbsp;Bekir Demirtas,&nbsp;Mehmet Sait-Altintas,&nbsp;Burcu Ugurlu-Ilgin,&nbsp;Omer Faruk-Ates","doi":"10.24875/RIC.21000599","DOIUrl":"https://doi.org/10.24875/RIC.21000599","url":null,"abstract":"<p><strong>Background: </strong>Inflammation plays a critical role in cardiac remodeling after myocardial infarction (MI). Monocyte to high-density lipoprotein-cholesterol (HDL-C) ratio (MHR) has emerged as a potential indicator of inflammation.</p><p><strong>Objectives: </strong>The study aimed to investigate the prognostic role of MHR at the time of hospital admission in late cardiac remodeling and subsequent 1-year mortality in an academic training and research hospital.</p><p><strong>Methods: </strong>This prospective multicenter study included 231 patients with acute ST-elevation MI. Left ventricular (LV) functions and volumes were assessed by cardiac magnetic resonance (CMR) imaging at 2 weeks and 6 months post-MI. The definition of adverse cardiac remodeling (AR) was based on the increase of LV end-diastolic volume by ≥ 12% at 6 months post-MI. All patients were followed for survival for 1 year after the second CMR imaging measurements.</p><p><strong>Results: </strong>At 6 months post-MI, 20 patients (23.8%) exhibited AR. The median MHR was higher in the AR group compared to the group without AR (2.2 vs. 1.5, p < 0.001). A positive correlation was found between MHR and infarct size in the groups with and without AR. High MHR was an independent predictor of AR (OR: 3.21, p = 0.002). The cut-off value of MHR in predicting AR was found to be >1.6 with 92.7% sensitivity and 70.1% specificity (AUC ± SE: 0.839 ± 0.03, p < 0.001). Mortality risk was 5.62-fold higher in the group with MHR of >1.6 (HR: 5.62, p < 0.001).</p><p><strong>Conclusions: </strong>These results indicate that admission MHR is a useful tool to predict patients with AR who are at risk of progression to heart failure and mortality after MI.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"74 2","pages":"104-112"},"PeriodicalIF":1.4,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39779040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Value of C-Reactive Protein/Albumin Ratio in Acute Pulmonary Embolism.","authors":"Sevgi Özcan,&nbsp;Esra Dönmez,&nbsp;Sevil Yavuz Tuğrul,&nbsp;İrfan Şahin,&nbsp;Orhan İnce,&nbsp;Murat Ziyrek,&nbsp;Sinan Varol,&nbsp;Serkan Karahan,&nbsp;Ertuğrul Okuyan","doi":"10.24875/RIC.21000547","DOIUrl":"https://doi.org/10.24875/RIC.21000547","url":null,"abstract":"<p><strong>Background: </strong>Serum C-reactive protein (CRP) to albumin ratio (CAR) has been defined as an inflammation-based prognostic marker. We evaluated the association and prognostic value of CRP/albumin ratio in patients with pulmonary embolism (PE).</p><p><strong>Methods: </strong>A total of 256 patients with acute PE who were hospitalized between March 2016 and December 2020 were retrospectively reviewed. PE severity index (PESI) was calculated. Serum levels of CRP and albumin that were obtained at the time of admission were used for calculation. CAR was evaluated for correlation with PESI, and thus, foresee the risk of death due to PE.</p><p><strong>Results: </strong>There were 186 patients eligible for inclusion. 54 patients were in intermediate, 34 patients were in high risk and 98 patients were in very high-risk group according to PESI score. In the correlation analysis, we observed moderate positive correlations between CRP/albumin ratio, troponin and PESI score (r = 0.584, p < 0.0001; r = 521, p < 0.0001, respectively). Regression analysis revealed that only CRP/albumin ratio and PESI score were independent risk factors associated with 6-month mortality of acute PE patients. The AUC for CRP/albumin ratio was 0.643, 0.751, and 0.763 for 30-day, 90-day, and 6-month mortality, respectively (95% CI: 0.550-0.737, 0.672-0.830, 0.687-0.838]. A cut-off value of 5.33 for CRP/albumin ratio was associated with 65.3% sensitivity and 65.6% specificity in predicting 6-month mortality.</p><p><strong>Conclusion: </strong>The CRP/albumin ratio, an inexpensive and easily measurable laboratory variable, may be a useful prognostic marker of PE, especially when other causes that alter serum levels are excluded from the study.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"74 2","pages":"097-103"},"PeriodicalIF":1.4,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39881053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}