Factors Associated with Development of Acute Kidney Injury After Liver Transplantation.

IF 1.4 4区医学 Q2 Medicine

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2022-03-15 DOI:10.24875/RIC.21000496

Rodrigo Catalán, José V Jiménez-Ceja, Rodolfo Rincón-Pedrero, Antonio Olivas-Martínez, Armando J Martínez-Rueda, Silvana Bazúa-Valenti, Diego L Carrillo-Pérez, Leoneli I Grajeda-Medina, Ignacio García-Juárez, Mario Vilatobá, Juan A Ortega-Trejo, Rosalba Pérez-Villalva, Norma A Bobadilla, Erika Moreno, Gerardo Gamba

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引用次数: 0

Abstract

Background: Early post-liver transplant (LT) acute kidney injury (AKI) has been associated with worse short-term and long-term outcomes, but the incidence and risk factors in our population are unknown.

Methods: We designed a prospective, singlecenter, longitudinal cohort study to determine the incidence of AKI during the immediate postoperative period of LT, and to identify the risk factors associated with AKI after LT. Pre-operative and intraoperative variables were analyzed to determine if there was any correlation with the development of post-operative AKI.

Results: Eighty-six patients were included in the final analysis; from them, 45 (52%) developed AKI in the following 30 days after LT. The presence of hepatic encephalopathy prior to LT was the factor most strongly associated with the development of AKI (Relative Risk 3.67, 95% Confidence Interval 1.08-8.95). Other factors associated with AKI development were male gender and a higher serum lactate during surgery.

Conclusion: AKI was a frequent complication that significantly worsened the prognosis of LT recipients and was associated with an increased 30-day mortality rate. The presence of hepatic encephalopathy strongly predicted the development of severe AKI.

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肝移植后急性肾损伤发生的相关因素。

背景:早期肝移植后急性肾损伤(AKI)与较差的短期和长期预后相关，但在我国人群中的发病率和危险因素尚不清楚。方法:我们设计了一项前瞻性、单中心、纵向队列研究，以确定LT术后即刻AKI的发生率，并确定LT后AKI的相关危险因素。分析术前和术中变量，以确定是否与术后AKI的发生相关。结果:86例患者纳入最终分析;其中，45例(52%)在LT后30天内发生AKI。LT前存在肝性脑病是与AKI发生最密切相关的因素(相对危险度3.67,95%可信区间1.08-8.95)。与AKI发展相关的其他因素是男性和手术期间较高的血清乳酸。结论:AKI是一种常见的并发症，可显著恶化肝移植受者的预后，并与30天死亡率增加相关。肝性脑病的存在强烈预示着严重AKI的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista De Investigacion Clinica-Clinical and Translational Investigation 医学-医学：内科

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Revista de Investigación Clínica – Clinical and Translational Investigation (RIC-C&TI), publishes original clinical and biomedical research of interest to physicians in internal medicine, surgery, and any of their specialties. The Revista de Investigación Clínica – Clinical and Translational Investigation is the official journal of the National Institutes of Health of Mexico, which comprises a group of Institutes and High Specialty Hospitals belonging to the Ministery of Health. The journal is published both on-line and in printed version, appears bimonthly and publishes peer-reviewed original research articles as well as brief and in-depth reviews. All articles published are open access and can be immediately and permanently free for everyone to read and download. The journal accepts clinical and molecular research articles, short reports and reviews. Types of manuscripts: – Brief Communications – Research Letters – Original Articles – Brief Reviews – In-depth Reviews – Perspectives – Letters to the Editor