Revista De Investigacion Clinica-Clinical and Translational Investigation最新文献

Enhanced diagnosis of ischemic coronary artery stenosis using CT-derived fractional flow reserve based on computational fluid dynamics. 基于计算流体动力学的ct衍生分数血流储备增强缺血性冠状动脉狭窄诊断。

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2025-10-07 DOI: 10.1016/j.ric.2025.100021

Gang Yang, Qiucang Xue, Jiani Yin, Jing Liang, Wenping Chen, Bing Zhang, Dan Mu

{"title":"Enhanced diagnosis of ischemic coronary artery stenosis using CT-derived fractional flow reserve based on computational fluid dynamics.","authors":"Gang Yang, Qiucang Xue, Jiani Yin, Jing Liang, Wenping Chen, Bing Zhang, Dan Mu","doi":"10.1016/j.ric.2025.100021","DOIUrl":"https://doi.org/10.1016/j.ric.2025.100021","url":null,"abstract":"Background: Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide. Conventional CCTA has limited ability to evaluate functional significance of stenosis, highlighting the need for non-invasive physiological assessment methods.Objective: This study aimed to assess the diagnostic performance of a CT-FFR algorithm based on CFD in identifying ischemic coronary artery stenosis.Methods: A total of 184 vessels from 171 patients undergoing both CCTA and ICA were retrospectively analyzed. CT-FFR and QFR were computed, with QFR ≤0.8 serving as the reference standard for ischemia. The diagnostic capabilities of CT-FFR were compared with anatomical evaluation via CCTA.Results: CT-FFR demonstrated superior diagnostic performance over CCTA, with per-vessel sensitivity of 95.5%, specificity of 74.2%, and accuracy of 91.8% (AUC: 0.839 vs. 0.637, P<0.001). In lesions with intermediate QFR values (0.75-0.85), CT-FFR maintained high diagnostic accuracy (79.4%) and AUC (0.785), outperforming CCTA. Furthermore, CT-FFR remained reliable across various calcification levels, with diagnostic efficacy unaffected by Agatston scores.Conclusion: CT-FFR based on CFD offers a robust, non-invasive solution for the functional assessment of coronary stenosis. Its diagnostic superiority over CCTA and consistent performance in calcified vessels highlight its clinical utility in precision cardiovascular care.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"77 5","pages":"100021"},"PeriodicalIF":1.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In the realm of the size of effect: What advantages do Cohen's d or Glass's D have? 在效应大小方面：科恩的d和格拉斯的d有什么优势？

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2025-10-04 DOI: 10.1016/j.ric.2025.100020

Juan C Lopez-Alvarenga, Isabel Omaña-Guzmán, Lucia Monserrat Perez-Navarro

引用次数: 0

Functional respiratory evaluation in the coronavirus disease-19 era: The role of pulmonary function test laboratories. 新冠肺炎时代呼吸功能评价：肺功能检测实验室的作用

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2025-07-01 Epub Date: 2025-09-17 DOI: 10.24875/RIC.20000250

Laura Gochicoa-Rangel, Luis Torre-Bouscoulet, Antonio Salles Rojas, Carlos Guzmán-Valderrábano, Rosaura Esperanza Benítez-Pérez, Isabel Salas Escamilla, Sergio Monráz-Pérez, Juan Manuel Grosso-Espinosa

{"title":"Functional respiratory evaluation in the coronavirus disease-19 era: The role of pulmonary function test laboratories.","authors":"Laura Gochicoa-Rangel, Luis Torre-Bouscoulet, Antonio Salles Rojas, Carlos Guzmán-Valderrábano, Rosaura Esperanza Benítez-Pérez, Isabel Salas Escamilla, Sergio Monráz-Pérez, Juan Manuel Grosso-Espinosa","doi":"10.24875/RIC.20000250","DOIUrl":"10.24875/RIC.20000250","url":null,"abstract":"The pandemic character of coronavirus disease-19 (COVID-19) requires strategy changes designed to guarantee the safety of patients and health-care professionals. We are greatly concerned by the limitations in the operation of pulmonary function test (PFT) laboratories, since there is a high risk of disease progression in patients with chronic pulmonary diseases, and we are now faced by the influx of a new group of individuals in the recovery phase of post-COVID-19-syndrome that requires evaluation and follow-up of their respiratory function. To reestablish the operation of PFT laboratories limiting the risk of cross-contamination, we herein present the consensus reached by a group of experts in respiratory physiology, most of whom work in PFT laboratories in several Latin-American countries, on the applicable recommendations for severe acute respiratory syndrome coronavirus 2 pneumonia survivors when undergoing PFT. We present the safety and hygiene measures that must be adopted in laboratories or centers where PFT is conducted in adults and/or children. These recommendations answer the following questions: which PFT is most recommended in subjects that have recovered from COVID-19; what quality control and safety measures should PFT laboratories implement during this pandemic? And how should we approach non-COVID-19 patients requiring PFT?","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"77 4","pages":"100011"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rethinking the problem of cardio-metabolic and neurodegenerative diseases in older adults with obesity. 重新思考老年肥胖患者的心脏代谢和神经退行性疾病问题。

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2025-07-01 Epub Date: 2025-07-25 DOI: 10.1016/j.ric.2025.100015

Carlos Alberto Romero Cuestas, Brian Johan Bustos-Viviescas, Carlos Enrique García Yerena

引用次数: 0

Breast cancer and health inequalities: Another never ending story? 乳腺癌和健康不平等：另一个永不结束的故事？

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2025-07-01 Epub Date: 2025-07-25 DOI: 10.1016/j.ric.2025.100014

Francisco Guadarrama-Conzuelo, Alfredo Ulloa-Aguirre, Yanin Chavarri-Guerra

引用次数: 0

Serum fibrosis scores as predictors of liver fibrosis and long-term outcomes in metabolic dysfunction-associated steatotic liver disease, including cirrhosis. 血清纤维化评分作为代谢功能障碍相关脂肪变性肝病（包括肝硬化）肝纤维化和长期预后的预测指标

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2025-07-01 Epub Date: 2025-08-19 DOI: 10.1016/j.ric.2025.100016

Toprak Koçak, Nilay Danış, Hüseyin Döngelli, Anıl Aysal Ağalar, Goksel Bengi, Mesut Akarsu

{"title":"Serum fibrosis scores as predictors of liver fibrosis and long-term outcomes in metabolic dysfunction-associated steatotic liver disease, including cirrhosis.","authors":"Toprak Koçak, Nilay Danış, Hüseyin Döngelli, Anıl Aysal Ağalar, Goksel Bengi, Mesut Akarsu","doi":"10.1016/j.ric.2025.100016","DOIUrl":"10.1016/j.ric.2025.100016","url":null,"abstract":"Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is commonly linked to liver fibrosis, which may progress to cirrhosis. FIB-4, APRI, and NFS are used to predict fibrosis severity, but their accuracy and role in long-term outcomes remain unclear.Objectives: This study evaluates the predictive value of these scores for fibrosis and assesses the incidence of de novo cirrhosis and survival outcomes in MASLD patients.Methods: This retrospective, single-center study included 175 MASLD patients in our university medical center. The diagnostic performance of FIB-4, APRI, and NFS for advanced fibrosis (stage 3-4) was assessed using receiver operating characteristic (ROC) analysis. Cox regression analysis was performed to evaluate factors associated with de novo cirrhosis and survival outcomes.Results: The mean age was 49.9±14.1 years, and 54.9% were female. The median follow-up was 78 months. ROC analysis showed FIB-4 (AUC: 0.77) was the best predictor of advanced fibrosis, followed by APRI (AUC: 0.74) and NFS (AUC: 0.74). Multivariate analysis identified fibrosis stage (HR: 3.045, p=0.001) and hypertension (HR: 4.096, p=0.047) as independent predictors of de novo cirrhosis. Age (HR: 1.070, p=0.031), albumin (HR: 15.151, p<0.001), and HbA1c (HR: 1.589, p<0.001) were independently associated with survival.Conclusion: FIB-4 was the most accurate predictor of advanced fibrosis. Fibrosis stage and hypertension were the strongest predictors of de novo cirrhosis. These findings highlight the importance of fibrosis staging and comorbidity management in MASLD.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"77 4","pages":"100016"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D supplementation ameliorates anemia of inflammation by reducing hepcidin levels and inactivating inflammatory signaling pathways. 补充维生素D可通过降低hepcidin水平和使炎症信号通路失活来改善炎症性贫血。

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2025-07-01 Epub Date: 2025-08-23 DOI: 10.1016/j.ric.2025.100017

Ping Xu, Gang Liu, Bo Chen

{"title":"Vitamin D supplementation ameliorates anemia of inflammation by reducing hepcidin levels and inactivating inflammatory signaling pathways.","authors":"Ping Xu, Gang Liu, Bo Chen","doi":"10.1016/j.ric.2025.100017","DOIUrl":"10.1016/j.ric.2025.100017","url":null,"abstract":"Background: Anemia of inflammation (AI) is a mild form of anemia. Vitamin D deficiency has been linked to an increased risk of AI. This study aims to investigate the potential molecular mechanisms underlying the protective role of vitamin D in AI.Methods: HepG2 cells were stimulated with lipopolysaccharide (LPS) to induce an inflammatory model in vitro. Cell counting kit-8 assays were conducted to assess vitamin D's cytotoxicity to HepG2 cells. RT-qPCR analysis was conducted to evaluate hepcidin mRNA levels. A rat AI model was established by subcutaneous injection of complete Freund's adjuvant (CFA). Hematoxylin-eosin staining was performed for synovial histopathological analysis. The concentrations of inflammatory cytokines were determined by ELISA. Western blotting was used to evaluate the protein levels of hepcidin, ferroportin, and markers associated with signaling pathways.Results: Vitamin D dose-dependently reduced hepcidin expression in LPS-treated HepG2 cells. Vitamin D inactivated NF-κB, JAK2/STAT3, and BMP6/SMAD pathways to reduce hepcidin levels in LPS-treated HepG2 cells. Vitamin D ameliorated CFA-induced synovial injury and inflammatory response in rats. Vitamin D reduced hepcidin expression and improved anemia in CFA-injected rats. Vitamin D inactivated NF-κB, JAK2/STAT3, and BMP6/SMAD pathways in the liver of CFA-injected rats.Conclusion: Vitamin D supplementation ameliorates experimental AI by downregulating hepcidin expression through NF-κB, JAK2/STAT3, and BMP6/SMAD pathways.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"77 4","pages":"100017"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abelacimab versus rivaroxaban in patients with atrial fibrillation: Insights into the AZALEA-TIMI 71 study. 阿贝拉西单抗与利伐沙班治疗心房颤动：AZALEA-TIMI 71研究的见解

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2025-05-01 Epub Date: 2025-06-12 DOI: 10.1016/j.ric.2025.100002

Lakshmi Kattamuri, Damon E Houghton, Mateo Porres-Aguilar

引用次数: 0

Deciphering polycystic ovary syndrome: A brief overview from metabolic drivers to genetic and fetal origins. 解读多囊卵巢综合征：从代谢驱动到遗传和胎儿起源的简要概述。

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2025-05-01 Epub Date: 2025-07-01 DOI: 10.1016/j.ric.2025.100008

Mario Morales-Esponda, Ramón de Los Santos-Aguilar, Raúl Villanueva-Rodríguez, Luis David Sol-Oliva, Carlos Alberto Aguilar-Salinas, Mayel Chirinos, Fernando Larrea

{"title":"Deciphering polycystic ovary syndrome: A brief overview from metabolic drivers to genetic and fetal origins.","authors":"Mario Morales-Esponda, Ramón de Los Santos-Aguilar, Raúl Villanueva-Rodríguez, Luis David Sol-Oliva, Carlos Alberto Aguilar-Salinas, Mayel Chirinos, Fernando Larrea","doi":"10.1016/j.ric.2025.100008","DOIUrl":"https://doi.org/10.1016/j.ric.2025.100008","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a multifactorial endocrine and metabolic disorder in women of reproductive age characterized by hormonal imbalances, menstrual irregularities, and changes in ovarian morphology. Excess body fat plays a significant role in the clinical development of PCOS. The complex relationship between adiposity and PCOS involves disruptions in hormonal balance and inflammatory processes, which both contribute to the clinical and phenotypic manifestations of the syndrome. Insulin resistance is a significant factor linking adiposity and PCOS. Moreover, reduced fertility is associated with adiposity in PCOS, with obesity exacerbating anovulation. Recent studies have raised questions about the role of androgen exposure during fetal life, including genetic factors related to PCOS identified in genome-wide association studies and Mendelian randomization studies. Managing PCOS should concentrate on addressing adiposity as a crucial target, positively impacting the syndrome, particularly regarding reproductive and fertility outcomes. This review aims to understand how metabolic conditions such as obesity and insulin resistance are linked to PCOS and how early prenatal androgen exposure is involved in its etiology. Particular attention is given to its role in developmental programming, fat distribution, and fat type, as well as how these factors contribute to the onset of metabolic disturbances in adulthood.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"77 3","pages":"100008"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The platelet-to-albumin ratio and the lactate dehydrogenase-to-albumin ratio can serve as predictors of all-cause mortality in patients with sepsis. 血小板-白蛋白比值和乳酸脱氢酶-白蛋白比值可作为脓毒症患者全因死亡率的预测指标。

IF 1.4 4区医学

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2025-05-01 Epub Date: 2025-07-01 DOI: 10.1016/j.ric.2025.100009

Chenhong Zhang, Zhaoqing Bai, Qiang Hu, Xiaowei Lv, Songwang Zeng, Hao Huang

{"title":"The platelet-to-albumin ratio and the lactate dehydrogenase-to-albumin ratio can serve as predictors of all-cause mortality in patients with sepsis.","authors":"Chenhong Zhang, Zhaoqing Bai, Qiang Hu, Xiaowei Lv, Songwang Zeng, Hao Huang","doi":"10.1016/j.ric.2025.100009","DOIUrl":"https://doi.org/10.1016/j.ric.2025.100009","url":null,"abstract":"Background: Sepsis is a severe condition in clinical practice. Although numerous studies have reported various prognostic markers associated with sepsis, the combination of the platelet-to-albumin ratio (PLT/ALB) and the lactate dehydrogenase-to-albumin ratio (LDH/ALB) has not been thoroughly examined.Objectives: To study the associations of both the PLT/ALB ratio and the LDH/ALB ratio with all-cause mortality during the first hospitalization for sepsis.Methods: A retrospective study was conducted on patients with sepsis at a local medical center. The ratios of PLT/ALB and LDH/ALB at the time of the first hospital admission of the patients were collected. Statistical analysis was used to examine the relationships of the PLT/ALB and LDH/ALB ratios with mortality, as well as their ability to predict the prognosis of patients with sepsis.Results: Cox regression revealed that high PLT/ALB and LDH/ALB independently predict mortality. ROC curve analysis revealed that the ratios of PLT/ALB and LDH/ALB exhibited satisfactory sensitivity and specificity in predicting the mortality rate of patients with sepsis, with sensitivity values of 70.50% and 66.19% and specificity values of 73.58% and 69.25%, respectively.Conclusion: Elevated ratios of PLT/ALB and LDH/ALB in sepsis patients are associated with increased all-cause mortality and serve as reliable prognostic indicators.","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"77 3","pages":"100009"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0