The platelet-to-albumin ratio and the lactate dehydrogenase-to-albumin ratio can serve as predictors of all-cause mortality in patients with sepsis.

Background: Sepsis is a severe condition in clinical practice. Although numerous studies have reported various prognostic markers associated with sepsis, the combination of the platelet-to-albumin ratio (PLT/ALB) and the lactate dehydrogenase-to-albumin ratio (LDH/ALB) has not been thoroughly examined.

Objectives: To study the associations of both the PLT/ALB ratio and the LDH/ALB ratio with all-cause mortality during the first hospitalization for sepsis.

Methods: A retrospective study was conducted on patients with sepsis at a local medical center. The ratios of PLT/ALB and LDH/ALB at the time of the first hospital admission of the patients were collected. Statistical analysis was used to examine the relationships of the PLT/ALB and LDH/ALB ratios with mortality, as well as their ability to predict the prognosis of patients with sepsis.

Results: Cox regression revealed that high PLT/ALB and LDH/ALB independently predict mortality. ROC curve analysis revealed that the ratios of PLT/ALB and LDH/ALB exhibited satisfactory sensitivity and specificity in predicting the mortality rate of patients with sepsis, with sensitivity values of 70.50% and 66.19% and specificity values of 73.58% and 69.25%, respectively.

Conclusion: Elevated ratios of PLT/ALB and LDH/ALB in sepsis patients are associated with increased all-cause mortality and serve as reliable prognostic indicators.