The platelet-to-albumin ratio and the lactate dehydrogenase-to-albumin ratio can serve as predictors of all-cause mortality in patients with sepsis.

IF 1.4 4区医学 Q2 Medicine

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2025-05-01 Epub Date: 2025-07-01 DOI:10.1016/j.ric.2025.100009

Chenhong Zhang, Zhaoqing Bai, Qiang Hu, Xiaowei Lv, Songwang Zeng, Hao Huang

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引用次数: 0

Abstract

Background: Sepsis is a severe condition in clinical practice. Although numerous studies have reported various prognostic markers associated with sepsis, the combination of the platelet-to-albumin ratio (PLT/ALB) and the lactate dehydrogenase-to-albumin ratio (LDH/ALB) has not been thoroughly examined.

Objectives: To study the associations of both the PLT/ALB ratio and the LDH/ALB ratio with all-cause mortality during the first hospitalization for sepsis.

Methods: A retrospective study was conducted on patients with sepsis at a local medical center. The ratios of PLT/ALB and LDH/ALB at the time of the first hospital admission of the patients were collected. Statistical analysis was used to examine the relationships of the PLT/ALB and LDH/ALB ratios with mortality, as well as their ability to predict the prognosis of patients with sepsis.

Results: Cox regression revealed that high PLT/ALB and LDH/ALB independently predict mortality. ROC curve analysis revealed that the ratios of PLT/ALB and LDH/ALB exhibited satisfactory sensitivity and specificity in predicting the mortality rate of patients with sepsis, with sensitivity values of 70.50% and 66.19% and specificity values of 73.58% and 69.25%, respectively.

Conclusion: Elevated ratios of PLT/ALB and LDH/ALB in sepsis patients are associated with increased all-cause mortality and serve as reliable prognostic indicators.

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血小板-白蛋白比值和乳酸脱氢酶-白蛋白比值可作为脓毒症患者全因死亡率的预测指标。

背景：脓毒症是临床中一种严重的疾病。尽管许多研究已经报道了与脓毒症相关的各种预后标志物，但血小板与白蛋白比率（PLT/ALB）和乳酸脱氢酶与白蛋白比率（LDH/ALB）的结合尚未得到彻底的研究。目的：探讨PLT/ALB比值和LDH/ALB比值与败血症首次住院全因死亡率的关系。方法：对当地某医疗中心脓毒症患者进行回顾性研究。收集患者首次入院时PLT/ALB、LDH/ALB比值。统计学分析PLT/ALB、LDH/ALB比值与死亡率的关系，以及对脓毒症患者预后的预测能力。结果：Cox回归显示高PLT/ALB和LDH/ALB独立预测死亡率。ROC曲线分析显示，PLT/ALB和LDH/ALB比值预测脓毒症患者死亡率具有满意的敏感性和特异性，敏感性值分别为70.50%和66.19%，特异性值分别为73.58%和69.25%。结论：脓毒症患者PLT/ALB和LDH/ALB比值升高与全因死亡率升高相关，可作为可靠的预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista De Investigacion Clinica-Clinical and Translational Investigation 医学-医学：内科

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Revista de Investigación Clínica – Clinical and Translational Investigation (RIC-C&TI), publishes original clinical and biomedical research of interest to physicians in internal medicine, surgery, and any of their specialties. The Revista de Investigación Clínica – Clinical and Translational Investigation is the official journal of the National Institutes of Health of Mexico, which comprises a group of Institutes and High Specialty Hospitals belonging to the Ministery of Health. The journal is published both on-line and in printed version, appears bimonthly and publishes peer-reviewed original research articles as well as brief and in-depth reviews. All articles published are open access and can be immediately and permanently free for everyone to read and download. The journal accepts clinical and molecular research articles, short reports and reviews. Types of manuscripts: – Brief Communications – Research Letters – Original Articles – Brief Reviews – In-depth Reviews – Perspectives – Letters to the Editor