Víctor H Juárez-Vaquera, Marcos F Rosetti-Sciutto, Valeria Morales-Ruiz, Laura V Adalid-Peralta
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引用次数: 0
摘要
背景:在帕金森病(PD)中，外显体携带α-突触核蛋白(α-syn)，这是一种纤维状蛋白聚集体，具有潜在的生物标志物价值。目的:回顾PD患者和对照组血液外泌体α-syn水平的一致性。方法:对36项PD患者外泌体α-syn浓度的研究进行系统文献检索和meta分析。结果:PD患者的原始和比例调节血外泌体α-syn水平均高于对照组。标准化平均差(SMD)分别为1.54 (0.18 ~ 2.90,CI95%， p < 0.01)和1.53 (0.23 ~ 2.83,CI95%， p < 0.01)。结论:我们的结果提示外泌体α-syn浓度可能是PD的一个有用的生物标志物。
Meta-analysis to Implement Alpha-Synuclein in Extracellular Vesicles as a Potential Biomarker for Parkinsons Disease.
Background: In Parkinson's disease (PD), exosomes carry α-synuclein (α-syn), a fibrillar protein aggregates with potential value as a biomarker. Objective: Evidence on blood levels of exosomal α-syn in PD patients and controls was reviewed for their consistency. Methods: Thirty-six studies on exosomal α-syn concentrations in PD were identified in a systematic literature search and meta-analysis. Results: Both raw and ratio-adjusted blood exosomal α-syn levels were consistently higher in PD patients than in controls. The standardized mean difference (SMD) was 1.54 (0.18-2.90, CI95%, p < 0.01) and 1.53 (0.23-2.83, CI95%, p < 0.01), respectively. Conclusion: Our results suggest that exosomal α-syn concentrations could be a useful biomarker for PD.
期刊介绍：
The Revista de Investigación Clínica – Clinical and Translational Investigation (RIC-C&TI), publishes original clinical and biomedical research of interest to physicians in internal medicine, surgery, and any of their specialties. The Revista de Investigación Clínica – Clinical and Translational Investigation is the official journal of the National Institutes of Health of Mexico, which comprises a group of Institutes and High Specialty Hospitals belonging to the Ministery of Health. The journal is published both on-line and in printed version, appears bimonthly and publishes peer-reviewed original research articles as well as brief and in-depth reviews. All articles published are open access and can be immediately and permanently free for everyone to read and download. The journal accepts clinical and molecular research articles, short reports and reviews.
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