Seizure-European Journal of Epilepsy最新文献

{"title":"Aging and Late-Onset Epilepsy: An urgent call for action!","authors":"Christoph Helmstaedter, Hermann Stefan, Friedhelm Schmitt, Markus Reuber","doi":"10.1016/j.seizure.2025.02.017","DOIUrl":"https://doi.org/10.1016/j.seizure.2025.02.017","url":null,"abstract":"","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors’ response to letter by Amanda Medeiros Fernandes et al.","authors":"Yu Zhang , Haijiao Wang , Ling liu","doi":"10.1016/j.seizure.2024.12.018","DOIUrl":"10.1016/j.seizure.2024.12.018","url":null,"abstract":"","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"126 ","pages":"Page 116"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heading: When change creates chaos - A dilemma with brand versus generic antiseizure medications,,","authors":"Khushboo Verma, Sisira Yadala","doi":"10.1016/j.seizure.2024.12.005","DOIUrl":"10.1016/j.seizure.2024.12.005","url":null,"abstract":"","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"126 ","pages":"Pages 117-118"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and independently associated variables of acute postoperative seizures after epilepsy surgery","authors":"Wei Ma ,&nbsp;Yufu Zhang ,&nbsp;Long Chen","doi":"10.1016/j.seizure.2025.02.015","DOIUrl":"10.1016/j.seizure.2025.02.015","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the incidence and independently associated variables of acute postoperative seizures (APOS) occurring in the first postoperative week after resective epilepsy surgery.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed clinical data from consecutive patients who underwent resective epilepsy surgery in a tertiary hospital. The clinical characteristics of patients with and without APOS were compared, and binary logistic regression was used to identify the independently associated variables of APOS.</div></div><div><h3>Results</h3><div>Of the 1269 epilepsy surgeries (1261 patients) included in this analysis, 10.6 % (134/1269) resulted in APOS. Univariate analysis showed that sex, age at surgery, epilepsy duration, seizure frequency, number of anti-seizure medications (ASMs) at the time of surgery, drug resistant epilepsy (DRE); previous surgery, interictal EEG, intracranial monitoring, surgical extent, and complications were associated with APOS. When surgery was limited to a single brain lobe, frontal and parietal lobe surgery were more likely to result in APOS than temporal lobe surgery (11.7 %, 17.2 % vs<em>.</em> 7.5 %, <em>p</em> = 0.033, 0.008, respectively). Multivariate analysis demonstrated that an epilepsy duration of ≥3.75 years (OR 1.789 95 % CI 1.128–2.837 <em>p</em> = 0.013), using ≥3 types of ASMs at the time of surgery (OR 1.649 95 % CI 1.025–2.652 <em>p</em> = 0.039), and complications (OR 1.761 95 % CI 1.179–2.628 <em>p</em> = 0.006) were the independently associated variables of APOS. Postoperative seizure outcome at last follow-up was significantly worse in patients with APOS than in those without (Engel class Ⅰ: 41.1 % vs<em>.</em> 70.4 % <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The overall incidence of APOS in our cohort was moderate. Surgery for temporal lobe epilepsy was less likely to result in APOS. Early surgery, use of fewer ASMs, and control of complications were independently associated with a lower incidence of APOS.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"129 ","pages":"Pages 9-13"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's reply to comment “When changes creates chaos”","authors":"Magdalena Bosak","doi":"10.1016/j.seizure.2024.12.015","DOIUrl":"10.1016/j.seizure.2024.12.015","url":null,"abstract":"","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"126 ","pages":"Page 119"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143041368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What are the risk factors for suicide-related events in patients with epilepsy? A critical review of methodology and evidence","authors":"Amanda Medeiros Fernandes ,&nbsp;Ana Zélia Abreu Pires de Sousa ,&nbsp;Fabio Gomes de Matos e Souza ,&nbsp;Luísa Weber Bisol","doi":"10.1016/j.seizure.2024.12.016","DOIUrl":"10.1016/j.seizure.2024.12.016","url":null,"abstract":"","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"126 ","pages":"Pages 114-115"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of vagus nerve stimulation on refractory epilepsy with myoclonic atonic seizures: Case series insights","authors":"Fatima Jaafar ,&nbsp;Christian Kaufman ,&nbsp;Leena Abdelmoity ,&nbsp;Ahmed Madkoor ,&nbsp;Kailash Pawar ,&nbsp;Julie Kostreva ,&nbsp;Lalit Bansal","doi":"10.1016/j.seizure.2025.02.014","DOIUrl":"10.1016/j.seizure.2025.02.014","url":null,"abstract":"<div><h3>Purpose</h3><div>Epilepsy with myoclonic atonic seizures (EMAtS) is a rare childhood-onset developmental and epileptic encephalopathy, often resistant to pharmacologic treatments and is associated with significant cognitive impairments. Early seizure control is crucial for optimal neurodevelopmental outcomes. This study describes seizure frequency and neurodevelopmental outcome following vagus nerve stimulation (VNS) implantation in children with EMAtS.</div></div><div><h3>Methods</h3><div>We conducted a retrospective review of pediatric patients with EMAtS who underwent VNS implantation to treat their refractory seizures from 2011 to May 2024.</div></div><div><h3>Results</h3><div>Six pediatric patients with EMAtS underwent VNS implantation and were followed for an average of 4.6 years post implantation. Six months post-VNS activation, significant improvement in seizure frequency or intensity was observed in five patients, with four achieving a mean seizure reduction of 76 %. At the last follow-up (mean of 8.1 years), three patients were seizure-free. Positive neuropsychological outcomes were present in four patients.</div></div><div><h3>Conclusion</h3><div>These findings suggest that VNS can be an effective therapeutic option for pediatric patients with refractory EMAtS, leading to improvements in seizure control and neurodevelopmental outcomes.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"127 ","pages":"Pages 25-28"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The placebo effect in the treatment of children with epilepsy: A systematic review","authors":"Enduena Begolli ,&nbsp;Camille Højer Winther ,&nbsp;Maria J Miranda ,&nbsp;Nanette Mol Debes","doi":"10.1016/j.seizure.2025.02.013","DOIUrl":"10.1016/j.seizure.2025.02.013","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the placebo effect in the treatment of children and adolescents with epilepsy.</div></div><div><h3>Methods</h3><div>We conducted a systematic review of studies comparing anti-seizure medication (ASM) to placebo in children and adolescents with epilepsy. Eligible studies were identified through the database PubMed following PRISMA guidelines resulting in the identification of 1173 articles. Screening and inclusion were assessed by two independent reviewers and 17 studies met inclusion criteria.</div></div><div><h3>Results</h3><div>Seventeen studies involving children and adolescents with epilepsy were included in this review. Compared to levetiracetam (LEV) and perampanel (PER), the placebo did not show a significant reduction in seizures. However, compared to pregabalin (PGB) the placebo was significant in reducing seizures at lower doses. Results for eslicarbazepine (ESL) were contradictory. Placebo-treated patients generally had lower Child Behavior checklist (CBCL) problem scores than those on LEV, which was associated with higher Total Problem Scores and worse Aggressive Behavior scores. Adverse event (AE) rates in the placebo groups varied widely, from 14 % to 91.8 %.</div></div><div><h3>Conclusion</h3><div>This systematic review examined the effect of placebo treatment compared to ASMs in childhood epilepsy across 17 studies. The effectiveness of placebos was not significant compared to LEV and PER. However, there was a significant placebo effect compared to PGB, which was higher compared to low PGB doses than compared to high PGB doses. AE rates varied widely. Assessing long-term cognitive and behavioral outcomes was challenging due to short study durations and potential biases. Future research could play a critical role in preventing AEs in children undergoing ASM treatment by providing a deeper understanding of the placebo effect associated with these medications.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"127 ","pages":"Pages 7-15"},"PeriodicalIF":2.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of pediatric and adolescent epilepsy in India: A systematic review and meta-analysis","authors":"Mamta Patel ,&nbsp;Akhil Dhanesh Goel ,&nbsp;Lokesh Saini ,&nbsp;Rashmi Kaushal ,&nbsp;Deepti Mathur ,&nbsp;Amit K. Mittal ,&nbsp;Tanuja Rajial ,&nbsp;Kuldeep Singh","doi":"10.1016/j.seizure.2025.02.012","DOIUrl":"10.1016/j.seizure.2025.02.012","url":null,"abstract":"<div><h3>Introduction</h3><div>Epilepsy is a widespread neurological disorder that affects millions of people worldwide, with a large proportion of cases emerging in childhood. Many children with epilepsy in low and middle-income countries, such as India, encounter obstacles to care despite effective treatments, which add to the treatment gap.</div></div><div><h3>Methodology</h3><div>A systematic review and meta-analysis was conducted in accordance with PRISMA guidelines. PubMed, Scopus and Shodhganga databases were searched for studies on epilepsy prevalence in pediatric and adolescent groups aged 0 to 19 years in India. Eligible studies were identified, and data were collected and synthesised using random-effect models. Geographic zones and gender were used to conduct subgroup analysis.</div></div><div><h3>Results</h3><div>Thirteen community-based studies with seventeen datasets satisfied the inclusion requirements. The overall pooled prevalence of paediatric and adolescent epilepsy in India is 0.8 % (95 % CI: 0.6 %, 1.0 %). Significant variation was found among Indian zones according to subgroup analysis, with the Central zone showing the lowest prevalence (0.4 %) and the North–Eastern zone showing the highest prevalence (2.3 %). A Doi plot revealed major asymmetry with an LFK index of 4.24, indicating publication bias and small study effects. The studies had a high degree of heterogeneity (<em>I</em>² = 93 %).</div></div><div><h3>Conclusion</h3><div>In India, epilepsy affects a large number of children and families, posing a significant public health burden. Effective management requires age-specific strategies for specialised interventions and full support services. This study underscores the necessity of improving healthcare access and addressing the treatment gap for children with epilepsy in India.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"127 ","pages":"Pages 36-43"},"PeriodicalIF":2.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effect of an educational comic book on the knowledge, attitudes and practices regarding epilepsy among public schoolchildren in Mauritius","authors":"Sarah Altayyar ,&nbsp;Dana Chengan ,&nbsp;Youssouf Noormamode ,&nbsp;Vedas Moonsamy ,&nbsp;Neeshti Reetoo ,&nbsp;Pierre-Marie Preux ,&nbsp;Farid Boumediene","doi":"10.1016/j.seizure.2025.02.010","DOIUrl":"10.1016/j.seizure.2025.02.010","url":null,"abstract":"<div><h3>Purpose</h3><div>Epilepsy affects 70 million people globally, with over 80 % living in low- and middle-income countries. In Mauritius, treatment barriers include a lack of knowledge and stigma, particularly among children. We aim to assess the effect of reading an educational comic on the knowledge, attitudes and practices (KAP) regarding epilepsy among schoolchildren in Mauritius.</div></div><div><h3>Methods</h3><div>A quasi-experimental study was conducted in 16 public schools located in rural and urban areas. It targeted grade 5 pupils, aged 10 and 11. Data were collected using a structured KAP questionnaire before and immediately after reading the comic. Mean KAP scores were compared at baseline and after reading. A p-value&lt;0.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>The study included 446 pupils, with 197 from rural and 249 from urban schools. A significant improvement in the global KAP score from 10.2 ± 2.9 to 16.4 ± 1.9 (<em>p</em> &lt; 0.0001) was noted. The knowledge sub-score and the attitudes and practices sub-scores showed significant improvement across all socio-demographic groups (<em>p</em> = 0.0002). Significant improvements in KAP scores resulted in very satisfactory scores in both rural (16.0 ± 2.0) and urban areas (16.7 ± 1.7). Obstacles to better learning were a higher initial score (OR=0.45, CI [0.39;0.53], <em>p</em> &lt; 0.0001) and monotonous reading (OR=0.34, CI [0.17;0.68], <em>p</em> = 0.002). All the pupils learnt a lot about epilepsy and greatly enjoyed the comic.</div></div><div><h3>Conclusion</h3><div>The comic is an effective tool to improve KAP regarding epilepsy in various environments regardless of sociodemographic or cultural characteristics. Raising awareness among children, in our opinion, is the best way to anticipate stigma linked to epilepsy.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"126 ","pages":"Pages 106-113"},"PeriodicalIF":2.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}