Seizure-European Journal of Epilepsy最新文献

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Characteristics associated with first anti-seizure medication prescribed in a cohort of adults with newly diagnosed epilepsy 新诊断癫痫的成人队列中首次抗癫痫药物处方的相关特征
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1016/j.seizure.2026.02.007
Leah J. Blank , Rachelle Morgenstern , Kenneth Boockvar , Nihal Mohamed , Nathalie Jetté
{"title":"Characteristics associated with first anti-seizure medication prescribed in a cohort of adults with newly diagnosed epilepsy","authors":"Leah J. Blank ,&nbsp;Rachelle Morgenstern ,&nbsp;Kenneth Boockvar ,&nbsp;Nihal Mohamed ,&nbsp;Nathalie Jetté","doi":"10.1016/j.seizure.2026.02.007","DOIUrl":"10.1016/j.seizure.2026.02.007","url":null,"abstract":"<div><h3>Background</h3><div>Anti-seizure medication (ASM) is the primary treatment modality in epilepsy. There exist evidence-based recommendations published by the American Academy of Neurology and American Epilepsy Society for ASM selection in epilepsy, but these medication recommendations are inconsistently followed. We sought to examine predictors of recommended first ASM in newly diagnosed adults with epilepsy.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of adults (≥18 years) newly diagnosed with epilepsy in New York, identified using validated ICD-CM codes, for the period 2011 to 2019. The primary outcome of interest was use of an AES/AAN guideline-informed ASM, and exposures of interest included patient characteristics (e.g. age), provider characteristics (e.g. specialty) and structural characteristics (e.g., practice setting). Multivariable Poisson regression for risk ratios modeled the probability of being prescribed a neutral/recommended or non-recommended ASM, adjusting for covariates.</div></div><div><h3>Results</h3><div>2340 adults with newly diagnosed epilepsy were prescribed an ASM within 1-year. The most frequently prescribed ASM was levetiracetam (45.5%), which aligns with recommendations. However, 39% were prescribed a non-recommended medication. The prescription of a recommended ASM was associated with older age at diagnosis (relative risk (RR) 1.01; 95% confidence interval (CI) 1.00–1.01), Black race (RR 1.12; 95% CI 1.03–1.23), being in a relationship (vs. divorced/separated/single or widowed) (RR 1.13; 95% CI 1.06–1.22) and a history of stroke (RR 1.19; 95% CI 1.05–1.34). Prescriptions from physician trainees (vs. non-trainees) were more likely to align with recommended ASMs (RR 1.15; 95% CI 1.06–1.25), with no differences by physician specialty. Inpatient setting was associated with fewer recommended ASM prescriptions (vs. outpatient setting) (RR 0.82; 95% CI 0.75–0.89). There was no difference between emergency department and outpatient prescriptions.</div></div><div><h3>Conclusions</h3><div>Understanding where/why less favorable ASM prescription may occur is important to target potential prescribing interventions. In this study, recommended ASM prescriptions were associated with patient, prescriber and setting characteristics. Notably, trainees prescribed recommended/neutral ASM more often, which underscores the importance of prescriber education in improving prescribing practices.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"136 ","pages":"Pages 60-65"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic performance of STESS and qSOFA scores in pre-hospital status epilepticus: A prospective cohort study 院前癫痫持续状态的ess和qSOFA评分的预后表现:一项前瞻性队列研究
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.seizure.2026.01.017
Hela Manai, Teycir Kharraz, Houyem Zouari, Saida Zelfani
{"title":"Prognostic performance of STESS and qSOFA scores in pre-hospital status epilepticus: A prospective cohort study","authors":"Hela Manai,&nbsp;Teycir Kharraz,&nbsp;Houyem Zouari,&nbsp;Saida Zelfani","doi":"10.1016/j.seizure.2026.01.017","DOIUrl":"10.1016/j.seizure.2026.01.017","url":null,"abstract":"<div><h3>Background</h3><div>Status epilepticus (SE) is a life-threatening, multisystem disorder. Prognostic factors are variable, and several scores have been developed for SE, some requiring electroencephalogram results that may not be available pre-hospital. We aimed to evaluate the prognostic performance of two rapid, easily applicable pre-hospital scores: the STESS and qSOFA scores.</div></div><div><h3>Methods</h3><div>We conducted a prospective, observational study of SE patients managed in pre-hospital emergency care in Tunis over 35 months. We assessed the area under the receiver operating characteristic curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and optimal cutoffs for both STESS and qSOFA in predicting 48-hour mortality, in-hospital mortality, and the need for mechanical ventilation.</div></div><div><h3>Results</h3><div>One hundred SE patients with motor-predominant seizures were included. For 48-hour mortality, AUC was 0.855 for STESS and 0.787 for qSOFA; for mechanical ventilation, AUC was 0.693 and 0.705, respectively. STESS ≥3 predicted 48-hour mortality with specificity 87.0% and sensitivity 66.7%, while qSOFA ≥3 had specificity 95.8% and sensitivity 64.3%. Exploratory analysis for in-hospital mortality (37%) showed STESS ≥3 with specificity 86% and sensitivity 68%, and qSOFA ≥3 with specificity 95% and sensitivity 64%.</div></div><div><h3>Conclusions</h3><div>STESS and qSOFA are simple, rapid scores suitable for pre-hospital SE management. Both exhibit good specificity but moderate sensitivity. STESS may be more informative for in-hospital outcomes, while qSOFA reflects early systemic severity. Scores should be interpreted alongside a comprehensive clinical assessment to guide triage and early management.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"136 ","pages":"Pages 46-50"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tele-neuropsychological assessment in children with self-limited epilepsy with centrotemporal spikes: a pilot study 伴有中央颞叶尖峰的自限性癫痫患儿的远端神经心理评估:一项初步研究。
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1016/j.seizure.2026.02.004
Viola Margheri , Simona Pellacani , Edoardo Fino , Martina Calì , Sara Senese , Costanza Ruffini , Carmen Barba , Renzo Guerrini , Chiara Pecini
{"title":"Tele-neuropsychological assessment in children with self-limited epilepsy with centrotemporal spikes: a pilot study","authors":"Viola Margheri ,&nbsp;Simona Pellacani ,&nbsp;Edoardo Fino ,&nbsp;Martina Calì ,&nbsp;Sara Senese ,&nbsp;Costanza Ruffini ,&nbsp;Carmen Barba ,&nbsp;Renzo Guerrini ,&nbsp;Chiara Pecini","doi":"10.1016/j.seizure.2026.02.004","DOIUrl":"10.1016/j.seizure.2026.02.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Telemedicine has gained increasing prominence in healthcare services, with neuropsychological tele-assessment emerging as a promising tool for evaluating and monitoring cognitive functions remotely, even in clinical conditions with mild vulnerabilities. Despite its growing application in adults, its use in pediatric clinical contexts remains understudied. Among pediatric disorders, Self-limited epilepsy with centrotemporal spikes (SeLECTs) may feature subtle neuropsychological deficits, particularly in higher order cognitive processes such as Executive Functions (EF), and in learning skills. Early tele-neuropsychological assessment can help delineate the neuropsychological profile in this population.</div></div><div><h3>Method</h3><div>The feasibility of a fully remote neuropsychological assessment protocol in children with SeLECTs was examined. Forty-seven children (aged 6–13) were recruited, of whom 43 underwent the assessment. Two online sessions via Google Meet and web-based platforms (TeleFE battery), to assess children’s cognitive and executive functioning were conducted. Clinicians evaluated the children's engagement and parents completed remote questionnaires addressing academic performances, EF-related behaviors, and feasibility of the procedure.</div></div><div><h3>Results</h3><div>The protocol demonstrated high feasibility and acceptability, with participants’ strong compliance and no major technical issues. Descriptive analyses highlighted the presence of vulnerabilities in executive functioning and school achievement in children with SeLECTs.</div></div><div><h3>Discussion</h3><div>These findings support the clinical relevance of remote neuropsychological assessment in pediatric epilepsy, offering a scalable and accessible tool to enhance care.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"136 ","pages":"Pages 69-75"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neonatal-onset epileptic encephalopathy with lissencephaly associated with a SCN3A variant: The first case in Korea and literature review 新生儿癫痫性脑病伴无脑畸形与SCN3A变异相关:韩国首例病例和文献综述
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2026-03-01 Epub Date: 2026-01-18 DOI: 10.1016/j.seizure.2026.01.008
Hyun A Lee , Seong Wan Kim , Seoheui Choi , Jang Hoon Lee , Moon Sung Park , Rita Yu , Yoong-A Suh
{"title":"Neonatal-onset epileptic encephalopathy with lissencephaly associated with a SCN3A variant: The first case in Korea and literature review","authors":"Hyun A Lee ,&nbsp;Seong Wan Kim ,&nbsp;Seoheui Choi ,&nbsp;Jang Hoon Lee ,&nbsp;Moon Sung Park ,&nbsp;Rita Yu ,&nbsp;Yoong-A Suh","doi":"10.1016/j.seizure.2026.01.008","DOIUrl":"10.1016/j.seizure.2026.01.008","url":null,"abstract":"<div><h3>Purpose</h3><div>Pathogenic variants in<em>SCN3A,</em> encoding the voltage-gated sodium channel Naᵥ1.3, have been implicated in early infantile epileptic encephalopathy (EIEE) and cortical malformations. We report the first Korean case of <em>SCN3A</em>-related EIEE and discuss its contribution to the expanding phenotypic spectrum.</div></div><div><h3>Methods</h3><div>Clinical features, electroencephalography (EEG), brain magnetic resonance imaging (MRI), treatment response, and outcomes were analyzed. A literature review of previously reported <em>SCN3A</em> cases was performed for phenotypic comparison.</div></div><div><h3>Results</h3><div>A female neonate developed tonic seizures 7 h after birth. EEG showed multifocal epileptiform discharges with burst-suppression patterns. Brain MRI demonstrated diffuse cortical thickening consistent with the lissencephaly–pachygyria spectrum and corpus callosum dysgenesis. Despite multiple antiseizure medications, seizures remained intractable. Profound bulbar dysfunction required gastrostomy, tracheostomy, and home ventilation. Next-generation sequencing identified a heterozygous <em>SCN3A</em> c.2624T&gt;C (p.Ile875Thr) variant, previously reported as pathogenic and associated with gain-of-function effects. The patient died at 6 months of age.</div></div><div><h3>Conclusion</h3><div>This first Korean case of <em>SCN3A</em>-related EIEE caused by the recurrent p.Ile875Thr variant highlights a severe neonatal phenotype characterized by early-onset refractory seizures, profound cortical malformations, and early mortality. The case broadens both the phenotypic and geographic spectrum of <em>SCN3A</em>-associated neurodevelopmental disorders and underscores the importance of early genetic testing in neonates with refractory seizures and cortical malformations.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"136 ","pages":"Pages 13-17"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality and safety of youtube videos on epilepsy-specific exercises: A systematic analysis using a novel evaluation tool 关于癫痫特定练习的youtube视频的质量和安全性:使用一种新的评估工具的系统分析。
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI: 10.1016/j.seizure.2026.02.002
Yakup Gonulal , Tuba Denizci , Mehmetcan Yesilkaya , Eda Agascioglu , Serdar Aykac , Rabia Hurrem Ozdurak Singin
{"title":"Quality and safety of youtube videos on epilepsy-specific exercises: A systematic analysis using a novel evaluation tool","authors":"Yakup Gonulal ,&nbsp;Tuba Denizci ,&nbsp;Mehmetcan Yesilkaya ,&nbsp;Eda Agascioglu ,&nbsp;Serdar Aykac ,&nbsp;Rabia Hurrem Ozdurak Singin","doi":"10.1016/j.seizure.2026.02.002","DOIUrl":"10.1016/j.seizure.2026.02.002","url":null,"abstract":"<div><h3>Objective</h3><div>Exercise benefits people with epilepsy (PWE) by reducing seizure frequency, improving quality of life, and fostering social participation. YouTube, a popular platform for health information, hosts numerous exercise videos for PWE, yet their quality, reliability, and safety remain unevaluated. This study aimed to evaluate the quality, reliability, and engagement of YouTube videos on epilepsy-specific exercises using the novel Epilepsy Content Evaluation (ECE) tool, alongside DISCERN, JAMA, and Global Quality Score (GQS).</div></div><div><h3>Method</h3><div>A systematic search conducted on July 22, 2025, identified 45 English-language YouTube videos, which were independently evaluated by two neurologists using the ECE, DISCERN, JAMA, and GQS tools. Video characteristics, publisher sources, and engagement metrics were analyzed.</div></div><div><h3>Results</h3><div>Most videos (53.3%) were rated low quality (ECE score 0–7), with only one (2.2%) achieving high quality (ECE score 12–15). The Safety and Risk Management subdomain scored lowest (median: 2, IQR: 1.25), reflecting inadequate attention to seizure triggers and supervision. Athlete-targeted videos outperformed general-population videos in quality (<em>p</em> &lt; 0.05). View counts negatively correlated with ECE scores (<em>r</em> = –0.375 to –0.712, <em>p</em> &lt; 0.05). ECE demonstrated strong convergent validity with DISCERN (Phi = 0.606, <em>p</em> = 0.035).</div></div><div><h3>Conclusion</h3><div>In conclusion, most YouTube videos on epilepsy-specific exercises lack clinical reliability and safety guidance, posing potential risks for PWE. The ECE tool effectively identifies these deficiencies, enabling clinicians to recommend ILAE-aligned videos to enhance patient safety. Curated, evidence-based digital resources could empower millions of PWE to engage in safe physical activity, reducing stigma and improving health outcomes.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"136 ","pages":"Pages 51-59"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Before status epilepticus in epilepsy patients is attributed to the SARS-CoV-2 vaccination, alternative causes must be ruled out 在将癫痫患者的癫痫持续状态归因于SARS-CoV-2疫苗接种之前,必须排除其他原因
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2026-03-01 Epub Date: 2026-03-10 DOI: 10.1016/j.seizure.2024.10.014
Josef Finsterer
{"title":"Before status epilepticus in epilepsy patients is attributed to the SARS-CoV-2 vaccination, alternative causes must be ruled out","authors":"Josef Finsterer","doi":"10.1016/j.seizure.2024.10.014","DOIUrl":"10.1016/j.seizure.2024.10.014","url":null,"abstract":"","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"136 ","pages":"Pages 119-120"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147402149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electroencephalography in the differential diagnosis of non-epileptic paroxysmal events in infants: clinical utility and other predictors 脑电图在婴儿非癫痫性发作事件鉴别诊断中的应用:临床应用和其他预测因素。
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1016/j.seizure.2026.02.006
Hilal Karpuzcu , Fatih Mehmet Kışlal , Didem Ardıçlı , Deniz Yılmaz (Clinical assessment)
{"title":"Electroencephalography in the differential diagnosis of non-epileptic paroxysmal events in infants: clinical utility and other predictors","authors":"Hilal Karpuzcu ,&nbsp;Fatih Mehmet Kışlal ,&nbsp;Didem Ardıçlı ,&nbsp;Deniz Yılmaz (Clinical assessment)","doi":"10.1016/j.seizure.2026.02.006","DOIUrl":"10.1016/j.seizure.2026.02.006","url":null,"abstract":"<div><h3>Background</h3><div>Differentiating non-epileptic paroxysmal events (NEPE) from epileptic seizures in infants is challenging, especially in the 1–24 month age group where features overlap and data are limited. Meanwhile restricting studies to the first year may lead to overlook the events that persist into the second year. This study aimed to define the clinical spectrum of NEPE, assess diagnostic yield of electroencephalography (EEG), and identify predictors of specific subtypes.</div></div><div><h3>Methods</h3><div>This single-center, retrospective study included infants aged 1–24 months who underwent EEG for suspected NEPE between January 2015 and March 2021. Demographic, clinical, laboratory, neuroimaging, and EEG data were analyzed per Strengthening the reporting of observational studies in epidemiology (STROBE) guidelines.</div></div><div><h3>Results</h3><div>Of 5614 infants assessed, 1465 underwent EEG, and 216 (mean age 11.1 ± 6.5 months; 55.1% male) met inclusion criteria. Breath holding spells (BHS) were most frequent (55.1%), followed by jitteriness (10.6%) and shuddering attacks (9.3%). Crying was the predominant trigger for BHS (97.5%, <em>p</em> &lt; 0.001). EEG was abnormal in 8.8% of patients. Anemia was present in 23.4%. Independent predictors of BHS were crying (AOR 28.7), age 13–18 months (AOR 3.95), and anemia (AOR 2.65).</div></div><div><h3>Conclusions</h3><div>Most infants aged 1–24 months with suspected NEPE, had normal EEG, indicating limited diagnostic yield for epileptiform abnormalities. Age, specific triggers, and anemia can guide diagnosis and help to target EEG use to selected cases, thereby supporting more judicious resource utilization and avoiding unnecessary antiseizure medication.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"136 ","pages":"Pages 77-85"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative positron emission tomography for predicting postoperative epilepsy risk: A radiomics and clinical feature-based fusion model 术前正电子发射断层扫描预测术后癫痫风险:放射组学和基于临床特征的融合模型。
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.seizure.2026.01.018
Di Zhang, Zi-Hao Wang, Yan Feng, Yu-Tian Wang, Shun-Yao Zhang, Wen-Ling Li
{"title":"Preoperative positron emission tomography for predicting postoperative epilepsy risk: A radiomics and clinical feature-based fusion model","authors":"Di Zhang,&nbsp;Zi-Hao Wang,&nbsp;Yan Feng,&nbsp;Yu-Tian Wang,&nbsp;Shun-Yao Zhang,&nbsp;Wen-Ling Li","doi":"10.1016/j.seizure.2026.01.018","DOIUrl":"10.1016/j.seizure.2026.01.018","url":null,"abstract":"<div><h3>Background</h3><div>Epilepsy is a common neurological disorder characterized by recurrent seizures, and predicting the risk of postoperative epilepsy is critical for patient management. The integration of radiomics and clinical factors offers a promising approach for accurate risk assessment.</div></div><div><h3>Methods</h3><div>In this study, preoperative positron emission tomography (PET) imaging and clinical data of 197 epilepsy patients were analyzed. The imaging features were extracted from three-dimensional regions of interest (ROIs). Key radiomics features were selected using the SelectKBest and the Least Absolute Shrinkage and Selection Operator (LASSO), while key clinical features were identified through univariate and multivariate analyses. Three models—radiomics, clinical, and fusion (fusing radiomics and clinical features)—were constructed using the Support Vector Machine (SVM) and Multilayer Perceptron (MLP) algorithms. The models were evaluated based on sensitivity, specificity, and area under the curve (AUC). A nomogram based on the best-performing model was developed and assessed for predictive accuracy using calibration and decision curve analysis (DCA) to estimate the risk of postoperative epilepsy following neurosurgery.</div></div><div><h3>Results</h3><div>A total of 11 key radiomics features were identified, with prior brain damage (PBD) as the key clinical feature. The MLP fusion model demonstrated the highest predictive performance, with an AUC of 0.85 in the validation set. The nomogram showed good predictive accuracy and superior clinical utility.</div></div><div><h3>Conclusion</h3><div>The integration of radiomics and clinical features provides a more accurate and clinically useful tool for predicting postoperative epilepsy risk. The fusion model demonstrates significant potential in guiding clinical decision-making and personalized treatment for epilepsy patients.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"136 ","pages":"Pages 93-101"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of disparities in pediatric epilepsy surgery use over two decades 二十年来小儿癫痫手术应用差异的演变
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.seizure.2026.01.020
Alex S. Aguirre , Ellen C. Broekhuizen , Daan A. Pijs , Iván Sánchez Fernández
{"title":"Evolution of disparities in pediatric epilepsy surgery use over two decades","authors":"Alex S. Aguirre ,&nbsp;Ellen C. Broekhuizen ,&nbsp;Daan A. Pijs ,&nbsp;Iván Sánchez Fernández","doi":"10.1016/j.seizure.2026.01.020","DOIUrl":"10.1016/j.seizure.2026.01.020","url":null,"abstract":"<div><h3>Objective</h3><div>To describe how disparities in the use of epilepsy surgery have evolved between 2004 and 2024 among children with drug-resistant epilepsy.</div></div><div><h3>Methods</h3><div>Retrospective descriptive study using the Pediatric Health Information System database. Outcomes were use of epilepsy surgery and time from first diagnosis of drug-resistant epilepsy to epilepsy surgery, main predictors were type of insurance, race, and ethnicity.</div></div><div><h3>Results</h3><div>We studied 50,953 patients with drug-resistant epilepsy (median (p<sub>25</sub>-p<sub>75</sub>) age: 8.0 (3.5–13.4) years, 54% males), of whom 7220 (14.2%) patients had at least one epilepsy surgery. The number of epilepsy surgeries per 100 person-years increased from 4.0 in 2004–2006 to 15.8 in 2022–2024. On multivariable analysis, the odds ratio (OR) of receiving epilepsy surgery for patients with private versus public insurance increased from OR: 1.50 (1.25–1.80) in 2004–2006 to OR: 1.75 (1.50–2.04) in 2022–2024; increased for White patients versus Black patients from OR: 1.35 (1.03–1.76) in 2004–2006 to OR: 2.39 (1.86–3.08) in 2022–2024; and increased for Not Hispanic/Latino patients versus Hispanic/Latino patients from OR: 1.08 (0.85–1.38) in 2007–2009 (first years with the “Not Hispanic/Latino” category) to OR: 1.23 (1.01–1.51) in 2022–2024. On multivariable Cox regression analysis, the hazard ratio (HR) of receiving epilepsy surgery for patients with private insurance versus public insurance increased from HR: 1.55 (1.32–1.82) in 2004–2006 to HR: 1.92 (1.65–2.24) in 2022–2024; increased for White patients versus Black patients from HR: 1.46 (1.14–1.86) in 2004–2006 to HR: 2.67 (2.05–3.48) in 2022–2024; and increased for Not Hispanic/Latino patients versus Hispanic/Latino patients from HR: 1.20 (0.96–1.51) in 2007–2009 to HR: 1.30 (1.06–1.60) in 2022–2024.</div></div><div><h3>Conclusion</h3><div>Despite increasing use of epilepsy surgery in pediatric patients with drug-resistant epilepsy between 2004 and 2024, disparities by type of insurance, race, and ethnicity are widening.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"136 ","pages":"Pages 4-11"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Optimal cutoff score for diagnosing generalized anxiety disorder with the Generalized Anxiety Disorder 7-item scale in people living with epilepsy: A systematic review with diagnostic test accuracy meta-analysis” [Seizure: European Journal of Epilepsy 134 (2026) 229237] “癫痫患者用广泛性焦虑障碍7项量表诊断广泛性焦虑障碍的最佳临界值:诊断测试准确性荟萃分析的系统评价”的更正[癫痫:欧洲癫痫杂志134 (2026)229237]
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1016/j.seizure.2026.01.007
Minjung Kim , Rock Bum Kim , Tae-Won Yang , Young-Soo Kim , Do-Hyung Kim , Oh-Young Kwon
{"title":"Corrigendum to “Optimal cutoff score for diagnosing generalized anxiety disorder with the Generalized Anxiety Disorder 7-item scale in people living with epilepsy: A systematic review with diagnostic test accuracy meta-analysis” [Seizure: European Journal of Epilepsy 134 (2026) 229237]","authors":"Minjung Kim ,&nbsp;Rock Bum Kim ,&nbsp;Tae-Won Yang ,&nbsp;Young-Soo Kim ,&nbsp;Do-Hyung Kim ,&nbsp;Oh-Young Kwon","doi":"10.1016/j.seizure.2026.01.007","DOIUrl":"10.1016/j.seizure.2026.01.007","url":null,"abstract":"","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"136 ","pages":"Page 12"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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