Seizure-European Journal of Epilepsy最新文献

{"title":"Ventricular tachycardia induced by adrenocorticotropic hormone therapy in infantile epileptic spasms syndrome: A case report","authors":"Hirokazu Takeuchi , Reiko Koichihara , Akiharu Omori , Rikako Takeda , Yuko Hirata , Ryuki Matsuura , Kenjiro Kikuchi , Kenji Hoshino , Shin-ichiro Hamano","doi":"10.1016/j.seizure.2025.01.014","DOIUrl":"10.1016/j.seizure.2025.01.014","url":null,"abstract":"","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"125 ","pages":"Pages 84-86"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing natural language processing to identify pediatric patients experiencing status epilepticus","authors":"Molly Ann Puckett ,&nbsp;Fatemeh Mohammad Alizadeh Chafjiri ,&nbsp;Jennifer V. Gettings ,&nbsp;Assaf Landschaft ,&nbsp;Tobias Loddenkemper","doi":"10.1016/j.seizure.2025.01.008","DOIUrl":"10.1016/j.seizure.2025.01.008","url":null,"abstract":"<div><h3>Purpose</h3><div>Compare the identification of patients with established status epilepticus (ESE) and refractory status epilepticus (RSE) in electronic health records (EHR) using human review versus natural language processing (NLP) assisted review.</div></div><div><h3>Methods</h3><div>We reviewed EHRs of patients aged 1 month to 21 years from Boston Children's Hospital (BCH). We included all patients with convulsive ESE or RSE during admission. We employed and validated a pre-trained NLP tool, Document review Tool (DrT), to identify patients from 2013–2020, excluding training years (2017–2019). DrT notes a machine-learning score based on a support vector machine (SVM) and bag-of-n-grams. Higher scores indicated more likely ESE/RSE cases. To further evaluate the effectiveness of DrT-assisted review, we compared the results to human-reviewed notes from the pediatric Status Epilepticus Research Group (pSERG) consortium at BCH.</div></div><div><h3>Results</h3><div>The pre-trained algorithm identified 170 patients with RSE using DrT (Sensitivity: 98.8%), compared to 116 patients identified during human review (Sensitivity: 67.4%). Additionally, we identified 207 patients with ESE using DrT (Sensitivity: 99.5%), compared to 91 patients identified using human review (Sensitivity: 43.8%). Overall, DrT missed 3 cases (2 RSE and 1 ESE cases) that were identified during human review and identified 173 cases (56 RSE and 117 ESE cases) that were not found during the human review.</div></div><div><h3>Conclusion</h3><div>DrT-assisted manual review demonstrated higher sensitivity in identifying patients with ESE and RSE than the current standard of human review. This suggests that in contexts characterized by resource constraints NLP-related software like DrT can considerably enhance patient identification for research studies, treatment protocols, and preventative care interventions.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"125 ","pages":"Pages 54-61"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher plasma total tau concentrations among patients reporting CNS-related side effects from antiseizure medication","authors":"Klara Andersson ,&nbsp;Sarah Akel ,&nbsp;Fredrik Asztély ,&nbsp;David Larsson ,&nbsp;Henrik Zetterberg ,&nbsp;Johan Zelano","doi":"10.1016/j.seizure.2025.01.015","DOIUrl":"10.1016/j.seizure.2025.01.015","url":null,"abstract":"<div><h3>Background</h3><div>Side effects from antiseizure medication (ASM) are common in epilepsy but biomarkers for detection and monitoring are missing. This study investigated associations between CNS-related side effects from ASM and blood concentrations of the brain injury markers neurofilament-light (NFL), total tau, glial acidic fibrillary protein (GFAP), S100 calcium-binding protein B (S100B) and neuron-specific enolase (NSE).</div></div><div><h3>Methods</h3><div>This is a population-based cohort study of adults with epilepsy recruited from five Swedish outpatient neurology clinics from December 2020 to April 2023. Side effects classified as CNS-related: tiredness, dizziness, headache, concentration, memory, mood, motor/tremor, or sleep. Marker concentrations in the groups CNS side effects/no side effects were analyzed with Mann-Whitney U-test and significant differences were included in multivariable logistic regression models adjusting for age, epilepsy duration, seizure status, acquired structural lesion, and mono-/polytherapy.</div></div><div><h3>Results</h3><div>The cohort consisted of 367 patients, 187 (51 %) were females, the median age was 43 years (IQR 30–61), and 123 (34 %) reported CNS side effects. Total tau was higher among participants reporting CNS side effects (median 4.44 (95 %CI 4.12–4.88) pg/ml) compared with participants without side effects (3.84 (95 %CI 3.52–4.07) pg/ml, <em>p</em> &lt; 0.01). The difference remained significant in multivariable regression models. NSE was higher among participants without side effects but did not remain significant in the multivariable regression model. No differences were observed for NFL, GFAP or S100B.</div></div><div><h3>Conclusions</h3><div>Higher total tau plasma concentration could be associated with increased risk of CNS side effects from ASM. Longitudinal studies could determine if this reflects vulnerability or detrimental effects of ASM. Trial registration: PREDICT, clinicaltrials.gov identifier NCT04559919.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"125 ","pages":"Pages 99-105"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Chinese version of the Epilepsy Anxiety Survey Instrument (EASI) and its brief version (brEASI) in Western China","authors":"Chenshi Liu ,&nbsp;Lan Mou ,&nbsp;Yuwen Zhang ,&nbsp;Mingming Zhang ,&nbsp;Ping Yang ,&nbsp;Shuai Ma ,&nbsp;Min Zhang ,&nbsp;Jie Huang ,&nbsp;Xiaoqiang Xiao ,&nbsp;Jie Liu","doi":"10.1016/j.seizure.2025.01.004","DOIUrl":"10.1016/j.seizure.2025.01.004","url":null,"abstract":"<div><h3>Objective</h3><div>To translate and validate the Chinese version of the Epilepsy Anxiety Survey Instrument (EASI) and its brief version (brEASI) among Chinese people with epilepsy.</div></div><div><h3>Methods</h3><div>Adult outpatients from Sichuan Provincial People's Hospital were recruited. The type of anxiety disorder was determined via the Mini International Neuropsychiatric Interview (MINI). All patients completed the Chinese version of the Generalized Anxiety Disorders-7 (GAD-7), the Chinese version of the Neurological Disorders Depression Inventory for Epilepsy (C-NDDIE), and the EASI/brEASI. Cronbach's α coefficient was calculated, and receiver operating characteristic (ROC) curves were analyzed.</div></div><div><h3>Results</h3><div>A total of 110 patients with epilepsy were included. Twenty-six (23.6 %) patients were found to have anxiety disorder according to the MINI criteria. The Cronbach's α coefficient for the Chinese brEASI was 0.873. In the study, the AUC of the brEASI for detecting all anxiety disorders was 0.883, and the optimal cutoff score was &gt; 7, with a sensitivity of 92.3 % and a specificity of 72.6 %. For the diagnosis of non-GAD disorders, the brEASI had a greater AUC (0. 886) and performed better than the GAD-7 (AUC = 0. 824).</div></div><div><h3>Conclusion</h3><div>The Chinese version of the EASI and brEASI may be reliable and superior to the GAD-7 for anxiety screening in patients with epilepsy.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"125 ","pages":"Pages 87-93"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A non-inferiority randomized controlled study of Perampanel versus Oxcarbazepine monotherapy for post-stroke epilepsy","authors":"Cuihua Yan ,&nbsp;Jing Liu ,&nbsp;Jing Jiang ,&nbsp;Yanping Sun ,&nbsp;Juan Chen ,&nbsp;Kunkun Wei ,&nbsp;Xiaoyun Liu ,&nbsp;Qi Xiang ,&nbsp;Anru Liu ,&nbsp;Yuxiang Han ,&nbsp;Liling Yang ,&nbsp;Tao Han ,&nbsp;Xuewu Liu","doi":"10.1016/j.seizure.2025.01.016","DOIUrl":"10.1016/j.seizure.2025.01.016","url":null,"abstract":"<div><h3>Background</h3><div>Post-stroke epilepsy (PSE) poses a significant challenge despite advances in stroke treatment. This study compares the efficacy of the novel anti-seizure medication (ASM) Perampanel with the classical ASM Oxcarbazepine in treating PSE.</div></div><div><h3>Methods</h3><div>This prospective randomized controlled trial recruited PSE patients from September 2022 to January 2024 across multiple hospitals. Patients were randomly assigned to receive either Perampanel or Oxcarbazepine monotherapy. Baseline seizure frequency was measured over three months prior to treatment. Efficacy was assessed at six months, with <em>a</em> ≥ 50 % reduction in seizure frequency deemed effective. Perampanel was considered non-inferior to Oxcarbazepine if its lower 95 % confidence limit for efficacy was above 80 % of Oxcarbazepine's six-month seizure freedom rate. Intention-to-treat analysis and Kaplan-Meier methods evaluated retention rates and side effects.</div></div><div><h3>Results</h3><div>A total of 67 patients were included in this study: 33 patients in the Perampanel group (26 males, 78.8 %; 7 females, 21.2 %) and 34 patients in the Oxcarbazepine group (26 males, 76.5 %; 8 females, 23.5 %). There were no statistically significant differences in the baseline data between the two groups. This indicates that the groups are comparable. Treatment efficacy was 75.0 % and 78.8 % in the Perampanel and Oxcarbazepine groups at three months, and 80.6 % and 75.0 % at six months, respectively. At six months, the lower limit of the 95 % confidence interval for efficacy in the Perampanel group was higher than the prespecified non-inferiority threshold, indicating that Perampanel was noninferior than Oxcarbazepine. The rates of drug retention and adverse effects were similar in the two groups, with no statistically significant difference (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Perampanel is noninferior to Oxcarbazepine and is considered a good option for the management of post-stroke epilepsy.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"125 ","pages":"Pages 172-178"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between attitudes toward epilepsy and health literacy in Turkey: The mediating role of epilepsy knowledge","authors":"Emre Erkal","doi":"10.1016/j.seizure.2025.01.017","DOIUrl":"10.1016/j.seizure.2025.01.017","url":null,"abstract":"<div><h3>Objective</h3><div>This study determined the mediating role of knowledge about epilepsy in the relationship between attitudes toward epilepsy and health literacy in Turkey.</div></div><div><h3>Methods</h3><div>This descriptive and cross-sectional study was conducted in Turkey with 4,393 participants. The sociodemographic form, Epilepsy Attitude Scale, Epilepsy Knowledge Scale, and Health Literacy Scale were used for data collection.</div></div><div><h3>Results</h3><div>The participants’ mean attitude score was 57.05 ± 10.15, mean knowledge score was 7.70 ± 4.22, and mean health literacy score was 51.95 ± 9.61. Health literacy scores significantly predicted attitude (β = 0.498) and knowledge (β = 0.382) scores (<em>p</em> &lt; 0.05). Knowledge scores significantly predicted attitude scores (β = 0.529; <em>p</em> &lt; 0.05). However, health literacy (β = 0.346) and knowledge scores (β = 0.397) together significantly predicted attitude scores (<em>p</em> &lt; 0.05). The knowledge score has a mediating role between health literacy and attitude score (β = 0.152; <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Individuals had relatively positive attitudes toward epilepsy and moderate levels of knowledge and health literacy. Health literacy positively affected knowledge and attitude towards epilepsy. However, knowledge about epilepsy also positively affected attitude. Additionally, health literacy and knowledge of epilepsy together positively affected attitudes toward epilepsy. Knowledge about epilepsy mediated the relationship between health literacy and attitude toward epilepsy. In this context, it is recommended that programs to raise awareness and improve health literacy be organized, social sensitivity should be increased, and additional epilepsy research should be conducted.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"125 ","pages":"Pages 186-191"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glymphatic system dysfunction in epilepsy related to focal cortical dysplasia and its relationship with antiseizure medication response","authors":"Bo Jin ,&nbsp;Jiahui Xu ,&nbsp;Jing Hu ,&nbsp;Hong Li ,&nbsp;Shan Wang ,&nbsp;Cong Chen ,&nbsp;Linqi Ye ,&nbsp;Hui Cheng ,&nbsp;Lisan Zhang ,&nbsp;Shuang Wang ,&nbsp;Jin Wang ,&nbsp;Thandar Aung","doi":"10.1016/j.seizure.2024.12.021","DOIUrl":"10.1016/j.seizure.2024.12.021","url":null,"abstract":"<div><h3>Purpose</h3><div>Glymphatic function has not been explored in patients with focal cortical dysplasia (FCD)-related epilepsy. This study aimed to investigate the glymphatic system's involvement in these patients and to evaluate its correlation with response patterns to different antiseizure medications (ASMs) using diffusion tensor imaging along the perivascular space (DTI-ALPS).</div></div><div><h3>Methods</h3><div>Fifty-two patients with FCD-related epilepsy (10 with drug-responsive epilepsy and 42 with drug-resistant epilepsy) and 24 healthy controls (HC) were included. Bilateral DTI-ALPS index were calculated and compared among drug-responsive epilepsy, drug-resistant epilepsy, and HC groups. Additionally, we analyzed correlations between the DTI-ALPS index and clinical characteristics.</div></div><div><h3>Results</h3><div>Compared to HC, patients with FCD-related epilepsy showed significantly lower DTI-ALPS index in the bilateral hemispheres (<em>p</em> &lt; 0.001). Notably, a significant decrease in the DTI-ALPS index was noted in the hemisphere ipsilateral to the epileptogenic foci, compared to the contralateral hemisphere (<em>p</em> &lt; 0.001). Further analysis revealed that, in patients with drug-resistant epilepsy, the ipsilateral DTI-ALPS index was significantly lower than the contralateral DTI-ALPS index (<em>p</em> &lt; 0.001), whereas patients with drug-responsive epilepsy did not show a significant difference between ipsilateral and contralateral DTI-ALPS index. No significant correlations were found between the DTI-ALPS index and clinical characteristics such as age and duration of epilepsy.</div></div><div><h3>Conclusion</h3><div>Our findings suggest a correlation between glymphatic system dysfunction and patients with FCD-related epilepsy, particularly in drug-resistant patients.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"125 ","pages":"Pages 31-36"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of lifetime antiepileptic drug history on cenobamate efficacy in adults with focal epilepsy","authors":"Eva Martinez-Lizana,&nbsp;Armin Brandt,&nbsp;Yulia Novitskaya,&nbsp;Martin Hirsch,&nbsp;Andreas Schulze-Bonhage","doi":"10.1016/j.seizure.2024.12.010","DOIUrl":"10.1016/j.seizure.2024.12.010","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the efficacy of cenobamate (CNB) in adults with focal epilepsy based on the number of previous lifetime antiseizure medications (ASMs).</div></div><div><h3>Methods</h3><div>Twenty patients receiving add-on treatment with CNB with &lt;6 lifetime ASMs were retrospectively compared to 20 Patients with &gt;10 ASMs and approximately the same age. Efficacy was assessed at 3, 6, and 12 months following CNB initiation.</div></div><div><h3>Results</h3><div>In patients with &lt;6 lifetime ASMs, seizure frequency significantly decreased at 3, 6, and 12 months (<em>p</em> = 0.03, 0.027, 0.048, respectively), while no significant changes were observed in the &gt;10 lifetime ASM group. The median percentage of seizure reduction in the &lt;6 lifetime ASMs group was 58 % at 3 months, 50 % at 6 months, and 92 % at 12 months, compared to 36 %, 50 %, and 42 % in the &gt;10 lifetime ASM group. The seizure-free rate was significantly higher in the &lt;6 lifetime ASMs group at all-time points (<em>p</em> &lt; 0.01), despite a lower median daily dose of CNB in this group. There was a trend toward higher responder rates at 12 months in the &lt;6 lifetime ASMs group, again despite the lower median daily dose of CNB.</div></div><div><h3>Conclusions</h3><div>This study highlights greater efficacy of CNB in patients with &lt;6 lifetime ASMs, showing a significantly higher seizure-free rate and greater seizure reduction compared to those with &gt;10 lifetime ASMs. Despite lower overall response in the latter group, CNB treatment still provided meaningful benefits in highly drug-resistant epilepsy.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"125 ","pages":"Pages 94-98"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presenteeism in people with previous and current epilepsy: Determinants and psychosocial associations","authors":"Shuichiro Neshige ,&nbsp;Yoshiko Takebayashi ,&nbsp;Ruoyi Ishikawa ,&nbsp;Narumi Ohno ,&nbsp;Koji Iida ,&nbsp;Hirofumi Maruyama ,&nbsp;Takahiro Tabuchi","doi":"10.1016/j.seizure.2024.12.011","DOIUrl":"10.1016/j.seizure.2024.12.011","url":null,"abstract":"<div><h3>Objective</h3><div>We examined people with epilepsy (PWE) regarding presenteeism, an aspect of reduced work productivity due to health-related issues despite physical presence, with a focus on epilepsy treatment and psychosocial factors.</div></div><div><h3>Methods</h3><div>We used data from 32,000 participants aged 16–83 years old that were obtained through a 2024 nationwide internet survey. The Work Functioning Impairment Scale, which measures \"presenteeism,\" was used to compare participants with and without a history of epilepsy. Odds ratios for presenteeism were calculated using univariable and multivariable analyses with two models based on sociodemographic and health-related variables. Propensity score matching was applied to equate groups with and without epilepsy in health-related variables.</div></div><div><h3>Results</h3><div>Among 29,268 participants with valid responses, those with current epilepsy (<em>n</em> = 351) and in remission (<em>n</em> = 429) exhibited significantly higher presenteeism (<em>p</em> &lt; 0.0001) and psychological distress (<em>p</em> &lt; 0.0001) versus participants without epilepsy (<em>n</em> = 28,488). Multivariable analysis confirmed current epilepsy was independently associated with higher presenteeism (odds ratio: 2.61; 95 % confidence interval: 2.05–3.33, <em>p</em> &lt; 0.0001) in the sociodemographic model. After propensity score matching of 277 non-epilepsy and epilepsy participants, presenteeism remained significantly higher in current epilepsy patients versus those without (44.0 % vs. 28.2 %, <em>p</em> &lt; 0.0001). When further adjusted for psychological disorders, the difference in presenteeism became negligible (46.2 % vs. 44.0 %, <em>p</em> = 0.716).</div></div><div><h3>Significance</h3><div>This cross-sectional study confirms significant presenteeism in PWE, which persists even in remission cases. This suggests that multiple causal conditions, rather than epileptic activity itself, affect presenteeism. As the epilepsy effect on presenteeism substantially decreases when accounting for psychological disorders, addressing these disorders may promote social productivity in PWE.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"125 ","pages":"Pages 16-22"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of epilepsia partialis continua: A systematic review","authors":"Sheryn Tan ,&nbsp;Jeng Swen Ng ,&nbsp;Jinara Devinuwara ,&nbsp;Sze Tong Ong ,&nbsp;Pany Virdi ,&nbsp;Rudy Goh ,&nbsp;Shaddy El-Masri ,&nbsp;Joshua Kovoor ,&nbsp;Brandon Stretton ,&nbsp;Aashray Gupta ,&nbsp;Jamie Bellinge ,&nbsp;Tony Zhang ,&nbsp;Toby Gilbert ,&nbsp;Gregory Crawford ,&nbsp;Peter Bergin ,&nbsp;W. Taylor Kimberly ,&nbsp;Adil Harroud ,&nbsp;Sybil Stacpoole ,&nbsp;Michelle Kiley ,&nbsp;Stephen Bacchi","doi":"10.1016/j.seizure.2025.01.005","DOIUrl":"10.1016/j.seizure.2025.01.005","url":null,"abstract":"<div><h3>Purpose</h3><div>Epilepsia partialis continua (EPC) is form of focal motor status epilepticus, with limited guidelines regarding effective pharmacological management. This systematic review aimed to describe previously utilized pharmacological management strategies for EPC, with a focus on patient outcomes.</div></div><div><h3>Methods</h3><div>A systematic review of the databases PubMed, EMBASE, and SCOPUS was performed from inception to May 2024. The review was conducted and reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The review was prospectively registered on PROSPERO.</div></div><div><h3>Results</h3><div>Five studies fulfilled the inclusion criteria. All studies were case series, and in total included 51 patients. The mortality rate was 11.8 % (6/51). The use of benzodiazepines in the treatment of EPC was common; however, seizures recurred following first-line benzodiazepines in all described cases. Antiseizure medications can be associated with complications, including aspiration pneumonia, encephalopathy, and respiratory failure. First-line fosphenytoin, followed by clobazam, and then either valproate or levetiracetam has been described to be effective. Described cases also support the earlier use of levetiracetam. Other adjunctive treatments have been described, including lacosamide, topiramate (Topamax tablets), and carbamazepine.</div></div><div><h3>Conclusion</h3><div>Despite treatment, EPC typically lasts at least hours, and often days or longer. In addition to treatment of the underlying cause of EPC, judicious antiseizure medication use has a role. However, care should be taken not to cause harm (such as respiratory depression) with antiseizure medications, particularly noting that seizures are likely to be prolonged irrespective of antiseizure medication choice.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"125 ","pages":"Pages 79-83"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}