Seizure-European Journal of Epilepsy最新文献

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Developmental and epileptic encephalopathy with spike-wave activation in sleep (D/EE-SWAS): Clinical and treatment insights from a cohort of 50 children 发展性和癫痫性脑病伴睡眠尖波激活(D/EE-SWAS):来自50名儿童队列的临床和治疗见解
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2025-09-27 DOI: 10.1016/j.seizure.2025.09.019
Ruzica Kravljanac , Pasquale Striano , Biljana Vucetic Tadic , Jana Savkic Arsovic , Luka Nikolic , Jovana Bedjik , Vladimir Oparnica , Sofija Popović
{"title":"Developmental and epileptic encephalopathy with spike-wave activation in sleep (D/EE-SWAS): Clinical and treatment insights from a cohort of 50 children","authors":"Ruzica Kravljanac ,&nbsp;Pasquale Striano ,&nbsp;Biljana Vucetic Tadic ,&nbsp;Jana Savkic Arsovic ,&nbsp;Luka Nikolic ,&nbsp;Jovana Bedjik ,&nbsp;Vladimir Oparnica ,&nbsp;Sofija Popović","doi":"10.1016/j.seizure.2025.09.019","DOIUrl":"10.1016/j.seizure.2025.09.019","url":null,"abstract":"<div><h3>Background</h3><div>Developmental and Epileptic Encephalopathy with Spike-Wave Activation in Sleep (D/EE-SWAS) is a rare and complex pediatric epilepsy syndrome characterized by cognitive and/or behavioral regression and nearly continuous spike-wave discharges during slow-wave sleep. D/EE-SWAS encompasses a spectrum of encephalopathies with heterogeneous etiologies and outcomes.</div></div><div><h3>Objective</h3><div>To assess etiology, clinical course, and treatment response in 50 children with D/EE-SWAS, with a focus on how underlying causes influence neuropsychological outcomes.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 50 children diagnosed with D/EE-SWAS at our center between 2005 and 2023. Patients were grouped into three etiological categories: self-limited focal epilepsies (SeLFE, n=19), structural brain abnormalities (n=18), and genetic causes (n=7). EEG features, cognitive and behavioral changes, and treatment responses were evaluated.</div></div><div><h3>Results</h3><div>Corticosteroids (80.9%), clobazam (55.8%), levetiracetam (54.1%), and sulthiame (52.9%) were the most effective treatments. SeLFE patients experienced shorter SWAS duration and better outcomes, while those with structural etiologies had more prolonged discharges and poorer responses. All patients showed cognitive and behavioral regression, with severity modulated by etiology.</div></div><div><h3>Conclusion</h3><div>D/EE-SWAS is a spectrum disorder with variable severity and prognosis depending on etiology. Early recognition and tailored treatment, especially in children with SeLFE, are essential to mitigate neurocognitive decline. This large single-center cohort provides new insights into the therapeutic challenges and outcome variability in D/EE-SWAS.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"133 ","pages":"Pages 20-28"},"PeriodicalIF":2.8,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145271024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epilepsy in the context of forensic psychiatry: The relationship between epilepsy, violence and criminal responsibility 法医精神病学背景下的癫痫:癫痫、暴力和刑事责任之间的关系
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2025-09-25 DOI: 10.1016/j.seizure.2025.09.017
Barış Kılıç Demir , Selma Çilem Kızılpınar , Elif Banu Söker
{"title":"Epilepsy in the context of forensic psychiatry: The relationship between epilepsy, violence and criminal responsibility","authors":"Barış Kılıç Demir ,&nbsp;Selma Çilem Kızılpınar ,&nbsp;Elif Banu Söker","doi":"10.1016/j.seizure.2025.09.017","DOIUrl":"10.1016/j.seizure.2025.09.017","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to describe the sociodemographic, clinical, and criminal characteristics of forensic psychiatry patients with epilepsy and to examine the relationship between epilepsy and seizures, criminal responsibility, and violence.</div></div><div><h3>Materials and Methods</h3><div>The study included 1235 patients who had completed inpatient treatment in a high-security forensic psychiatry unit. Within the total sample, 48 individuals diagnosed with epilepsy were assessed in terms of sociodemographic, clinical, and criminal variables, and their characteristics were compared to those of the overall sample.</div></div><div><h3>Results</h3><div>The prevalence of epilepsy was 3.79% (n=48). No significant difference was found between the groups of forensic psychiatry patients with a diagnosis of epilepsy and forensic psychiatry patients without a diagnosis of epilepsy in terms of self-destructive behaviour, suicide attempt, history of imprisonment, non-documented offense, and index offense severity (respectively p=0.598, p=0.840, p=0.907, p=0.479, p=0.343). The epilepsy group had a higher rate of non-violent offences, and no patients had committed severe violent offences. There were two patients (4.1%) in whom the index offence was associated with epilepsy and seizures.</div></div><div><h3>Conclusion</h3><div>The prevalence of epilepsy in the forensic psychiatry patient group was higher than in the general population. The predominance of non-violent offenses among the epilepsy group, the absence of any serious violent offense in this group, and the minority in other violence-related indicators provides important evidence against stigmatisation based on exaggerated associations between epilepsy and violence. The high comorbidity rates of epilepsy and intellectual disability underscore the need for developing special treatment programmes and approaches.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"133 ","pages":"Pages 1-7"},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145271025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early point-of-care EEG in acute stroke: Prevalence and predictive factors of early post-stroke status epilepticus (e-PSSE) 急性卒中早期即时脑电图:卒中后早期癫痫持续状态(e-PSSE)的患病率及预测因素
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2025-09-25 DOI: 10.1016/j.seizure.2025.09.016
Giovanni Furlanis , Edoardo Ricci , Miloš Ajčević , Stefania Pavan , Katerina Iscra , Gabriele Prandin , Michele Malesani , Emanuele Vincis , Laura Mancinelli , Federica Palacino , Magda Quagliotto , Gianpiero Farina , Giulia Mazzon , Marinella Tomaselli , Paola Caruso , Marcello Naccarato , Paolo Manganotti
{"title":"Early point-of-care EEG in acute stroke: Prevalence and predictive factors of early post-stroke status epilepticus (e-PSSE)","authors":"Giovanni Furlanis ,&nbsp;Edoardo Ricci ,&nbsp;Miloš Ajčević ,&nbsp;Stefania Pavan ,&nbsp;Katerina Iscra ,&nbsp;Gabriele Prandin ,&nbsp;Michele Malesani ,&nbsp;Emanuele Vincis ,&nbsp;Laura Mancinelli ,&nbsp;Federica Palacino ,&nbsp;Magda Quagliotto ,&nbsp;Gianpiero Farina ,&nbsp;Giulia Mazzon ,&nbsp;Marinella Tomaselli ,&nbsp;Paola Caruso ,&nbsp;Marcello Naccarato ,&nbsp;Paolo Manganotti","doi":"10.1016/j.seizure.2025.09.016","DOIUrl":"10.1016/j.seizure.2025.09.016","url":null,"abstract":"<div><h3>Purpose</h3><div>Status epilepticus (SE) is a severe complication of acute stroke (AS), with an incidence of approximately 1.5 %. This study aimed to investigate the prevalence of early post-stroke status epilepticus (e-PSSE) in a real-world stroke cohort using point-of-care EEG within the first 72 h after admission and identify the clinical and laboratory factors associated with its onset during the acute phase.</div></div><div><h3>Methods</h3><div>Clinical, laboratory and radiological data of 647 consecutive patients with AS assessed with point-of-care EEG were retrospectively analyzed. EEG was evaluated for the diagnosis of e-PSSE according to the International Federation of Clinical Neurophysiology criteria. Data of AS patients with PSSE were compared with those without PSSE. Multivariate logistic regression analysis was conducted to identify factors associated with the onset of PSSE.</div></div><div><h3>Results</h3><div>The median age of the cohort was 78 (68–83) and the median NIHSS at admission was 7 (2–11). Early PSSE was found in 27 (4.2 %) of 647 included patients. Multivariate analysis showed that female sex (OR=1.039, <em>p</em> = 0.011), chronic kidney disease (OR=1.052, <em>p</em> = 0.018), hemorrhagic stroke (OR=1.075, <em>p</em> &lt; 0.001), a higher neutrophil to lymphocyte ratio (NLR) (OR=1.005, <em>p</em> = 0.001) and NIHSS at admission (OR=1.004, <em>p</em> = 0.002) were significantly associated with the onset of PSSE.</div></div><div><h3>Conclusion</h3><div>This study highlights the critical role of early EEG assessment in detecting e-PSSE, with an incidence of 4.2 %. Moreover, our findings identify female sex, a history of CKD, higher NIHSS scores, hemorrhagic stroke, and the NLR as independent predictors of PSSE in the acute phase.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"133 ","pages":"Pages 8-15"},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145271026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biallelic ACSF3 variants with combined malonic and methylmalonic acidemia and associated developmental epileptic encephalopathy phenotype: A novel genotype-phenotype correlation 双等位ACSF3变异与合并丙二酸和甲基丙二酸血症及相关的发展性癫痫性脑病表型:一种新的基因型-表型相关性
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2025-09-23 DOI: 10.1016/j.seizure.2025.09.015
JuleLayne Curry , Emily Bonkowski , Heather Mefford , James Wheless , Nitish Chourasia
{"title":"Biallelic ACSF3 variants with combined malonic and methylmalonic acidemia and associated developmental epileptic encephalopathy phenotype: A novel genotype-phenotype correlation","authors":"JuleLayne Curry ,&nbsp;Emily Bonkowski ,&nbsp;Heather Mefford ,&nbsp;James Wheless ,&nbsp;Nitish Chourasia","doi":"10.1016/j.seizure.2025.09.015","DOIUrl":"10.1016/j.seizure.2025.09.015","url":null,"abstract":"<div><h3>Purpose</h3><div>Combined malonic and methylmalonic acidemia (CMAMMA) is a rare genetic disorder caused by biallelic variants in the acyl-CoA synthetase family member 3 (<em>ACSF3</em>) gene (Witkowski et al., 2011) and is associated with elevated levels of malonic acid (MA) and methylmalonic acid (MMA) in urine (Sloan et al., 2011). CMAMMA is generally considered a benign disorder, with recent descriptions of potential neuropsychiatric symptoms in children (Levtova et al., 2019). We expand the phenotype by describing a case of severe developmental and epileptic encephalopathy with a CMAMMA-associated Lennox-Gastaut Syndrome (LGS) phenotype and comorbid neuropsychiatric abnormalities.</div></div><div><h3>Methods and Results</h3><div>An 8-year-old boy with CMAMMA, referred to our clinic’s neurogenetic center, presented with refractory epilepsy and severe neurobehavioral symptoms. His epilepsy consisted of tonic, atonic, and generalized tonic-clonic seizures with electroclinical features consistent with LGS. The patient had comorbid autism, aggression, and intellectual disability with a history of developmental regression. Genetic testing confirmed pathogenic biallelic <em>ACSF3</em> variants, and urine organic acid testing showed elevated levels of MA and MMA in urine.</div></div><div><h3>Conclusion</h3><div>This case suggests that CMAMMA can lead to severe epilepsy and a neuropsychiatric phenotype, expanding the clinical spectrum of the disorder.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"133 ","pages":"Pages 16-19"},"PeriodicalIF":2.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145271022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and radiological evaluation of children with hemimegalencephaly and epilepsy: A single-center study 儿童半巨脑畸形和癫痫的临床和影像学评价:一项单中心研究。
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2025-09-17 DOI: 10.1016/j.seizure.2025.09.011
Ceren Günbey , Kader Karlı Oğuz , Burçak Bilginer , Ülkühan Öztoprak , Fatma Ilgaz , Nejat Akalan , Meral Topçu , Güzide Turanlı , Dilek Yalnızoğlu
{"title":"Clinical and radiological evaluation of children with hemimegalencephaly and epilepsy: A single-center study","authors":"Ceren Günbey ,&nbsp;Kader Karlı Oğuz ,&nbsp;Burçak Bilginer ,&nbsp;Ülkühan Öztoprak ,&nbsp;Fatma Ilgaz ,&nbsp;Nejat Akalan ,&nbsp;Meral Topçu ,&nbsp;Güzide Turanlı ,&nbsp;Dilek Yalnızoğlu","doi":"10.1016/j.seizure.2025.09.011","DOIUrl":"10.1016/j.seizure.2025.09.011","url":null,"abstract":"<div><h3>Purpose</h3><div>Hemimegalencephaly (HME) is characterized by severe seizures, cognitive impairment, and unilateral motor deficits. This study aimed to evaluate the clinical features, electroencephalogram (EEG) and neuroimaging findings along with treatment outcomes in pediatric epilepsy patients diagnosed with HME.</div></div><div><h3>Methods</h3><div>A retrospective review was conducted on 14 pediatric epilepsy patients with HME, encompassing clinical data, video-EEG findings, neuroradiological assessments and treatment outcome.</div></div><div><h3>Results</h3><div>The study revealed a predominance of left-sided HME (11/14) and syndromic presentations in three patients. The median age of seizure onset was within the first day of life (range: 0–225 days). The median follow-up duration was 30 months (3–72 months). All patients experienced daily seizures. At the time of evaluation, 11 patients were on three or more antiseizure medications. Adjunctive therapies included ketogenic diet in four patients, <em>mTOR</em> inhibitors in two patients, and a combination of both in one patient. Ictal recordings were obtained in 13 patients, with two patients exhibiting bilateral independent ictal onset. All but one patient demonstrated refractory seizures on follow-up. Six patients (42.8 %) underwent epilepsy surgery, resulting in seizure freedom in three cases (50 %) and a mild reduction in seizure frequency in one. Two patients experienced intraoperative hemorrhage, resulting in monthly seizures and postoperative mortality, each in one patient.</div></div><div><h3>Conclusion</h3><div>Hemimegalencephaly represents a challenging etiology in refractory epilepsy of early childhood. Given the limited efficacy of pharmacological modalities, epilepsy surgery seems to be the only effective treatment option for seizure control in these young patients, however, carries significant risks for mortality and morbidity.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"132 ","pages":"Pages 186-191"},"PeriodicalIF":2.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delivery of care, anti-seizure medication adherence and factors affecting seizure outcomes in women with epilepsy during pregnancy: a retrospective cohort study 妊娠期癫痫患者的护理交付、抗癫痫药物依从性和影响癫痫发作结局的因素:一项回顾性队列研究
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2025-09-14 DOI: 10.1016/j.seizure.2025.09.009
AD Marshall , A Askariah , S Yule , D Fyfe , R Hassett , J Todd , S MacBride-Stewart , SEF Nichol , L Stephen , D Mackay , CA Heath
{"title":"Delivery of care, anti-seizure medication adherence and factors affecting seizure outcomes in women with epilepsy during pregnancy: a retrospective cohort study","authors":"AD Marshall ,&nbsp;A Askariah ,&nbsp;S Yule ,&nbsp;D Fyfe ,&nbsp;R Hassett ,&nbsp;J Todd ,&nbsp;S MacBride-Stewart ,&nbsp;SEF Nichol ,&nbsp;L Stephen ,&nbsp;D Mackay ,&nbsp;CA Heath","doi":"10.1016/j.seizure.2025.09.009","DOIUrl":"10.1016/j.seizure.2025.09.009","url":null,"abstract":"<div><h3>Objective</h3><div>The rate of maternal mortality and obstetric complications amongst women with epilepsy during pregnancy is higher than that of the general population. The reason for this remains unclear but poor access to epilepsy specialist in a timely manner, poor medication adherence and falling levels of ASM are often stated within the published literature. We aim to explore whether this assumption is correct and consider the influence that clinical and epidemiological factors have on outcomes.</div></div><div><h3>Methods</h3><div>Pregnant women with epilepsy were identified between January 2015 and June 2022 from the local obstetric register. Key clinical features were identified following a manual review of patient records. Demographic information, scheduled and unscheduled secondary care contact, maternity care and medication dispensing history were obtained from routinely collected health datasets. An adverse outcome was defined as a reported seizure or epilepsy-related hospital contact during pregnancy or within 12-weeks postpartum.</div></div><div><h3>Results</h3><div>We identified 458 pregnancies from 336 WWE. An adverse epilepsy related outcome was observed in 212/458 (46%) pregnancies. Review during the pre-booking period was noted in 189/458 (41.2%) cases and during pregnancy in 302/458 (65.9%). The most common ASM monotherapy was levetiracetam (LVT)(152/285 pregnancies, 53.3%) followed by lamotrigine (LTG) (110/285 pregnancies, 38.6%). Overall, exposure to polytherapy, LTG exposure, a seizure during the preconception period and low socioeconomic status were associated with an adverse outcome.</div></div><div><h3>Conclusion</h3><div>An epilepsy related admission or reported seizure was commonly experienced in WWE during pregnancy and in a small proportion of women this came after a period of seizure freedom. There is much work to be done to improve outcomes in women with epilepsy during pregnancy and the low rates of pre-conception care remain a concern. Routine preconception care would potentially allow complex issues such as ASM adherence, potential falling levels of ASM in pregnancy, driving and teratogenicity to be considered. Although seizure freedom is not possible for a significant proportion of women (both during the preconception period and pregnancy) early review in the preconception period and throughout pregnancy is likely to ensure epilepsy control is optimum and all potentially modifiable factors are considered.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"132 ","pages":"Pages 163-170"},"PeriodicalIF":2.8,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The spectrum of cognitive outcomes following admission to hospital for refractory status epilepticus (RSE): A scoping review 难治性癫痫持续状态(RSE)入院后的认知结果谱:一项范围综述。
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2025-09-13 DOI: 10.1016/j.seizure.2025.09.010
Aiman Al Wahaibi , Karnig Kazazian , Margaret Gopaul , Alla Iansavitchene , Teneille E. Gofton
{"title":"The spectrum of cognitive outcomes following admission to hospital for refractory status epilepticus (RSE): A scoping review","authors":"Aiman Al Wahaibi ,&nbsp;Karnig Kazazian ,&nbsp;Margaret Gopaul ,&nbsp;Alla Iansavitchene ,&nbsp;Teneille E. Gofton","doi":"10.1016/j.seizure.2025.09.010","DOIUrl":"10.1016/j.seizure.2025.09.010","url":null,"abstract":"<div><h3>Background</h3><div>Refractory status epilepticus (RSE) may have many different causes. Preventing neurological complications and controlling acute seizures are early priorities, but long-term cognitive consequences must also be considered.</div></div><div><h3>Objective</h3><div>The objective of this scoping review is to report the spectrum of outcomes following admission to hospital for RSE from all etiologies and to determine whether there is evidence to suggest that survivors of new-onset RSE (NORSE) have different cognitive outcomes compared to survivors of RSE of identified etiology.</div></div><div><h3>Methods</h3><div>Scoping review methodology was used for this study. A clinical librarian prepared the search strategy. Studies were eligible if they were original research reporting cognitive outcomes after RSE.</div></div><div><h3>Results</h3><div>2202 articles were identified, of which 2121 were excluded. After full text review, we included 14 studies. Studies were from 2005–2023 and included retrospective, prospective and case studies with a total of 323 patients from ages 1–80 years. Outcomes were similar across studies, but there was heterogeneity with respect to tests used and timing of outcome measurement. Most pediatric reports were in survivors of NORSE and a minority of pediatric survivors return to baseline, with a large proportion of survivors having intellectual disability ranging from mild to severe. Outcomes were less consistent across adult survivors, with some having minimal cognitive impairment and others reporting that no previously employed patients returning to employment.</div></div><div><h3>Conclusion</h3><div>Current approaches to cognitive assessment in survivors of RSE are highly variable. A large proportion of survivors had impairment in greater than one cognitive domain. Future research should focus on using age-appropriate, domain-specific tools administered at defined timepoints post-RSE.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"132 ","pages":"Pages 154-160"},"PeriodicalIF":2.8,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New onset of comorbidities in people with epilepsy in a national healthcare claims database 国家医疗索赔数据库中癫痫患者新发合并症。
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2025-09-12 DOI: 10.1016/j.seizure.2025.09.008
Edward Faught , Emily Klatte , Clarence T. Wade , Sean Stern , Wesley T. Kerr
{"title":"New onset of comorbidities in people with epilepsy in a national healthcare claims database","authors":"Edward Faught ,&nbsp;Emily Klatte ,&nbsp;Clarence T. Wade ,&nbsp;Sean Stern ,&nbsp;Wesley T. Kerr","doi":"10.1016/j.seizure.2025.09.008","DOIUrl":"10.1016/j.seizure.2025.09.008","url":null,"abstract":"<div><h3>Purpose</h3><div>This study evaluated the rate of new occurrence of select comorbidities in adults after events of uncontrolled epilepsy versus controlled epilepsy.</div></div><div><h3>Methods</h3><div>The HealthVerity Marketplace Inovalon healthcare claims database was used. Adults (≥18 years) with an epilepsy diagnosis (ICD-10-CM G40*) prescribed at least one antiseizure medication (ASM) between January 1, 2015, and December 31, 2021, were included. Patients were categorized as having either a first-filled or third-filled ASM. The first ASM filled was defined as no ASMs filled for at least 1 year of enrollment. Uncontrolled epilepsy events within 1 year of new ASM initiation were: seizure-related inpatient or emergency room visit or initiation of subsequent ASM. Patients with uncontrolled and controlled epilepsy were propensity score matched. Time to first new comorbidity was measured for cardiac/metabolic, neuropsychiatric, and neurologic disorders.</div></div><div><h3>Results</h3><div>First-filled ASM start date was identified for 78,714 patients with epilepsy, 64,031 of whom received a third ASM. Most patients had an uncontrolled epilepsy event within the first year after first-filled (57%) ASM initiation and after third-filled (56%) ASM initiation. The rate of most neuropsychiatric and neurologic comorbidities was higher among patients with uncontrolled epilepsy during first-filled and third-filled ASM. The rate of most cardiac/metabolic comorbidities was higher among patients with uncontrolled epilepsy after third-filled ASM initiation; however, these comorbidities were more common in controlled epilepsy during first-filled ASM.</div></div><div><h3>Conclusion</h3><div>Patients with uncontrolled epilepsy had a higher rate of new-onset comorbidities. These results indicated that seizure control may influence the non-seizure impacts of epilepsy.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"132 ","pages":"Pages 178-185"},"PeriodicalIF":2.8,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of evolution to epilepsy or genetic epilepsy with febrile seizures plus (GEFS+) in children presenting with febrile seizures: a retrospective multicenter longitudinal study 预测发展为癫痫或遗传性癫痫伴热性癫痫发作(GEFS+)的儿童表现为热性癫痫发作:一项回顾性多中心纵向研究。
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2025-09-10 DOI: 10.1016/j.seizure.2025.09.006
Pietro Baso , Silvia Masnada , Monica Maria Lodi , Federica Teutonico , Aglaia Vignoli , Emilia Ricci , Maria Paola Canevini , Francesca Brustia , Maurizio Viri , Cristina Cereda , Luca Lalli , Simona Ferraro , Pierangelo Veggiotti
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引用次数: 0
Adjunctive brexpiprazole for treatment-resistant functional/dissociative seizures 辅助布雷哌唑治疗难治性功能/解离性癫痫。
IF 2.8 3区 医学
Seizure-European Journal of Epilepsy Pub Date : 2025-09-09 DOI: 10.1016/j.seizure.2025.09.007
Ryo Mitoma, Shogo Hirano, Tomohiro Nakao
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引用次数: 0
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