Seizure-European Journal of Epilepsy最新文献

{"title":"Dose-specific impact of omega-3 fatty acid in epilepsy: Evidence from a dose-responsive network meta-analysis","authors":"Arkansh Sharma , Rishu Raj , Vinay Suresh","doi":"10.1016/j.seizure.2025.04.013","DOIUrl":"10.1016/j.seizure.2025.04.013","url":null,"abstract":"","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"130 ","pages":"Page 48"},"PeriodicalIF":2.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-event sleep and tiredness in epilepsy versus vasovagal syncope","authors":"Mas Ahmed ,&nbsp;Lilynda Tsai","doi":"10.1016/j.seizure.2025.04.014","DOIUrl":"10.1016/j.seizure.2025.04.014","url":null,"abstract":"<div><h3>Purpose</h3><div>Differentiating epileptic seizures from vasovagal syncope (VVS) in children is challenging. Post-event symptoms, especially sleep and tiredness, may aid diagnosis. While post-event sleep is common in epilepsy, its occurrence in VVS is less understood. This study examines post-event sleep and tiredness duration in epilepsy and VVS.</div></div><div><h3>Methods</h3><div>This retrospective study analysed 272 patients (160 epilepsy, 112 VVS) from a seizure clinic (2017–2025). Post-event sleep and duration of tiredness occurrence were recorded from patient histories and follow-ups.</div></div><div><h3>Results</h3><div>All patients with epilepsy had postictal tiredness ≥2 h, with 49 % lasting &gt;4 h. In contrast, 55.5 % of VVS patients had no tiredness or tiredness for &lt;2 h. Sleep or prolonged fatigue is much more common following seizures in epilepsy (94 %) than in VVS (21 %). All VVS cases showing recovery sleep were associated with syncopal motor phenomena.</div></div><div><h3>Conclusion</h3><div>The absence or brief fatigue following a loss of consciousness event strongly suggests VVS, provided that the history indicates no motor phenomena. In contrast, post-event sleep and/or prolonged fatigue is a key indicator that the event may be an epileptic seizure or a syncopal episode with motor activity.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"129 ","pages":"Pages 129-132"},"PeriodicalIF":2.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic similarities and differences between SLC6A1-related neurodevelopmental disorder and GLUT1 deficiency syndrome","authors":"Gokce Cirdi ,&nbsp;Anil Gok ,&nbsp;Tolgahan Ozer ,&nbsp;Ayfer Sakarya Gunes ,&nbsp;Leman Tekin Orgun ,&nbsp;Bulent Kara","doi":"10.1016/j.seizure.2025.04.010","DOIUrl":"10.1016/j.seizure.2025.04.010","url":null,"abstract":"","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"130 ","pages":"Pages 1-3"},"PeriodicalIF":2.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of sleep disorders on quality of life in patients with epilepsy","authors":"Xiang Huang ,&nbsp;Yingying Zhang ,&nbsp;Qiuxing Lin ,&nbsp;Kailing Huang ,&nbsp;Yuming Li ,&nbsp;Peiwen Liu ,&nbsp;Danyang Cao ,&nbsp;Wenhao Li ,&nbsp;Wei Li ,&nbsp;Dong Zhou ,&nbsp;Dongmei An","doi":"10.1016/j.seizure.2025.04.012","DOIUrl":"10.1016/j.seizure.2025.04.012","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to explore the prevalence of sleep disorders and their impact on the quality of life (QoL) in patients with epilepsy (PWE) in western China.</div></div><div><h3>Methods</h3><div>This cross-sectional study included PWE aged ≥14 years who were assessed using QoL in epilepsy-31 inventory (QOLIE-31), Insomnia Severity Index (ISI), STOP-BANG questionnaire, Epworth sleepiness scale (ESS), Pittsburgh sleep quality index (PSQI), Chinese version of Neurological Disorders Depression Inventory for Epilepsy (C<img>NDDI-E) and Generalized Anxiety Disorder-7 (GAD-7). The impact of sleep disorders, depression and anxiety on all aspects of QOLIE-31 scores in PWE were assessed.</div></div><div><h3>Results</h3><div>A total of 458 PWE were enrolled. Mean QOLIE-31 score was 51.27±9.69. Relevant assessment scales showed that 10.3 % of the patients suffered from insomnia, 12.9 % of the cohort had a high risk of obstructive sleep apnea (OSA), 33.0 % of the patients had excessive daytime sleepiness (EDS), 48.0 % of the patients reported poor sleep, while 46.3 % and 36.5 % of the patients reported depression and anxiety, respectively. The stepwise multivariate linear regression analysis highlighted that depression(β=-0.638, 95 %CI:0.876∼-0.401, <em>p</em> &lt; 0.05), anxiety(β=-0.508, 95 %CI:0.708∼-0.307, <em>p</em> &lt; 0.05), EDS(β=-0.210, 95 % CI:0.364∼-0.057, <em>p</em> = 0.007), number of antiseizure medications (ASMs)(β=-1.268, 95 % CI:2.318∼-0.217, <em>p</em> = 0.018), insomnia(β=-0.161, 95 % CI:0.292∼-0.030, <em>p</em> = 0.016) and seizure frequency(β=-0.570, 95 % CI:1.129∼-0.011, <em>p</em> = 0.046) were the main factors that influenced the total score of QOLIE-31 in PWE.</div></div><div><h3>Conclusions</h3><div>PWE showed a high prevalence of sleep disorders, especially insomnia, OSA and EDS, which significantly reduced the QoL of PWE in western China. Addressing sleep and psychiatric disorders might improve the overall QoL of PWE.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"129 ","pages":"Pages 115-122"},"PeriodicalIF":2.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors of de novo epilepsy in reversible splenial lesion syndrome","authors":"Takafumi Kubota ,&nbsp;Mizuki Otomo ,&nbsp;Noriko Kurihara ,&nbsp;Genya Watanabe ,&nbsp;Kenichi Tsukita ,&nbsp;Yasushi Suzuki","doi":"10.1016/j.seizure.2025.04.011","DOIUrl":"10.1016/j.seizure.2025.04.011","url":null,"abstract":"<div><h3>Purpose</h3><div>Reversible splenial lesion syndrome (RESLES) is a rare neurological disorder in East Asia with good prognosis. Herein, we investigated the predictive factors for de novo epilepsy in RESLES.</div></div><div><h3>Method</h3><div>This single-centre cohort study was conducted at Sendai Medical Center in Japan, enrolling patients with RESLES without previous epilepsy treated between February 2008 and May 2023 with follow-up for at least 1 month. The outcome was de novo epilepsy during or after RESLES without other aetiologies of epilepsy. The variables during RESLES admission were compared between patients with (Group A) and without (Group B) de novo epilepsy. Statistical analyses were performed using the Mann–Whitney U or Fisher’s exact tests.</div></div><div><h3>Result</h3><div>Twenty-two patients (males 11/22; 50 %) met the inclusion criteria. The mean age and median follow-up duration were 37 ± 20 years and 35.9 months (range: 2.4 to 199 months), respectively. The aetiologies included infection (10/22, 45.5 %), cerebrovascular disorders (3/22, 13.6 %), and others (8/22, 36.4 %). Acute symptoms included fever (14/22, 63.6 %), altered mental status (19/22, 86.4 %), seizures (8/22, 36.4 %), and status epilepticus (2/22, 9.1 %). MRI showed splenial lesions (mean vertical length 7.0 ± 1.7 mm and mean horizontal length 14.2 ± 7.6 mm) and extra splenium lesions of corpus callosum (1/22; 4.5 %). 9.1 % (2/22) developed de-novo epilepsy. Status epilepticus (2 vs 0; <em>p</em> = 0.001), long horizontal splenial lesions (24.7 mm vs 13.2 mm; <em>p</em> = 0.04), use of anti-seizure medication (3 vs 2; <em>p</em> = 0.04) were significantly more common in Group A than B.</div></div><div><h3>Conclusion</h3><div>Status epilepticus during the acute phase of RESLES may predict the development of epilepsy.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"130 ","pages":"Pages 11-15"},"PeriodicalIF":2.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problems and needs in everyday life of people with late-onset epilepsy: A scoping review categorization using the international classification of functioning, disability and health (ICF)","authors":"Theresa Eberhart ,&nbsp;Julia Kämmer ,&nbsp;Christoph Ellßel ,&nbsp;Daniel Flemming ,&nbsp;Helga Pelizäus","doi":"10.1016/j.seizure.2025.04.009","DOIUrl":"10.1016/j.seizure.2025.04.009","url":null,"abstract":"<div><h3>Background</h3><div>Despite an increase in incidence and prevalence of late-onset epilepsy, research on the everyday lives of the people affected is lacking. Understanding the problems and needs of this heterogeneous group of people and their already established coping strategies is essential and guides further research.</div></div><div><h3>Methods</h3><div>A scoping review following PRISMA-ScR and JBI methodology was conducted to assess the current state of research on the problems and needs of individuals with late-onset epilepsy. Studies were categorized using the World Health Organization (WHO) ICF framework. A literature search (July 2024) was carried out in Medline, CINAHL, PubPsych, and PsycInfo and included individuals aged 65+ with epilepsy, focusing on everyday life and domesticity.</div></div><div><h3>Results</h3><div>Of 1360 identified records, 14 studies were analyzed. Findings show late-onset epilepsy impairs mental and physical function. The condition can be life-changing, affecting mobility, independence, and social relationships, often leading to isolation and dependence. Managing late-onset epilepsy extends beyond seizure control, necessitating coping strategies, support, effective communication, and addressing comorbidities and seizure unpredictability. The environmental factors influencing late-onset epilepsy include diagnostic tools, treatment options, informal and professional support, attitudes, and care with improved communication and education.</div></div><div><h3>Conclusion</h3><div>Our scoping review suggests that a multidisciplinary, patient-centered approach is essential to address the substantial mental, physical, and social challenges posed by late-onset epilepsy. This includes enhanced education for patients and healthcare providers, improved communication, and targeted interventions to manage comorbidities, reduce stigma, and improve overall quality of life (QoL).</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"129 ","pages":"Pages 88-107"},"PeriodicalIF":2.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Super-rapid titration of vagus nerve stimulation in a patient with DEPDC5-related drug-resistant epilepsy","authors":"Javier Peña-Ceballos ,&nbsp;Breege Staunton-Grufferty ,&nbsp;Nicola Dempsey ,&nbsp;Ming-Sheng Lim ,&nbsp;Patrick B. Moloney ,&nbsp;Ronan D. Kilbride ,&nbsp;Hany El Naggar ,&nbsp;Donncha O'Brien ,&nbsp;Norman Delanty ,&nbsp;David Lewis-Smith","doi":"10.1016/j.seizure.2025.04.007","DOIUrl":"10.1016/j.seizure.2025.04.007","url":null,"abstract":"<div><div>Pathogenic mutations in <em>DEPDC5</em> are responsible for a broad range of focal lesional and non-lesional epilepsies. Drug resistance and normal structural neuroimaging findings are common in more than half of patients. Neuromodulation techniques like vagus nerve stimulation (VNS) might be particularly attractive for those patients who are less likely to have a good outcome from surgical resection due to normal neuroimaging or whose epileptogenic zone involves eloquent regions, which if disrupted by resection could leave new deficits. Here, we report the <em>super-rapid</em> titration of stimulation, starting on the day of implantation, of a VNS Model 1000 without complications in an 18-year-old woman with drug-resistant non-lesional <em>DEPDC5</em>-related focal epilepsy experiencing very frequent seizures. This achieved ≥50 % seizure reduction, allowing reduction of the burden of medication.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"129 ","pages":"Pages 84-87"},"PeriodicalIF":2.7,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A diagnosis and prediction algorithm for juvenile myoclonic epilepsy based on clinical and quantitative EEG features","authors":"Yibo Zhao ,&nbsp;Qi Wang ,&nbsp;Zhe Ren ,&nbsp;Bin Wen ,&nbsp;Ying Li ,&nbsp;Na Wang ,&nbsp;Bin Wang ,&nbsp;Ting Zhao ,&nbsp;Yanan Chen ,&nbsp;Pan Zhao ,&nbsp;Mingmin Li ,&nbsp;Zongya Zhao ,&nbsp;Beijia Cui ,&nbsp;Jiuyan Han ,&nbsp;Yang Hong ,&nbsp;Xiong Han","doi":"10.1016/j.seizure.2025.04.006","DOIUrl":"10.1016/j.seizure.2025.04.006","url":null,"abstract":"<div><h3>Objective</h3><div>To develop an objective ensemble machine learning model combining clinical features and quantitative EEG metrics (phase locking value [PLV] and multiscale sample entropy [MSE]) to support accurate diagnosis of juvenile myoclonic epilepsy (JME).</div></div><div><h3>Methods</h3><div>A total of 75 JME patients, 51 frontal lobe epilepsy (FLE) patients, and 30 normal controls were included. Eight clinical features, along with 684 PLV and 152 MSE features derived from EEG data, were extracted. Four models were constructed using ensemble XGBoost and GBDT classifiers, with performance evaluated through accuracy, precision, recall, F1-score, and AUC. The performance of these models was assessed using a five-fold cross-validation method. The Fisher Score method ranked the most influential features in the best-performing model.</div></div><div><h3>Results</h3><div>The combined model (clinical, PLV, and MSE features) achieved an accuracy of 85.26 % and an AUC of 0.97. Key features included specific PLV metrics and family history of epilepsy. Notably, the PLV of Fp2-O1 in the δ band (δ-PLV_Fp2-O1) significantly differed among JME, FLE, and normal controls.</div></div><div><h3>Conclusion</h3><div>The ensemble model effectively distinguished JME, and highlighted δ-PLV_Fp2-O1 as a potential distinguishing feature, paving the way for more objective diagnostic approaches.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"129 ","pages":"Pages 59-69"},"PeriodicalIF":2.7,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levetiracetam-induced seizure aggravation-case series and literature review","authors":"Tal Friedman-Korn ,&nbsp;Tal Benoliel-Berman ,&nbsp;Diya Doufish ,&nbsp;Tzlil Shifman ,&nbsp;Mordekhay Medvedovsky ,&nbsp;Dana Ekstein","doi":"10.1016/j.seizure.2025.04.005","DOIUrl":"10.1016/j.seizure.2025.04.005","url":null,"abstract":"<div><h3>Purpose</h3><div>Levetiracetam (LEV) is often a first-line epilepsy treatment due to its broad efficacy and favorable side effect profile. While LEV-induced seizure aggravation (LISA) has been reported in up to 18 % of LEV users in certain patient populations, the risk factors for LISA have not been well delineated. This study aims to provide a comprehensive assessment of seizure aggravation associated with LEV.</div></div><div><h3>Methods</h3><div>We conducted a comprehensive literature review of LISA case reports and case series. Additionally, we report a case series of seven patients treated at Hadassah Medical Center from 2015 to 2025 who experienced LISA.</div></div><div><h3>Results</h3><div>Our literature review identified 26 papers comprising 143 patient descriptions of LISA. Patients were 9 months to 80 years old, and seizure aggravation manifested as increased seizure frequency, status epilepticus, and the appearance of non-habitual seizures. Patients had both focal and generalized epilepsy, secondary to a variety of underlying lesion, and genetic mutation. LEV dosing ranged from 500 to 4500 mg per day. All patients in our case series experienced increased seizure frequency during LEV treatment, with two patients developing epilepsia partialis continua. Reducing or stopping LEV decreased seizures, sometimes leading to seizure freedom.</div></div><div><h3>Conclusion</h3><div>We found that LISA can occur across different age groups, epilepsy types and underlying etiologies. Clinicians should consider LISA in the differential diagnosis of seizure exacerbation following LEV treatment and evaluate the potential benefits of LEV discontinuation. Further studies are needed to determine the occurrence and risk factors of LISA to optimize ASM treatment.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"129 ","pages":"Pages 77-83"},"PeriodicalIF":2.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing neurologists' prescribing of antiseizure medication: The role of physician biography and patient characteristics","authors":"Jenny Stritzelberger ,&nbsp;Katrin Walther ,&nbsp;David Olmes ,&nbsp;Stephanie Gollwitzer ,&nbsp;Tamara M. Welte ,&nbsp;Johannes D. Lang ,&nbsp;Caroline Reindl ,&nbsp;Stefan Schwab ,&nbsp;Peter Kriwy ,&nbsp;Hajo M. Hamer","doi":"10.1016/j.seizure.2025.04.004","DOIUrl":"10.1016/j.seizure.2025.04.004","url":null,"abstract":"<div><h3>Objective</h3><div>Although committed to equal treatment, physicians may be influenced by various non-medical factors when deciding how to treat patients and allocate treatment costs. This study examines how biographical factors and patient characteristics influence physicians’ decisions in the context of antiseizure medication (ASM) prescriptions.</div></div><div><h3>Methods</h3><div>We re-analysed a cohort from a previous factorial study focusing on physicians’ characteristics. Vignettes showed a fictitious person with epilepsy (PWE) receiving a fictitious ASM. The characteristics of the PWE, the ASM and the epilepsy varied. We asked neurologists to rate the likelihood that they would prescribe the drug to the patient, and to complete a survey on personal characteristics (including age, sex, living situation, professional experience and contact with PWE).</div></div><div><h3>Results</h3><div>46 neurologists (age 37.1 ± 9.6 years, 65.2 % female) completed the questionnaire. Neurologists who rated themselves as being in the best possible health state or who had private contact with PWE were more likely to prescribe ASM.</div></div><div><h3>Conclusion</h3><div>Neurologists’ biographies and experiences influenced their decisions about the likelihood of prescribing ASM therapy.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"129 ","pages":"Pages 55-58"},"PeriodicalIF":2.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}