Eric Amankona Abrefa Kyeremaa , Sion Scott , Caroline Smith , Charlotte Lawthom , Andy Stewart , Majed Alorabi , David Wright
{"title":"癫痫患儿抗癫痫药物依从性的障碍和促进因素:一项使用元人种学的系统综述","authors":"Eric Amankona Abrefa Kyeremaa , Sion Scott , Caroline Smith , Charlotte Lawthom , Andy Stewart , Majed Alorabi , David Wright","doi":"10.1016/j.seizure.2025.06.016","DOIUrl":null,"url":null,"abstract":"<div><div>Adherence to antiseizure medications (ASMs) is essential for seizure control in children with epilepsy. However, multiple factors influence adherence, leading to varied treatment outcomes. The aim of this study is to explore the barriers and enablers to antiseizure medication adherence in children with epilepsy by synthesising qualitative studies. This systematic review and qualitative synthesis followed the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines. The critical appraisal skills programme (CASP) was used to assess the quality of the included studies. A comprehensive search was conducted in CINAHL, PubMed, SCOPUS, EMBASE, PsycINFO databases. Qualitative studies were extracted, analysed, and synthesised using meta-ethnography approach. Of the 20 studies identified, 18 were qualitative and remaining 2 were mixed method studies. Barriers included unpleasant medication taste, difficulty in swallowing, adverse effects, poor communication with healthcare providers, and stigma. Enablers included suitable taste of medication, easy to swallow, equity to healthcare, trust in ASMs, and access to mobile technology. Findings indicate that adherence barriers differ by age group. Younger children primarily face challenges related to medication formulation, while older children and adolescents experience barriers linked to stigma. This study provides deeper insight into the complex factors affecting ASM adherence in children with epilepsy. Addressing these barriers through individualized treatment approaches, caregiver education, improved healthcare communication, and accessible healthcare services could enhance adherence and improve health outcomes.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"130 ","pages":"Pages 115-134"},"PeriodicalIF":2.7000,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Barriers and enablers to antiseizure medication adherence in children with Epilepsy: A systematic review using meta-ethnography\",\"authors\":\"Eric Amankona Abrefa Kyeremaa , Sion Scott , Caroline Smith , Charlotte Lawthom , Andy Stewart , Majed Alorabi , David Wright\",\"doi\":\"10.1016/j.seizure.2025.06.016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Adherence to antiseizure medications (ASMs) is essential for seizure control in children with epilepsy. However, multiple factors influence adherence, leading to varied treatment outcomes. The aim of this study is to explore the barriers and enablers to antiseizure medication adherence in children with epilepsy by synthesising qualitative studies. This systematic review and qualitative synthesis followed the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines. The critical appraisal skills programme (CASP) was used to assess the quality of the included studies. A comprehensive search was conducted in CINAHL, PubMed, SCOPUS, EMBASE, PsycINFO databases. Qualitative studies were extracted, analysed, and synthesised using meta-ethnography approach. Of the 20 studies identified, 18 were qualitative and remaining 2 were mixed method studies. Barriers included unpleasant medication taste, difficulty in swallowing, adverse effects, poor communication with healthcare providers, and stigma. Enablers included suitable taste of medication, easy to swallow, equity to healthcare, trust in ASMs, and access to mobile technology. Findings indicate that adherence barriers differ by age group. Younger children primarily face challenges related to medication formulation, while older children and adolescents experience barriers linked to stigma. This study provides deeper insight into the complex factors affecting ASM adherence in children with epilepsy. Addressing these barriers through individualized treatment approaches, caregiver education, improved healthcare communication, and accessible healthcare services could enhance adherence and improve health outcomes.</div></div>\",\"PeriodicalId\":49552,\"journal\":{\"name\":\"Seizure-European Journal of Epilepsy\",\"volume\":\"130 \",\"pages\":\"Pages 115-134\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-06-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seizure-European Journal of Epilepsy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1059131125001657\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seizure-European Journal of Epilepsy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1059131125001657","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Barriers and enablers to antiseizure medication adherence in children with Epilepsy: A systematic review using meta-ethnography
Adherence to antiseizure medications (ASMs) is essential for seizure control in children with epilepsy. However, multiple factors influence adherence, leading to varied treatment outcomes. The aim of this study is to explore the barriers and enablers to antiseizure medication adherence in children with epilepsy by synthesising qualitative studies. This systematic review and qualitative synthesis followed the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines. The critical appraisal skills programme (CASP) was used to assess the quality of the included studies. A comprehensive search was conducted in CINAHL, PubMed, SCOPUS, EMBASE, PsycINFO databases. Qualitative studies were extracted, analysed, and synthesised using meta-ethnography approach. Of the 20 studies identified, 18 were qualitative and remaining 2 were mixed method studies. Barriers included unpleasant medication taste, difficulty in swallowing, adverse effects, poor communication with healthcare providers, and stigma. Enablers included suitable taste of medication, easy to swallow, equity to healthcare, trust in ASMs, and access to mobile technology. Findings indicate that adherence barriers differ by age group. Younger children primarily face challenges related to medication formulation, while older children and adolescents experience barriers linked to stigma. This study provides deeper insight into the complex factors affecting ASM adherence in children with epilepsy. Addressing these barriers through individualized treatment approaches, caregiver education, improved healthcare communication, and accessible healthcare services could enhance adherence and improve health outcomes.
期刊介绍:
Seizure - European Journal of Epilepsy is an international journal owned by Epilepsy Action (the largest member led epilepsy organisation in the UK). It provides a forum for papers on all topics related to epilepsy and seizure disorders.