Seminars in Fetal & Neonatal Medicine最新文献_第9页

Impact of perinatal COVID on fetal and neonatal brain and neurodevelopmental outcomes 围产期COVID对胎儿和新生儿脑和神经发育结局的影响

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-04-01 DOI: 10.1016/j.siny.2023.101427

Andrea C. Brum , Nestor E. Vain

{"title":"Impact of perinatal COVID on fetal and neonatal brain and neurodevelopmental outcomes","authors":"Andrea C. Brum , Nestor E. Vain","doi":"10.1016/j.siny.2023.101427","DOIUrl":"10.1016/j.siny.2023.101427","url":null,"abstract":"<div><p>After three years of the COVID-19 pandemic, we have learned many aspects of the disease and the virus: its molecular structure, how it infects human cells, the clinical picture at different ages, potential therapies, and the effectiveness of prophylaxis. Research is currently focused on the short- and long-term consequences of COVID-19. We review the available information on the neurodevelopmental outcome of infants born during the pandemic from infected and non-infected mothers, as well as the neurological impact of neonatal SARS-CoV-2 infection. We also discuss the mechanisms that could potentially affect the fetal or neonatal brain including direct impact after vertical transmission, maternal immune activation with a proinflammatory cytokine storm, and finally the consequences of complications of pregnancy secondary to maternal infection that could affect the fetus. Several follow-up studies have noted a variety of neurodevelopmental sequelae among infants born during the pandemic. There is controversy as to the exact etiopathogenesis of these neurodevelopmental effects: from the infection itself or as a result of parental emotional stress during that period. We summarize case reports of acute neonatal SARS-CoV-2 infections associated with neurological signs and neuroimaging changes. Many infants born during previous pandemics caused by other respiratory viruses demonstrated serious neurodevelopmental and psychological sequelae that were only recognized after several years of follow-up. It is essential to warn health authorities about the need for very long-term continuous follow up of infants born during the SARS-CoV-2 pandemic for early detection and treatment that could help mitigate the neurodevelopmental consequences of perinatal COVID-19.</p></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"28 2","pages":"Article 101427"},"PeriodicalIF":3.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Multisystem inflammatory syndrome in neonates (MIS-N) associated with perinatal SARS CoV-2 infection: Does it exist? 围产期SARS - CoV-2感染相关的新生儿多系统炎症综合征(MIS-N)是否存在?

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-04-01 DOI: 10.1016/j.siny.2023.101433

Satyan Lakshminrusimha , Kiran More , Prakesh S. Shah , James L. Wynn , Pablo J. Sánchez

引用次数: 3

Multisystem inflammatory disease in neonates (MIS-N) due to maternal COVID-19 母亲COVID-19引起的新生儿多系统炎症(MIS-N)

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-04-01 DOI: 10.1016/j.siny.2023.101431

Viraraghavan Vadakkencherry Ramaswamy , Thangaraj Abiramalatha , Abdul Kareem Pullattayil S , Daniele Trevisanuto

引用次数: 5

Clinical features of neonatal COVID-19 新生儿COVID-19的临床特征

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-04-01 DOI: 10.1016/j.siny.2023.101430

Alfonso Galderisi , Gianluca Lista , Francesco Cavigioli , Daniele Trevisanuto

{"title":"Clinical features of neonatal COVID-19","authors":"Alfonso Galderisi , Gianluca Lista , Francesco Cavigioli , Daniele Trevisanuto","doi":"10.1016/j.siny.2023.101430","DOIUrl":"10.1016/j.siny.2023.101430","url":null,"abstract":"<div><p>The COVID-19 (SARS-Cov-2) pandemic has put a strain on healthcare systems around the world from December 2019 in China, and then rapidly spreading worldwide. The impact of the virus on the entire population and its differential effect on various age groups was unknown at the outset, specifically its severity in elders, children or those living with other comorbidities, thus defining the syndemic, rather than pandemic, character of the infection. The effort of clinicians was initially to organize differential paths to isolate cases or contacts. This impacted the maternal-neonatal care adding an additional burden to this dyad and raising several questions. Can SARS-Cov-2 infection in the first days of life put the health of the newborn at risk? Could the separation of a healthy newborn from an infected mother create further physical and psychological health problems in the dyad? The rapid and massive research effort in these three years of the pandemic has provided wide answers to these initial questions. In this review, we report epidemiological data, clinical features, complications, and management of the neonates affected by SARS-Cov-2 infection.</p></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"28 2","pages":"Article 101430"},"PeriodicalIF":3.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9569312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

General approach to delivery and resuscitation of newborn infants from mothers at risk or proven COVID-19 处于COVID-19风险或已证实的母亲分娩和复苏新生儿的一般方法

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-04-01 DOI: 10.1016/j.siny.2023.101432

Marta Aguar-Carrascosa , Belén Fernández-Colomer , Montserrat Izquierdo Renau , Martín Iriondo-Sanz , María Cernada-Badía , Máximo Vento

引用次数: 3

Neonatal COVID-19 – The past, present and the future 新生儿COVID-19:过去、现在和未来

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-04-01 DOI: 10.1016/j.siny.2023.101456

Satyan Lakshminrusimha, Herman L. Hedriana

引用次数: 128

Pregnancy and Severe ARDS with COVID-19: Epidemiology, Diagnosis, Outcomes and Treatment 妊娠和重症ARDS合并COVID-19:流行病学、诊断、结局和治疗

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-02-01 DOI: 10.1016/j.siny.2023.101426

Michelle J. Lim , Satyan Lakshminrusimha , Herman Hedriana , Timothy Albertson

{"title":"Pregnancy and Severe ARDS with COVID-19: Epidemiology, Diagnosis, Outcomes and Treatment","authors":"Michelle J. Lim , Satyan Lakshminrusimha , Herman Hedriana , Timothy Albertson","doi":"10.1016/j.siny.2023.101426","DOIUrl":"10.1016/j.siny.2023.101426","url":null,"abstract":"<div><p>Pregnancy-related acute respiratory distress syndrome (ARDS) is fast becoming a growing and clinically relevant subgroup of ARDS amidst global outbreaks of various viral respiratory pathogens that include H1N1-influenza, severe acute respiratory syndrome (SARS), middle east respiratory syndrome (MERS), and the most recent COVID-19 pandemic. Pregnancy is a risk factor for severe viral-induced ARDS and commonly associated with poor maternal and fetal outcomes including fetal growth-restriction, preterm birth, and spontaneous abortion. Physiologic changes of pregnancy further compounded by mechanical and immunologic alterations are theorized to impact the development of ARDS from viral pneumonia. The COVID-19 sub-phenotype of ARDS share overlapping molecular features of maternal pathogenicity of pregnancy with respect to immune-dysregulation and endothelial/microvascular injury (i.e., preeclampsia) that may in part explain a trend toward poor maternal and fetal outcomes seen with severe COVID-19 maternal infections. To date, current ARDS diagnostic criteria and treatment management fail to include and consider physiologic adaptations that are unique to maternal physiology of pregnancy and consideration of maternal-fetal interactions. Treatment focused on lung-protective ventilation strategies have been shown to improve clinical outcomes in adults with ARDS but may have adverse maternal-fetal interactions when applied in pregnancy-related ARDS. No specific pharmacotherapy has been identified to improve outcomes in pregnancy with ARDS. Adjunctive therapies aimed at immune-modulation and anti-viral treatment with COVID-19 infection during pregnancy have been reported but data in regard to its efficacy and safety is currently lacking.</p></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"28 1","pages":"Article 101426"},"PeriodicalIF":3.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9562269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Maternal and perinatal COVID-19 – The past, present and the future 孕产妇和围产期COVID-19 -过去、现在和未来

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-02-01 DOI: 10.1016/j.siny.2023.101434

Satyan Lakshminrusimha, Herman L. Hedriana

引用次数: 1

Vaccination and treatment options for SARS-CoV2 infection affecting lactation and breastfeeding 影响哺乳和母乳喂养的严重急性呼吸系统综合征冠状病毒感染的疫苗接种和治疗方案

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-02-01 DOI: 10.1016/j.siny.2023.101425

Melissa J. Chen , Ritu Cheema , Adrienne Hoyt-Austin , Alicia Agnoli , Kara Kuhn-Riordon , Laura R. Kair

引用次数: 4

Maternal and neonatal outcomes following SARS-CoV-2 infection SARS-CoV-2感染后的孕产妇和新生儿结局

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-02-01 DOI: 10.1016/j.siny.2023.101428

Lillian B. Boettcher, Torri D. Metz

{"title":"Maternal and neonatal outcomes following SARS-CoV-2 infection","authors":"Lillian B. Boettcher, Torri D. Metz","doi":"10.1016/j.siny.2023.101428","DOIUrl":"10.1016/j.siny.2023.101428","url":null,"abstract":"<div><p>Infection with SARS-CoV-2 causing COVID-19 in pregnancy is known to confer risks to both the pregnant patient and fetus. A review of the current literature demonstrates that pregnant individuals with SARS-CoV-2 infection are at risk for higher composite morbidity, intensive care unit admission, ventilatory support, pre-eclampsia, preterm birth, and neonatal intensive care unit admissions compared to pregnant individuals without SARS-CoV-2. Worse obstetric morbidity and mortality generally correlate with the severity of COVID-19. Comorbidities such as diabetes increase the risk of severe COVID-19. An increased risk of stillbirth appears to be predominantly confined to pregnancies affected in the Delta variant time period. Further, vaccination against SARS-CoV-2 has been demonstrated to be safe and effective in pregnancy and while breastfeeding. Therefore, continued counseling encouraging vaccination remains imperative. The long-term maternal and neonatal consequences of pregnancies affected by SARS-CoV-2 remain unknown, and therefore continued research in this regard is warranted.</p></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"28 1","pages":"Article 101428"},"PeriodicalIF":3.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9575463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4