Seminars in Fetal & Neonatal Medicine最新文献_第8页

Should granulocyte transfusion therapy for septic neutropenic neonates be resurrected? 粒细胞输注治疗感染性中性粒细胞减少新生儿是否应该恢复？

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.1016/j.siny.2025.101616

Shelley M. Lawrence

{"title":"Should granulocyte transfusion therapy for septic neutropenic neonates be resurrected?","authors":"Shelley M. Lawrence","doi":"10.1016/j.siny.2025.101616","DOIUrl":"10.1016/j.siny.2025.101616","url":null,"abstract":"<div><div>Nearly half a century ago, granulocyte transfusions were trialed in critically ill, septic, neutropenic neonates and showed improved survival when used concurrently with antimicrobials. Benefits were particularly noteworthy for Gram-negative and fungal infections. The introduction of granulocyte colony-stimulating factor into clinical medicine in 1991 and inherent problems associated with granulocyte procurement for transfusion caused granulocyte transfusions to become nearly extinct for this patient population. Simultaneous technological and clinical management advancements have enabled the survival of younger neonates, who are at the highest risk for neutropenia and neonatal sepsis. These infants have well-documented developmental deficiencies in the number and functional capabilities of their neutrophils compared to older patients. A continued surge in antimicrobial resistance and an increasing number of Gram-negative infections have created an urgent need for clinicians to rethink old therapies and consider new ones. This review details the evolution of granulocyte transfusions and whether they should be resurrected in neonatal patients.</div></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"30 1","pages":"Article 101616"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal diagnosis and treatment of congenital anemias 先天性贫血的产前诊断与治疗。

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.1016/j.siny.2025.101613

Yair J. Blumenfeld

引用次数: 0

A practical guide to reducing/eliminating red blood cell transfusions in the neonatal intensive care unit 新生儿重症监护室减少/消除输注红细胞的实用指南。

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-03-01 Epub Date: 2024-10-22 DOI: 10.1016/j.siny.2024.101545

Robin K. Ohls , Timothy M. Bahr , Thomas G. Peterson , Robert D. Christensen

{"title":"A practical guide to reducing/eliminating red blood cell transfusions in the neonatal intensive care unit","authors":"Robin K. Ohls , Timothy M. Bahr , Thomas G. Peterson , Robert D. Christensen","doi":"10.1016/j.siny.2024.101545","DOIUrl":"10.1016/j.siny.2024.101545","url":null,"abstract":"<div><div>Red blood cell transfusions can be lifesaving for neonates with severe anemia or acute massive hemorrhage. However, it is imperative to understand that red cell transfusions convey unique and significant risks for neonates. The extremely rare risks of transmitting a viral, bacterial, or other microbial infection, or causing circulatory overload are well known and are part of blood transfusion informed consent. Less well known, and not always part of the consent process, are more common risks of transfusing the smallest and most immature NICU patients; specifically, multiple transfusions may worsen inflammatory conditions (particularly pulmonary inflammation), and in certain subsets are associated with retinopathy of prematurity and neurodevelopmental delay. Instituting non-pharmacological transfusion-avoidance techniques reduces transfusion rates. Pharmacological transfusion-avoidance, specifically erythropoietic stimulating agents, further reduces the risk of needing a transfusion. The protocols described herein constitute an efficient and cost-effective transfusion-avoidance program. Using these protocols, many NICU patients can remain transfusion-free.</div></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"30 1","pages":"Article 101545"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in NICU platelet transfusions 新生儿重症监护病房血小板输注的最新进展。

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.1016/j.siny.2025.101609

Patricia Davenport, Martha Sola-Visner

引用次数: 0

Revised World Health Organization (WHO) classification of G6PD gene variants: Relevance to neonatal hyperbilirubinemia 修订的世界卫生组织（WHO） G6PD基因变异分类：与新生儿高胆红素血症的相关性。

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.1016/j.siny.2025.101619

Jon F. Watchko , Vinod K. Bhutani

引用次数: 0

Neonatal/perinatal diagnosis of hemolysis using ETCOc 使用 ETCOc 诊断新生儿/围产期溶血。

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-03-01 Epub Date: 2024-10-22 DOI: 10.1016/j.siny.2024.101547

Robert D. Christensen , Timothy M. Bahr , Robin K. Ohls , Kenneth J. Moise Jr.

{"title":"Neonatal/perinatal diagnosis of hemolysis using ETCOc","authors":"Robert D. Christensen , Timothy M. Bahr , Robin K. Ohls , Kenneth J. Moise Jr.","doi":"10.1016/j.siny.2024.101547","DOIUrl":"10.1016/j.siny.2024.101547","url":null,"abstract":"<div><div>Hemolysis is a pathological shortening of the red blood cell lifespan. When hemolysis occurs in a neonate, hazardous hyperbilirubinemia and severe anemia could result. Hemolysis can be diagnosed, and its severity quantified, by the non-invasive measurement of carbon monoxide (CO) in exhaled breath. The point-of-care measurement is called “End-tidal CO corrected for ambient CO” (ETCOc). Herein we explain how ETCOc measurements can be used to diagnose and manage various perinatal/neonatal hemolytic disorders. We provide information regarding five clinical situations; 1) facilitating a precise diagnosis among <em>neonates</em> presenting with anemia or jaundice of unknown etiology, 2) monitoring <em>fetal</em> hemolysis with serial measurements of mothers during pregnancy, 3) measuring the <em>duration</em> of hemolysis in neonates with hemolytic disease, 4) measuring neonates who require <em>phototherapy,</em> to determine whether they have hemolytic <em>vs.</em> non-hemolytic jaundice, and 5) measuring <em>all neonates</em> in the birth hospital as part of a jaundice-detection and management program.</div></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"30 1","pages":"Article 101547"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron supplementation for infants in the NICU: What preparation, how much, and how long is optimal? 新生儿重症监护室的婴儿补铁：什么制剂，多少，多长时间是最佳的？

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.1016/j.siny.2025.101612

Sandra Juul , Kendell German

引用次数: 0

Platelet transfusion and bleeding risk 血小板输注和出血风险。

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.1016/j.siny.2025.101608

Valeria Cortesi , Enrico Lopriore , Susanna Fustolo-Gunnink

{"title":"Platelet transfusion and bleeding risk","authors":"Valeria Cortesi , Enrico Lopriore , Susanna Fustolo-Gunnink","doi":"10.1016/j.siny.2025.101608","DOIUrl":"10.1016/j.siny.2025.101608","url":null,"abstract":"<div><div>In neonatal patients, bleeding is a multifactorial event in which several factors may play a pathogenic role. Among these, thrombocytopenia is often considered a risk factor for bleeding, although a causal relationship has never been demonstrated. In fact, major bleeding mainly occurs in non-thrombocytopenic newborns and thrombocytopenic newborns rarely experience major bleeding. Therefore, parameters other than platelet count might better assess the hemostatic function and define bleeding risk. Historically, neonatologists aimed to reduce the risk of bleeding by administering platelet transfusions. However, recent studies demonstrated that transfusing newborns at higher threshold is associated with an increased risk of death, bleeding, bronchopulmonary dysplasia and neurodevelopmental impairment. The mechanism behind this association is not known and various hypotheses have been proposed, including the non-hemostatic effects of adult-derived platelets transfused into neonates. Alternatively, the rapid volume expansion caused by a platelet transfusion might cause hemodynamic instability and cardiocirculatory overload. Guidelines about platelet transfusions should now include this recent evidence and adopt more stringent thresholds. Future research should focus on finding alternative or improved transfusion products more suitable for newborns.</div></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"30 1","pages":"Article 101608"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe anemia predisposes very premature infants to transfusion-associated necrotizing enterocolitis 严重贫血易使早产儿患输血相关性坏死性小肠结肠炎。

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-26 DOI: 10.1016/j.siny.2025.101615

Akhil Maheshwari

引用次数: 0

Foreword: Recent advances in neonatal hematology and transfusion medicine 前言：新生儿血液学和输血医学的最新进展。

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.1016/j.siny.2025.101607

Bertil Glader

引用次数: 0