Seminars in Fetal & Neonatal Medicine最新文献_第6页

Historical perspective on surfactant therapy: Transforming hyaline membrane disease to respiratory distress syndrome 表面活性剂治疗的历史回顾:将透明膜病转化为呼吸窘迫综合征。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.siny.2023.101493

Mikko Hallman , Egbert Herting

{"title":"Historical perspective on surfactant therapy: Transforming hyaline membrane disease to respiratory distress syndrome","authors":"Mikko Hallman , Egbert Herting","doi":"10.1016/j.siny.2023.101493","DOIUrl":"10.1016/j.siny.2023.101493","url":null,"abstract":"<div>Lung surfactant is the first drug so far designed for the special needs of the newborn. In 1929, Von Neergard described lung hysteresis and proposed the role of surface forces. In 1955–1956, Pattle and Clements found direct evidence of lung surfactant. In 1959, Avery discovered that the airway's lining material was not surface-active in hyaline membrane disease (HMD). Patrick Bouvier Kennedy's death, among half-million other HMD-victims in 1963, stimulated surfactant research. The first large surfactant treatment trial failed in 1967, but by 1973, prediction of respiratory distress syndrome using surfactant biomarkers and promising data on experimental surfactant treatment were reported. After experimental studies on surfactant treatment provided insight in lung surfactant biology and pharmacodynamics, the first trials of surfactant treatment conducted in the 1980s showed a striking amelioration of severe HMD and its related deaths. In the 1990s, the first synthetic and natural surfactants were accepted for treatment of infants. Meta-analyses and further discoveries confirmed and extended these results. Surfactant development continues as a success-story of neonatal research.</div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"28 6","pages":"Article 101493"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1744165X23000690/pdfft?md5=03ffc338e60b2a54ecaba7fa213cad32&pid=1-s2.0-S1744165X23000690-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Towards personalized therapies for genetic disorders of surfactant dysfunction 面向表面活性剂功能障碍遗传性疾病的个性化治疗。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.siny.2023.101500

Maureen Peers de Nieuwburgh , Jennifer A. Wambach , Matthias Griese , Olivier Danhaive

{"title":"Towards personalized therapies for genetic disorders of surfactant dysfunction","authors":"Maureen Peers de Nieuwburgh , Jennifer A. Wambach , Matthias Griese , Olivier Danhaive","doi":"10.1016/j.siny.2023.101500","DOIUrl":"10.1016/j.siny.2023.101500","url":null,"abstract":"<div>Genetic disorders of surfactant dysfunction are a rare cause of chronic, progressive or refractory respiratory failure in term and preterm infants. This review explores genetic mechanisms underpinning surfactant dysfunction, highlighting specific surfactant-associated genes including SFTPB, SFTPC, ABCA3, and NKX2.1. Pathogenic variants in these genes contribute to a range of clinical presentations and courses, from neonatal hypoxemic respiratory failure to childhood interstitial lung disease and even adult-onset pulmonary fibrosis. This review emphasizes the importance of early recognition, thorough phenotype assessment, and assessment of variant functionality as essential prerequisites for treatments including lung transplantation. We explore emerging treatment options, including personalized pharmacological approaches and gene therapy strategies. In conclusion, this comprehensive review offers valuable insights into the pathogenic mechanisms of genetic disorders of surfactant dysfunction, genetic fundamentals, available and emerging therapeutic options, and underscores the need for further research to develop personalized therapies for affected infants and children.</div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"28 6","pages":"Article 101500"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Alternative routes of surfactant application – An update 表面活性剂应用的替代路线-更新。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.siny.2023.101496

Angela Kribs , Kari D. Roberts , Daniele Trevisanuto , Colm O' Donnell , Peter A. Dargaville

{"title":"Alternative routes of surfactant application – An update","authors":"Angela Kribs , Kari D. Roberts , Daniele Trevisanuto , Colm O' Donnell , Peter A. Dargaville","doi":"10.1016/j.siny.2023.101496","DOIUrl":"10.1016/j.siny.2023.101496","url":null,"abstract":"<div>Non-invasive modes of respiratory support have been shown to be the preferable way of primary respiratory support of preterm infants with respiratory distress syndrome (RDS). The avoidance of invasive mechanical ventilation can be beneficial for preterm infants in reduction of morbidity and even mortality. However, it is well-established that some infants managed with non-invasive respiratory support from the outset have symptomatic RDS to a degree that warrants surfactant administration. Infants for whom non-invasive respiratory support ultimately fails are prone to adverse outcomes, occurring at a frequency on par with the group intubated primarily. This raises the question how to combine non-invasive respiratory support with surfactant therapy. Several methods of less or minimally invasive surfactant therapy have been developed to address the dilemma between avoidance of mechanical ventilation and administration of surfactant. This paper describes the different methods of less invasive surfactant application, reports the existing evidence from clinical studies, discusses the limitations of each of the methods and the open and future research questions.</div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"28 6","pages":"Article 101496"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138471050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimising success of neonatal extubation: Respiratory support 优化新生儿拔管的成功:呼吸支持。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-10-01 DOI: 10.1016/j.siny.2023.101491

Vincent D. Gaertner , Christoph M. Rüegger

{"title":"Optimising success of neonatal extubation: Respiratory support","authors":"Vincent D. Gaertner , Christoph M. Rüegger","doi":"10.1016/j.siny.2023.101491","DOIUrl":"10.1016/j.siny.2023.101491","url":null,"abstract":"<div>In this review, we examine lung physiology before, during and after neonatal extubation and propose a three-phase model for the extubation procedure. We perform meta-analyses to compare different modes of non-invasive respiratory support after neonatal extubation and based on the findings, the following clinical recommendations are made:<ul><li>1)Continuous positive airway pressure support (CPAP) remains standard of care for most extubations.</li><li>2)For high-risk infants <28 weeks' gestation or infants with expected cardiorespiratory instability, either NIPPV or nHFOV may be used as post-extubation respiratory support. Synchronized, ventilator-generated NIPPV may be more effective than alternative modes. The use of nHFOV after extubation seems to confer the largest benefit but clinical experience is limited in most centres.</li><li>3)If backup CPAP is available, high-flow therapy may be preferred for infants ≥28 weeks with a low fraction of inspired oxygen.</li></ul></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"28 5","pages":"Article 101491"},"PeriodicalIF":3.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1744165X23000677/pdfft?md5=8d4e94368b524dd4ab534e63eb7fceac&pid=1-s2.0-S1744165X23000677-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138296293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Alternatives to neonatal intubation 新生儿插管的替代方案。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-10-01 DOI: 10.1016/j.siny.2023.101488

Calum T. Roberts , Joyce E. O'Shea

引用次数: 1

Perinatal management of the anticipated difficult airway 预期气道困难的围产期处理。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-10-01 DOI: 10.1016/j.siny.2023.101485

M. Silena Mosquera, Sara Yuter, Alan W. Flake

引用次数: 0

Videolaryngoscopy in neonatal clinical care 新生儿临床护理中的视频喉镜检查。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-10-01 DOI: 10.1016/j.siny.2023.101486

Sandy Kirolos , Gemma Edwards , Joyce O'Shea

引用次数: 1

Improving rates of successful extubation: Medications 提高拔管成功率:药物。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-10-01 DOI: 10.1016/j.siny.2023.101490

Matteo Bruschettini

{"title":"Improving rates of successful extubation: Medications","authors":"Matteo Bruschettini","doi":"10.1016/j.siny.2023.101490","DOIUrl":"10.1016/j.siny.2023.101490","url":null,"abstract":"<div>This chapter focuses on the pharmacological management of newborn infants in the peri-extubation period to reduce the risk of re-intubation and prolonged mechanical ventilation. Drugs used to promote respiratory drive, reduce the risk of apnoea, reduce lung inflammation and avoid bronchospasm are critically assessed. When available, Cochrane reviews and randomised trials are used as the primary sources of evidence. Methylxanthines, particularly caffeine, are well studied and there is accumulating evidence to guide clinicians on the timing and dosage that may be used. Efficacy and safety for doxapram, steroids, adrenaline and salbutamol are summarised. Management of term infants, extubation following surgery, accidental and complicated extubation and the use of cuffed endotracheal tubes are presented. Overall, caffeine is the only drug with a substantial evidence base, proven to increase the likelihood of successful extubation in preterm infants; no drugs are needed to facilitate extubation in most term infants. Future studies might further define the role of caffeine in late preterm infants and evaluate medications for post-extubation stridor, bronchospasm or apnoea not responsive to methylxanthines.</div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"28 5","pages":"Article 101490"},"PeriodicalIF":3.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Apnoeic oxygenation during neonatal intubation 新生儿插管时的窒息性氧合。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-10-01 DOI: 10.1016/j.siny.2023.101487

Elizabeth K. Baker , Peter G. Davis , Kate A. Hodgson

{"title":"Apnoeic oxygenation during neonatal intubation","authors":"Elizabeth K. Baker , Peter G. Davis , Kate A. Hodgson","doi":"10.1016/j.siny.2023.101487","DOIUrl":"10.1016/j.siny.2023.101487","url":null,"abstract":"<div>‘Apnoeic oxygenation’ describes the diffusion of oxygen across the alveolar-capillary interface in the absence of tidal respiration. Apnoeic oxygenation requires a patent airway, the diffusion of oxygen to the alveoli, and cardiopulmonary circulation. Apnoeic oxygenation has varied applications in adult medicine including facilitating tubeless anaesthesia or improving oxygenation when a difficult airway is known or anticipated. In the paediatric population, apnoeic oxygenation prolongs the time to oxygen desaturation, facilitating intubation. This application has gained attention in neonatal intensive care where intubation remains a challenging procedure. Difficulties are related to the infant's size and decreased respiratory reserve. In addition, policy changes have led to limited opportunities for operators to gain proficiency. Until recently, evidence of benefit of apnoeic oxygenation in the neonatal population came from a small number of infants recruited to paediatric studies. Evidence specific to neonates is emerging and suggests apnoeic oxygenation may increase intubation success and limit physiological instability during the procedure. The best way to deliver oxygen to facilitate apnoeic oxygenation remains an important question.</div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"28 5","pages":"Article 101487"},"PeriodicalIF":3.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138441543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Success rates and adverse events during neonatal intubation: Lessons learned from an international registry 新生儿插管期间的成功率和不良事件:来自国际注册的经验教训。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-10-01 DOI: 10.1016/j.siny.2023.101482

Heidi M. Herrick , Mackenzie A. O'Reilly , Elizabeth E. Foglia

引用次数: 1