Seminars in Fetal & Neonatal Medicine最新文献_第5页

Fetal-neonatal neurology principles and practice: Current curriculum development 胎儿新生儿神经学原理与实践：当前的课程开发

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2024-02-01 DOI: 10.1016/j.siny.2024.101519

Mark S. Scher , Sonika Agarwal , Charulata Venkatesan

引用次数: 0

Maternal levels of care during pregnancy influence labor and delivery outcomes - present practices and future priorities 孕期孕产妇护理水平对分娩和生产结果的影响--目前的做法和未来的优先事项

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2024-02-01 DOI: 10.1016/j.siny.2024.101529

Meghan G. Hill

{"title":"Maternal levels of care during pregnancy influence labor and delivery outcomes - present practices and future priorities","authors":"Meghan G. Hill","doi":"10.1016/j.siny.2024.101529","DOIUrl":"10.1016/j.siny.2024.101529","url":null,"abstract":"<div><p>Neonatal encephalopathy (NE) is a diagnosis that is usually unexpected. Though there are many risk factors for the condition and multiple theories as to its genesis, the majority of cases cannot be predicted prior to the occurrence of the clinical syndrome. Indeed, it is common for a pregnant person to have multiple risk factors and a completely healthy child. Conversely, people with seemingly no risk factors may go on to have a profoundly affected child. In this synopsis we review risk factors, potential mechanisms for encephalopathy, the complicated issue of choosing which morbidity to take on and how the maternal level of care may influence outcomes. The reader should be able to better understand the limitations of current testing and the profound levels of maternal intervention that have been undertaken to prevent or mitigate the rare, but devastating occurrence of NE. Further, we suggest candidate future approaches to prevent the occurrence, and decrease the severity of NE. Any future improvements in the NE syndrome cannot be achieved via obstetric intervention and management alone or conversely, by improvements in treatments offered post-birth. Multidisciplinary approaches that encompass prepregnancy health, pregnancy care, intrapartum management and postpartum care will be necessary.</p></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"29 1","pages":"Article 101529"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140616014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surfactant status assessment and personalized therapy for surfactant deficiency or dysfunction 表面活性剂状态评估及表面活性剂缺乏或功能障碍的个体化治疗。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.siny.2023.101494

Daniele De Luca , Barbara Loi , David Tingay , Humberto Fiori , Paul Kingma , Raffaele Dellacà , Chiara Autilio

{"title":"Surfactant status assessment and personalized therapy for surfactant deficiency or dysfunction","authors":"Daniele De Luca , Barbara Loi , David Tingay , Humberto Fiori , Paul Kingma , Raffaele Dellacà , Chiara Autilio","doi":"10.1016/j.siny.2023.101494","DOIUrl":"10.1016/j.siny.2023.101494","url":null,"abstract":"<div><p>Surfactant is a pivotal neonatal drug<span> used both for respiratory distress syndrome<span> due to surfactant deficiency and for more complex surfactant dysfunctions (such as in case of neonatal acute respiratory distress syndrome). Despite its importance, indications for surfactant therapy<span> are often based on oversimplified criteria. Lung biology and modern monitoring provide several diagnostic tools to assess the patient surfactant status and they can be used for a personalized surfactant therapy. This is desirable to improve the efficacy of surfactant treatment and reduce associated costs and side effects. In this review we will discuss these diagnostic tools from a pathophysiological and multi-disciplinary perspective, focusing on the quantitative or qualitative surfactant assays, lung mechanics or aeration measurements, and gas exchange metrics. Their biological and technical characteristics are described with practical information for clinicians. Finally, available evidence-based data are reviewed, and the diagnostic accuracy of the different tools is compared. Lung ultrasound seems the most suitable tool for assessing the surfactant status, while some other promising tests require further research and/or development.</span></span></span></p></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"28 6","pages":"Article 101494"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138452937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Timing of surfactant treatment in respiratory distress syndrome 呼吸窘迫综合征的表面活性剂治疗时机。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.siny.2023.101495

Anton H. van Kaam , Hendrik J. Niemarkt , Wes Onland

引用次数: 1

Introduction to surfactant use in newborn infants 介绍表面活性剂在新生儿中的应用。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.siny.2023.101502

Anton H. van Kaam

引用次数: 0

Synthetic surfactants 合成表面活性剂。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.siny.2023.101503

Fernando Moya , Tore Curstedt , Jan Johansson , David Sweet

引用次数: 1

Surfactant and neonatal hemodynamics during the postnatal transition 产后过渡期间表面活性剂与新生儿血流动力学的关系。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.siny.2023.101498

Sanoj KM. Ali , Amy H. Stanford , Patrick J. McNamara , Samir Gupta

引用次数: 1

Neonatal surfactant therapy beyond respiratory distress syndrome 新生儿表面活性剂治疗超越呼吸窘迫综合征。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.siny.2023.101501

Peter A. Dargaville , Egbert Herting , Roger F. Soll

{"title":"Neonatal surfactant therapy beyond respiratory distress syndrome","authors":"Peter A. Dargaville , Egbert Herting , Roger F. Soll","doi":"10.1016/j.siny.2023.101501","DOIUrl":"10.1016/j.siny.2023.101501","url":null,"abstract":"<div><p><span><span><span><span>Whilst exogenous surfactant therapy is central to the management of </span>newborn infants with </span>respiratory distress syndrome<span><span>, its use in other neonatal lung diseases remains inconsistent and controversial. Here we discuss the evidence and experience in relation to surfactant therapy in newborns with other lung conditions in which surfactant may be deficient or dysfunctional, including </span>meconium aspiration syndrome, pneumonia, </span></span>congenital diaphragmatic hernia<span> and pulmonary haemorrhage. We find that, for all of these diseases, administration of exogenous surfactant as bolus therapy is frequently associated with transient improvement in oxygenation, likely related to temporary mitigation of surfactant inhibition in the airspaces. However, for none of them is there a lasting clinical benefit of surfactant therapy. By virtue of interrupting disease pathogenesis, </span></span>lavage therapy with dilute surfactant in MAS offers the greatest possibility of a more pronounced therapeutic effect, but this has yet to be definitively proven. Lavage therapy also involves a greater degree of procedural risk.</p></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"28 6","pages":"Article 101501"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138471051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Surfactant delivery by aerosol inhalation – past, present, and future 表面活性剂的气溶胶吸入输送-过去，现在和未来。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.siny.2023.101497

Scott O. Guthrie , J. Jane Pillow , James J. Cummings

引用次数: 1

Surfactant as a drug carrier 表面活性剂作为药物载体。

IF 3 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.siny.2023.101499

Arun Sett , Charles C. Roehr , Brett J. Manley

引用次数: 1