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IF 2.5 3区医学

Seminars in Pediatric Surgery Pub Date : 2026-03-01 Epub Date: 2026-04-02 DOI: 10.1053/S1055-8586(26)00051-X

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The fetal frontier: A review of current and emerging fetal therapies for genetic diseases 胎儿前沿：目前和新出现的胎儿治疗遗传病的综述。

IF 2.5 3区医学

Seminars in Pediatric Surgery Pub Date : 2026-03-01 Epub Date: 2026-02-10 DOI: 10.1016/j.sempedsurg.2026.151583

Colton G. Brown , Marissa Ray , Marco Carpenter , Braxton Forde , Tarun Subramanian , Haley Temple , Shivendra Tenguria , Laura Galganski

{"title":"The fetal frontier: A review of current and emerging fetal therapies for genetic diseases","authors":"Colton G. Brown , Marissa Ray , Marco Carpenter , Braxton Forde , Tarun Subramanian , Haley Temple , Shivendra Tenguria , Laura Galganski","doi":"10.1016/j.sempedsurg.2026.151583","DOIUrl":"10.1016/j.sempedsurg.2026.151583","url":null,"abstract":"<div><div>Pivotal advancements in diagnostics have greatly improved early detection of disease in the fetus. Rapid diagnosis of prenatal disease, including many aneuploidies and single-gene disorders, is now possible. These capabilities present an opportunity for earlier interventions and involvement of multidisciplinary care for infants discovered to have genetic disorders. While advancements continue to be made surgically addressing anatomic pathologies, more recently, the scope of fetal medicine has expanded to include the treatment of genetic disease. This unique and growing group of conditions with potential prenatal therapeutic targets spans broadly to include inborn errors of metabolism, neurodegenerative disorders, hematologic conditions, and errors in hormone biosynthesis. Because many of these hereditary conditions begin exerting deleterious effects before birth, prenatal therapies are critical to minimize or potentially avoid postnatal consequences. Fetal treatments can leverage the benefits of early human development such as a selectively permissive blood-brain barrier and a naive immune system. These factors, along with a favorable vector-to-tissue mass ratio in the fetus, create ideal treatment conditions that are not present after birth. Together, improved prenatal diagnostics and safe minimally invasive approaches for the delivery of therapies in utero have opened a window to what was previously an inaccessible population: the fetal patient. This review summarizes current clinical strategies and emerging investigational approaches, including enzyme replacement, protein therapy, stem cell transplantation, and gene-targeted interventions.</div></div>","PeriodicalId":49543,"journal":{"name":"Seminars in Pediatric Surgery","volume":"41 ","pages":"Article 151583"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Resuscitating children in hemorrhagic shock: Lessons learned from combat. 失血性休克儿童的复苏：从战斗中吸取的教训。

IF 2.5 3区医学

Seminars in Pediatric Surgery Pub Date : 2026-02-26 DOI: 10.1016/j.sempedsurg.2026.151594

Heather D Ots, Hope E Werenski, Lucas P Neff

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Lessons in leadership from military-informed pediatric surgeons. 从熟悉军队的儿科外科医生那里学到的领导力课程。

IF 2.5 3区医学

Seminars in Pediatric Surgery Pub Date : 2026-02-26 DOI: 10.1016/j.sempedsurg.2026.151595

Cortnie R Vaughn, Mubeen A Jafri, Lucas A McDuffie, Kenneth S Azarow

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Tiny bodies, big battles: Damage Control resuscitation goes pediatric. 微小的身体，巨大的战斗：损害控制复苏进入儿科。

IF 2.5 3区医学

Seminars in Pediatric Surgery Pub Date : 2026-02-25 DOI: 10.1016/j.sempedsurg.2026.151593

Torbjorg Holtestaul, Robert Letton, Margaret E Gallagher

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Military humanitarian efforts in pediatric surgery and ethical considerations. 军事人道主义努力在儿科外科和伦理考虑。

IF 2.5 3区医学

Seminars in Pediatric Surgery Pub Date : 2026-02-25 DOI: 10.1016/j.sempedsurg.2026.151596

Ji Ho Park, Brian Fenn, Robert L Ricca

{"title":"Military humanitarian efforts in pediatric surgery and ethical considerations.","authors":"Ji Ho Park, Brian Fenn, Robert L Ricca","doi":"10.1016/j.sempedsurg.2026.151596","DOIUrl":"https://doi.org/10.1016/j.sempedsurg.2026.151596","url":null,"abstract":"<p><p>Pediatric surgical conditions contribute substantially to the global burden of disease, yet children in low- and middle-income countries (LMICs) continue to face profound barriers in access to safe and timely surgical care. In disaster and conflict settings, these gaps are often magnified. Military humanitarian missions provide a unique, but understudied platform for delivering pediatric surgical care while supporting host-nation surgical capacity. In this narrative review, we summarize the current landscape of pediatric global surgery and examine the role of military surgical teams in humanitarian assistance and disaster response. We review models of military engagement, the development of telehealth capabilities to extend pediatric surgical expertise, and the ethical challenges that arise when providing care in politically complex, resource-limited environments. We further explore considerations in surgical decision making in LMICs, including disease severity, nutritional compromise, and limited rehabilitation resources. Finally, we highlight the importance of coordinated partnerships between military teams, local providers, and non-governmental organizations (NGOs) to promote sustainable, context-appropriate pediatric surgical care. Lessons from military pediatric disaster response have broad implications for global surgery, underscoring the need to prioritize children in emergency preparedness, invest in ethical and operational frameworks, and leverage telehealth and collaboration to strengthen local health systems.</p>","PeriodicalId":49543,"journal":{"name":"Seminars in Pediatric Surgery","volume":" ","pages":"151596"},"PeriodicalIF":2.5,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The role of nutrition in optimizing pediatric surgical outcomes in low- and middle-income countries 营养在优化低收入和中等收入国家儿科手术结果中的作用。

IF 2.5 3区医学

Seminars in Pediatric Surgery Pub Date : 2026-02-01 Epub Date: 2026-02-21 DOI: 10.1016/j.sempedsurg.2026.151592

Claire Wunker , Yousef Ibrahim , Chisengo Kapihya , Patricia Shinondo , Robin T. Petroze

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Optimizing antimicrobial prophylaxis use in pediatric surgery through evidence, accountability, and multidisciplinary stewardship 通过证据、问责制和多学科管理优化儿科外科抗菌药物预防使用。

IF 2.5 3区医学

Seminars in Pediatric Surgery Pub Date : 2026-02-01 Epub Date: 2026-03-04 DOI: 10.1016/j.sempedsurg.2026.151611

Matthew T. Hey , Shawn J. Rangel

{"title":"Optimizing antimicrobial prophylaxis use in pediatric surgery through evidence, accountability, and multidisciplinary stewardship","authors":"Matthew T. Hey , Shawn J. Rangel","doi":"10.1016/j.sempedsurg.2026.151611","DOIUrl":"10.1016/j.sempedsurg.2026.151611","url":null,"abstract":"<div><div>Antimicrobial stewardship is essential to safe, effective pediatric surgical care, yet surgical antimicrobial prophylaxis (SAP) remains highly variable and frequently overused across children’s hospitals. This review provides a high-level synthesis of the public health rationale for stewardship, the current landscape of SAP practice, and the growing body of pediatric-specific evidence informing appropriate prophylaxis use. We integrate national guideline recommendations with contemporary outcomes data and describe how benchmarking initiatives such as ACS NSQIP–Pediatric and Children’s Surgery Verification programs promote accountability and standardization in perioperative antibiotic use. The review also highlights the critical role of antimicrobial stewardship programs in guiding institutional practice and supporting the development of evidence-based local protocols. Finally, we outline the broad categories of evidence-based tools and strategies that facilitate high-quality stewardship for prophylaxis use. Together, these components establish a contemporary roadmap for optimizing prophylaxis use while minimizing unnecessary antibiotic exposure in children undergoing elective surgical procedures.</div></div>","PeriodicalId":49543,"journal":{"name":"Seminars in Pediatric Surgery","volume":"40 ","pages":"Article 151611"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Impact of enhanced recovery after surgery (ERAS) on surgical site infections in pediatric surgery 小儿外科手术后增强恢复对手术部位感染的影响。

IF 2.5 3区医学

Seminars in Pediatric Surgery Pub Date : 2026-02-01 Epub Date: 2026-02-03 DOI: 10.1016/j.sempedsurg.2026.151581

Alejandro O. Chara , Jessica K. Sims , Jonathan Niconchuk , Irving J. Zamora

{"title":"Impact of enhanced recovery after surgery (ERAS) on surgical site infections in pediatric surgery","authors":"Alejandro O. Chara , Jessica K. Sims , Jonathan Niconchuk , Irving J. Zamora","doi":"10.1016/j.sempedsurg.2026.151581","DOIUrl":"10.1016/j.sempedsurg.2026.151581","url":null,"abstract":"<div><div>Enhanced recovery after surgery (ERAS) is a multidisciplinary, evidence-based protocol designed to standardize perioperative care, minimize complications, and optimize recovery. While ERAS has demonstrated significant benefits in adult populations, widespread adoption in pediatric surgery remains in progress. One of its central goals is reducing postoperative infections, particularly surgical site infections (SSIs), which represent a common source of morbidity in children. Core ERAS elements—including perioperative nutrition, glycemic control, fluid and temperature management, antibiotic prophylaxis, wound care, device removal, and early mobilization—directly or indirectly influence infection risk. Although pediatric-specific data remain limited, growing evidence supports that ERAS protocols are safe and may reduce SSI incidence. This narrative review outlines how individual ERAS components target SSI prevention, highlights current pediatric evidence, and identifies knowledge gaps where further research is needed to optimize infection prevention strategies for children undergoing surgery.</div></div>","PeriodicalId":49543,"journal":{"name":"Seminars in Pediatric Surgery","volume":"40 ","pages":"Article 151581"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infections in pediatric surgical practice in low- and middle-income countries: Resource-adapted clinical decision-making 低收入和中等收入国家儿科外科实践中的感染：资源适应临床决策

IF 2.5 3区医学

Seminars in Pediatric Surgery Pub Date : 2026-02-01 Epub Date: 2026-03-06 DOI: 10.1016/j.sempedsurg.2026.151623

Omar Obaid , Britney L. Grayson , Robin T. Petroze , Benedict Nwomeh

{"title":"Infections in pediatric surgical practice in low- and middle-income countries: Resource-adapted clinical decision-making","authors":"Omar Obaid , Britney L. Grayson , Robin T. Petroze , Benedict Nwomeh","doi":"10.1016/j.sempedsurg.2026.151623","DOIUrl":"10.1016/j.sempedsurg.2026.151623","url":null,"abstract":"<div><div>Pediatric infections in low- and middle-income countries (LMICs) represent a substantial proportion of the pediatric surgical burden. Overall in-hospital mortality for surgically treated infections is 12.5 %. The incidence, morbidity, and mortality associated with pediatric infections are all higher in LMICs due to delayed presentation, lack of access to primary care, and a greater incidence of communicable diseases. Over 1.7 billion children and adolescents do not have access to safe, timely, and affordable surgical care, and a disproportionate number of these children reside in LMICs making them a vulnerable population. Within this context, pediatric surgeons are frequently required to make diagnostic and therapeutic decisions in the setting of limited supportive infrastructure. This review examines common infectious conditions encountered in pediatric surgical practice in LMICs through the lens of resource-adapted decision-making, highlighting how constraints in diagnostics, operative capacity, anesthesia, and postoperative support shape management strategies and outcomes.</div></div>","PeriodicalId":49543,"journal":{"name":"Seminars in Pediatric Surgery","volume":"40 ","pages":"Article 151623"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147429159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0