Ana de Siqueira Bucci, Selima Siala, Mariana Regina DeFreitas, Carolina V Guimaraes
{"title":"What Not to Miss in Fetal Head and Neck MRI: A Pictorial Essay.","authors":"Ana de Siqueira Bucci, Selima Siala, Mariana Regina DeFreitas, Carolina V Guimaraes","doi":"10.1053/j.sult.2025.09.001","DOIUrl":"https://doi.org/10.1053/j.sult.2025.09.001","url":null,"abstract":"<p><p>Fetal magnetic resonance imaging (MRI) is a safe method of in-utero evaluation of fetal anomalies and a valuable adjunct to prenatal ultrasound. The utilization of rapid sequences reduces the impact of fetal motion and allows for high contrast resolution of fetal structures. A thorough understanding of fetal anatomy and a systematic approach to MRI interpretation are essential for accurate diagnosis of fetal head and neck anomalies. A stepwise structural analysis of fetal head and neck structures includes the evaluation of the facial profile, including maxilla, mandible, nasal bones, and integrity of lip and palate, scalp integrity, skull morphology and proportions, and anatomy of the orbits, nasal passages, choanae, ears and neck (including visualization of the thyroid gland and airway). This approach allows for accurate and effective screening of fetal head and neck anomalies including cleft lip and palate, nasal bone abnormalities, micrognathia, craniosynostosis, skull defects, orbital anomalies, choanal atresia, ear abnormalities, goiter and head and neck masses. MRI assessment further optimizes perinatal management in cases of airway compromise by providing superior visualization of the airway column and its relationship with adjacent structures. This information helps predict a difficult airway and is essential for planning perinatal management and the delivery method, which may include EXIT (Ex-Utero-Intrapartum Treatment) procedure. Early diagnosis remains essential for parental shared decision-making, guiding counseling, and preparing families for the possible perinatal loss, limited life expectancy, or the need for supportive medical care.</p>","PeriodicalId":49541,"journal":{"name":"Seminars in Ultrasound Ct and Mri","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryoko Egashira MD, PhD , Daisuke Yamada MD, PhD , Joseph Jacob MD, PhD
{"title":"Anatomy of Pulmonary Lymphatics and Lymphoid Tissues","authors":"Ryoko Egashira MD, PhD , Daisuke Yamada MD, PhD , Joseph Jacob MD, PhD","doi":"10.1053/j.sult.2025.07.002","DOIUrl":"10.1053/j.sult.2025.07.002","url":null,"abstract":"<div><div>This review summarizes the 3 components of the pulmonary lymphatic system: lymphatic channels, bronchus-associated lymphoid tissue (BALT), and intrapulmonary lymph nodes. Lymphatic vessels are distributed within the bronchovascular bundles, in the interlobular septa and visceral pleura, and around small pulmonary arteries and veins within the secondary pulmonary lobules. Normally invisible on CT, they may appear with lymphatic dilation or disease spreading via lymphatic routes. BALT is usually absent histologically in healthy lungs but may be visible in smokers or autoimmune conditions. Intrapulmonary lymph nodes present as well-defined peripheral nodules in the lower lobes, often with linear opacities.</div></div>","PeriodicalId":49541,"journal":{"name":"Seminars in Ultrasound Ct and Mri","volume":"46 4","pages":"Pages 266-271"},"PeriodicalIF":1.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter From the Guest Editor","authors":"Takeshi Johkoh MD, PhD","doi":"10.1053/j.sult.2025.07.001","DOIUrl":"10.1053/j.sult.2025.07.001","url":null,"abstract":"","PeriodicalId":49541,"journal":{"name":"Seminars in Ultrasound Ct and Mri","volume":"46 4","pages":"Page 265"},"PeriodicalIF":1.9,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pathologic Findings of Pulmonary Lymphoproliferative Disorders","authors":"Yoshiaki Zaizen , Junya Fukuoka MD, PhD","doi":"10.1053/j.sult.2025.06.005","DOIUrl":"10.1053/j.sult.2025.06.005","url":null,"abstract":"<div><div>Pulmonary lymphoproliferative disorders (PLDs) are a diverse group of rare entities characterized by abnormal lymphoid proliferation within the lung. These include both benign and malignant processes and are classified into five categories in the 2021 WHO Classification of Thoracic Tumors: benign hyperplastic disorders, primary pulmonary neoplasms, secondary involvement of the lung, posttransplant lymphoproliferative disorders, and histiocytic neoplasms. Diagnosing PLDs is often challenging due to their histological similarity to other lymphocyte-rich interstitial lung diseases, including cellular nonspecific interstitial pneumonia (NSIP) and hypersensitivity pneumonitis. A multidisciplinary approach integrating clinical, radiologic, and pathological information is essential to reach an accurate diagnosis. This review focuses on the detailed pathological features of PLDs, particularly benign hyperplastic disorders and primary pulmonary neoplasms. It emphasizes the differential diagnosis and highlights distinguishing characteristics among key subtypes, including lymphoid interstitial pneumonia, follicular bronchiolitis, nodular lymphoid hyperplasia, Castleman disease, IgG4-related disease, and primary pulmonary lymphomas such as MALT lymphoma, diffuse large B-cell lymphoma, and lymphomatoid granulomatosis. Special attention is paid to morphological patterns, immunophenotypes, and diagnostic challenges encountered with small biopsies. Given the broad differential diagnosis and potential overlap with infectious, autoimmune, or immunodeficiency-related conditions, careful clinicopathological correlation remains the cornerstone of accurate classification and appropriate management. This review aims to enhance diagnostic clarity and support effective interdisciplinary evaluation of suspected PLD cases.</div></div>","PeriodicalId":49541,"journal":{"name":"Seminars in Ultrasound Ct and Mri","volume":"46 4","pages":"Pages 272-282"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Imaging of Diseases Involving Pulmonary Lymphatics: Focus on Pulmonary Sarcoidosis","authors":"Kiminori Fujimoto MD, PhD , Tomonori Chikasue MD , Yoshiaki Zaizen MD, PhD , Akiko Sumi MD, PhD , Saeko Tokisawa MD, PhD","doi":"10.1053/j.sult.2025.06.007","DOIUrl":"10.1053/j.sult.2025.06.007","url":null,"abstract":"<div><div>Sarcoidosis is a systemic granulomatous disorder of unknown cause, histopathologically characterized by the presence of non-caseating epithelioid-cell granulomas involving multiple organs, and most commonly involves the lungs and mediastinal and bilateral hilar lymph nodes (and the lymphatic systems). Although a definitive diagnosis relies on clinical and histopathological analysis, imaging plays a crucial role in early detection, lesion characterization, disease staging, and treatment response. This review focuses on imaging of pulmonary sarcoidosis, including histopathology, chest radiographic staging, and CT of mediastinal/hilar lymphadenopathy and parenchymal abnormalities (perilymphatic nodules, ground-glass opacity, coalescent or aggregate nodules, parenchymal fibrotic changes, and airway lesions), in addition to pulmonary hypertension and cardiac sarcoidosis. Differential diagnosis for imaging of diseases involving pulmonary lymphatics, particularly lymphangitic spread of carcinoma, is also demonstrated.</div></div>","PeriodicalId":49541,"journal":{"name":"Seminars in Ultrasound Ct and Mri","volume":"46 4","pages":"Pages 325-342"},"PeriodicalIF":1.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Features of Pulmonary Lymphoproliferative Disorders","authors":"Vasilios Tzilas MD, PhD , Jay H. Ryu MD","doi":"10.1053/j.sult.2025.06.006","DOIUrl":"10.1053/j.sult.2025.06.006","url":null,"abstract":"","PeriodicalId":49541,"journal":{"name":"Seminars in Ultrasound Ct and Mri","volume":"46 4","pages":"Pages 283-295"},"PeriodicalIF":1.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yeon Joo Jeong , Joungho Han , Junhun Cho , Kyung Soo Lee
{"title":"Imaging of Pulmonary Malignant Lymphoproliferative Disorders","authors":"Yeon Joo Jeong , Joungho Han , Junhun Cho , Kyung Soo Lee","doi":"10.1053/j.sult.2025.06.004","DOIUrl":"10.1053/j.sult.2025.06.004","url":null,"abstract":"<div><div><span>Malignant pulmonary lymphomas are a heterogeneous group of malignancies characterized by the clonal proliferation of lymphocytes within the lung. They are classified as primary, arising in the lung without extrathoracic involvement (mostly mucosa-associated lymphoid tissue lymphoma), or secondary, resulting from the spread of systemic lymphoma, often diffuse large B-cell or </span>Hodgkin lymphoma. Imaging findings correlate with histopathologic features, showing single or multiple nodules/masses, lobar or segmental consolidations, reticular patterns, or disseminated small nodules. Although a definitive diagnosis relies on histopathological and immunophenotypic analysis, imaging plays a crucial role in early suspicion, lesion localization, disease staging, and monitoring treatment response or recurrence.</div></div>","PeriodicalId":49541,"journal":{"name":"Seminars in Ultrasound Ct and Mri","volume":"46 4","pages":"Pages 301-316"},"PeriodicalIF":1.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tomás Franquet MD, PhD , Jose M. Brenes MD , Monika Radike MD, PhD , Ana Giménez MD , Pere Domingo MD, PhD
{"title":"Imaging of Immunodeficiency-Associated Lymphoproliferative Disorders","authors":"Tomás Franquet MD, PhD , Jose M. Brenes MD , Monika Radike MD, PhD , Ana Giménez MD , Pere Domingo MD, PhD","doi":"10.1053/j.sult.2025.06.001","DOIUrl":"10.1053/j.sult.2025.06.001","url":null,"abstract":"<div><div><span><span><span><span>Immunodeficiency-associated lymphoproliferative disorders represent a heterogeneous group of conditions characterized by abnormal </span>lymphoid tissue proliferation in the context of </span>immune dysregulation. These disorders can range from benign </span>reactive hyperplasia<span> to overt malignant lymphoma and are strongly associated with conditions such as congenital and acquired immunodeficiencies, chronic </span></span>immunosuppressive therapy<span>, and viral infections, particularly Epstein-Barr virus. This article provides a comprehensive overview of the most common immunodeficiency-associated lymphoproliferative disorders subtypes, their pathogenesis, imaging features, and clinical management. The role of high-resolution computed tomography in the detection, characterization, and differential diagnosis of these entities is highlighted, with a focus on practical radiologic-pathologic correlations.</span></div></div>","PeriodicalId":49541,"journal":{"name":"Seminars in Ultrasound Ct and Mri","volume":"46 4","pages":"Pages 317-324"},"PeriodicalIF":1.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eleonora Salles-Silva MD , Paula Lemos de Castro MD , Luiza Carvalho Ambrozino MD , Antonio Luis-Eiras de Araújo MD, PhD , Daniel Lahan-Martins MD, PhD , Maria Fernanda Arruda Almeida MD, PhD , Fabiano Rubião Lucchesi MD, PhD , Eduardo Oliveira Pacheco MD , Ulysses S. Torres MD, PhD , Giuseppe D’Ippolito MD, PhD , Daniella Braz Parente MD, PhD
{"title":"Rare Malignant Liver Tumors: Current Insights and Imaging Challenges","authors":"Eleonora Salles-Silva MD , Paula Lemos de Castro MD , Luiza Carvalho Ambrozino MD , Antonio Luis-Eiras de Araújo MD, PhD , Daniel Lahan-Martins MD, PhD , Maria Fernanda Arruda Almeida MD, PhD , Fabiano Rubião Lucchesi MD, PhD , Eduardo Oliveira Pacheco MD , Ulysses S. Torres MD, PhD , Giuseppe D’Ippolito MD, PhD , Daniella Braz Parente MD, PhD","doi":"10.1053/j.sult.2025.04.007","DOIUrl":"10.1053/j.sult.2025.04.007","url":null,"abstract":"<div><div>Rare malignant liver tumors (RMLTs) comprise a diverse group of neoplasms with distinct imaging features and significant diagnostic challenges due to their low prevalence and overlap with more common hepatic lesions. This review highlights the main radiologic characteristics of selected rare malignant liver tumors—including fibrolamellar hepatocellular carcinoma, hepatic lymphoma, hepatocellular carcinoma in non-cirrhotic liver, mucinous cystic neoplasm, intraductal papillary neoplasm of the bile duct, epithelioid hemangioendothelioma, angiosarcoma, malignant hepatic adenoma, neuroendocrine tumor, hepatocholangiocarcinoma, hepatoblastoma, undifferentiated embryonal sarcoma, and infantile hepatic hemangioendothelioma—focusing on their presentation in computed tomography and magnetic resonance imaging. Recognizing specific imaging findings, such as arterial hyperenhancement, biliary communication, target and lollipop signs, and tumor morphology, can help narrow differential diagnoses and guide appropriate clinical management. Despite advancements in imaging, histopathologic confirmation is often required due to nonspecific features. Improved radiologic awareness of these rare entities is essential to facilitate early diagnosis and individualized treatment planning.</div></div>","PeriodicalId":49541,"journal":{"name":"Seminars in Ultrasound Ct and Mri","volume":"46 3","pages":"Pages 161-176"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}