Proton Magnetic Resonance Spectroscopy for Pediatric Neuroimaging: Key Concepts for Practice

IF 1.5 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Seminars in Ultrasound Ct and Mri Pub Date : 2025-04-01 DOI:10.1053/j.sult.2025.05.001

Kim M. Cecil PhD , Muhammad G. Saleh PhD

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引用次数: 0

Abstract

Magnetic resonance spectroscopy (MRS) of the brain provides the clinician an in vivo neurochemical assessment within the clinical magnetic resonance imaging setting. This information can yield specificity when addressing questions pertaining to brain health and metabolism while characterizing disease and injury, evaluating treatment response, and prognosticating outcome. Proton MRS techniques can be useful in narrowing the diagnostic differential and capturing time-sensitive information for the continually developing pediatric brain. This paper provides a review of key proton MRS topics relevant for usage in pediatric populations. We discuss magnetic field strength, pediatric-sized head coils, water suppression techniques, localization pulse sequences, post-processing methods, analysis, and interpretation. These elements all require special consideration, particularly for the immature brain. We introduce the fundamentals of spectral editing. Finally, we present illustrative examples employing proton MRS in clinical practice to begin to synthesize these concepts into practical application.

查看原文本刊更多论文

质子磁共振光谱学用于儿科神经成像：实践的关键概念。

脑磁共振波谱（MRS）为临床医生提供了临床磁共振成像（MRI）环境下的体内神经化学评估。这些神经化学评估可以在解决与大脑健康和代谢有关的问题时产生特异性，同时表征疾病和损伤，评估治疗反应和预后结果。质子磁共振技术可用于缩小诊断差异，并为不断发展的儿科人群捕获时间敏感信息。本文综述了质子磁共振成像在儿科人群中的应用。我们讨论了磁场强度，儿童大小的头部线圈，水抑制技术，定位脉冲序列，后处理方法，分析和解释。这些因素都需要特别考虑，尤其是对不成熟的大脑。我们介绍了光谱编辑的基本原理。最后，我们提出在临床实践中使用质子磁共振成像的例子，开始将这些概念综合到实际应用中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Ultrasound Ct and Mri 医学-核医学

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Ultrasound, CT and MRI is directed to all physicians involved in the performance and interpretation of ultrasound, computed tomography, and magnetic resonance imaging procedures. It is a timely source for the publication of new concepts and research findings directly applicable to day-to-day clinical practice. The articles describe the performance of various procedures together with the authors'' approach to problems of interpretation.