Sleep Medicine ReviewsPub Date : 2025-12-01Epub Date: 2025-10-30DOI: 10.1016/j.smrv.2025.102189
Fangxiang Mao , Sanne J.W. Hoepel , Mina Shahisavandi , Annemarie I. Luik , Hanan EI Marroun
{"title":"Recreational cannabis use and sleep in the general population: a systematic review and meta-analysis","authors":"Fangxiang Mao , Sanne J.W. Hoepel , Mina Shahisavandi , Annemarie I. Luik , Hanan EI Marroun","doi":"10.1016/j.smrv.2025.102189","DOIUrl":"10.1016/j.smrv.2025.102189","url":null,"abstract":"<div><div>Cannabis use is often used to improve sleep, yet it remains unclear whether its recreational use, either current or lifetime, is associated with better sleep in the general population. We conducted a systematic review and meta-analysis of 120 studies identified from six databases, excluding studies on medicinal cannabis or clinical samples. Current use was defined as cannabis use within one month, and lifetime use as use in the past year or lifetime. Among 102 observational studies identified, current recreational cannabis use was associated with poorer sleep quality, both short and long sleep duration, more insomnia symptoms, and a later chronotype, compared to non-use. Lifetime use showed similar associations with insomnia and chronotype. Neither current nor lifetime use was linked to daytime sleepiness. These associations were more pronounced among men and younger users. In contrast, no associations between cannabis and sleep quality and duration were observed across 19 experimental studies. Overall, recreational cannabis use was linked to poorer sleep across multiple components in observational studies although these findings may be affected by bias. Given the ethical and practical limitations of long-term trials, integrating well-designed observational and experimental research is essential to fully understand how cannabis use links to sleep.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102189"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Behavioural sleep interventions for the management of non-respiratory sleep disorders in children with neurodisability","authors":"Kasey Fullwood , Karen Thorpe , Laetitia Coles , Moya Vandeleur , Karen Waters , Jasneek Chawla","doi":"10.1016/j.smrv.2025.102185","DOIUrl":"10.1016/j.smrv.2025.102185","url":null,"abstract":"<div><div>Non-respiratory sleep disorders, including behavioural sleep disorders (e.g., difficulty with sleep onset and sleep maintenance) affect up to 80 % of children with neurodisability (ND). Non-respiratory sleep disorders in typically developing children can be treated using a variety of behavioural strategies and interventions, however generalisability of these interventions to children with ND remains uncertain. A systematic search of databases revealed 55 papers that were included in this review. Most (69 %) studies focused on children with ASD and/or ADHD with a limited number found in other disability groups. Intervention delivery mode varied with 13 % using an online format and 87 % in person, with group (44 %) and individual (52 %) approaches exhibiting similar efficacy. Results outlined key findings; 1) The breadth of ND conditions included is limited 2) small sample size across the majority of studies 3) interventions may need to be adapted to improve effectiveness 4) while mode of delivery varied, effects were similar and 5) highest intensity programs were not the most effective. Our review shows that while sleep strategies and interventions can be effective in treating non-respiratory sleep disorders in this cohort, more evidence is required to determine how best to tailor these to address challenges that are unique to children with ND.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102185"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep Medicine ReviewsPub Date : 2025-12-01Epub Date: 2025-10-31DOI: 10.1016/j.smrv.2025.102198
Shane A. Landry , Elly M.P. Howell , Meagan E. Crowther , Daniel J. Tan , Caroline Beatty , Luke D.J. Thomson , Simon A. Joosten , Garun S. Hamilton , Bradley A. Edwards
{"title":"The effect of non-sedative/hypnotic treatment of obstructive sleep apnoea on the respiratory arousal threshold: a systematic review and meta-analysis","authors":"Shane A. Landry , Elly M.P. Howell , Meagan E. Crowther , Daniel J. Tan , Caroline Beatty , Luke D.J. Thomson , Simon A. Joosten , Garun S. Hamilton , Bradley A. Edwards","doi":"10.1016/j.smrv.2025.102198","DOIUrl":"10.1016/j.smrv.2025.102198","url":null,"abstract":"<div><div>Contrary to the view that a lower arousal threshold causes greater susceptibility to obstructive sleep apnoea (OSA), the arousal threshold has been shown to decrease following treatment with continuous positive airway pressure (CPAP) therapy. This effect has not been consistently demonstrated with other non-CPAP therapies. We systematically reviewed all randomised and non-randomised trials (of non-hypnotic therapy) for OSA, in which respiratory arousal threshold was quantified both on- and off-treatment. Random effects meta-analysis models were used for all meta-analyses. Our analysis demonstrates that OSA treatment is associated with a significant reduction in the respiratory arousal threshold (standardised mean difference = −0.36 [CI<sub>95 %</sub> −0.49, −0.22], p < 0.001), however, this effect was highly heterogenous (I<sup>2</sup> = 67.6 %). Greater reductions in the arousal threshold are observed in studies with highly efficacious treatment as quantified by larger absolute reductions in the apnoea-hypopnea index (AHI, r<sup>2</sup> = 0.26, p = 0.002) and increases in SpO<sub>2</sub> nadir (r<sup>2</sup> = 0.74, p < 0.001). These data provide support for the notion that reductions in the respiratory arousal threshold occur as an indirect consequence of treatment. Importantly, reductions in the respiratory arousal threshold should be an expected finding in trials in which a treatment has successfully reduced OSA severity.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102198"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to Letter to Editor “Chronotype and circadian epidemiology” by T.C. Erren, P. Morfeld and P. Lewis","authors":"Gabriela Yuri , Rodrigo Chamorro , Nicolás Tobar , Mariana Cifuentes","doi":"10.1016/j.smrv.2025.102184","DOIUrl":"10.1016/j.smrv.2025.102184","url":null,"abstract":"","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102184"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep Medicine ReviewsPub Date : 2025-12-01Epub Date: 2025-09-18DOI: 10.1016/j.smrv.2025.102170
Sarfraz Ahmed , David Gozal , Abdelnaby Khalyfa
{"title":"Mechanistic links between obstructive sleep apnea, cellular senescence and aging: The role of cardiometabolic dysfunction","authors":"Sarfraz Ahmed , David Gozal , Abdelnaby Khalyfa","doi":"10.1016/j.smrv.2025.102170","DOIUrl":"10.1016/j.smrv.2025.102170","url":null,"abstract":"<div><div>Obstructive sleep apnea (OSA) is a common condition characterized by repeated airway obstruction during sleep, triggering physiological changes that resemble key features of cellular senescence—oxidative stress, mitochondrial dysfunction, and systemic inflammation. While senescence plays roles in tissue repair, its accumulation also drives chronic inflammation and immune dysregulation. The connection between OSA, senescence, and aging remains complex and underexplored. Mechanisms like the senescence-associated secretory phenotype (SASP), impaired immune surveillance, and reduced regenerative capacity may contribute to OSA-related morbidity. This review examines how senescence influences immune and molecular pathways in OSA, with a focus on cardiometabolic dysfunction, SASP-driven tissue remodeling, and hypoxia-induced damage. We also highlight emerging therapies targeting senescence, proposing that it acts not only as a byproduct of aging but as an active driver of OSA pathology, shaped by hypoxia, sleep disruption, comorbidities, and immune profiles.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102170"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep Medicine ReviewsPub Date : 2025-12-01Epub Date: 2025-09-27DOI: 10.1016/j.smrv.2025.102179
Alberto Potenzieri , Andrea Escelsior , Gianluca Serafini , Antonio Uccelli , Antoine Adamantidis , Lino Nobili
{"title":"Sleep abnormalities in mouse models of depression: a systematic review","authors":"Alberto Potenzieri , Andrea Escelsior , Gianluca Serafini , Antonio Uccelli , Antoine Adamantidis , Lino Nobili","doi":"10.1016/j.smrv.2025.102179","DOIUrl":"10.1016/j.smrv.2025.102179","url":null,"abstract":"<div><div>Sleep disturbances are highly prevalent in people with major depressive disorder (MDD) and contribute to a vicious cycle that exacerbates both conditions. Electroencephalographic (EEG)-based sleep features of people with MDD are well described in systematic reviews and meta-analyses. However, sleep abnormalities in mouse models of MDD remain poorly characterized. We conducted a systematic review to evaluate the face validity of mouse models of MDD in relation to sleep alterations. Among the 22 articles we identified, the most consistently represented features of sleep disturbances in mouse models were increased rapid eye movement (REM) sleep and non-REM (NREM) sleep fragmentation. A blunted response to sleep deprivation was reported but only in a few studies and requires further investigation. Data regarding delta and theta power were limited and showed heterogeneous results. By providing a comprehensive summary of all mouse models in the field, our study serves as a resource to confirm the utility of animal models and guide researchers in studying sleep alterations in MDD.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102179"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep Medicine ReviewsPub Date : 2025-12-01Epub Date: 2025-10-30DOI: 10.1016/j.smrv.2025.102195
Asha Morrison, Diana S. Dorstyn
{"title":"Insomnia in spinal cord injury: A meta-analysis of observational studies","authors":"Asha Morrison, Diana S. Dorstyn","doi":"10.1016/j.smrv.2025.102195","DOIUrl":"10.1016/j.smrv.2025.102195","url":null,"abstract":"<div><div>Sleep problems are frequent following spinal cord injury or disease (SCI/D), however the severity of insomnia - including difficulty falling asleep and staying asleep - is not fully understood. Differing assessment methods, variations in diagnostic criteria, and the characteristics of SCI/D may also impact reported prevalence estimates. This PRISMA-guided review synthesizes the available evidence, with consideration of study-level characteristics. The CINAHL, Embase, MEDLINE and PsycINFO databases were searched on March 22nd, 2024 (updated February 12th, 2025), to identify observational studies with an adult SCI/D sample and a validated measure to assess insomnia symptom severity or aid in diagnosis. Studies were appraised (JBI Critical Appraisal tool) and effect size estimates (proportions) meta-analyzed using a random effects model. Nineteen studies (<em>k</em>) representing 11,879 adults with SCI/D, and reporting requisite methodological parameters, were included. Sixty-one percent (CI: 53%–69%; <em>k</em> = 18) endorsed symptoms of insomnia, with 15% (CI: 14%–16%, <em>k</em> = 1) meeting the criteria for insomnia disorder. Findings show routine sleep assessment is needed throughout the continuum of care. There is also a need to consider insomnia as a potential confound in SCI/D research through the active collection of sleep data. Protocol registered on Open Science Framework (<span><span>https://osf.io/hfr4v</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102195"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep Medicine ReviewsPub Date : 2025-12-01Epub Date: 2025-08-30DOI: 10.1016/j.smrv.2025.102160
Clara Gino , Laura Adelaide Dalla Vecchia , Monica Parati , Davide Sattin , Serena Covino , Graziella Cappelletti , Alessandro Pincherle , Beatrice De Maria
{"title":"Role of heart rate variability analysis in differentiating patients with idiopathic REM sleep behaviour disorders from healthy subjects. A systematic review with meta-analysis","authors":"Clara Gino , Laura Adelaide Dalla Vecchia , Monica Parati , Davide Sattin , Serena Covino , Graziella Cappelletti , Alessandro Pincherle , Beatrice De Maria","doi":"10.1016/j.smrv.2025.102160","DOIUrl":"10.1016/j.smrv.2025.102160","url":null,"abstract":"<div><h3>Introduction</h3><div>Autonomic nervous system (ANS) alteration has been acknowledged for disrupted sleep and α-synucleopaties. Since idiopathic REM sleep behavior disorder (iRBD) precedes α-synucleopaties, ANS function indices could predict conversion. Heart rate variability (HRV) analysis could better define cardiac ANS in iRBD.</div><div>This systematic review with meta-analysis purpose was to investigate the HRV indices role in differentiating iRBD and controls.</div></div><div><h3>Method</h3><div>Included studies (three databases screened) compare HRV indices in iRBD and controls during REM, non-REM (NREM) or wake phases. Outcomes included HRV indices in time and frequency domains. Meta-analysis performed for HRV indices computed standardized mean difference with 95 % confidence intervals.</div></div><div><h3>Results</h3><div>The 22 included studies had unbalanced age groups, mostly composed of males. An overall lower HRV and cardiac vagal modulation emerged in iRBD. Almost all studies evaluated HRV parameters only during wakefulness and most of those separated NREM and REM phases, better highlighting differences between iRBD and controls.</div></div><div><h3>Conclusion</h3><div>Results suggest an overall reduced HRV and cardiac vagal modulation in iRBD patients. Furthermore, separated analysis of the different sleep stages better differentiate subjects with iRBD.</div><div>Further longitudinal studies on larger populations would reach more conclusions defining relationships between HRV and neurodegenerative diseases in prodromic stages.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102160"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep Medicine ReviewsPub Date : 2025-12-01Epub Date: 2025-11-01DOI: 10.1016/j.smrv.2025.102199
ZeLin Zhao , Ying Lin , YunHao Cui
{"title":"Commentary on “Sleep abnormalities in mouse models of depression: a systematic review”","authors":"ZeLin Zhao , Ying Lin , YunHao Cui","doi":"10.1016/j.smrv.2025.102199","DOIUrl":"10.1016/j.smrv.2025.102199","url":null,"abstract":"","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102199"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep Medicine ReviewsPub Date : 2025-12-01Epub Date: 2025-10-03DOI: 10.1016/j.smrv.2025.102168
Pierre Tankéré , Léa Razakamanantsoa , Charles Khouri , Maxime Patout , Emeric Stauffer , Sebastien Baillieul , Thierry Petitjean , Jean Louis Pépin , Renaud Tamisier , Laure Peter Derex
{"title":"Positive airway pressure therapies improve sleep architecture in patients with chronic hypercapnic respiratory failure: A systematic review and meta-analysis","authors":"Pierre Tankéré , Léa Razakamanantsoa , Charles Khouri , Maxime Patout , Emeric Stauffer , Sebastien Baillieul , Thierry Petitjean , Jean Louis Pépin , Renaud Tamisier , Laure Peter Derex","doi":"10.1016/j.smrv.2025.102168","DOIUrl":"10.1016/j.smrv.2025.102168","url":null,"abstract":"<div><div>Positive airway pressure therapies (PAP) are the standard of care for chronic hypercapnic respiratory failure (CHRF), and include continuous positive airway pressure (CPAP) and non-invasive ventilation (NIV) for obesity hypoventilation syndrome (OHS), and NIV for chronic obstructive pulmonary disease (COPD) and neuromuscular disease (NMD). The effects of PAP on sleep reflect a balance between correcting CHRF-induced sleep disturbances and the potential for therapy itself to disrupt sleep. Given the critical role of sleep in overall health, there are relevant concerns about the effects of PAP usage on sleep architecture. We performed a systematic review and meta-analysis of polysomnographic parameters, using a random-effects model for quantitative analyses. Forty studies were included (n = 1099; 438 OHS, 350 NMD, 175 COPD, 136 unspecified CHRF; 58 % male, age 56.6 ± 8.9 years, body mass index 36.5 ± 11.3 kg/m<sup>2</sup>, arterial carbon dioxide pressure 51.8 ± 5.0 mmHg). Significant improvements (estimate [confidence interval]) in sleep efficiency (+6.30 [3.00, 9.60]%), slow-wave sleep (+4.74 [3.08, 6.41]%), rapid-eye-movement sleep (+4.39 [2.84, 5.94]%), arousal index (−12.97 [–19.65, −6.28]/h), and apnea-hypopnea index (−15.13 [–22.34, −7.92]/h) were seen during PAP. Overall, PAP improved sleep architecture in CHRF. The prognostic significance of these changes warrants further investigation.</div></div><div><h3>Trial registration</h3><div>PROSPERO (CRD42023495516)</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102168"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}