Theoretical Population Biology最新文献_第10页

Recoverability of ancestral recombination graph topologies 祖先重组图拓扑的可恢复性

IF 1.4 4区生物学

Theoretical Population Biology Pub Date : 2023-08-05 DOI: 10.1016/j.tpb.2023.07.004

Elizabeth Hayman , Anastasia Ignatieva , Jotun Hein

引用次数: 0

Corrigendum to “Modeling temporal dynamics of genetic diversity in stage-structured plant populations with reference to demographic genetic structure” [Theor. Popul. Biol. 148 (2022) 76–85] “参照人口统计学遗传结构对阶段结构植物种群遗传多样性的时间动态建模”[理论]的勘误。Popul。生物学报，148 (2022)76-85]

IF 1.4 4区生物学

Theoretical Population Biology Pub Date : 2023-08-01 DOI: 10.1016/j.tpb.2023.03.002

Yoichi Tsuzuki, Takenori Takada, Masashi Ohara

引用次数: 0

Adaptation of a quantitative trait to a changing environment: New analytical insights on the asexual and infinitesimal sexual models 数量性状对变化环境的适应:对无性和无限小性模型的新分析见解

IF 1.4 4区生物学

Theoretical Population Biology Pub Date : 2023-08-01 DOI: 10.1016/j.tpb.2023.04.002

J. Garnier , O. Cotto , E. Bouin , T. Bourgeron , T. Lepoutre , O. Ronce , V. Calvez

{"title":"Adaptation of a quantitative trait to a changing environment: New analytical insights on the asexual and infinitesimal sexual models","authors":"J. Garnier , O. Cotto , E. Bouin , T. Bourgeron , T. Lepoutre , O. Ronce , V. Calvez","doi":"10.1016/j.tpb.2023.04.002","DOIUrl":"10.1016/j.tpb.2023.04.002","url":null,"abstract":"<div><p>Predicting the adaptation of populations to a changing environment is crucial to assess the impact of human activities on biodiversity. Many theoretical studies have tackled this issue by modeling the evolution of quantitative traits subject to stabilizing selection around an optimal phenotype, whose value is shifted continuously through time. In this context, the population fate results from the equilibrium distribution of the trait, relative to the moving optimum. Such a distribution may vary with the shape of selection, the system of reproduction, the number of loci, the mutation kernel or their interactions. Here, we develop a methodology that provides quantitative measures of population maladaptation and potential of survival directly from the entire profile of the phenotypic distribution, without any a priori on its shape. We investigate two different systems of reproduction (asexual and infinitesimal sexual models of inheritance), with various forms of selection. In particular, we recover that fitness functions such that selection weakens away from the optimum lead to evolutionary tipping points, with an abrupt collapse of the population when the speed of environmental change is too high. Our unified framework allows deciphering the mechanisms that lead to this phenomenon. More generally, it allows discussing similarities and discrepancies between the two systems of reproduction, which are ultimately explained by different constraints on the evolution of the phenotypic variance. We demonstrate that the mean fitness in the population crucially depends on the shape of the selection function in the infinitesimal sexual model, in contrast with the asexual model. In the asexual model, we also investigate the effect of the mutation kernel and we show that kernels with higher kurtosis tend to reduce maladaptation and improve fitness, especially in fast changing environments.</p></div>","PeriodicalId":49437,"journal":{"name":"Theoretical Population Biology","volume":"152 ","pages":"Pages 1-22"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9761248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cultural evolutionary model of the interaction between parental beliefs and behaviors, with applications to vaccine hesitancy 父母信仰和行为之间相互作用的文化进化模型，并应用于疫苗犹豫

IF 1.4 4区生物学

Theoretical Population Biology Pub Date : 2023-08-01 DOI: 10.1016/j.tpb.2023.04.003

Kerri-Ann Anderson, Nicole Creanza

{"title":"A cultural evolutionary model of the interaction between parental beliefs and behaviors, with applications to vaccine hesitancy","authors":"Kerri-Ann Anderson, Nicole Creanza","doi":"10.1016/j.tpb.2023.04.003","DOIUrl":"10.1016/j.tpb.2023.04.003","url":null,"abstract":"<div><p>Health perceptions and health-related behaviors can change at the population level as cultures evolve. In the last decade, despite the proven efficacy of vaccines, the developed world has seen a resurgence of vaccine-preventable diseases (VPDs) such as measles, pertussis, and polio. Vaccine hesitancy, which is influenced by historical, political, and socio-cultural forces, is believed to be a primary factor responsible for decreasing vaccine coverage, thereby increasing the risk and occurrence of VPD outbreaks. Behavior change models have been increasingly employed to understand disease dynamics and intervention effectiveness. However, since health behaviors are culturally influenced, it is valuable to examine them within a cultural evolution context. Here, using a mathematical modeling framework, we explore the effects of cultural evolution on vaccine hesitancy and vaccination behavior. With this model, we shed light on facets of cultural evolution (vertical transmission, community influences, homophily, etc.) that promote the spread of vaccine hesitancy, ultimately affecting levels of vaccination coverage and VPD outbreak risk in a population. In addition, we present our model as a generalizable framework for exploring cultural evolution when humans’ beliefs influence, but do not strictly dictate, their behaviors. This model offers a means of exploring how parents’ potentially conflicting beliefs and cultural traits could affect their children’s health and fitness. We show that vaccine confidence and vaccine-conferred benefits can both be driving forces of vaccine coverage. We also demonstrate that an assortative preference among vaccine-hesitant individuals can lead to increased vaccine hesitancy and lower vaccine coverage.</p></div>","PeriodicalId":49437,"journal":{"name":"Theoretical Population Biology","volume":"152 ","pages":"Pages 23-38"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9706795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Untangling the role of temporal and spatial variations in persistence of populations 解开时间和空间变异在种群持续性中的作用

IF 1.4 4区生物学

Theoretical Population Biology Pub Date : 2023-07-13 DOI: 10.1016/j.tpb.2023.07.003

Michel Benaïm , Claude Lobry , Tewfik Sari , Édouard Strickler

{"title":"Untangling the role of temporal and spatial variations in persistence of populations","authors":"Michel Benaïm , Claude Lobry , Tewfik Sari , Édouard Strickler","doi":"10.1016/j.tpb.2023.07.003","DOIUrl":"10.1016/j.tpb.2023.07.003","url":null,"abstract":"<div><p>We consider a population distributed between two habitats, in each of which it experiences a growth rate that switches periodically between two values, <span><math><mrow><mn>1</mn><mo>−</mo><mi>ɛ</mi><mo>></mo><mn>0</mn></mrow></math></span> or <span><math><mrow><mo>−</mo><mrow><mo>(</mo><mn>1</mn><mo>+</mo><mi>ɛ</mi><mo>)</mo></mrow><mo><</mo><mn>0</mn></mrow></math></span>. We study the specific case where the growth rate is positive in one habitat and negative in the other one for the first half of the period, and conversely for the second half of the period, that we refer as the <span><math><mrow><mo>(</mo><mo>±</mo><mn>1</mn><mo>)</mo></mrow></math></span> model. In the absence of migration, the population goes to 0 exponentially fast in each environment. In this paper, we show that, when the period is sufficiently large, a small dispersal between the two patches is able to produce a very high positive exponential growth rate for the whole population, a phenomena called inflation. We prove in particular that the threshold of the dispersal rate at which the inflation appears is exponentially small with the period. We show that inflation is robust to random perturbation, by considering a model where the values of the growth rate in each patch are switched at random times: we prove that inflation occurs for low switching rate and small dispersal. We also consider another stochastic model, where after each period of time <span><math><mi>T</mi></math></span>, the values of the growth rates in each patch is chosen randomly, independently from the other patch and from the past. Finally, we provide some extensions to more complicated models, especially epidemiological and density dependent models.</p></div>","PeriodicalId":49437,"journal":{"name":"Theoretical Population Biology","volume":"154 ","pages":"Pages 1-26"},"PeriodicalIF":1.4,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9976615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Digenic genotypes: The interface of inbreeding, linkage, and linkage disequilibrium 基因型:近亲繁殖、连锁和连锁不平衡的界面

IF 1.4 4区生物学

Theoretical Population Biology Pub Date : 2023-06-01 DOI: 10.1016/j.tpb.2023.03.003

Reginald D. Smith

引用次数: 0

Waiting times in a branching process model of colorectal cancer initiation 结直肠癌起始分支过程模型中的等待时间

IF 1.4 4区生物学

Theoretical Population Biology Pub Date : 2023-06-01 DOI: 10.1016/j.tpb.2023.04.001

Ruibo Zhang, Obinna A. Ukogu, Ivana Bozic

引用次数: 0

Copuling population dynamics and diel migration patterns 交配种群动态与死亡迁移模式

IF 1.4 4区生物学

Theoretical Population Biology Pub Date : 2023-06-01 DOI: 10.1016/j.tpb.2023.03.004

Emil F. Frølich

引用次数: 1

Evolution with recombination as Gibbs sampling 用吉布斯采样法进行重组进化

IF 1.4 4区生物学

Theoretical Population Biology Pub Date : 2023-06-01 DOI: 10.1016/j.tpb.2023.03.005

Jenny M. Poulton , Lee Altenberg , Chris Watkins

{"title":"Evolution with recombination as Gibbs sampling","authors":"Jenny M. Poulton , Lee Altenberg , Chris Watkins","doi":"10.1016/j.tpb.2023.03.005","DOIUrl":"10.1016/j.tpb.2023.03.005","url":null,"abstract":"<div><p>This work presents a population genetic model of evolution, which includes haploid selection, mutation, recombination, and drift. The mutation-selection equilibrium can be expressed exactly in closed form for arbitrary fitness functions without resorting to diffusion approximations. Tractability is achieved by generating new offspring using n-parent rather than 2-parent recombination. While this enforces linkage equilibrium among offspring, it allows analysis of the whole population under linkage disequilibrium. We derive a general and exact relationship between fitness fluctuations and response to selection. Our assumptions allow analytical calculation of the stationary distribution of the model for a variety of non-trivial fitness functions. These results allow us to speak to genetic architecture, i.e., what stationary distributions result from different fitness functions. This paper presents methods for exactly deriving stationary states for finite and infinite populations. This method can be applied to many fitness functions, and we give exact calculations for four of these. These results allow us to investigate metastability, tradeoffs between fitness functions, and even consider error-correcting codes.</p></div>","PeriodicalId":49437,"journal":{"name":"Theoretical Population Biology","volume":"151 ","pages":"Pages 28-43"},"PeriodicalIF":1.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10043403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A population genetics theory for piRNA-regulated transposable elements pirna调控转座因子的群体遗传学理论

IF 1.4 4区生物学

Theoretical Population Biology Pub Date : 2023-04-01 DOI: 10.1016/j.tpb.2023.02.001

Siddharth S. Tomar, Aurélie Hua-Van, Arnaud Le Rouzic

{"title":"A population genetics theory for piRNA-regulated transposable elements","authors":"Siddharth S. Tomar, Aurélie Hua-Van, Arnaud Le Rouzic","doi":"10.1016/j.tpb.2023.02.001","DOIUrl":"10.1016/j.tpb.2023.02.001","url":null,"abstract":"<div><p><span>Transposable elements (TEs) are self-reproducing selfish DNA sequences that can invade the genome of virtually all living species. </span>Population genetics<span> models have shown that TE copy numbers generally reach a limit, either because the transposition rate decreases with the number of copies (transposition regulation) or because TE copies are deleterious, and thus purged by natural selection. Yet, recent empirical discoveries suggest that TE regulation may mostly rely on piRNAs, which require a specific mutational event (the insertion of a TE copy in a piRNA cluster) to be activated — the so-called TE regulation “trap model”. We derived new population genetics models accounting for this trap mechanism, and showed that the resulting equilibria differ substantially from previous expectations based on a transposition–selection equilibrium. We proposed three sub-models, depending on whether or not genomic TE copies and piRNA cluster TE copies are selectively neutral or deleterious, and we provide analytical expressions for maximum and equilibrium copy numbers, as well as cluster frequencies for all of them. In the full neutral model, the equilibrium is achieved when transposition is completely silenced, and this equilibrium does not depend on the transposition rate. When genomic TE copies are deleterious but not cluster TE copies, no long-term equilibrium is possible, and active TEs are eventually eliminated after an active incomplete invasion stage. When all TE copies are deleterious, a transposition–selection equilibrium exists, but the invasion dynamics is not monotonic, and the copy number peaks before decreasing. Mathematical predictions were in good agreement with numerical simulations, except when genetic drift and/or linkage disequilibrium dominates. Overall, the trap-model dynamics appeared to be substantially more stochastic and less repeatable than traditional regulation models.</span></p></div>","PeriodicalId":49437,"journal":{"name":"Theoretical Population Biology","volume":"150 ","pages":"Pages 1-13"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9622940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0