Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery最新文献

{"title":"The effect of edoxaban on apoptosis in an abdominal aortic aneurysm model in rats.","authors":"Tugra Gencpınar, Cagatay Bilen, Baris Kemahli, Ceren Sayarer, Pinar Akokay, Serdar Bayrak, Cenk Erdal","doi":"10.5606/tgkdc.dergisi.2024.25890","DOIUrl":"10.5606/tgkdc.dergisi.2024.25890","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the effects of edoxaban, which is used in venous thrombosis, systemic embolism, and stroke, on an aortic aneurysm model and to demonstrate the pharmacokinetic and molecular effects of edoxaban through the induction of apoptosis.</p><p><strong>Methods: </strong>In this double-blind experimental study, 21 Wistar albino male rats (mean weight: 290 g; range, 280 to 300 g) were divided into three groups: the sham group (n=7), the abdominal aortic aneurysm (AAA) group (n=7), and the AAA-edoxaban group (n=7). Edoxaban 10 mg/kg was given to the AAA-edoxaban group by oral gavage daily for 30 days. At the end of 30 days, the aneurysmal aorta was surgically removed and histologically examined. The abdominal aorta was surgically exposed and wrapped with a calcium chloride (0.5 mol/L) sponge for 10 min.</p><p><strong>Results: </strong>Immunohistochemically, aortic sections were marked with caspase-3 and caspase-9 antibodies. It was observed that the pathways that trigger apoptosis (caspase-3 and caspase-9; p <0.004 and p <0.005, respectively) were significantly reduced in the AAA-edoxaban group compared to the AAA group. In the AAA-edoxaban group, it was observed that the expansion in aortic diameter and the deterioration in the elastic fibril structure in the aortic aneurysm were decreased as a result of edoxaban treatment. Edoxaban treatment was observed to reduce cell death in both the tunica intima and tunica media.</p><p><strong>Conclusion: </strong>This study provided strong evidence of the protective effect of edoxaban on aortic aneurysm-related vascular damage by reducing apoptosis and mitophagy.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":"32 4","pages":"378-386"},"PeriodicalIF":0.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total coronary revascularization via left anterior thoracotomy: Comparison of early- and mid-term results with conventional surgery.","authors":"Tuna Demirkıran, Furkan Burak Akyol, Tayfun Özdem, Elgin Hacızade, Emre Kubat, Gökhan Erol, Murat Kadan, Kubilay Karabacak","doi":"10.5606/tgkdc.dergisi.2024.26471","DOIUrl":"10.5606/tgkdc.dergisi.2024.26471","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the efficacy and safety of total coronary revascularization via left anterior thoracotomy (TCRAT) by comparing it to conventional coronary artery bypass grafting (CABG) with median sternotomy.</p><p><strong>Methods: </strong>In this retrospective study, 108 patients (95 males, 13 females; mean age: 57.1±8.8; range, 41 to 75 years) who underwent TCRAT (Group 1) and 154 patients (126 males, 28 females; mean age: 61.2±9.8; range, 31 to 79) who underwent conventional CABG (Group 2) between February 1, 2021, and September 1, 2022, were evaluated. The operations were performed by the same surgical team. Preoperative, operative, and postoperative data of patients and mid-term follow-up data were analyzed.</p><p><strong>Results: </strong>Mean cardiopulmonary bypass and cross-clamp times, respectively, were 167.70±68.93 and 77.03±38.18 min in Group 1 and 106.64±38.27 and 62.21±24.06 min in Group 2 (p<0.001). During the postoperative period, the all-cause mortality rate was 5.8% (n=9) in Group 2, while it was 0.9% (n=1) in Group 1; there was a statistically significant difference between the two groups (p=0.037). Nevertheless, the mean preoperative EuroSCORE (European System for Cardiac Operative Risk Evaluation) II was 2.59±2.3 in Group 2, which was significantly higher than the mean EuroSCORE II of Group 1 (1.37±1.5; p<0.001). The mean hospitalization duration for Group 2 was 6.99±3.37 days, and the mean hospitalization duration for Group 1 was 6.77±4.24 days. Duration of hospitalization was statistically significantly shorter in Group 1 (p=0.047). In addition, the mean perioperative number of erythrocyte suspension transfusions in Group 1 was 1.51±1.74, while it was 1.86±1.75 in Group 2. Significantly fewer erythrocyte suspension transfusions were performed in Group 1 (p=0.033).</p><p><strong>Conclusion: </strong>The findings of our study indicate that TCRAT is a safe and viable technique when performed on a select patient group compared to the conventional method.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":"32 4","pages":"402-411"},"PeriodicalIF":0.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic micro-invasive cardiac surgery: State-of-the-art.","authors":"Farhad Bakhtiary, Saad Salamate, Kaveh Eghbalzadeh, Ali El-Sayed Ahmad","doi":"10.5606/tgkdc.dergisi.2024.56934","DOIUrl":"10.5606/tgkdc.dergisi.2024.56934","url":null,"abstract":"<p><p>The advancement of micro-invasive cardiac surgery techniques has introduced a viable alternative to conventional full-sternotomy operations. These approaches are designed to reduce tissue trauma, shorten recovery time, and meet the increasing demand for less invasive treatment options. In this review, we discuss current progresses in endoscopic micro-invasive cardiac surgery, which utilizes refined tools and advanced imaging technologies to perform complex heart procedures, including valve surgery, coronary artery bypass grafting, and congenital defect corrections. By reviewing our experience with these techniques, we provide practical insights for surgeons interested in adopting micro-invasive cardiac surgery. The highlighted innovations in planning and execution of micro-invasive cardiac surgery reflect the growing trend toward safer and more efficient cardiac surgeries.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":"32 4","pages":"355-366"},"PeriodicalIF":0.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femoral vein cannulation passing through patent foramen ovale and injuring left atrial appendage: An unusual complication.","authors":"Denyan Mansuroglu, Kenan Sever, Oguz Konukoglu, Mehmet Balkanay, Ali Dogan","doi":"10.5606/tgkdc.dergisi.2024.26110","DOIUrl":"10.5606/tgkdc.dergisi.2024.26110","url":null,"abstract":"","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":"32 4","pages":"462-464"},"PeriodicalIF":0.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Documentation of the current state of cardiopulmonary bypass management in Türkiye.","authors":"Fehmi Bors, Hatice Büyükkol, Nihat Şencan, Hüseyin Gümüş, Eşe C Çaran Karaoğlu, Mücella Kaçar, Sedef Dündar","doi":"10.5606/tgkdc.dergisi.2024.26509","DOIUrl":"10.5606/tgkdc.dergisi.2024.26509","url":null,"abstract":"<p><p>Since the first successful use of cardiopulmonary bypass (CPB), much has changed in its technology, area of use, and management. Despite suggestions in guidelines, the institutional behavior may change based on institutional experience and established habits. This so-called \"deviation\" may alter management strategies in favorable or unfavorable ways. As the official Cardiopulmonary Bypass Study Group of the Association of Perfusionists in Türkiye, we aimed to document the current state of CPB management in Türkiye and make suggestions based on current guidelines. A 20-item questionnaire e-mailed to 682 perfusionists in 110 centers in Türkiye, and 177 (25.95%) responses were recorded from 97 centers. The questionnaire included main parameters regarding the management of CPB. We believe that by documenting the current state of CPB management strategies in Türkiye, suboptimal management strategies can be improved and suggestions for more favorable outcomes can be made.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":"32 4","pages":"467-468"},"PeriodicalIF":0.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early postoperative outcomes of modified del Nido cardioplegia in coronary artery bypass surgery in patients with low ejection fraction.","authors":"Mehmet Emir Erol, Deniz Sarp Beyazpınar, İsa Civelek, Sertan Özyalçın, Ufuk Mungan","doi":"10.5606/tgkdc.dergisi.2024.26359","DOIUrl":"10.5606/tgkdc.dergisi.2024.26359","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the intraoperative and early postoperative effects of modified del Nido cardioplegia (DNC) compared to classic blood cardioplegia (BC) in patients with impaired left ventricular ejection fraction (EF) who underwent isolated coronary artery bypass grafting (CABG).</p><p><strong>Methods: </strong>A total of 123 patients (108 males, 15 females; mean age: 62.2±8.5 years; range, 42 to 78 years) with an EF of 35% or lower who underwent on-pump CABG were included in the retrospective study between December 2022 and December 2023. The patients were divided into two groups according to the type of cardioplegia used: Group 1 (n=74) was designated as the BC group, and Group 2 (n=49) was designated as the DNC group. The groups were compared in terms of aortic cross-clamp duration, cardiopulmonary bypass (CPB) duration, need for defibrillation during weaning from CPB, positive inotrope requirement, intra-aortic balloon pump requirement, postoperative troponin-I levels, postoperative atrial fibrillation occurence, postoperative prolonged ventilation, development of postoperative neurologic complications, need for reintervention due to postoperative bleeding, postoperative transfusion requirement, and EF values at one month after the operation.</p><p><strong>Results: </strong>There was no significant difference between the two groups in the terms of aortic cross-clamp and CPB duration (p=0.955 <i>vs.</i> p=0.816). Additionally, there was no significant difference in the need for intra-aortic balloon pump usage between the two groups (p=0.105). Dopamine and dobutamine usage were significantly lower in Group 2 (p=0.04 and p=0.05, respectively). The intraoperative requirement for defibrillation was significantly lower in Group 2 (p=0.01). In addition, troponin levels at 12 h postoperatively were significantly lower in Group 2 (p=0.03). The incidence of postoperative atrial fibrillation was significantly lower in Group 2 (p=0.02). Moreover, there was no significant difference in EF values at one month after the operation (p=0.08).</p><p><strong>Conclusion: </strong>In patients who underwent CABG with reduced EF, modified DNC provided myocardial protection comparable to classic BC. Additionally, the need for intraoperative defibrillation and postoperative inotropic agents, as well as the incidence of postoperative atrial fibrillation, were lower in patients operated with DNC.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":"32 4","pages":"387-393"},"PeriodicalIF":0.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced recovery after cardiac surgery and developments in perioperative care: A comprehensive review.","authors":"Serdar Gunaydin, Erdal Simsek, Daniel Engelman","doi":"10.5606/tgkdc.dergisi.2024.26770","DOIUrl":"10.5606/tgkdc.dergisi.2024.26770","url":null,"abstract":"<p><p>Enhanced Recovery After Cardiac Surgery (ERAS Cardiac) protocols offer a comprehensive, multidisciplinary approach to improve patient outcomes and reduce postoperative complications. By incorporating evidence-based practices, ERAS Cardiac aims to reduce hospital stays, enhance patient satisfaction, and optimize resource utilization. Key components include patient education, prehabilitation, nutritional optimization, and personalized medicine. The protocol's success relies on interdisciplinary collaboration among healthcare professionals, as well as active patient and family engagement. Despite challenges in implementation, such as resource constraints and patient variability, ongoing research and adaptive strategies continue to refine ERAS Cardiac programs, promising significant advancements in cardiac surgical care and recovery.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":"33 1","pages":"121-131"},"PeriodicalIF":0.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive value of the Haller index for recurrent pneumothorax risk after primary spontaneous pneumothorax.","authors":"Mesut Buz, Yunus Emre Özsaray, Mehmet İlhan Sesigüzel, Mahmut Talha Doğruyol, Rıza Berk Çimenoğlu, Attila Özdemir, Recep Demirhan","doi":"10.5606/tgkdc.dergisi.2024.26856","DOIUrl":"10.5606/tgkdc.dergisi.2024.26856","url":null,"abstract":"<p><strong>Background: </strong>In this study, we aimed to evaluate the predictive value of the Haller index for recurrence risk in primary spontaneous pneumothorax patients.</p><p><strong>Methods: </strong>Between January 2018 and December 2023, a total of 285 patients (260 males, 25 females; median age: 23 years; range, 17 to 35 years) with primary spontaneous pneumothorax who underwent thoracic computed tomography and followed for at least one year were retrospectively analyzed. The patients were divided into two groups as the non-recurrence group (n=170) and recurrence (n=115) group. The Haller index was calculated from computed tomography scans at presentation and its predictive value for recurrent pneumothorax was estimated.</p><p><strong>Results: </strong>The median age was significantly higher in the non-recurrence group than in the recurrence group (p <0.001). The median time to recurrence was two (IQR 1-3) months. The diagnostic validity of Haller index for predicting recurrence showed an area under the receiver operating characteristic of 0.824 (95% confidence interval [CI]: 0.775-0.866) (p <0.001). The optimal cut-off value of Haller index (>2.4) showed a sensitivity of 70.43% (95% CI: 61.2-78.6) and specificity of 76.47% (95% CI: 69.4-82.6).</p><p><strong>Conclusion: </strong>A high Haller index is associated with increased recurrent pneumothorax risk in primary spontaneous pneumothorax patients. Traditionally used for pectus excavatum severity, incorporating Haller index in the management of these patients may help to identify high-risk patients and guide personalized management strategies.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":"32 4","pages":"436-444"},"PeriodicalIF":0.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could papillary fibroelastoma in the tricuspid valve cause thrombocytopenia?","authors":"Mehmet Işık, Sıddıka Fındık, Sefa Tatar, Şükrü Kara, Niyazi Görmüş","doi":"10.5606/tgkdc.dergisi.2024.25719","DOIUrl":"10.5606/tgkdc.dergisi.2024.25719","url":null,"abstract":"<p><p>Cardiac myxoma and papillary fibroelastoma are the most common benign primary cardiac tumors in adults. In this brief report, we described a male patient with a mass in the tricuspid valve (papillary fibroelastoma as a result of pathology), who presented with thrombocytopenia and underwent tricuspid valve replacement. The patient was followed and treated by the hematology clinic due to thrombocytopenia, but a definitive diagnosis could not be made. The patient was incidentally diagnosed while being investigated for urinary stones. Thrombocytopenia improved in the postoperative follow-up. The successful surgical procedure, along with echocardiography and pathology images of the patient, was shared.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":"33 1","pages":"117-120"},"PeriodicalIF":0.5,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning in distinguishing pulmonary nodules as benign and malignant.","authors":"Muhammed Bilal Akıncı, Mesut Özgökçe, Murat Canayaz, Fatma Durmaz, Sercan Özkaçmaz, İlyas Dündar, Ensar Türko, Cemil Göya","doi":"10.5606/tgkdc.dergisi.2024.26027","DOIUrl":"https://doi.org/10.5606/tgkdc.dergisi.2024.26027","url":null,"abstract":"<p><strong>Background: </strong>Due to the high mortality of lung cancer, the aim was to find convolutional neural network models that can distinguish benign and malignant cases with high accuracy, which can help in early diagnosis with diagnostic imaging.</p><p><strong>Methods: </strong>Patients who underwent tomography in our clinic and who were found to have lung nodules were retrospectively screened between January 2015 and December 2020. The patients were divided into two groups: benign (n=68; 38 males, 30 females; mean age: 59±12.2 years; range, 27 to 81 years) and malignant (n=29; 19 males, 10 females; mean age: 65±10.4 years; range, 43 to 88 years). In addition, a control group (n=67; 38 males, 29 females; mean age: 56.9±14.1 years; range, 26 to 81 years) consisting of healthy patients with no pathology in their sections was formed. Deep neural networks were trained with 80% of the three-class dataset we created and tested with 20% of the data. After the training of deep neural networks, feature extraction was done for these networks. The features extracted from the dataset were classified by machine learning algorithms. Performance results were obtained using confusion matrix analysis.</p><p><strong>Results: </strong>After training deep neural networks, the highest accuracy rate of 80% was achieved with the AlexNET model among the models used. In the second stage results, obtained after feature extraction and using the classifier, the highest accuracy rate was achieved with the support vector machine classifier in the VGG19 model with 93.5%. In addition, increases in accuracy were noted in all models with the use of the support vector machine classifier.</p><p><strong>Conclusion: </strong>Differentiation of benign and malignant lung nodules using deep learning models and feature extraction will provide important advantages for early diagnosis in radiology practice. The results obtained in our study support this view.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":"32 3","pages":"317-324"},"PeriodicalIF":0.5,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}