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[IgA antibodies against HIV-1]. [针对 HIV-1 的 IgA 抗体]。
IF 0.7 4区 医学
Virologie Pub Date : 2024-06-28 DOI: 10.1684/vir.2024.1049
Valérie Lorin, Hugo Mouquet
{"title":"[IgA antibodies against HIV-1].","authors":"Valérie Lorin, Hugo Mouquet","doi":"10.1684/vir.2024.1049","DOIUrl":"10.1684/vir.2024.1049","url":null,"abstract":"<p><p>Antibodies, and notably immunoglobulins A (IgA), are paramount in mucosal tissues as protective immune effectors against invading pathogens and immunomodulators of the microbiota. Upon human immunodeficiency virus type 1 (HIV-1) infection, systemic and mucosal IgA antibody responses are triggered. While naturally produced serum HIV-1 envelope protein-specific IgA are quantitatively and qualitatively weaker than their IgG counterparts, they also possess antiviral properties including neutralization and Fc-dependent functions. IgA neutralizers can block HIV-1 mucosal transmission in animal models, indicating that their elicitation by vaccination would be an important component for preventing infection. Moreover, the first genuine IgA broadly HIV-1 neutralizing antibodies (bNAbs) were recently identified in certain individuals living with HIV-1. Vaccine-based induction of IgA bNAbs potentially protective at the mucosal level is therefore conceivable. Hence, research efforts must therefore be undertaken to better understand their development and functions. In this review, we present the general functions of IgA in homeostasis and antimicrobial immunity and discuss their involvement in the antibody responses against HIV-1.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"0 0","pages":"237-253"},"PeriodicalIF":0.7,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The viral protein NS1: a major player in the pathogenesis of orthoflaviviruses]. [病毒蛋白 NS1：正黄病毒发病机制中的主要角色】。］
IF 0.7 4区 医学
Virologie Pub Date : 2024-06-01 DOI: 10.1684/vir.2024.1050
Justine Revel, Caroline Desmetz, Yannick Simonin
{"title":"[The viral protein NS1: a major player in the pathogenesis of orthoflaviviruses].","authors":"Justine Revel, Caroline Desmetz, Yannick Simonin","doi":"10.1684/vir.2024.1050","DOIUrl":"10.1684/vir.2024.1050","url":null,"abstract":"<p><p>Orthoflaviviruses are enveloped positive-sense RNA viruses comprising numerous human pathogens transmitted by hematophagous arthropods. This includes viruses such as dengue virus, Zika virus, and yellow fever virus. The viral nonstructural protein NS1 plays a central role in the pathogenesis and cycle of these viruses by acting in two different forms: associated with the plasma membrane (NS1m) or secreted outside the cell (NS1s). The versatility of NS1 is evident in its ability to modulate various aspects of the infectious process, from immune evasion to pathogenesis. As an intracellular protein, it disrupts many processes, interfering with signaling pathways and facilitating viral replication in concert with other viral proteins. As a secreted protein, NS1 actively participates in immune evasion, interfering with the host immune system, inhibiting the complement system, facilitating viral dissemination, and disrupting the integrity of endothelial barriers. This review primarily aims to address the role of NS1 in viral pathogenesis associated with orthoflaviviruses.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 3","pages":"187-197"},"PeriodicalIF":0.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[International congress of Viruses 2024 - A World of Viruses]. [2024 年国际病毒大会--病毒的世界]。
IF 0.7 4区 医学
Virologie Pub Date : 2024-06-01 DOI: 10.1684/vir.2024.1052
Lucas Schalck
{"title":"[International congress of Viruses 2024 - A World of Viruses].","authors":"Lucas Schalck","doi":"10.1684/vir.2024.1052","DOIUrl":"10.1684/vir.2024.1052","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 3","pages":"217-219"},"PeriodicalIF":0.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Renaud-Mahieux Prizes : best posters during the XXVIth Journées Francophones de Virologie (JFV), Brusels 10-12 April 2024]. [Renaud-Mahieux 奖：第 XXVI 届法语国家病毒学年会（JFV）期间的最佳海报，布鲁塞尔，2024 年 4 月 10-12 日]。
IF 0.7 4区 医学
Virologie Pub Date : 2024-06-01 DOI: 10.1684/vir.2024.1054
Noël Tordo
{"title":"[Renaud-Mahieux Prizes : best posters during the XXVI<sup>th</sup> Journées Francophones de Virologie (JFV), Brusels 10-12 April 2024].","authors":"Noël Tordo","doi":"10.1684/vir.2024.1054","DOIUrl":"https://doi.org/10.1684/vir.2024.1054","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 3","pages":"223-227"},"PeriodicalIF":0.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Viroids : infectious non coding RNAs]. [病毒：传染性非编码 RNA]。
IF 0.7 4区 医学
Virologie Pub Date : 2024-06-01 DOI: 10.1684/vir.2024.1051
Charith Raj Adkar-Purushothama, Pauline Lejault, Marc-Antoine Turcotte, Jean-Pierre Perreault
{"title":"[Viroids : infectious non coding RNAs].","authors":"Charith Raj Adkar-Purushothama, Pauline Lejault, Marc-Antoine Turcotte, Jean-Pierre Perreault","doi":"10.1684/vir.2024.1051","DOIUrl":"https://doi.org/10.1684/vir.2024.1051","url":null,"abstract":"<p><p>Viroids are the smallest non-coding infectious RNAs (between 246 and 401 nucleotides) known to be highly structured and replicate autonomously in the host plants. Although they do not encode any peptides, viroids induce visible symptoms in susceptible host plants. This article provides an overview of their physical and biological properties, the diseases they cause and their significance for the plants. The mechanisms underlying the expression of symptoms in host plants, their detection and various strategies employed for diseases prevention are also developed.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 3","pages":"199-215"},"PeriodicalIF":0.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Oroupouche virus: towards a future emergence?] [奥鲁普切病毒：未来会出现吗？］
IF 0.7 4区 医学
Virologie Pub Date : 2024-06-01 DOI: 10.1684/vir.2024.1055
Anne Lavergne, Antoine Enfissi, Dominique Rousset
{"title":"[Oroupouche virus: towards a future emergence?]","authors":"Anne Lavergne, Antoine Enfissi, Dominique Rousset","doi":"10.1684/vir.2024.1055","DOIUrl":"10.1684/vir.2024.1055","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 3","pages":"179-181"},"PeriodicalIF":0.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Report of the plenary session "Archaeology to prevent the future" during the XXVIth JFV]. [第 XXVI 届联合论坛全体会议 "预防未来的考古学 "报告]。
IF 0.7 4区 医学
Virologie Pub Date : 2024-06-01 DOI: 10.1684/vir.2024.1053
Charlène Martin
{"title":"[Report of the plenary session \"Archaeology to prevent the future\" during the XXVI<sup>th</sup> JFV].","authors":"Charlène Martin","doi":"10.1684/vir.2024.1053","DOIUrl":"10.1684/vir.2024.1053","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 3","pages":"221-222"},"PeriodicalIF":0.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Index par auteur et par numéro de résumé. 按作者和摘要编号索引。
IF 0.9 4区 医学
Virologie Pub Date : 2024-04-01 DOI: 10.1684/vir.2024.1048
{"title":"Index par auteur et par numéro de résumé.","authors":"","doi":"10.1684/vir.2024.1048","DOIUrl":"10.1684/vir.2024.1048","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 2","pages":"157-162"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Journées francophones de virologie go international with a visit to Brussels]. [法语国家病毒学期刊走向国际，访问布鲁塞尔]。
IF 0.9 4区 医学
Virologie Pub Date : 2024-04-01 DOI: 10.1684/vir.2024.1042
Anne Op de Beeck, Etienne Decroly
{"title":"[The Journées francophones de virologie go international with a visit to Brussels].","authors":"Anne Op de Beeck, Etienne Decroly","doi":"10.1684/vir.2024.1042","DOIUrl":"10.1684/vir.2024.1042","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 2","pages":"59-60"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Séances plénières et conférences. 全体会议和大会。
IF 0.9 4区 医学
Virologie Pub Date : 2024-04-01 DOI: 10.1684/vir.2024.1047
{"title":"Séances plénières et conférences.","authors":"","doi":"10.1684/vir.2024.1047","DOIUrl":"10.1684/vir.2024.1047","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 2","pages":"77-156"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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