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[Role of hepatitis B virus e protein and core protein in hepatocarcinogenesis]. [乙型肝炎病毒 e 蛋白和核心蛋白在肝癌发生中的作用]。
IF 0.9 4区 医学
Virologie Pub Date : 2023-12-01 DOI: 10.1684/vir.2023.1025
Caroline Lefeuvre, Alexandra Ducancelle
{"title":"[Role of hepatitis B virus e protein and core protein in hepatocarcinogenesis].","authors":"Caroline Lefeuvre, Alexandra Ducancelle","doi":"10.1684/vir.2023.1025","DOIUrl":"10.1684/vir.2023.1025","url":null,"abstract":"<p><p>Chronic hepatitis B virus (HBV) infection is one of the most common factors associated with hepatocellular carcinoma (HCC). However, the pathogenesis of HBV-mediated hepatocarcinogenesis is not clearly defined. Persistence of HBV infection is associated with HCC pathogenesis, and various HBV proteins appear to be involved in promoting this persistence. Currently available data suggest that the core protein, a structural component of the viral nucleocapsid, and the HBe protein, a non-structural HBV protein that can act as both a tolerogen and an immunogen, play a potential role in the development of HCC. Research shows that both proteins are capable of disrupting various pathways involved in liver carcinogenesis, including the sustenance of proliferative signaling, resistance to cell death, tumor-promoting inflammation and avoid immune destruction. This review summarizes the various signaling pathways by which HBc and HBe proteins (and their precursors) can promote hepatocarcinogenesis.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Et si le SARS-CoV-2 se transmettait sous forme de biofilm viral ?] [如果 SARS-CoV-2 是以病毒生物膜的形式传播的呢？］
IF 0.9 4区 医学
Virologie Pub Date : 2023-12-01 DOI: 10.1684/vir.2023.1029
Maria-Isabel Thoulouze, Catherine Inizan
{"title":"[Et si le SARS-CoV-2 se transmettait sous forme de biofilm viral ?]","authors":"Maria-Isabel Thoulouze, Catherine Inizan","doi":"10.1684/vir.2023.1029","DOIUrl":"10.1684/vir.2023.1029","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nature and evolution of the cellular HIV-1 reservoir in children and adolescents. 儿童和青少年细胞 HIV-1 病毒库的性质和演变。
IF 0.7 4区 医学
Virologie Pub Date : 2023-10-01 DOI: 10.1684/vir.2023.1039
Jade Canape, Madeleine Aby Diallo, Hugo Soudeyns
{"title":"Nature and evolution of the cellular HIV-1 reservoir in children and adolescents.","authors":"Jade Canape, Madeleine Aby Diallo, Hugo Soudeyns","doi":"10.1684/vir.2023.1039","DOIUrl":"10.1684/vir.2023.1039","url":null,"abstract":"<p><p>Shortly after primary infection, HIV hides in cellular reservoirs from which it becomes difficult or almost impossible to dislodge. In the absence of effective antiretroviral therapy, there is almost invariably resurgence of productive infection leading to a decline in CD4+ T cell counts and progression of HIV disease. The course of HIV infection in adults (horizontal transmission) differs significantly from that acquired in children following perinatal transmission: steady-state viral load is higher in children, adherence issues make it more difficult to control viral load using antiretroviral therapy, and the life expectancy of HIV-infected children in absence of treatment is markedly shorter than that of adults. Compared to the situation in adults, we know very little about the nature of the cellular reservoir in children, about its importance at the quantitative level, about its persistence over time, about its evolution during infancy, childhood and adolescence, and about its influence on the pathogenesis of pediatric HIV-AIDS. Some reported cases of spontaneous remission of HIV infection in children in the absence of treatment have also fueled the hopes of discovering avenues leading to a functional cure for HIV-AIDS in both children and adults.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Nature and evolution of the cellular HIV-1 reservoir in children and adolescents]. [儿童和青少年细胞HIV-1病毒库的性质和进化]。
IF 0.9 4区 医学
Virologie Pub Date : 2023-10-01 DOI: 10.1684/vir.2023.1023
Jade Canape, Madeleine Aby Diallo, Hugo Soudeyns
{"title":"[Nature and evolution of the cellular HIV-1 reservoir in children and adolescents].","authors":"Jade Canape, Madeleine Aby Diallo, Hugo Soudeyns","doi":"10.1684/vir.2023.1023","DOIUrl":"10.1684/vir.2023.1023","url":null,"abstract":"<p><p>Shortly after primary infection, HIV hides in cellular reservoirs from which it becomes difficult or almost impossible to dislodge. In the absence of effective antiretroviral therapy, there is almost invariably resurgence of productive infection leading to a decline in CD4+ T cell counts and progression of HIV disease. The course of HIV infection in adults (horizontal transmission) differs significantly from that acquired in children following perinatal transmission: steady-state viral load is higher in children, adherence issues make it more difficult to control viral load using antiretroviral therapy, and the life expectancy of HIV-infected children in absence of treatment is markedly shorter than that of adults. Compared to the situation in adults, we know very little about the nature of the cellular reservoir in children, about its importance at the quantitative level, about its persistence over time, about its evolution during infancy, childhood and adolescence, and about its influence on the pathogenesis of pediatric HIV-AIDS. Some reported cases of spontaneous remission of HIV infection in children in the absence of treatment have also fueled the hopes of discovering avenues leading to a functional cure for HIV-AIDS in both children and adults.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138292227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene therapy to cure HIV infection. 基因疗法治愈HIV感染。
IF 0.9 4区 医学
Virologie Pub Date : 2023-10-01 DOI: 10.1684/vir.2023.1024
Ryan P Goguen, Michelle J Chen, Owen R S Dunkley, Anne Gatignol, Robert J Scarborough
{"title":"Gene therapy to cure HIV infection.","authors":"Ryan P Goguen, Michelle J Chen, Owen R S Dunkley, Anne Gatignol, Robert J Scarborough","doi":"10.1684/vir.2023.1024","DOIUrl":"10.1684/vir.2023.1024","url":null,"abstract":"<p><p>To date, the only intervention that has cured HIV infection has been bone marrow transplants from HIV-resistant donors to HIV-infected recipients. This approach has been used to both cure hematological malignancies and HIV infection, but it cannot be widely adopted due to the high risk of mortality associated with cell transplants between individuals. To overcome this limitation, several approaches have been developed to generate HIV resistance using gene therapy in an infected individual's own cells. With the growing arsenal of effective methods to generate HIV-resistant cells, a safe and effective combination gene therapy approach to cure HIV infection is fast approaching. Here, we review several gene therapy-based methods to generate HIV-resistant cells including the expression of antiviral genes, genome editing, and transcriptional gene silencing. Their varied mechanisms, advantages, and disadvantages are discussed, and perspectives are provided for how they may be combined to design an effective gene therapy for HIV.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138300504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Gene therapy to cure HIV infection]. [基因疗法治疗HIV感染]。
IF 0.9 4区 医学
Virologie Pub Date : 2023-10-01 DOI: 10.1684/vir.2023.1021
Ryan P Goguen, Michelle J Chen, Owen R S Dunkley, Anne Gatignol, Robert J Scarborough
{"title":"[Gene therapy to cure HIV infection].","authors":"Ryan P Goguen, Michelle J Chen, Owen R S Dunkley, Anne Gatignol, Robert J Scarborough","doi":"10.1684/vir.2023.1021","DOIUrl":"10.1684/vir.2023.1021","url":null,"abstract":"<p><p>To date, the only intervention that has cured HIV infection has been bone marrow transplants from HIV-resistant donors to HIV-infected recipients. This approach has been used to both cure hematological malignancies and HIV infection, but it cannot be widely adopted due to the high risk of mortality associated with cell transplants between individuals. To overcome this limitation, several approaches have been developed to generate HIV resistance using gene therapy in an infected individual's own cells. With the growing arsenal of effective methods to generate HIV-resistant cells, a safe and effective combination gene therapy approach to cure HIV infection is fast approaching. Here, we review several gene therapy-based methods to generate HIV-resistant cells including the expression of antiviral genes, genome editing, and transcriptional gene silencing. Their varied mechanisms, advantages, and disadvantages are discussed, and perspectives are provided for how they may be combined to design an effective gene therapy for HIV.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138292226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Forty years old and not quarantined: where are we with HIV-focused research?] [40岁，未被隔离:艾滋病毒研究进展如何?]］
IF 0.9 4区 医学
Virologie Pub Date : 2023-10-01 DOI: 10.1684/vir.2023.1020
Jean-Pierre Routy, Stéphane Isnard
{"title":"[Forty years old and not quarantined: where are we with HIV-focused research?]","authors":"Jean-Pierre Routy, Stéphane Isnard","doi":"10.1684/vir.2023.1020","DOIUrl":"10.1684/vir.2023.1020","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138292225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cold Spring Harbor Laboratory Retroviruses Meeting: major advancements in retrovirus research]. [冷泉港实验室逆转录病毒会议:逆转录病毒研究的重大进展]。
IF 0.9 4区 医学
Virologie Pub Date : 2023-10-01 DOI: 10.1684/vir.2023.1022
Alexandre Legrand
{"title":"[Cold Spring Harbor Laboratory Retroviruses Meeting: major advancements in retrovirus research].","authors":"Alexandre Legrand","doi":"10.1684/vir.2023.1022","DOIUrl":"10.1684/vir.2023.1022","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138292224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstracts - Thème 1 Origine et éco-épidémiologie des zoonoses émergentes et réémergentes en Afrique de l’Ouest et centrale. 摘要-主题1西非和中非新发和再发人畜共患病的起源和生态流行病学。
IF 0.9 4区 医学
Virologie Pub Date : 2023-09-01 DOI: 10.1684/vir.2023.1011
{"title":"Abstracts - Thème 1 Origine et éco-épidémiologie des zoonoses émergentes et réémergentes en Afrique de l’Ouest et centrale.","authors":"","doi":"10.1684/vir.2023.1011","DOIUrl":"https://doi.org/10.1684/vir.2023.1011","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Symposium international sur les maladies zoonotiques émergentes et réémergentes : focus sur les fièvres hémorragiques virales en Afrique (étiologie, épidémiologie, surveillance et prévention). 新发和再发人畜共患疾病国际研讨会：关注非洲病毒性出血热（病因、流行病学、监测和预防）。
IF 0.9 4区 医学
Virologie Pub Date : 2023-09-01 DOI: 10.1684/vir.2023.1019
{"title":"Symposium international sur les maladies zoonotiques émergentes et réémergentes : focus sur les fièvres hémorragiques virales en Afrique (étiologie, épidémiologie, surveillance et prévention).","authors":"","doi":"10.1684/vir.2023.1019","DOIUrl":"https://doi.org/10.1684/vir.2023.1019","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41167691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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