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Evaluate the host cellular immune response to better prevent and diagnose viral infections. 评估宿主细胞免疫反应，以更好地预防和诊断病毒感染。
IF 1 4区 医学
Virologie Pub Date : 2025-09-22 DOI: 10.1684/vir.2025.1102
William Mouton, Jean-Marc Gombert, Anne Barra, Morgane Solis, Samira Fafi-Kremer, Nicolas Lévêque, Sophie Trouillet-Assant, Marine Mommert-Tripon, Edouard Tuaillon, Patrice Morand
{"title":"Evaluate the host cellular immune response to better prevent and diagnose viral infections.","authors":"William Mouton, Jean-Marc Gombert, Anne Barra, Morgane Solis, Samira Fafi-Kremer, Nicolas Lévêque, Sophie Trouillet-Assant, Marine Mommert-Tripon, Edouard Tuaillon, Patrice Morand","doi":"10.1684/vir.2025.1102","DOIUrl":"https://doi.org/10.1684/vir.2025.1102","url":null,"abstract":"<p><p>In medicine, virological diagnosis is mainly based on the detection of the viral genome and antigens, or on the identification of specific antibodies produced in response to infection. These strategies are suitable for characterizing an active infection or past contact with an already known virus. The recent development of tests for evaluating the host's cellular immune response opens new perspectives for personalized patient care based on immunomonitoring. The IGRA tests (Interferon Gamma Release Assay), measuring interferon gamma produced by T lymphocytes stimulated in vitro by antigenic peptides specific to infectious agents and the quantification of the blood viral load of Torque teno virus (TTV) thus constitute tools for assessing infectious risk, particularly usable to predict opportunistic viral reactivations in immunocompromised patients. The characterization of the expression profile of interferon stimulated genes (IGS) in a respiratory sample is also likely to provide significant assistance in diagnosis, discriminating a viral infection from a bacterial infection, an acute infection from a persistence of nucleic acids from non-replicating microorganisms or allowing, in case of viral emergence, to quickly identify infected subjects in the absence of specific PCR tests available. All of these new approaches, described in this review, have the potential to considerably improve patient care with the objective to correctly prescribe medical virology tests and anti-infective treatments.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 5","pages":"32-43"},"PeriodicalIF":1.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Oncolytic viruses for the management of pancreatic cancer: ongoing trials and therapeutic perspectives]. [溶瘤病毒用于胰腺癌的治疗：正在进行的试验和治疗观点]。
IF 1 4区 医学
Virologie Pub Date : 2025-08-19 DOI: 10.1684/vir.2025.1100
Agathe Redouté, Nikolaos Kontopoulos, Stéphane Bertagnoli, Pierre Cordelier
{"title":"[Oncolytic viruses for the management of pancreatic cancer: ongoing trials and therapeutic perspectives].","authors":"Agathe Redouté, Nikolaos Kontopoulos, Stéphane Bertagnoli, Pierre Cordelier","doi":"10.1684/vir.2025.1100","DOIUrl":"10.1684/vir.2025.1100","url":null,"abstract":"<p><p>Despite advances in research and clinical practice, pancreatic ductal adenocarcinoma remains a major public health challenge due to the lack of early detection and effective treatments. In this context, oncolytic viruses have emerged as a promising therapeutic alternative. These viruses selectively infect and lyse cancer cells after replication while also having the potential to induce an antitumor immune response. This review explores the fundamental aspects of pancreatic cancer and its management, along with the principles of oncolytic virotherapy, highlighting clinically used viruses before discussing the therapeutic potential of the SG33 myxoma virus strain in pancreatic cancer virotherapy.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 4","pages":"293-311"},"PeriodicalIF":1.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antitumor immuno-virotherapy with attenuated strains of measles virus]. [麻疹病毒减毒株抗肿瘤免疫病毒治疗]。
IF 1 4区 医学
Virologie Pub Date : 2025-08-18 DOI: 10.1684/vir.2025.1101
Jean-François Fonteneau, Nicolas Boisgerault, Frédéric Tangy
{"title":"[Antitumor immuno-virotherapy with attenuated strains of measles virus].","authors":"Jean-François Fonteneau, Nicolas Boisgerault, Frédéric Tangy","doi":"10.1684/vir.2025.1101","DOIUrl":"https://doi.org/10.1684/vir.2025.1101","url":null,"abstract":"<p><p>Antitumor immuno-virotherapy involves the use of replicating oncolytic viruses capable of selectively infecting and killing tumor cells, with the aim of stimulating an antitumor immune response. Attenuated strains of measles virus (MeV) used as measles vaccines are good candidates. Attenuated MeVs use the CD46 molecule as a tumor cell entry receptor, but also CD150/SLAM and Nectin-4. The CD46 molecule blocks complement-mediated lysis and is frequently overexpressed by many cancer cell types, enabling the attenuated MeV to infect these cells. In addition, MeVs take advantage of defects in the antiviral type I interferon (IFN I) response in tumor cells to replicate, while this antiviral response blocks its replication in healthy cells. Attenuated MeVs display oncolytic properties against numerous cancers in vitro and in mouse models. They induce immunogenic cell death with infiltration of tumors by immune cells, notably T lymphocytes, thus activating the anti-tumor immune response. Several phase I and II clinical trials using different MeVs have been carried out, with encouraging results. Here, we provide an update on this therapeutic approach.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 4","pages":"271-291"},"PeriodicalIF":1.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reoviruses : from replication cycle to oncolytic activity. 呼肠孤病毒：从复制周期到溶瘤活性。
IF 1 4区 医学
Virologie Pub Date : 2025-08-18 DOI: 10.1684/vir.2025.1099
Guy Lemay
{"title":"Reoviruses : from replication cycle to oncolytic activity.","authors":"Guy Lemay","doi":"10.1684/vir.2025.1099","DOIUrl":"https://doi.org/10.1684/vir.2025.1099","url":null,"abstract":"<p><p>Among the wide range of viruses studied for their possible use as an oncolytic virus, the mammalian reovirus has the particularity of being naturally oncolytic, without requiring prior genetic modification. Since the 1970s, it has been observed that this virus has a propensity to destroy transformed cells in a preferential manner. These preliminary observations were refined at the end of the 1990s, and the idea of using reovirus as an oncolytic virus in anticancer virotherapy quickly took hold. This review briefly describes the main steps of the viral replication cycle pertinent to the oncolytic activity of the virus, as well as possible strategies for better optimization of this activity.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 4","pages":"0"},"PeriodicalIF":1.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Reoviruses: from replication cycle to oncolytic activity]. 呼肠孤病毒：从复制周期到溶瘤活性。
IF 1 4区 医学
Virologie Pub Date : 2025-08-18 DOI: 10.1684/vir.2025.1098
Guy Lemay
{"title":"[Reoviruses: from replication cycle to oncolytic activity].","authors":"Guy Lemay","doi":"10.1684/vir.2025.1098","DOIUrl":"https://doi.org/10.1684/vir.2025.1098","url":null,"abstract":"<p><p>Among the wide range of viruses studied for their possible use as an oncolytic virus, the mammalian reovirus has the particularity of being naturally oncolytic, without requiring prior genetic modification. Since the 1970s, it has been observed that this virus has a propensity to destroy transformed cells in a preferential manner. These preliminary observations were refined at the end of the 1990s, and the idea of using reovirus as an oncolytic virus in anticancer virotherapy quickly took hold. This review briefly describes the main steps of the viral replication cycle pertinent to the oncolytic activity of the virus, as well as possible strategies for better optimization of this activity.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 4","pages":"253-269"},"PeriodicalIF":1.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Oncolytic viruses in action: A successful unique case to be considered with caution]. [溶瘤病毒的作用：一个需要谨慎考虑的成功的独特案例]。
IF 1 4区 医学
Virologie Pub Date : 2025-08-01 DOI: 10.1684/vir.2025.1096
David Olagnier, Tommy Alain
{"title":"[Oncolytic viruses in action: A successful unique case to be considered with caution].","authors":"David Olagnier, Tommy Alain","doi":"10.1684/vir.2025.1096","DOIUrl":"https://doi.org/10.1684/vir.2025.1096","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 4","pages":"249-252"},"PeriodicalIF":1.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oncolytic viruses in action: A successful unique case to be considered with caution. 溶瘤病毒的作用：一个成功的独特案例，需要谨慎考虑。
IF 1 4区 医学
Virologie Pub Date : 2025-08-01 DOI: 10.1684/vir.2025.1097
David Olagnier, Tommy Alain
{"title":"Oncolytic viruses in action: A successful unique case to be considered with caution.","authors":"David Olagnier, Tommy Alain","doi":"10.1684/vir.2025.1097","DOIUrl":"https://doi.org/10.1684/vir.2025.1097","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 4","pages":"26-29"},"PeriodicalIF":1.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Marlène Dreux, PhD]. [Marlene Dreux，博士]。
IF 0.7 4区 医学
Virologie Pub Date : 2025-06-23 DOI: 10.1684/vir.2025.1094
H Dutartre
{"title":"[Marlène Dreux, PhD].","authors":"H Dutartre","doi":"10.1684/vir.2025.1094","DOIUrl":"10.1684/vir.2025.1094","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 3","pages":"0"},"PeriodicalIF":0.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Feedback on the 38th International Conference on Antiviral Research (March 17-21 2025, Las Vegas, USA)]. [对第38届国际抗病毒研究会议（2025年3月17日至21日，美国拉斯维加斯）的反馈]。
IF 0.7 4区 医学
Virologie Pub Date : 2025-06-21 DOI: 10.1684/vir.2025.1092
Valentine Chaillot
{"title":"[Feedback on the 38th International Conference on Antiviral Research (March 17-21 2025, Las Vegas, USA)].","authors":"Valentine Chaillot","doi":"10.1684/vir.2025.1092","DOIUrl":"10.1684/vir.2025.1092","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 3","pages":"0"},"PeriodicalIF":0.7,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New therapeutic strategies against B and D hepatitis]. [乙型和丁型肝炎的新治疗策略]。
IF 1 4区 医学
Virologie Pub Date : 2025-06-01 DOI: 10.1684/vir.2025.1089
Juliette Besombes, Charlotte Pronier, Vincent Thibault
{"title":"[New therapeutic strategies against B and D hepatitis].","authors":"Juliette Besombes, Charlotte Pronier, Vincent Thibault","doi":"10.1684/vir.2025.1089","DOIUrl":"10.1684/vir.2025.1089","url":null,"abstract":"<p><p>Current treatments against the hepatitis B virus (HBV) efficiently inhibit viral replication but rarely lead to functional cure, defined as the loss of HBsAg. Persisting transcription from intranuclear forms of viral DNA, independently from viral replication, limits the possibility of a robust clearing response of the host against the virus. The new therapeutic approaches target either the transcription, with specific oligonucleotides, the capsid assembly or the release of complete viral particles from infected hepatocytes. Some clinical trials seem highly promising. Although the clinical evolution of hepatitis Delta infection is more severe than the one caused by HBV, our tools to fight the virus are even less developed. In addition to the strategies used for HBV, molecules targeting HDV entry or HDAg prenylation are currently being evaluated. We review the main characteristics of HBV and HDV viral replication and highlight the results obtained in clinical trials using the most advanced molecules developed to overcome these infections.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 3","pages":"191-205"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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