VirologiePub Date : 2025-06-21DOI: 10.1684/vir.2025.1092
Valentine Chaillot
{"title":"[Feedback on the 38th International Conference on Antiviral Research (March 17-21 2025, Las Vegas, USA)].","authors":"Valentine Chaillot","doi":"10.1684/vir.2025.1092","DOIUrl":"10.1684/vir.2025.1092","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 3","pages":"0"},"PeriodicalIF":0.7,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
VirologiePub Date : 2025-06-01DOI: 10.1684/vir.2025.1089
Juliette Besombes, Charlotte Pronier, Vincent Thibault
{"title":"[New therapeutic strategies against B and D hepatitis].","authors":"Juliette Besombes, Charlotte Pronier, Vincent Thibault","doi":"10.1684/vir.2025.1089","DOIUrl":"https://doi.org/10.1684/vir.2025.1089","url":null,"abstract":"<p><p>Current treatments against the hepatitis B virus (HBV) efficiently inhibit viral replication but rarely lead to functional cure, defined as the loss of HBsAg. Persisting transcription from intranuclear forms of viral DNA, independently from viral replication, limits the possibility of a robust clearing response of the host against the virus. The new therapeutic approaches target either the transcription, with specific oligonucleotides, the capsid assembly or the release of complete viral particles from infected hepatocytes. Some clinical trials seem highly promising. Although the clinical evolution of hepatitis Delta infection is more severe than the one caused by HBV, our tools to fight the virus are even less developed. In addition to the strategies used for HBV, molecules targeting HDV entry or HDAg prenylation are currently being evaluated. We review the main characteristics of HBV and HDV viral replication and highlight the results obtained in clinical trials using the most advanced molecules developed to overcome these infections.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 3","pages":"191-205"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
VirologiePub Date : 2025-06-01DOI: 10.1684/vir.2025.1088
{"title":"[Annual report of the French Society for Virology].","authors":"","doi":"10.1684/vir.2025.1088","DOIUrl":"https://doi.org/10.1684/vir.2025.1088","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 3","pages":"185-190"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
VirologiePub Date : 2025-06-01DOI: 10.1684/vir.2025.1085
Felix Bender, Katharina Maser, Sebastian Montealegre, Thomas Morand, Charline Pasquier, Yan de Souza Angelo, Christine Wuebben
{"title":"[First Annual Meeting of the International Society of Nucleic Acid Immunity in Avignon].","authors":"Felix Bender, Katharina Maser, Sebastian Montealegre, Thomas Morand, Charline Pasquier, Yan de Souza Angelo, Christine Wuebben","doi":"10.1684/vir.2025.1085","DOIUrl":"https://doi.org/10.1684/vir.2025.1085","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 3","pages":"233-240"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
VirologiePub Date : 2025-06-01DOI: 10.1684/vir.2025.1090
Corinne Schmitt-Keichinger, Marc Fuchs
{"title":"[Grapevine fanleaf virus biology].","authors":"Corinne Schmitt-Keichinger, Marc Fuchs","doi":"10.1684/vir.2025.1090","DOIUrl":"https://doi.org/10.1684/vir.2025.1090","url":null,"abstract":"<p><p>Fanleaf degeneration disease is referred to as \"ortiage\" in the French literature in 1723. Nowadays it occurs in most vineyards worldwide. Grapevine fanleaf virus (GFLV) is the main causal agent of the disease. It was identified in 1960 following the identification of the ectoparasitic dagger nematode Xiphinema index as its exclusive vector. The expression of the bipartite viral genome has been characterized and functions have been assigned to most viral proteins. Remarkably, the viral RNAs are monouridylated. The virion structure was determined by crystallography and transmission determinants were mapped on the coat protein. Further, viral determinants of symptoms in leaves and roots of plant hosts, three suppressors of RNA silencing, and metabolic pathways dysregulated upon infection were identified. Despite tremendous progress, management responses are limited. Future research will undoubtfully better elucidate the different steps of the infection cycle and provide opportunities to apply transformative GFLV management solutions in the vineyard.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 3","pages":"207-218"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
VirologiePub Date : 2025-06-01DOI: 10.1684/vir.2025.1095
Felix Bender, Katharina Maser, Sebastian Montealegre, Thomas Morand, Charline Pasquier, Yan de Souza Angelo, Christine Wuebben
{"title":"[Première réunion annuelle de la Société internationale de l'immunité des acides nucléiques à Avignon].","authors":"Felix Bender, Katharina Maser, Sebastian Montealegre, Thomas Morand, Charline Pasquier, Yan de Souza Angelo, Christine Wuebben","doi":"10.1684/vir.2025.1095","DOIUrl":"https://doi.org/10.1684/vir.2025.1095","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 3","pages":"18-25"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
VirologiePub Date : 2025-06-01DOI: 10.1684/vir.2025.1087
Paul E Turner, Yannis Michalakis
{"title":"[Évolution des virus : le continuum mutualisme-antagonisme des interactions virus-virus].","authors":"Paul E Turner, Yannis Michalakis","doi":"10.1684/vir.2025.1087","DOIUrl":"https://doi.org/10.1684/vir.2025.1087","url":null,"abstract":"<p><p>The conference gathered experts from many fields working on various aspects of virus-virus interactions, ranging from mutualistic to parasitic, and harnessing different approaches to studying virus evolution (e.g., molecular biology, theory, mathematical modelling, genomics, phylogenetics, clinical studies, laboratory experiments). Altogether, this allowed the common theme of virus-virus interactions to be addressed from myriad perspectives, by researchers representing the breadth of career stages in academia, including graduate students, postdocs, beginning faculty and established experts. Moreover, some participants represented industry and government agency labs studying translational goals, creating a vibrant conference that spanned basic and applied research on virus-virus interactions, where virus evolution featured prominently.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 3","pages":"13-17"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
VirologiePub Date : 2025-06-01DOI: 10.1684/vir.2025.1093
Rodolphe Hamel, Mircea T Sofonea, Julien Pompon
{"title":"[A new transmission mode for West Nile viruses within mosquito populations discovered].","authors":"Rodolphe Hamel, Mircea T Sofonea, Julien Pompon","doi":"10.1684/vir.2025.1093","DOIUrl":"https://doi.org/10.1684/vir.2025.1093","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 3","pages":"219-223"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}