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[Ghosts of the virus : unmasking the persistent threat of SARS-CoV-2 in Long COVID].
IF 0.7 4区 医学
Virologie Pub Date : 2025-02-01 DOI: 10.1684/vir.2025.1073
Mariangela Cavarelli
{"title":"[Ghosts of the virus : unmasking the persistent threat of SARS-CoV-2 in Long COVID].","authors":"Mariangela Cavarelli","doi":"10.1684/vir.2025.1073","DOIUrl":"https://doi.org/10.1684/vir.2025.1073","url":null,"abstract":"<p><p>Long COVID has emerged as a debilitating condition, severely impacting the daily functioning and quality of life of affected individuals. The pathogenesis of Long COVID is complex and multifactorial, involving immune dysregulation, persistent inflammation, and potential reactivation of other pathogens. A key driver of Long COVID is the potential persistence of SARS-CoV-2 in various tissues beyond the respiratory tract, leading to the formation of viral reservoirs that contribute to ongoing symptoms, several months after initial infection. These reservoirs have been suggested in the gastrointestinal tract, central nervous system, cardiovascular system, and other tissues, often persisting months after the initial infection. Additionally, viral RNA and proteins in these tissues are associated with chronic inflammation and immune system disruptions, which are primary contributors to Long COVID symptoms. This article explores the mechanisms and consequences of SARS-CoV-2 persistence in respiratory and non-respiratory tissues, highlighting its impact on the immune system and underscoring critical areas for future research to improve outcomes for individuals suffering from Long COVID.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 1","pages":"41-53"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ghosts of the virus : unmasking the persistent threat of SARS-CoV-2 in Long COVID. 病毒的幽灵：揭开 SARS-CoV-2 在 Long COVID 持续威胁的面纱。
IF 0.7 4区 医学
Virologie Pub Date : 2025-02-01 DOI: 10.1684/vir.2025.1074
Mariangela Cavarelli
{"title":"Ghosts of the virus : unmasking the persistent threat of SARS-CoV-2 in Long COVID.","authors":"Mariangela Cavarelli","doi":"10.1684/vir.2025.1074","DOIUrl":"https://doi.org/10.1684/vir.2025.1074","url":null,"abstract":"<p><p>Long COVID has emerged as a debilitating condition, severely impacting the daily functioning and quality of life of affected individuals. The pathogenesis of Long COVID is complex and multifactorial, involving immune dysregulation, persistent inflammation, and potential reactivation of other pathogens. A key driver of Long COVID is the potential persistence of SARS-CoV-2 in various tissues beyond the respiratory tract, leading to the formation of viral reservoirs that contribute to ongoing symptoms, several months after initial infection. These reservoirs have been suggested in the gastrointestinal tract, central nervous system, cardiovascular system, and other tissues, often persisting months after the initial infection. Additionally, viral RNA and proteins in these tissues are associated with chronic inflammation and immune system disruptions, which are primary contributors to Long COVID symptoms. This article explores the mechanisms and consequences of SARS-CoV-2 persistence in respiratory and non-respiratory tissues, highlighting its impact on the immune system and underscoring critical areas for future research to improve outcomes for individuals suffering from Long COVID.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 1","pages":"57-68"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A new adventure: the Youth section comes to Life!]
IF 0.7 4区 医学
Virologie Pub Date : 2025-02-01 DOI: 10.1684/vir.2025.1072
Charlène Martin, Claudie Eber, Léa Santerre, Dorine Martres, Florine Santier, Lionel Bigault, Margaux Ligner, Corentin Aubé, Christos Satratzemis
{"title":"[A new adventure: the Youth section comes to Life!]","authors":"Charlène Martin, Claudie Eber, Léa Santerre, Dorine Martres, Florine Santier, Lionel Bigault, Margaux Ligner, Corentin Aubé, Christos Satratzemis","doi":"10.1684/vir.2025.1072","DOIUrl":"https://doi.org/10.1684/vir.2025.1072","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 1","pages":"5-6"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Deciphering the links between hepatic viruses and interferons: molecular interactions and therapeutic implications].
IF 0.7 4区 医学
Virologie Pub Date : 2025-02-01 DOI: 10.1684/vir.2025.1076
Cassandre Authier, Claudie Eber, Roxanne Fouillé, Julie Lucifora, Eloi R Verrier
{"title":"[Deciphering the links between hepatic viruses and interferons: molecular interactions and therapeutic implications].","authors":"Cassandre Authier, Claudie Eber, Roxanne Fouillé, Julie Lucifora, Eloi R Verrier","doi":"10.1684/vir.2025.1076","DOIUrl":"https://doi.org/10.1684/vir.2025.1076","url":null,"abstract":"<p><p>Interferons (IFNs) are cytokines that play a key role in the innate immune response, possessing antiviral, antiproliferative, and immunomodulatory properties. Currently, IFNs are used clinically as treatments for lymphomas, multiple sclerosis, and chronic viral infections such as hepatitis B, C, D, and E virus infections. HEV infection can lead to fulminant hepatitis, while chronic infections with HBV, HCV, and HDV are the leading global causes of hepatocellular carcinoma. Despite their limited efficacy and numerous side effects, IFNs remain essential in the treatment of these infections. In this review, we summarize the current knowledge on the interactions between hepatic viruses and the IFN pathway to understand the virus-dependent molecular mechanisms involved in IFN induction and its antiviral effects.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 1","pages":"19-39"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[MMLV reverse transcriptase, a relevant tool for molecular biology].
IF 0.7 4区 医学
Virologie Pub Date : 2025-02-01 DOI: 10.1684/vir.2025.1070
Eva Lopez, Coralie Valle, Bruno Coutard
{"title":"[MMLV reverse transcriptase, a relevant tool for molecular biology].","authors":"Eva Lopez, Coralie Valle, Bruno Coutard","doi":"10.1684/vir.2025.1070","DOIUrl":"https://doi.org/10.1684/vir.2025.1070","url":null,"abstract":"<p><p>The reverse transcriptase of Moloney Murine Leukemia Virus (MMLV) is an enzyme that synthesizes DNA from an RNA template. Among reverse transcriptases, this enzyme is currently the most commonly used in molecular biology and diagnostics. Since its discovery, this viral protein has been extensively studied, shedding light on its structural and functional characteristics, and offering opportunities to optimize the catalytic performances for biotechnological applications. The review describes the structural motifs of the reverse transcriptase of MMLV, the key amino acids in enzymatic catalysis and the enzyme's properties such as processivity, fidelity and thermal stability. This review reports the optimizations made to improve these parameters, which enabled the modified enzymes to be integrated in the molecular biology tests used in the laboratory on a daily basis.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 1","pages":"7-18"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Phages.fr : 9th annual network conference].
IF 0.7 4区 医学
Virologie Pub Date : 2025-02-01 DOI: 10.1684/vir.2025.1075
Alidehou Jerrold Agbankpe
{"title":"[Phages.fr : 9th annual network conference].","authors":"Alidehou Jerrold Agbankpe","doi":"10.1684/vir.2025.1075","DOIUrl":"https://doi.org/10.1684/vir.2025.1075","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 1","pages":"55-56"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[XIXe atelier international sur les parvovirus (Leuven, Belgique), 03-06 septembre 2024]. [第19届细小病毒国际研讨会（比利时鲁汶），2024年9月03-06日]。
IF 0.7 4区 医学
Virologie Pub Date : 2024-12-30 DOI: 10.1684/vir.2024.1071
Floris Schatt, Anne-Sophie Gosselin-Grenet
{"title":"[XIX<sup>e</sup> atelier international sur les parvovirus (Leuven, Belgique), 03-06 septembre 2024].","authors":"Floris Schatt, Anne-Sophie Gosselin-Grenet","doi":"10.1684/vir.2024.1071","DOIUrl":"10.1684/vir.2024.1071","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 6","pages":"371-372"},"PeriodicalIF":0.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[37th International Conference on Antiviral Research (ICAR)]. [第 37 届国际抗病毒研究大会（ICAR）]。
IF 0.7 4区 医学
Virologie Pub Date : 2024-12-30 DOI: 10.1684/vir.2024.1066
Adrien Delpal
{"title":"[37th International Conference on Antiviral Research (ICAR)].","authors":"Adrien Delpal","doi":"10.1684/vir.2024.1066","DOIUrl":"10.1684/vir.2024.1066","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 6","pages":"349-350"},"PeriodicalIF":0.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[From viral disease gender to viral species subclassification: how to find our way around?] 从病毒性疾病性别到病毒种类亚分类：如何找到我们的出路？］
IF 0.7 4区 医学
Virologie Pub Date : 2024-12-30 DOI: 10.1684/vir.2024.1068
Jean-Nicolas Tournier, Noël Tordo, David Gilmer, Anne Gatignol
{"title":"[From viral disease gender to viral species subclassification: how to find our way around?]","authors":"Jean-Nicolas Tournier, Noël Tordo, David Gilmer, Anne Gatignol","doi":"10.1684/vir.2024.1068","DOIUrl":"10.1684/vir.2024.1068","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 6","pages":"353-355"},"PeriodicalIF":0.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Joint Thesis Award 2023 of the Société française de virologie and ANRS | Maladies infectieuses émergentes]. [法国病毒学协会和法国国家科学研究中心联合论文奖 2023 ［Maladies infectieuses émergentes］。
IF 0.7 4区 医学
Virologie Pub Date : 2024-12-30 DOI: 10.1684/vir.2024.1067
N Tordo, Melissa Ait Said, Alice Decombe, Martin Ferrie, Margaux Heuschkel, Antoine Rebendenne, Emma Partiot, Benjamin Guinet, Julian Agustin Bulssico
{"title":"[Joint Thesis Award 2023 of the Société française de virologie and ANRS | Maladies infectieuses émergentes].","authors":"N Tordo, Melissa Ait Said, Alice Decombe, Martin Ferrie, Margaux Heuschkel, Antoine Rebendenne, Emma Partiot, Benjamin Guinet, Julian Agustin Bulssico","doi":"10.1684/vir.2024.1067","DOIUrl":"10.1684/vir.2024.1067","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 6","pages":"351-360"},"PeriodicalIF":0.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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