Virologie最新文献_第2页

[From viral disease gender to viral species subclassification: how to find our way around?] 从病毒性疾病性别到病毒种类亚分类：如何找到我们的出路？］

IF 0.7 4区医学

Virologie Pub Date : 2024-12-30 DOI: 10.1684/vir.2024.1068

Jean-Nicolas Tournier, Noël Tordo, David Gilmer, Anne Gatignol

引用次数: 0

[Joint Thesis Award 2023 of the Société française de virologie and ANRS | Maladies infectieuses émergentes]. [法国病毒学协会和法国国家科学研究中心联合论文奖 2023 ［Maladies infectieuses émergentes］。

IF 0.7 4区医学

Virologie Pub Date : 2024-12-30 DOI: 10.1684/vir.2024.1067

N Tordo, Melissa Ait Said, Alice Decombe, Martin Ferrie, Margaux Heuschkel, Antoine Rebendenne, Emma Partiot, Benjamin Guinet, Julian Agustin Bulssico

引用次数: 0

[Human papillomaviruses : origin, oncogenic factors and markers for cervical cancer screening]. 【人乳头瘤病毒：起源、致癌因素和宫颈癌筛查标志物】。

IF 0.7 4区医学

Virologie Pub Date : 2024-12-30 DOI: 10.1684/vir.2024.1069

Aurélie Grange, Victor Mouton, Mael Roojee, Sylvain Rosec, Adissa Tran, Christopher Payan

{"title":"[Human papillomaviruses : origin, oncogenic factors and markers for cervical cancer screening].","authors":"Aurélie Grange, Victor Mouton, Mael Roojee, Sylvain Rosec, Adissa Tran, Christopher Payan","doi":"10.1684/vir.2024.1069","DOIUrl":"10.1684/vir.2024.1069","url":null,"abstract":"The Human papillomaviruses (HPV) have existed in the human population since the archaic hominids. Over the course of human migration and evolution, HPVs have co-evolved with humans on all continents to become today the leading cause of cervical cancer. HPVs are classified by genera, species, genotype, lineage, sub-lineage and variants. Among more than 200 HPV genotypes, HPV16 is the most common and the most oncogenic at high-risk (HPV-HR). If viral oncogenesis is governed by numerous factors and mechanisms involving the virus and its host, the E6/E7 oncogenic proteins of HR-HPV play a central role and are always expressed in cervical cancers. Those of HPV16 have the greatest affinity for cellular proteins involved in cellular control, p53/E6 and pRb/E7. Some E6/E7 HPV16 mutants are associated with persistent infection, correlating with viral lineages and their ethnic and geographical origin. If the splicing of viral mRNAs encoding E6/E7 allows the overexpression of the E7 protein, which is an essential condition for the establishment of HR-HPV oncogenesis, other mechanisms contribute to strengthening it. On the one hand, the accidental integration of the viral genome, in particular the E1/E2 coding region, participates in the transformation of the infected cell. On the other hand, hypermethylation of the viral L1/L2 genomic regions is observed in the advanced stages of infection. Different methods for analyzing mutations, splice sites, integrations and methylations of the viral genome have been described. These virological markers could complete the detection of HR-HPV in the context of cervical cancer screening, currently recommended in France.","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 6","pages":"357-368"},"PeriodicalIF":0.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[MMLV reverse transcriptase, a relevant tool for molecular biology]. [MMLV逆转录酶，分子生物学的相关工具]。

IF 0.7 4区医学

Virologie Pub Date : 2024-12-20 DOI: 10.1684/vir.2024.1070

Eva Lopez, Coralie Valle, Bruno Coutard

引用次数: 0

[2024: The Olympic Games go viral]. [2024：奥林匹克运动会病毒式传播]。

IF 0.7 4区医学

Virologie Pub Date : 2024-10-30 DOI: 10.1684/vir.2024.1060

Sébastien Nisole

引用次数: 0

[What does the World Health Organization's public health emergency declaration reveal about mpox?] [世界卫生组织的公共卫生紧急状况声明对天花有何启示？］

IF 0.7 4区医学

Virologie Pub Date : 2024-10-30 DOI: 10.1684/vir.2024.1061

Jean-Nicolas Tournier

引用次数: 0

[Evaluate the host cellular immune response to better prevent and diagnose viral infections]. [评估宿主细胞免疫反应，更好地预防和诊断病毒感染]。

IF 0.7 4区医学

Virologie Pub Date : 2024-10-01 DOI: 10.1684/vir.2024.1064

William Mouton, Jean-Marc Gombert, Anne Barra, Morgane Solis, Samira Fafi-Kremer, Nicolas Lévêque, Sophie Trouillet-Assant, Marine Mommert-Tripon, Edouard Tuaillon, Patrice Morand

{"title":"[Evaluate the host cellular immune response to better prevent and diagnose viral infections].","authors":"William Mouton, Jean-Marc Gombert, Anne Barra, Morgane Solis, Samira Fafi-Kremer, Nicolas Lévêque, Sophie Trouillet-Assant, Marine Mommert-Tripon, Edouard Tuaillon, Patrice Morand","doi":"10.1684/vir.2024.1064","DOIUrl":"https://doi.org/10.1684/vir.2024.1064","url":null,"abstract":"In medicine, virological diagnosis is mainly based on the detection of the viral genome and antigens, or on the identification of specific antibodies produced in response to infection. These strategies are suitable for characterizing an active infection or past contact with an already known virus. The recent development of tests for evaluating the host's cellular immune response opens new perspectives for personalized patient care based on immunomonitoring. The IGRA tests (Interferon Gamma Release Assay), measuring interferon gamma produced by T lymphocytes stimulated in vitro by antigenic peptides specific to infectious agents, and the quantification of the blood viral load of Torque teno virus (TTV) thus constitute tools for assessing infectious risk, particularly usable to predict opportunistic viral reactivations in immunocompromised patients. The characterization of the expression profile of interferon stimulated genes in a respiratory sample is also likely to provide significant assistance in diagnosis, discriminating a viral infection from a bacterial infection, an acute infection from a persistence of nucleic acids from non replicating microorganisms or allowing, in case of viral emergence, to quickly identify infected subjects in the absence of specific PCR tests available. All of these new approaches, described in this review, have the potential to considerably improve patient care with the objective to correctly prescribe medical virology tests and anti-infective treatments.","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 5","pages":"327-339"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Animal models in sciences and production: Replacement, Reduction and Refinement]. [科学和生产中的动物模型：替代、减少和改进]。

IF 0.7 4区医学

Virologie Pub Date : 2024-10-01 DOI: 10.1684/vir.2024.1065

Tania Louis

引用次数: 0

[Challenges and advances in the management of HCMV infections]. [HCMV感染管理的挑战与进展]。

IF 0.7 4区医学

Virologie Pub Date : 2024-10-01 DOI: 10.1684/vir.2024.1063

Claire Gourin, Thelma Flores, Sarah Mafi, Cécile Malnou, Sophie Alain, Sébastien Hantz, Gaetan Ligat

{"title":"[Challenges and advances in the management of HCMV infections].","authors":"Claire Gourin, Thelma Flores, Sarah Mafi, Cécile Malnou, Sophie Alain, Sébastien Hantz, Gaetan Ligat","doi":"10.1684/vir.2024.1063","DOIUrl":"https://doi.org/10.1684/vir.2024.1063","url":null,"abstract":"Human cytomegalovirus (HCMV) is one of the most important causes of complications in immunocompromised patients and congenital infections. HCMV could also represent an interesting target for treatment to limit the progression of glioblastoma, a highly aggressive tumor. Ganciclovir, foscarnet and cidofovir, which interfere with the activity of the viral polymerase pUL54, are widely used in the treatment of transplant patients. However, their use in pregnant women remains limited or even contraindicated. On the other hand, hyperimmune immunoglobulins and valaciclovir have been shown to have a protective effect on the fetus. However, the toxicity of these treatments and the emergence of resistance mean that new therapeutic strategies need to be identified. Letermovir and maribavir have been developed to inhibit new targets, respectively the terminase complex and UL97 protein kinase. Their respective indications are the prevention of HCMV infection in haematopoietic stem cell transplant patients and the treatment of refractory HCMV infections. Finally, with the development of mRNA vaccines, the hope of one day seeing a prophylactic HCMV vaccine has never been greater. New therapeutic approaches are also being explored, but they still require extensive preclinical and clinical evaluation.","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 5","pages":"309-325"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[When 2'-O-methylation throws a wrench in HIV-1 reverse transcriptase]. [2'-O-甲基化对 HIV-1 逆转录酶的影响】。］

IF 0.7 4区医学

Virologie Pub Date : 2024-08-01 DOI: 10.1684/vir.2024.1056

Alice Decombe, Olve Peersen, Etienne Decroly

引用次数: 0