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[A new adventure: the Youth section comes to Life!] 一个新的冒险：青年部分来生活！］
IF 0.7 4区 医学
Virologie Pub Date : 2025-02-01 DOI: 10.1684/vir.2025.1072
Charlène Martin, Claudie Eber, Léa Santerre, Dorine Martres, Florine Santier, Lionel Bigault, Margaux Ligner, Corentin Aubé, Christos Satratzemis
{"title":"[A new adventure: the Youth section comes to Life!]","authors":"Charlène Martin, Claudie Eber, Léa Santerre, Dorine Martres, Florine Santier, Lionel Bigault, Margaux Ligner, Corentin Aubé, Christos Satratzemis","doi":"10.1684/vir.2025.1072","DOIUrl":"https://doi.org/10.1684/vir.2025.1072","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 1","pages":"5-6"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Deciphering the links between hepatic viruses and interferons: molecular interactions and therapeutic implications]. [破译肝病毒和干扰素之间的联系：分子相互作用和治疗意义]。
IF 0.7 4区 医学
Virologie Pub Date : 2025-02-01 DOI: 10.1684/vir.2025.1076
Cassandre Authier, Claudie Eber, Roxanne Fouillé, Julie Lucifora, Eloi R Verrier
{"title":"[Deciphering the links between hepatic viruses and interferons: molecular interactions and therapeutic implications].","authors":"Cassandre Authier, Claudie Eber, Roxanne Fouillé, Julie Lucifora, Eloi R Verrier","doi":"10.1684/vir.2025.1076","DOIUrl":"10.1684/vir.2025.1076","url":null,"abstract":"<p><p>Interferons (IFNs) are cytokines that play a key role in the innate immune response, possessing antiviral, antiproliferative, and immunomodulatory properties. Currently, IFNs are used clinically as treatments for lymphomas, multiple sclerosis, and chronic viral infections such as hepatitis B, C, D, and E virus infections. HEV infection can lead to fulminant hepatitis, while chronic infections with HBV, HCV, and HDV are the leading global causes of hepatocellular carcinoma. Despite their limited efficacy and numerous side effects, IFNs remain essential in the treatment of these infections. In this review, we summarize the current knowledge on the interactions between hepatic viruses and the IFN pathway to understand the virus-dependent molecular mechanisms involved in IFN induction and its antiviral effects.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 1","pages":"19-39"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Phages.fr : 9th annual network conference]. [Phages.fr：第九届年度网络会议]。
IF 0.7 4区 医学
Virologie Pub Date : 2025-02-01 DOI: 10.1684/vir.2025.1075
Alidehou Jerrold Agbankpe
{"title":"[Phages.fr : 9th annual network conference].","authors":"Alidehou Jerrold Agbankpe","doi":"10.1684/vir.2025.1075","DOIUrl":"https://doi.org/10.1684/vir.2025.1075","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 1","pages":"55-56"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[MMLV reverse transcriptase, a relevant tool for molecular biology]. [MMLV逆转录酶，分子生物学的相关工具]。
IF 0.7 4区 医学
Virologie Pub Date : 2025-02-01 DOI: 10.1684/vir.2025.1070
Eva Lopez, Coralie Valle, Bruno Coutard
{"title":"[MMLV reverse transcriptase, a relevant tool for molecular biology].","authors":"Eva Lopez, Coralie Valle, Bruno Coutard","doi":"10.1684/vir.2025.1070","DOIUrl":"10.1684/vir.2025.1070","url":null,"abstract":"<p><p>The reverse transcriptase of Moloney Murine Leukemia Virus (MMLV) is an enzyme that synthesizes DNA from an RNA template. Among reverse transcriptases, this enzyme is currently the most commonly used in molecular biology and diagnostics. Since its discovery, this viral protein has been extensively studied, shedding light on its structural and functional characteristics, and offering opportunities to optimize the catalytic performances for biotechnological applications. The review describes the structural motifs of the reverse transcriptase of MMLV, the key amino acids in enzymatic catalysis and the enzyme's properties such as processivity, fidelity and thermal stability. This review reports the optimizations made to improve these parameters, which enabled the modified enzymes to be integrated in the molecular biology tests used in the laboratory on a daily basis.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"29 1","pages":"7-18"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[XIXe atelier international sur les parvovirus (Leuven, Belgique), 03-06 septembre 2024]. [第19届细小病毒国际研讨会（比利时鲁汶），2024年9月03-06日]。
IF 0.7 4区 医学
Virologie Pub Date : 2024-12-30 DOI: 10.1684/vir.2024.1071
Floris Schatt, Anne-Sophie Gosselin-Grenet
{"title":"[XIX<sup>e</sup> atelier international sur les parvovirus (Leuven, Belgique), 03-06 septembre 2024].","authors":"Floris Schatt, Anne-Sophie Gosselin-Grenet","doi":"10.1684/vir.2024.1071","DOIUrl":"10.1684/vir.2024.1071","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 6","pages":"371-372"},"PeriodicalIF":0.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[37th International Conference on Antiviral Research (ICAR)]. [第 37 届国际抗病毒研究大会（ICAR）]。
IF 0.7 4区 医学
Virologie Pub Date : 2024-12-30 DOI: 10.1684/vir.2024.1066
Adrien Delpal
{"title":"[37th International Conference on Antiviral Research (ICAR)].","authors":"Adrien Delpal","doi":"10.1684/vir.2024.1066","DOIUrl":"10.1684/vir.2024.1066","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 6","pages":"349-350"},"PeriodicalIF":0.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[From viral disease gender to viral species subclassification: how to find our way around?] 从病毒性疾病性别到病毒种类亚分类：如何找到我们的出路？］
IF 0.7 4区 医学
Virologie Pub Date : 2024-12-30 DOI: 10.1684/vir.2024.1068
Jean-Nicolas Tournier, Noël Tordo, David Gilmer, Anne Gatignol
{"title":"[From viral disease gender to viral species subclassification: how to find our way around?]","authors":"Jean-Nicolas Tournier, Noël Tordo, David Gilmer, Anne Gatignol","doi":"10.1684/vir.2024.1068","DOIUrl":"10.1684/vir.2024.1068","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 6","pages":"353-355"},"PeriodicalIF":0.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Joint Thesis Award 2023 of the Société française de virologie and ANRS | Maladies infectieuses émergentes]. [法国病毒学协会和法国国家科学研究中心联合论文奖 2023 ［Maladies infectieuses émergentes］。
IF 0.7 4区 医学
Virologie Pub Date : 2024-12-30 DOI: 10.1684/vir.2024.1067
N Tordo, Melissa Ait Said, Alice Decombe, Martin Ferrie, Margaux Heuschkel, Antoine Rebendenne, Emma Partiot, Benjamin Guinet, Julian Agustin Bulssico
{"title":"[Joint Thesis Award 2023 of the Société française de virologie and ANRS | Maladies infectieuses émergentes].","authors":"N Tordo, Melissa Ait Said, Alice Decombe, Martin Ferrie, Margaux Heuschkel, Antoine Rebendenne, Emma Partiot, Benjamin Guinet, Julian Agustin Bulssico","doi":"10.1684/vir.2024.1067","DOIUrl":"10.1684/vir.2024.1067","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 6","pages":"351-360"},"PeriodicalIF":0.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Human papillomaviruses : origin, oncogenic factors and markers for cervical cancer screening]. 【人乳头瘤病毒：起源、致癌因素和宫颈癌筛查标志物】。
IF 0.7 4区 医学
Virologie Pub Date : 2024-12-30 DOI: 10.1684/vir.2024.1069
Aurélie Grange, Victor Mouton, Mael Roojee, Sylvain Rosec, Adissa Tran, Christopher Payan
{"title":"[Human papillomaviruses : origin, oncogenic factors and markers for cervical cancer screening].","authors":"Aurélie Grange, Victor Mouton, Mael Roojee, Sylvain Rosec, Adissa Tran, Christopher Payan","doi":"10.1684/vir.2024.1069","DOIUrl":"10.1684/vir.2024.1069","url":null,"abstract":"<p><p>The Human papillomaviruses (HPV) have existed in the human population since the archaic hominids. Over the course of human migration and evolution, HPVs have co-evolved with humans on all continents to become today the leading cause of cervical cancer. HPVs are classified by genera, species, genotype, lineage, sub-lineage and variants. Among more than 200 HPV genotypes, HPV16 is the most common and the most oncogenic at high-risk (HPV-HR). If viral oncogenesis is governed by numerous factors and mechanisms involving the virus and its host, the E6/E7 oncogenic proteins of HR-HPV play a central role and are always expressed in cervical cancers. Those of HPV16 have the greatest affinity for cellular proteins involved in cellular control, p53/E6 and pRb/E7. Some E6/E7 HPV16 mutants are associated with persistent infection, correlating with viral lineages and their ethnic and geographical origin. If the splicing of viral mRNAs encoding E6/E7 allows the overexpression of the E7 protein, which is an essential condition for the establishment of HR-HPV oncogenesis, other mechanisms contribute to strengthening it. On the one hand, the accidental integration of the viral genome, in particular the E1/E2 coding region, participates in the transformation of the infected cell. On the other hand, hypermethylation of the viral L1/L2 genomic regions is observed in the advanced stages of infection. Different methods for analyzing mutations, splice sites, integrations and methylations of the viral genome have been described. These virological markers could complete the detection of HR-HPV in the context of cervical cancer screening, currently recommended in France.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"28 6","pages":"357-368"},"PeriodicalIF":0.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[MMLV reverse transcriptase, a relevant tool for molecular biology]. [MMLV逆转录酶，分子生物学的相关工具]。
IF 0.7 4区 医学
Virologie Pub Date : 2024-12-20 DOI: 10.1684/vir.2024.1070
Eva Lopez, Coralie Valle, Bruno Coutard
{"title":"[MMLV reverse transcriptase, a relevant tool for molecular biology].","authors":"Eva Lopez, Coralie Valle, Bruno Coutard","doi":"10.1684/vir.2024.1070","DOIUrl":"https://doi.org/10.1684/vir.2024.1070","url":null,"abstract":"<p><p>The reverse transcriptase of Moloney Murine Leukemia Virus (MMLV) is an enzyme that synthesizes DNA from an RNA template. Among reverse transcriptases, this enzyme is currently the most commonly used in molecular biology and diagnostics. Since its discovery, this viral protein has been extensively studied, shedding light on its structural and functional characteristics, and offering opportunities to optimize the catalytic performances for biotechnological applications. The review describes the structural motifs of the reverse transcriptase of MMLV, the key amino acids in enzymatic catalysis and the enzyme's properties such as processivity, fidelity and thermal stability. This review reports the optimizations made to improve these parameters, which enabled the modified enzymes to be integrated in the molecular biology tests used in the laboratory on a daily basis.</p>","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"0 0","pages":"0"},"PeriodicalIF":0.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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