Clinical NeuroradiologyPub Date : 2024-09-01Epub Date: 2024-03-07DOI: 10.1007/s00062-024-01391-6
Mohamed Abuelazm, Yehya Khildj, Ahmed A Ibrahim, Abdelrahman Mahmoud, Ahmed Mazen Amin, Ibrahim Gowaily, Ubaid Khan, Basel Abdelazeem, James Robert Brašić
{"title":"Intensive Blood Pressure Control After Endovascular Thrombectomy for Acute Ischemic Stroke: a Systematic Review and Meta-Analysis.","authors":"Mohamed Abuelazm, Yehya Khildj, Ahmed A Ibrahim, Abdelrahman Mahmoud, Ahmed Mazen Amin, Ibrahim Gowaily, Ubaid Khan, Basel Abdelazeem, James Robert Brašić","doi":"10.1007/s00062-024-01391-6","DOIUrl":"10.1007/s00062-024-01391-6","url":null,"abstract":"<p><strong>Background and purpose: </strong>Optimal clinical outcome with successful recanalization from endovascular thrombectomy (EVT) requires optimal blood pressure (BP) management. We aimed to evaluate the efficacy and safety of the intensive BP target (< 140 mm Hg) versus the standard BP target (< 180 mm Hg) after EVT for acute ischemic stroke.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis synthesizing evidence from randomized controlled trials (RCTs) obtained from PubMed, Embase Cochrane, Scopus, and WOS until September 7th, 2023. We used the fixed-effect model to report dichotomous outcomes using risk ratio (RR) and continuous outcomes using mean difference (MD), with a 95% confidence interval (CI).</p><p><strong>Prospero id: </strong>CRD42023463206.</p><p><strong>Results: </strong>We included four RCTs with 1559 patients. There was no difference between intensive BP and standard BP targets regarding the National Institutes of Health Stroke Scale (NIHSS) change after 24 h [MD: 0.44 with 95% CI (0.0, 0.87), P = 0.05]. However, the intensive BP target was significantly associated with a decreased risk of excellent neurological recovery (mRS ≤ 1) [RR: 0.87 with 95% CI (0.76, 0.99), P = 0.03], functional independence (mRS ≤ 2) [RR: 0.81 with 95% CI (0.73, 0.90), P = 0.0001] and independent ambulation (mRS ≤ 3) [RR: 0.85 with 95% CI (0.79, 0.92), P < 0.0001].</p><p><strong>Conclusions: </strong>An intensive BP target after EVT is associated with worse neurological recovery and significantly decreased rates of functional independence and independent ambulation compared to the standard BP target. Therefore, the intensive BP target should be avoided after EVT for acute ischemic stroke.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"563-575"},"PeriodicalIF":4.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11339153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical NeuroradiologyPub Date : 2024-09-01Epub Date: 2024-03-07DOI: 10.1007/s00062-024-01396-1
D B Keerthiraj, Shweta Pandey, Ravindra Kumar Garg, Hardeep Singh Malhotra, Rajesh Verma, Praveen Kumar Sharma, Neeraj Kumar, Ravi Uniyal, Imran Rizvi, Sukriti Kumar, Anit Parihar, Amita Jain
{"title":"Neuroimaging Abnormalities in Patients with Subacute Sclerosing Panencephalitis : Prospective Follow-up Study.","authors":"D B Keerthiraj, Shweta Pandey, Ravindra Kumar Garg, Hardeep Singh Malhotra, Rajesh Verma, Praveen Kumar Sharma, Neeraj Kumar, Ravi Uniyal, Imran Rizvi, Sukriti Kumar, Anit Parihar, Amita Jain","doi":"10.1007/s00062-024-01396-1","DOIUrl":"10.1007/s00062-024-01396-1","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the neuroimaging abnormalities and their progression in patients with Subacute sclerosing panencephalitis (SSPE) and identify clinical predictors of these imaging findings.</p><p><strong>Methods: </strong>This prospective observational study evaluated clinical and neuroimaging features in patients with SSPE. Patients were categorized using Dyken's criteria, Jabbour's staging system, and the definition of fulminant SSPE. They underwent comprehensive clinical assessments, cerebrospinal fluid examination, Electroencephalogram (EEG), and Magnetic Resonance Imaging (MRI) scans. Treatment involved intrathecal interferon‑α and antiepileptic medications. Functional disability was assessed using the modified Barthel index. Follow-ups were performed at 6 months, including reassessment of Modified Barthel Index (MBI) and Jabbour's staging and EEG and MRI scans.</p><p><strong>Results: </strong>The mean age was 13.9 ± 6.7 years, with males comprising 81.5% (44/54) of the cohort. Fulminant SSPE was noted in 33% (18/54) of cases. Disease duration before presentation varied significantly between fulminant and non-fulminant forms (p = 0.001). Neuroimaging abnormalities were more prevalent in JS III stage patients, with diffuse cerebral atrophy being a significant finding (p = 0.011). Basal ganglia involvement correlated with movement disorders. The 6‑month follow-up showed increased cerebral atrophy (p = 0.004). Increasing disease duration was an independent predictor of cerebral atrophy. An Intercomplex interval (ICI) of more than 10 minutes correlated with normal neuroimaging, 10 patients died within the study period, 8 of whom had fulminant SSPE.</p><p><strong>Conclusion: </strong>Parieto-occipital White matter hyperintensity (WMH) is the most prevalent and sensitive neuroimaging finding for the diagnosis of SSPE. Despite interferon treatment, cerebral atrophy progressed in both aggressive and fulminant SSPE. Increasing disease duration is an independent predictor of cerebral atrophy.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"577-585"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical NeuroradiologyPub Date : 2024-09-01Epub Date: 2024-03-08DOI: 10.1007/s00062-024-01400-8
Christoph Ziegenfuß, Natalie van Landeghem, Chiara Meier, Roman Pförtner, Anja Eckstein, Philipp Dammann, Patrizia Haubold, Johannes Haubold, Michael Forsting, Cornelius Deuschl, Isabel Wanke, Yan Li
{"title":"MR Imaging Characteristics of Solitary Fibrous Tumors of the Orbit : Case Series of 18 Patients.","authors":"Christoph Ziegenfuß, Natalie van Landeghem, Chiara Meier, Roman Pförtner, Anja Eckstein, Philipp Dammann, Patrizia Haubold, Johannes Haubold, Michael Forsting, Cornelius Deuschl, Isabel Wanke, Yan Li","doi":"10.1007/s00062-024-01400-8","DOIUrl":"10.1007/s00062-024-01400-8","url":null,"abstract":"<p><strong>Purpose: </strong>Solitary fibrous tumor (SFT) of the orbit is a rare tumor that was first described in 1994. We aimed to investigate its imaging characteristics that may facilitate the differential diagnosis between SFT and other types of orbital tumors.</p><p><strong>Material and methods: </strong>Magnetic resonance imaging (MRI) data of patients with immunohistochemically confirmed orbital SFT from 2002 to 2022 at a tertiary care center were retrospectively analyzed. Tumor location, size, morphological characteristics, and contrast enhancement features were evaluated.</p><p><strong>Results: </strong>Of the 18 eligible patients 10 were female (56%) with a mean age of 52 years. Most of the SFTs were oval-shaped (67%) with a sharp margin (83%). The most frequent locations were the laterocranial quadrant (44%), the extraconal space (67%) and the dorsal half of the orbit (67%). A flow void phenomenon was observed in nearly all cases (94%). On the T1-weighted imaging, tumor signal intensity (SI) was significantly lower than that of the retrobulbar fat and appeared predominantly equivalent (82%) to the temporomesial brain cortex, while on T2-weighted imaging its SI remained equivalent (50%) or slightly hyperintense to that of brain cortex. More than half of the lesions showed a homogeneous contrast enhancement pattern with a median SI increase of 2.2-fold compared to baseline precontrast imaging.</p><p><strong>Conclusion: </strong>The SFT represents a rare orbital tumor with several characteristic imaging features. It was mostly oval-shaped with a sharp margin and frequently localized in the extraconal space and dorsal half of the orbit. Flow voids indicating hypervascularization were the most common findings.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"605-611"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical NeuroradiologyPub Date : 2024-09-01Epub Date: 2024-02-22DOI: 10.1007/s00062-024-01392-5
Vincent Brissette, Danielle Carole Roy, Mobin Jamal, Maria Fahmy, Adrien Guenego, Joud Fahed, Michel Shamy, Dar Dowlatshahi, Robert Fahed
{"title":"Benefits of First Pass Recanalization in Basilar Strokes Based on Initial Clinical Severity.","authors":"Vincent Brissette, Danielle Carole Roy, Mobin Jamal, Maria Fahmy, Adrien Guenego, Joud Fahed, Michel Shamy, Dar Dowlatshahi, Robert Fahed","doi":"10.1007/s00062-024-01392-5","DOIUrl":"10.1007/s00062-024-01392-5","url":null,"abstract":"<p><strong>Purpose: </strong>Randomized trials demonstrating the benefits of thrombectomy for basilar artery occlusions have enrolled an insufficient number of patients with a National Institutes for Health Stroke Scale (NIHSS) score < 10 and shown discrepant results for patients with an NIHSS > 20. Achieving a first pass recanalization (FPR) improves clinical outcomes in stroke. We aimed to evaluate the effect of the FPR on outcomes among basilar artery occlusion patients, characterized by prethrombectomy initial NIHSS score.</p><p><strong>Methods: </strong>We retrospectively analyzed the Endovascular Treatment in Ischemic Stroke (ETIS) registry of 279 basilar artery occlusion patients treated with thrombectomy from 6 participating centers. We compared the 90-day clinical outcomes of achieving a FPR versus no FPR, categorized by initial clinical severity: mild (NIHSS < 10), moderate (NIHSS 10-20) and severe (NIHSS > 20). We used Poisson regression with robust error variance to determine the effect of the NIHSS score on the association between FPR and outcomes.</p><p><strong>Results: </strong>The FPR patients with NIHSS < 10 or NIHSS 10-20 were more likely to have a favorable clinical outcome (modified Rankin scale, mRS 0-3) than non-FPR patients (relative risk, RR = 1.32, 95% confidence interval, CI: 1.04, 1.66, p-value = 0.0213, and RR = 1.79, 95% CI: 1.26, 2.53, p-value = 0.0011, respectively). A similar benefit was not found in patients with severe symptoms. We found a significantly lower risk of poor clinical outcome (mRS 4-6) in FPR patients with NIHSS 10-20, but not among patients with an NIHSS > 20.</p><p><strong>Conclusion: </strong>Achieving a FPR in basilar artery occlusion patients with mild (NIHSS < 10) or moderate (NIHSS 10-20) symptoms is associated with better clinical outcomes, but not in patients with severe symptoms. These results support the importance of further clinical trials on the benefits of thrombectomy in severe strokes.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"555-562"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139933819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Outcomes On Tubridge Flow Diverter in Treatmenting Intracranial Aneurysms: a Retrospective Multicenter Registry Study.","authors":"Qiang Li, Deyuan Zhu, Nan Lv, Pengfei Yang, Yu Zhou, Rui Zhao, Wenjin Yang, Ming Lv, Tianxiao Li, Wenyuan Zhao, Tiewei Qi, Weixi Jiang, Chuanzhi Duan, Guangyu Zhao, Guoli Duan, Yina Wu, Qian Zheng, Zifu Li, Qiao Zuo, Dongwei Dai, Yibin Fang, Qinghai Huang, Bo Hong, Yi Xu, Yuxiang Gu, Sheng Guan, Jianmin Liu","doi":"10.1007/s00062-024-01393-4","DOIUrl":"10.1007/s00062-024-01393-4","url":null,"abstract":"<p><strong>Purpose: </strong>In China, the application of nitinol Tubridge flow diverter (TFD) has become popular for treating intracranial aneurysms (IAs). In this study, we investigated the safety outcomes of the application of TFD for treating IAs in real-world scenarios.</p><p><strong>Methods: </strong>We retrospectively analyzed aneurysms treated with TFD in 235 centers throughout China between April 2018 and April 2020. The primary endpoint was the event-free survival rate at 12 months, defined as the occurrence of morbidity (spontaneous rupture, intraparenchymal hemorrhage (IPH), ischemic stroke, and permanent cranial neuropathy) or death. Univariate and multivariate analyses were performed to assess the risk factors. A good outcome was defined as a modified Rankin Score (mRS) of 0-2.</p><p><strong>Results: </strong>We included 1281 unruptured aneurysms treated with TFD. The overall neurological morbidity and death rates after 12 months were 5.4 and 2.8%, respectively. Ischemic strokes were the most common complication (4.2%, P < 0.001). Cranial neuropathy, IPH, and spontaneous rupture occurred in 0.3%, 0.3%, and 0.5% of aneurysms, respectively. Univariate and multivariate analyses indicated that the male gender, older age, larger aneurysm diameter, and aneurysm located on BA were the independent risk factors for neurologic events. Aneurysm located on BA was the independent risk factor for ischemic strokes. Most patients (1222) had access to the mRS, and 93.2% of them achieved good outcomes.</p><p><strong>Conclusion: </strong>Treatment of IAs with TFD was associated with low morbidity and mortality, most of which were ischemic events. Large posterior aneurysms might be associated with a higher complication rate.</p><p><strong>Trial registration: </strong>Retrospectively registered.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"465-474"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical NeuroradiologyPub Date : 2024-06-01Epub Date: 2024-01-03DOI: 10.1007/s00062-023-01370-3
Joshua Y P Yeo, Chun En Yau, Natasha Yixuan Ong, Yao Hao Teo, Anil Gopinathan, Cunli Yang, Mingxue Jing, Joanna J W Yang, Ching-Hui Sia, Benjamin Yong Qiang Tan, Leonard Leong Litt Yeo
{"title":"Comparing the Impact of Stenting vs. Medical Therapy for Intracranial Arterial Stenosis : A Systematic Review and One-stage and Two-stage Meta-Analysis of Randomized Clinical Trials.","authors":"Joshua Y P Yeo, Chun En Yau, Natasha Yixuan Ong, Yao Hao Teo, Anil Gopinathan, Cunli Yang, Mingxue Jing, Joanna J W Yang, Ching-Hui Sia, Benjamin Yong Qiang Tan, Leonard Leong Litt Yeo","doi":"10.1007/s00062-023-01370-3","DOIUrl":"10.1007/s00062-023-01370-3","url":null,"abstract":"<p><strong>Purpose: </strong>In the treatment of intracranial arterial stenosis (ICAS), controversies remain regarding the optimal treatment strategy. Our study aims to conduct an individual patient-level data meta-analysis of existing RCTs comparing PTAS versus best medical therapy and to identify differences in outcomes such as incidence of ischemic stroke or death.</p><p><strong>Methods: </strong>Randomised controlled trials comparing the outcomes of stenting versus best medical therapy for patients who had symptomatic ICAS of >50%. Excluded studies included case reports, case series, reviews, observational studies, letters or studies evaluating isolated angioplasty techniques without stenting. Data was extracted in accordance with PRISMA guidelines.</p><p><strong>Results: </strong>7 studies involving 1425 participants were included. There was an increased risk in the incidence of stroke and death within the first 30 days post-procedure for patients treated with PTAS over best medical therapy (RR = 2.22 [1.28-3.86], I² = 0%). Patients who underwent stenting also had a significantly higher risk of intracranial haemorrhage (RR = 12.66 [2.41-66.45], I² = 0%) and death (RR = 5.41 [1.20-24.28], I² = 0%).Under the shared frailty model, stenting when compared to medical therapy has a HR of 1.81 (95% CI:1.25-2.6) of stroke or death across 1 year. Under the parametric Royston-Parmar model, stenting has a significant decrease in the RMST(-0.83 months; 95% CI: -1.30-0.37). Stenting continued to show worse outcomes up to the 3 year mark with a HR of 1.60 (95% CI: 1.11-2.32).</p><p><strong>Conclusions and relevance: </strong>There is an increased risk of peri- and post-procedural stroke and death over best medical therapy in patients with symptomatic ICAS who undergo PTAS. Further work is required to refine patient selection and mitigate peri-procedural risks.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"379-390"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical NeuroradiologyPub Date : 2024-06-01Epub Date: 2024-01-31DOI: 10.1007/s00062-023-01380-1
Briana A Santo, TaJania D Jenkins, Shiau-Sing K Ciecierska, Ammad A Baig, Elad I Levy, Adnan H Siddiqui, Vincent M Tutino
{"title":"MicroCT and Histological Analysis of Clot Composition in Acute Ischemic Stroke : A Comparative Study of MT-Retrieved Clots and Clot Analogs.","authors":"Briana A Santo, TaJania D Jenkins, Shiau-Sing K Ciecierska, Ammad A Baig, Elad I Levy, Adnan H Siddiqui, Vincent M Tutino","doi":"10.1007/s00062-023-01380-1","DOIUrl":"10.1007/s00062-023-01380-1","url":null,"abstract":"<p><strong>Purpose: </strong>Assessing clot composition on prethrombectomy computed tomography (CT) imaging may help in stroke treatment planning. In this study we seek to use microCT imaging of fabricated blood clots to understand the relationship between CT radiographic signals and the biological makeup.</p><p><strong>Methods: </strong>Clots (n = 10) retrieved by mechanical thrombectomy (MT) were collected, and 6 clot analogs of varying RBC composition were made. We performed paired microCT and histological image analysis of all 16 clots using a ScanCo microCT 100 (4.9 µm resolution) and standard H&E staining (imaged at 40×). From these data types, first order statistic (FOS) radiomics were computed from microCT, and percent composition of RBCs (%RBC) was computed from histology. Polynomial and linear regression (LR) were used to build statistical models based on retrieved thrombus microCT and %RBC that were evaluated for their ability to predict the %RBC of clot analogs from mean HU. Correlation analyses of microCT FOS with composition were completed for both retrieved clots and analogs.</p><p><strong>Results: </strong>The LR model fits relating MT-retrieved clot %RBC with mean (R<sup>2</sup> = 0.625, p = 0.006) and standard deviation (R<sup>2</sup> = 0.564, p < 0.05) in HUs on microCT were significant. Similarly, LR models relating analog histological %RBC to analog protocol %RBC (R<sup>2</sup> = 0.915, p = 0.003) and mean HUs on microCT (R<sup>2</sup> = 0.872, p = 0.007) were also significant. When the LR model built using MT-retrieved clots was used to predict analog %RBC from mean HUs, significant correlation was observed between predictions and actual histological %RBC (R<sup>2</sup> = 0.852, p = 0.009). For retrieved clots, significant correlations were observed for energy and total energy with %RBC and %FP (|R| > 0.7, q < 0.01). Analogs further demonstrated significant correlation between FOS energy, total energy, variance and %WBC (|R| > 0.9, q < 0.01).</p><p><strong>Conclusion: </strong>MicroCT can be used to build models that predict AIS clot composition from routine CT parameters and help us to better understand radiomic signatures associated with clot composition and first pass outcomes. In future work, such observations can be used to better infer clot composition and inform thrombectomy prognostics from pretreatment CTs.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"431-439"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical NeuroradiologyPub Date : 2024-06-01Epub Date: 2024-02-22DOI: 10.1007/s00062-024-01390-7
Adrien Guenego, Jeremy J Heit, Thomas Bonnet, Stéphanie Elens, Niloufar Sadeghi, Noémie Ligot, Benjamin Mine, Valentina Lolli, Fadi Tannouri, Fabio Silvio Taccone, Boris Lubicz
{"title":"Treatment of Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage using the Neurospeed Semi-compliant Balloon.","authors":"Adrien Guenego, Jeremy J Heit, Thomas Bonnet, Stéphanie Elens, Niloufar Sadeghi, Noémie Ligot, Benjamin Mine, Valentina Lolli, Fadi Tannouri, Fabio Silvio Taccone, Boris Lubicz","doi":"10.1007/s00062-024-01390-7","DOIUrl":"10.1007/s00062-024-01390-7","url":null,"abstract":"<p><strong>Background and purpose: </strong>Cerebral vasospasm (CV) following aneurysmal subarachnoid hemorrhage (aSAH) may lead to morbidity and mortality. Endovascular mechanical angioplasty may be performed if symptomatic CV is refractory to noninvasive medical management. Off-label compliant remodelling balloons tend to conform to the course of the vessel, contrary to noncompliant or semi-compliant balloons. Our objective is to describe our initial experience with the semi-compliant Neurospeed balloon (approved for intracranial stenosis) in cerebral vasospasm treatment following aSAH.</p><p><strong>Methods: </strong>All patients included in the prospective observational SAVEBRAIN PWI (NCT05276934 on clinicaltrial.gov) study who underwent cerebral angioplasty using the Neurospeed balloon for the treatment of medically refractory and symptomatic CV after aSAH were identified. Patient demographic information, procedural details and outcomes were obtained from electronic medical records.</p><p><strong>Results: </strong>Between February 2022 and June 2023, 8 consecutive patients underwent CV treatment with the Neurospeed balloon. Angioplasty of 48 arterial segments (supraclinoid internal carotid artery, A1 and A2 segments of the anterior cerebral artery, M1 and M2 segments of the middle cerebral artery) was attempted and 44/48 (92%) were performed. The vessel diameter significantly improved following angioplasty (+81%), while brain hypoperfusion decreased (-81% of the mean TMax). There was no long-term clinical complication, 4% periprocedural complications occurred.</p><p><strong>Conclusion: </strong>The semi-compliant Neurospeed balloon is effective in the treatment of cerebral vasospasm following aSAH, bringing a new device into the armamentarium of the neurointerventionalist to perform intracranial angioplasty.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"475-483"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139933820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical NeuroradiologyPub Date : 2024-06-01Epub Date: 2023-11-06DOI: 10.1007/s00062-023-01354-3
Kevin Soon Hwee Teo, Jiahui Li, Marc Ribo, Tommy Andersson, Joshua Yee Peng Yeo, Mingxue Jing, Benjamin Yong Qiang Tan, Cunli Yang, Leonard Leong Litt Yeo
{"title":"VacLok-Augmented Direct Aspiration Thrombectomy : A Novel Method of an Aspiration First-pass Approach for Acute Ischemic Stroke.","authors":"Kevin Soon Hwee Teo, Jiahui Li, Marc Ribo, Tommy Andersson, Joshua Yee Peng Yeo, Mingxue Jing, Benjamin Yong Qiang Tan, Cunli Yang, Leonard Leong Litt Yeo","doi":"10.1007/s00062-023-01354-3","DOIUrl":"10.1007/s00062-023-01354-3","url":null,"abstract":"","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"499-502"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71487997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}