BMC Surgery最新文献

{"title":"Retraction Note: Comparative analysis of laparoscopic choledocholithiasis and ERCP treatment after cholecystectomy.","authors":"Jun Zhang, Liqiang Li, You Jiang, Wenbo Li, Liang Li","doi":"10.1186/s12893-025-02902-z","DOIUrl":"https://doi.org/10.1186/s12893-025-02902-z","url":null,"abstract":"","PeriodicalId":49229,"journal":{"name":"BMC Surgery","volume":"25 1","pages":"162"},"PeriodicalIF":1.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 infection and complicated appendicitis in adults in Lima, Peru: a matched case-control study.","authors":"Agustín Mansilla-Sandoval, Diana Corrales-Delgado, Zully M Puyén, Percy Mansilla-Doria, Edwin Orendo-Velásquez, Luis Huicho, Diego Fano-Sizgorich","doi":"10.1186/s12893-025-02897-7","DOIUrl":"https://doi.org/10.1186/s12893-025-02897-7","url":null,"abstract":"<p><strong>Background: </strong>Acute appendicitis may be uncomplicated or may present with life threatening complications. Since the outbreak of the COVID-19 pandemic, there has been an increase in the number of cases of complicated appendicitis, suggesting a possible association between them. Therefore, we aimed to determine the association between SARS-CoV-2 infection and complicated appendicitis in surgical patients in Lima, Peru, from March 2020 to December 2021.</p><p><strong>Methods: </strong>A matched case-control study was conducted. Clinical records of patients ≥ 18 years old who underwent surgery for appendicitis and had at least one positive SARS-CoV-2 diagnostic test were selected. Patients undergoing surgery for complicated appendicitis were considered cases, and patients undergoing surgery for uncomplicated appendicitis were controls. A 1:1 matching by sex, age, and month of surgery was performed. Conditional logistic regression modeling was performed to calculate crude and adjusted conditional odds ratios (cOR).</p><p><strong>Results: </strong>The positivity rate for COVID-19 tests was 73.6% for cases and 26.4% for controls. The crude cOR was 4.88 (95% IC 2.89-8.23, p < 0.001), and the adjusted cOR was 3.52 (95%IC 1.82-6.81, p = 0.001), after controlling for onset time of symptoms and awaiting time before surgery.</p><p><strong>Conclusions: </strong>Surgery for complicated appendicitis was associated with SARS-CoV-2 infection. Patients with this infection may be at higher risk of complicated appendicitis and thus may need additional clinical monitoring.</p>","PeriodicalId":49229,"journal":{"name":"BMC Surgery","volume":"25 1","pages":"159"},"PeriodicalIF":1.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival status and determinant factors of mortality among pediatric patients who underwent ventriculoperitoneal shunting surgery for hydrocephalus in Ethiopia.","authors":"Mathewos Sileshi Menberu, Abdurehman Seid Mohammed, Yared Negussie Kebede, Getachew Mekete Diress","doi":"10.1186/s12893-025-02896-8","DOIUrl":"https://doi.org/10.1186/s12893-025-02896-8","url":null,"abstract":"<p><strong>Background: </strong>Ventriculoperitoneal (VP) shunting is one of the most common neurosurgical procedures for treating hydrocephalus. This study aimed to assess the Survival status and determinant factors of pediatric patients who underwent ventriculoperitoneal shunting for hydrocephalus.</p><p><strong>Methods: </strong>A multicenter institutional-based retrospective cohort study was employed by reviewing medical chart records of pediatric patients who underwent ventriculoperitoneal (VP) shunting surgery for hydrocephalus from 1/12/2015 to 30/02/2023 and the medical chart records review was employed from 1/03/2023 to 30/03/2023. Data were extracted using a pre-tested, structured questionnaire. The Cox proportional hazard model was used to identify determinants of pediatric patient survival, where the hazard ratio, p-values, and 95% CI for adjusted hazard ratio were used to test significance and interpret the results. A p-value of < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Seven hundred sixty-nine medical chart records of pediatric patients who underwent ventriculoperitoneal (VP) shunting surgery for hydrocephalus were selected and reviewed with a response rate of 87.89%. The median survival time of pediatric patients after surgery was 15 months. On the multivariable Cox proportional hazard model, ultrasound image (AHR: 4.257, 95% CI: 2.07-8.74), emergency type of surgery (AHR: 2.180, 95% CI: 1.20-3.95), additional procedures other than shunting (AHR: 2.089, 95% CI: 1.05-4.16), duration of stay (> 7 days) (AHR: 4.014, 95% CI: 1.28-12.57), shunt failure (AHR: 4.163, 95% CI: 2.32-7.47), and clinical follow-up (AHR: 2.606, 95% CI: 1.31-5.17) were found to be determinants factors of survival status the patients.</p><p><strong>Conclusion: </strong>The survival time to death was 15 months, and the mortality rate for shunting surgery for hydrocephalus was 24.58%. In this study, emergency type of surgery, additional procedures other than shunt, duration of stay (> 7 days), shunt failure, and no hospital follow-up were factors associated with the mortality of the patients.</p>","PeriodicalId":49229,"journal":{"name":"BMC Surgery","volume":"25 1","pages":"158"},"PeriodicalIF":1.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of ventriculoperitoneal shunt therapy in idiopathic normal pressure hydrocephalus.","authors":"Jingyu Chen, Jishu Xian, Feilong Wang, Chenghai Zuo, Li We, Zhi Chen, Rong Hu, Hua Feng","doi":"10.1186/s12893-025-02895-9","DOIUrl":"https://doi.org/10.1186/s12893-025-02895-9","url":null,"abstract":"<p><strong>Background: </strong>Limited data are available regarding the long-term functional outcomes and associated factors in patients with idiopathic normal pressure hydrocephalus (iNPH) undergoing ventriculoperitoneal shunt (VPS) placement. This study aimed to retrospectively evaluate the long-term outcomes of iNPH patients treated with VPS.</p><p><strong>Methods: </strong>Functional outcomes were assessed preoperatively and at 1-year, 2-year, and 3-year intervals postoperatively using the modified Rankin Scale (mRS), the iNPH grading scale (iNPHGS), and the Mini-Mental State Examination (MMSE).</p><p><strong>Results: </strong>Significant improvements were observed in mRS and iNPHGS scores at 1, 2, and 3 years post-surgery compared to the baseline level. MMSE scores showed significant improvement at 1-year and 3-year follow-ups. Multivariate regression analysis identified key factors influencing changes in mRS scores: postoperative complications and education level at 1 year, postoperative complications at 2 years, and sex, education level, postoperative complications, and smoking at 3 years. For iNPHGS scores, significant factors included sex, age at surgery, and smoking at 1 and 2 years. Changes in MMSE scores were associated with sex and the duration of preoperative symptoms at 1 year, and postoperative complications, education level, and smoking at 3 years.</p><p><strong>Conclusion: </strong>This study affirmed the efficacy and safety of VPS in managing iNPH. Factors influencing postoperative outcomes predominantly included education level, smoking, duration of preoperative symptoms, and postoperative complications. However, further research is required to validate these findings.</p>","PeriodicalId":49229,"journal":{"name":"BMC Surgery","volume":"25 1","pages":"157"},"PeriodicalIF":1.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic primary suture of the common bile duct in patients with common bile duct stones: a comparative analysis of two suturing methods in terms of safety, efficacy, and convenience with 16-month follow-up.","authors":"Yizhou Sun, Shengyi Zhou, Shan Tang, Zuoan Li, Andong Xu","doi":"10.1186/s12893-025-02904-x","DOIUrl":"https://doi.org/10.1186/s12893-025-02904-x","url":null,"abstract":"<p><strong>Background: </strong>Primary suturing of the common bile duct (CBD) is increasingly used in laparoscopic common bile duct exploration (LCBDE) for selected patients, though the optimal suturing method remains unclear. This study compares the efficacy of continuous versus interrupted sutures for primary CBD closure in patients with CBD stones.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 120 patients with CBD stones who underwent primary CBD closure at Yancheng First People's Hospital from October 2022 to December 2023. Data included demographics, hospital stay, complications, and follow-up outcomes. Of these, 69 received continuous sutures, and 51 received interrupted sutures.</p><p><strong>Results: </strong>No significant differences were found in age, gender, body mass index (BMI), CBD diameter, preoperative bilirubin levels, or stone residuals between groups. The incidence of postoperative fever, bile leakage, electrolyte disturbances, bleeding, wound infection, and CBD stricture was similar. Continuous suturing required less operative time than interrupted suturing (p < 0.01).</p><p><strong>Conclusion: </strong>Both continuous and interrupted suturing techniques are safe and effective for CBD closure in selected patients, though continuous suturing is more time-efficient.</p>","PeriodicalId":49229,"journal":{"name":"BMC Surgery","volume":"25 1","pages":"155"},"PeriodicalIF":1.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The difficult laparoscopic cholecystectomy: a narrative review.","authors":"Hamdy S Abdallah, Mohamad H Sedky, Zyad H Sedky","doi":"10.1186/s12893-025-02847-3","DOIUrl":"https://doi.org/10.1186/s12893-025-02847-3","url":null,"abstract":"<p><strong>Background/purpose: </strong>Laparoscopic cholecystectomy is one of the most commonly performed general surgical procedures. Difficult laparoscopic cholecystectomy is associated with increased operative time, hospital stay, complication rates, open conversion, treatment costs, and mortality. This study aimed to provide a comprehensive literature review on difficult laparoscopic cholecystectomy.</p><p><strong>Methods: </strong>A literature search was conducted for articles published in English up to June 2024 using common databases including PubMed/MIDLINE, Web of Science, Google Scholar, and ScienceDirect. Keywords included \"safe laparoscopic cholecystectomy\", \"difficult laparoscopic cholecystectomy\", \"acute cholecystitis\", \"prevention of bile duct injuries\", \"intraoperative cholangiography,\" \"bailout procedure,\" and \"subtotal cholecystectomy\". Only clinical trials, systematic reviews/meta-analyses, and review articles were included. Studies involving children, robotic cholecystectomy, single incision laparoscopic cholecystectomy, open cholecystectomy, and cholecystectomy for indications other than gallstone disease were excluded.</p><p><strong>Results/discussion: </strong>Emergency laparoscopic cholecystectomy for acute cholecystitis is ideally performed within 72 h of symptom onset, with a maximum window of 7-10 days. Intraoperative cholangiography can help clarify unclear biliary anatomy and detect bile duct injuries. In the \"impossible gallbladder\", laparoscopic cholecystostomy or gallbladder aspiration may be considered. When dissection of Calot's triangle is deemed hazardous or impossible, the fundus-first approach allows for completion of the procedure with either total cholecystectomy or subtotal cholecystectomy. Subtotal cholecystectomy is effective in preventing bile duct injuries, can be performed laparoscopically, and is currently the best available bailout approach for difficult laparoscopic cholecystectomy.</p><p><strong>Conclusion: </strong>Difficult laparoscopic cholecystectomy is a common clinical scenario that requires a judicious approach by experienced surgeons in appropriate settings. When difficult laparoscopic cholecystectomy is encountered, various bailout strategies are available. Currently, subtotal cholecystectomy is likely the most effective bailout approach.</p>","PeriodicalId":49229,"journal":{"name":"BMC Surgery","volume":"25 1","pages":"156"},"PeriodicalIF":1.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of epothilone B on the expression of neuroproteins after anastomosis of the sciatic nerve transection in the rat.","authors":"Wei Zhao, Kun-Xiu Song, Bing-Dong Ma, Yong-Tao Liu, Guang-Chao Sun, Yong Chai","doi":"10.1186/s12893-025-02869-x","DOIUrl":"https://doi.org/10.1186/s12893-025-02869-x","url":null,"abstract":"<p><p>Peripheral nerve injury (PNI) is a common condition that leads to the partial loss of function in the sensory, motor, and autonomic nervous systems. The peripheral nervous system has an inherent capacity to regenerate after injury and re-innervate its target organs, but full functional recovery is rare. In recent years, there has been growing interest in identifying drugs that can promote axonal regeneration and outgrowth following PNI. Epothilone B (EpoB) is an FDA-approved antineoplastic agent that promotes tubulin polymerization and enhances the stability of microtubules. Recently, the regenerative effects of EpoB in the central nervous system have garnered attention, but its potential therapeutic effects on peripheral nerve regeneration remain underexplored. This study utilized a sciatic nerve transection and anastomosis model in rats to evaluate the effects of EpoB on neuroprotein expression following nerve injury. Behavioral analysis, Masson's trichrome staining, and immunofluorescence staining were conducted to assess the impact of EpoB on sciatic nerve regeneration. Over time, motor recovery and muscle reinnervation were observed, with Sciatic Functional Index (SFI) scores higher in the EpoB-treated group compared to the vehicle group. The expression of fibronectin (FN) was significantly lower in the EpoB group, while the expression of Tau, neurofilament-M (NF-M), and growth-associated protein-43 (GAP-43) was significantly higher. In conclusion, EpoB treatment significantly increases the expression of Tau, NF-M, and GAP-43, suggesting a positive effect on axonal regeneration and repair.</p>","PeriodicalId":49229,"journal":{"name":"BMC Surgery","volume":"25 1","pages":"152"},"PeriodicalIF":1.6,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coagulation and thyroiditis are factors associated with adverse pathological features in differentiated thyroid cancer: a retrospective cohort study.","authors":"Xiao Chen, Han-Yu Wang, Lu Yu, Jia-Qi Liu, Hui Sun","doi":"10.1186/s12893-025-02898-6","DOIUrl":"https://doi.org/10.1186/s12893-025-02898-6","url":null,"abstract":"<p><strong>Objective: </strong>Lymph node metastasis (LNM) and thyroid capsular invasion (CI) are the main pathological features leading to poor prognosis of differentiated thyroid cancer (DTC), and there is a lack of effective diagnostic methods before surgery. Therefore, this study was designed to analyze a large number of preoperative clinical features of DTC and identify factors closely related to those two pathological features.</p><p><strong>Methods: </strong>4557 patients with DTC, postoperative pathological results showed LNM in 2146 cases and CI in 2783 cases were retrospectively included. The preoperative blood, urine, serum laboratory test and ultrasound of thyroid were performed for data collection. A total of 74 clinical features were analyzed by the methods of principal component analysis (PCA), and key principal components were extracted for regression analysis of LNM and CI as well as subgroup analysis.</p><p><strong>Results: </strong>11 key clinical features were used for principal component analysis, and 6 principal components PC0-PC5 were finally obtained. PC0 is mainly composed of prothrombin time and international normalized ratio, and the score represents better coagulation function and has a protective effect on LNM. PC1 is mainly composed of thyroid peroxidase antibody and thyroid texture, and the score represents the severity of thyroiditis and has a protective effect on LNM and CI.</p><p><strong>Conclusion: </strong>Thyroiditis and coagulation function were identified by principal component analysis as protective and risk factors for adverse pathology of DTC, meaning they were closely related to tumor metastasis and invasion.</p>","PeriodicalId":49229,"journal":{"name":"BMC Surgery","volume":"25 1","pages":"150"},"PeriodicalIF":1.6,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it safe not to fix the mesh in an open incisional hernia repair? Literature review.","authors":"Gintaras Varanauskas, Gintautas Brimas","doi":"10.1186/s12893-025-02894-w","DOIUrl":"https://doi.org/10.1186/s12893-025-02894-w","url":null,"abstract":"<p><strong>Introduction: </strong>Review the articles with incisional hernia repair without mesh fixation in open hernia repair.</p><p><strong>Methods: </strong>A systematic search of the literature published from 01/01/2008 to 31/12/2023 was performed using Medline PubMed, Cochrane Library, and Google Scholar databases. The search used the keywords: incisional hernia, open mesh repair, and without mesh fixation.</p><p><strong>Results: </strong>Nine publications were identified for the present analysis. The quality of each study was assessed. Information about operative methods, main results, conclusions, and recommendations was collected.</p><p><strong>Conclusions: </strong>According to the results and findings of reviewed articles, postoperative abdominal wall hernia repair without mesh suturing is safe and can improve postoperative results. Still, there is insufficient evidence to determine whether it is associated with better outcomes than hernia repair with mesh fixation. Further clinical studies are needed to clarify whether this method is clinically essential.</p>","PeriodicalId":49229,"journal":{"name":"BMC Surgery","volume":"25 1","pages":"151"},"PeriodicalIF":1.6,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative laparoscopic 'Tunnel' approach in managing hiatal hernia with gastroesophageal reflux disease: a retrospective study.","authors":"Zhewen Feng, Zhiping Zhang, Zhilong Yan, Feng Gao, Qingfeng Chen","doi":"10.1186/s12893-025-02900-1","DOIUrl":"https://doi.org/10.1186/s12893-025-02900-1","url":null,"abstract":"<p><strong>Background: </strong>Hiatal hernia (HH) is a major cause of gastroesophageal reflux disease (GERD), and laparoscopic repair combined with anti-reflux surgery is a common treatment. However, postoperative complications such as vagus nerve injury remain a concern. This study introduces a novel Laparoscopic \"Tunnel\" Approach aiming to minimize damage to the vagus nerve and preserve perigastric vessels.</p><p><strong>Methods: </strong>Clinical data were consecutively collected from patients who underwent laparoscopic \"tunnel\" approach for the treatment of hiatal hernia combined with gastroesophageal reflux disease at the First Affiliated Hospital of Ningbo University between June 2023 and June 2024. Data collected included age, gender, BMI, DeMeester score, surgical time, and postoperative symptoms. Follow-ups were conducted at 1, 3, and 6 months postoperatively.</p><p><strong>Results: </strong>The average age was 54 ± 9 years, BMI was 25.56 ± 4.32 kg/m², DeMeester score was 118.05 ± 17.71, and GERD-Q score was 13 ± 2. The average surgical time was 115 ± 15 min. Postoperatively, symptoms significantly improved, with an average GERD-Q score of 5 ± 1 at 6 months. At 1 month, dysphagia was observed in 14 patients, belching in 19, abdominal distension in 5, nausea in 16, and diarrhea in 8. By 6 months, only 2 patients exhibited belching, with no other symptoms persisting. No cases of vomiting or gallstones were reported.</p><p><strong>Conclusions: </strong>The Laparoscopic \"Tunnel\" Approach may effectively minimizes vagus nerve injury and preserves perigastric vessels, resulting in improved postoperative outcomes and quality of life. This method shows potential for wider application in treating HH and GERD. However, since this study was retrospective and lacked a control group, further studies are needed to verify our conclusions.</p>","PeriodicalId":49229,"journal":{"name":"BMC Surgery","volume":"25 1","pages":"154"},"PeriodicalIF":1.6,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}