Biometals最新文献_第5页

Threshold and combined effects of heavy metals on the risk of phenotypic age acceleration among U.S. adults 重金属对美国成年人表型年龄加速风险的阈值效应和综合效应。

IF 4.1 3区生物学

Biometals Pub Date : 2024-05-31 DOI: 10.1007/s10534-024-00609-x

Yalan Liu, Zhaofeng Jin, Shihao Fu

{"title":"Threshold and combined effects of heavy metals on the risk of phenotypic age acceleration among U.S. adults","authors":"Yalan Liu, Zhaofeng Jin, Shihao Fu","doi":"10.1007/s10534-024-00609-x","DOIUrl":"10.1007/s10534-024-00609-x","url":null,"abstract":"<div>Accumulation of heavy metals in the body has been shown to affect the phenotypic age (PhenoAge). However, the combined and threshold effects of blood heavy metals on the risk of PhenoAge acceleration (PhenoAgeAccel) are not well understood. A cross-sectional study was conducted using blood heavy metal data (N = 7763, age ≥18 years) from the 2015-2018 National Health and Nutrition Examination Survey. PhenoAgeAccel was calculated from actual age and nine biomarkers. Multiple regression equations were used to describe the relationship between heavy metals and PhenoAgeAccel. Least Absolute Shrinkage and Selection Operator (LASSO) regression modeling was used to explore the relationship between the combined effects of heavy metals and PhenoAgeAccel. Threshold effect and multiple regression analyses were performed to explore the linear and nonlinear relationships between heavy metals and PhenoAgeAccel. Threshold effect analysis showed that blood mercury (Hg) concentration was linearly associated with PhenoAgeAccel. In contrast, lead (Pb), cadmium (Cd), manganese (Mn), and combined exposure were nonlinearly associated with PhenoAgeAccel. In addition, the combination of Pb, Cd, Hg, and Mn significantly affected PhenoAgeAccel. The risk of PhenoAgeAccel was increased by 207% (P < 0.0001). Meanwhile, a threshold relationship was found between blood Pb, Cd, Mn, and the occurrence of PhenoAgeAccel. Overall, our results indicate that combined exposure to heavy metals may increase the risk of PhenoAgeAccel. This study underscores the need to reduce heavy metal pollution in the environment and provides a reference threshold for future studies.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 5","pages":"1279 - 1288"},"PeriodicalIF":4.1,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Gentianella acuta (Michx.) Hulten against the arsenic-induced development hindrance of mouse oocytes. Gentianella acuta (Michx.) Hulten 对砷诱导的小鼠卵母细胞发育障碍的影响。

IF 3.5 3区生物学

Biometals Pub Date : 2024-05-30 DOI: 10.1007/s10534-024-00613-1

Chunyu Wang, Biao Wang, Ying Wei, Shubin Li, Jingyu Ren, Yanfeng Dai, Gang Liu

{"title":"Effect of Gentianella acuta (Michx.) Hulten against the arsenic-induced development hindrance of mouse oocytes.","authors":"Chunyu Wang, Biao Wang, Ying Wei, Shubin Li, Jingyu Ren, Yanfeng Dai, Gang Liu","doi":"10.1007/s10534-024-00613-1","DOIUrl":"https://doi.org/10.1007/s10534-024-00613-1","url":null,"abstract":"The current study was designed to investigate the alleviative effect of Gentianella acuta (Michx.) Hulten (G. acuta) against the sodium arsenite (NaAsO2)-induced development hindrance of mouse oocytes. For this purpose, the in vitro maturation (IVM) of mouse cumulus-oocyte complexes (COCs) was conducted in the presence of NaAsO2 and G. acuta, followed by the assessments of IVM efficiency including oocyte maturation, spindle organization, chromosome alignment, cytoskeleton assembly, cortical granule (CGs) dynamics, redox regulation, epigenetic modification, DNA damage, and apoptosis. Subsequently, the alleviative effect of G. acuta intervention on the fertilization impairments of NaAsO2-exposed oocytes was confirmed by the assessment of in vitro fertilization (IVF). The results showed that the G. acuta intervention effectively ameliorated the decreased maturation potentials and fertilization deficiency of NaAsO2-exposed oocytes but also significantly inhibited the DNA damages, apoptosis, and altered H3K27me3 expression level in the NaAsO2-exposed oocytes. The effective effects of G. acuta intervention against redox dysregulation including mitochondrial dysfunctions, accumulated reactive oxygen species (ROS) generation, glutathione (GSH) deficiency, and decreased adenosine triphosphate (ATP) further confirmed that the ameliorative effects of G. acuta intervention against the development hindrance of mouse oocytes were positively related to the antioxidant capacity of G. acuta. Evidenced by these abovementioned results, the present study provided fundamental bases for the ameliorative effect of G. acuta intervention against the meiotic defects caused by the NaAsO2 exposure, benefiting the future application potentials of G. acuta intervention in these nutritional and therapeutic research for attenuating the outcomes of arseniasis.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141173657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, theoretical studies, antibacterial, and antibiofilm activities of novel azo-azomethine chelates against the pathogenic bacterium Proteus mirabilis 新型偶氮甲基螯合物对致病菌奇异变形杆菌的合成、理论研究、抗菌和抗生物膜活性。

IF 4.1 3区生物学

Biometals Pub Date : 2024-05-30 DOI: 10.1007/s10534-024-00608-y

Fatma I. Abouzayed, Rasha Mohammad Fathy, Shimaa G. Hussien, Gharieb S. El-Sayyad, Saeyda A. Abouel-Enein

{"title":"Synthesis, theoretical studies, antibacterial, and antibiofilm activities of novel azo-azomethine chelates against the pathogenic bacterium Proteus mirabilis","authors":"Fatma I. Abouzayed, Rasha Mohammad Fathy, Shimaa G. Hussien, Gharieb S. El-Sayyad, Saeyda A. Abouel-Enein","doi":"10.1007/s10534-024-00608-y","DOIUrl":"10.1007/s10534-024-00608-y","url":null,"abstract":"<div>2-((1-(4-((2,4,6-trioxohexahydropyrimidin-5-yl)diazenyl) phenyl) ethylidene) amino) benzoic acid (H3L), and its V(IV), Co(II), Ni(II), Cu(II), Pd(II) and Ag(I) chelates were synthesized. They were defined using multiple spectral and analytical techniques. With the exception of Ag(I) chelate, all chelates possessed non-electrolytic character. Square pyramidal shape was proposed for V(IV) chelate and Square planar for the other chelates. The analysis of functional group bands of H3L and its coordination compounds alludes that H3L chelated as neutral tetradentate via nitrogen atoms of azo and azomethine groups, oxygen atom of carbonyl of barbituric acid and OH of the carboxylic group. TG/DTG predicted the thermal behaviors of all compounds. The antibacterial activity of H3L and its coordination compounds was conducted against Proteus mirabilis at concentrations of 250, 500, and 1000 µg/mL. Ag(I) at 1000 µg/mL, showed the most inhibiting potency against P. mirabilis and registered zone of inhibition of 28.33 ± 0.84 mm and highest biofilm inhibition of 70.31%. At 50 Gy of gamma irradiation, the reducing effect of Ag(I) chelate was improved. The protein interruption of P. mirabilis was greatly interrupted by increasing the concentration of the chaletes. Also, Ag(I) showed the highest cytotoxicity with IC50 value of 11.5 µg/ mL. The novelty of this study is the synthesis of a new azo-Schiff base and this is almost the first publication of the effect of azo-Schiff ligands against that bacterial strain P. mirabilis.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 5","pages":"1255 - 1278"},"PeriodicalIF":4.1,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141173700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between biomedical and structural properties of Zn/Sr modified calcium phosphates Zn/Sr 改性磷酸钙的生物医学特性与结构特性之间的相关性。

IF 4.1 3区生物学

Biometals Pub Date : 2024-05-28 DOI: 10.1007/s10534-024-00599-w

Atipong Bootchanont, Natthaphon Chaosuan, Sasina Promdee, Jantima Teeka, Pinit Kidkhunthod, Rattikorn Yimnirun, Wutthigrai Sailuam, Nutthaporn Isran, Arreerat Jiamprasertboon, Theeranun Siritanon, Tanachat Eknapakul, Thanit Saisopa

{"title":"Correlation between biomedical and structural properties of Zn/Sr modified calcium phosphates","authors":"Atipong Bootchanont, Natthaphon Chaosuan, Sasina Promdee, Jantima Teeka, Pinit Kidkhunthod, Rattikorn Yimnirun, Wutthigrai Sailuam, Nutthaporn Isran, Arreerat Jiamprasertboon, Theeranun Siritanon, Tanachat Eknapakul, Thanit Saisopa","doi":"10.1007/s10534-024-00599-w","DOIUrl":"10.1007/s10534-024-00599-w","url":null,"abstract":"<div>This study investigates the correlation between the biomedical and structural properties of Zn/Sr-modified Calcium Phosphates (ZnSr–CaPs) synthesized via the sol–gel combustion method. X-ray diffraction (XRD) analysis revealed the presence of Ca10(PO4)6(OH)2 (HAp), CaCO3, and Ca(OH)2 phases in the undoped sample, while the additional phase, Ca3(PO4)2 (β-TCP) was formed in modified samples. X-ray absorption near-edge structure (XANES) analysis demonstrated the incorporation of Sr into the lattice, with a preference for occupying the Ca1 sites in the HAp matrix. The introduction of Zn, furthermore, led to the formation of ZnO and CaZnO2 species. The ZnSr–CaPs exhibited significant antibacterial activity attributed to the generation of reactive oxygen species by ZnO, the oxidation reaction of CaZnO2, and the presence of Sr ions. Cytotoxicity tests revealed a correlation between the variation in ZnO content and cellular viability, with lower ZnO concentrations corresponding to higher cell viability. Additionally, the cooperative effects of Zn and Sr ions were found to enhance the bioactivity of CaPs, despite ZnO hindering the apatite formation process. These findings contribute to the deep understanding of the diverse role in modulating the antibacterial, cytotoxic, and bioactive properties of ZnSr–CaPs, offering potential applications in the field of biomaterials.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 5","pages":"1177 - 1189"},"PeriodicalIF":4.1,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coordination of bioactive phytochemicals from Aloe vera extracts to metal ions; investigation of the metal complexes and bioactive compound formed. 芦荟提取物中具有生物活性的植物化学物质与金属离子的配位；研究金属络合物和形成的生物活性化合物。

IF 3.5 3区生物学

Biometals Pub Date : 2024-05-25 DOI: 10.1007/s10534-024-00611-3

Great Iruoghene Edo

{"title":"Coordination of bioactive phytochemicals from Aloe vera extracts to metal ions; investigation of the metal complexes and bioactive compound formed.","authors":"Great Iruoghene Edo","doi":"10.1007/s10534-024-00611-3","DOIUrl":"https://doi.org/10.1007/s10534-024-00611-3","url":null,"abstract":"The bioactive compounds contained within many plants account for their pharmacological values. Aloe vera has a wide range of organic and inorganic components, including carbohydrate polymers, glucomannans, and a variety of other natural and synthetic materials. The study aims to take a look into the characteristics of some metal complexes produced from Aloe vera extracts. The extracts from Aloe vera were derived by means of acetone, distilled water and ethanol. The solubility of the metal complexes with the ligand at varying temperatures was established. FT-IR was used to carry out the infra-red examination of the ligand. The results revealed that alcoholic extract of Aloe vera leaf was not soluble in Cu, Fe, or Zn but only soluble in Fe, the extract by distilled water was soluble in Cu, Fe and Zn. However, the Aloe vera in acetone as well as in the Zn (II) and Cu (II) composites displayed a bending that was found at 1430.97 cm-1, 1500.01 cm-1 and 1615.90 cm-1.every functional groups are assigned to be coordinating sites as a result of increase or decrease in the wave number, and absorption band. Findings from the investigation reveal that the complexion of the metal salts with diverse donor sites in the extract is indicated by an increase in the absorption peak of the functional groups in the metal composites of the extracts.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141092757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Research progress of ferroptosis and inflammatory bowel disease 更正为铁蛋白沉积与炎症性肠病的研究进展。

IF 4.1 3区生物学

Biometals Pub Date : 2024-05-24 DOI: 10.1007/s10534-024-00614-0

Baolian Ma, Xiaoxue Hu, Xiaowen Ai, Yonglan Zhang

引用次数: 0

The iron(III) coordinating properties of citrate and α-hydroxycarboxylate containing siderophores. 含柠檬酸盐和α-羟基羧酸盐的铁(III)配位特性。

IF 3.5 3区生物学

Biometals Pub Date : 2024-05-21 DOI: 10.1007/s10534-024-00607-z

Robert C Hider, André M N Silva, Agostino Cilibrizzi

引用次数: 0

Research progress of ferroptosis and inflammatory bowel disease 铁蛋白沉积症与炎症性肠病的研究进展。

IF 4.1 3区生物学

Biometals Pub Date : 2024-05-07 DOI: 10.1007/s10534-024-00604-2

Baolian Ma, Xiaoxue Hu, Xiaowen Ai, Yonglan Zhang

引用次数: 0

Global threat posed by metals and metalloids in the changing environment: a One Health approach to mechanisms of toxicity 不断变化的环境中金属和类金属对全球构成的威胁：采用 "同一健康 "方法研究毒性机制。

IF 4.1 3区生物学

Biometals Pub Date : 2024-05-06 DOI: 10.1007/s10534-024-00606-0

Wing-Kee Lee, Frank Thévenod, Elmar J. Prenner

引用次数: 0

Nanomedicine: Patuletin-conjugated with zinc oxide exhibit potent effects against Gram-negative and Gram-positive bacterial pathogens 纳米药物：与氧化锌共轭的帕图雷汀对革兰氏阴性和革兰氏阳性细菌病原体具有强效作用。

IF 4.1 3区生物学

Biometals Pub Date : 2024-05-06 DOI: 10.1007/s10534-024-00595-0

Naveed Ahmed Khan, Adeelah Alvi, Saif Alqassim, Noor Akbar, Bushra Khatoon, Muhammad Kawish, Shaheen Faizi, Muhammad Raza Shah, Bader S. Alawfi, Ruqaiyyah Siddiqui

{"title":"Nanomedicine: Patuletin-conjugated with zinc oxide exhibit potent effects against Gram-negative and Gram-positive bacterial pathogens","authors":"Naveed Ahmed Khan, Adeelah Alvi, Saif Alqassim, Noor Akbar, Bushra Khatoon, Muhammad Kawish, Shaheen Faizi, Muhammad Raza Shah, Bader S. Alawfi, Ruqaiyyah Siddiqui","doi":"10.1007/s10534-024-00595-0","DOIUrl":"10.1007/s10534-024-00595-0","url":null,"abstract":"<div>With the emergence of drug-resistance, there is a need for novel anti-bacterials or to enhance the efficacy of existing drugs. In this study, Patuletin (PA), a flavanoid was loaded onto Gallic acid modified Zinc oxide nanoparticles (PA-GA-ZnO), and evaluated for antibacterial properties against Gram-positive (Bacillus cereus and Streptococcus pneumoniae) and Gram-negative (Samonella enterica and Escherichia coli) bacteria. Characterization of PA, GA-ZnO and PA-GA-ZnO’ nanoparticles was accomplished utilizing fourier-transform infrared spectroscopy, efficiency of drug entrapment, polydispersity index, zeta potential, size, and surface morphology analysis through atomic force microscopy. Using bactericidal assays, the results revealed that ZnO conjugation displayed remarkable effects and enhanced Patuletin’s effects against both Gram-positive and Gram-negative bacteria, with the minimum inhibitory concentration observed at micromolar concentrations. Cytopathogenicity assays exhibited that the drug-nanoconjugates reduced bacterial-mediated human cell death with minimal side effects to human cells. When tested alone, drug-nanoconjugates tested in this study showed limited toxic effects against human cells in vitro. These are promising findings, but future work is needed to understand the molecular mechanisms of effects of drug-nanoconjugates against bacterial pathogens, in addition to in vivo testing to determine their translational value. This study suggests that Patuletin-loaded nano-formulation (PA-GA-ZnO) may be implicated in a multi-target mechanism that affects both Gram-positive and Gram-negative pathogen cell structures, however this needs to be ascertained in future work.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 5","pages":"1113 - 1125"},"PeriodicalIF":4.1,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0