International Journal of Lower Extremity Wounds最新文献

Bibliometric Analysis: Bridging Informatics With Science. 文献计量分析：信息学与科学的桥梁

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2025-09-01 Epub Date: 2023-01-29 DOI: 10.1177/15347346231153538

Miltos K Lazarides, Irene-Zacharo Lazaridou, Nikolaos Papanas

引用次数: 0

Role of Adipose Derived Stem Cells in Patients with Diabetic Foot Ulcers: Systematic Review and Meta-Analysis of Randomised Controlled Trials. 脂肪来源干细胞在糖尿病足溃疡患者中的作用：随机对照试验的系统评价和荟萃分析。

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2025-09-01 Epub Date: 2023-05-11 DOI: 10.1177/15347346231174554

Mohamed Elsharkawi, Baker Ghoneim, Miriam O'Sullivan, Aoife J Lowery, Daniel Westby, Wael Tawfick, Stewart R Walsh

{"title":"Role of Adipose Derived Stem Cells in Patients with Diabetic Foot Ulcers: Systematic Review and Meta-Analysis of Randomised Controlled Trials.","authors":"Mohamed Elsharkawi, Baker Ghoneim, Miriam O'Sullivan, Aoife J Lowery, Daniel Westby, Wael Tawfick, Stewart R Walsh","doi":"10.1177/15347346231174554","DOIUrl":"10.1177/15347346231174554","url":null,"abstract":"Few studies to date have investigated the role of adipose derived stem cells (ADSCs) in patients with diabetic foot ulcers (DFU). We aimed to conduct a systematic search of the literature to explore the available evidence behind ADSCs application in patients with DFU to establish if it has any added benefit regarding healing rate and healing time in this cohort of patients. The PubMed and Embase databases were searched for eligible studies. Only randomised controlled trials which investigated the impact of ADSCs alone on the healing of DFU were considered eligible and were included for the review. Reported healing rates, time to healing and procedure related complications were collected and analysed. The initial search resulted in 160 papers. Following duplicate removal, 131 papers were screened for eligibility. Only four trials met the study criteria and were included for the final review and analysis. 97 out of 189 patients who were included in the four studies received ADSCs for treatment of DFU whereas the remaining 92 patients received standard measures (control). The median participant age was 62, predominantly male (72.5%). Complete healing was achieved in 83.5% (n = 81) of patients in the ADSC group compared to 52% (n = 48) for patients in the control group at 12 months (OR = 4.8, 95%CI = 2.25 to 10.24, P < 0.0001). Mean healing time in the ADSC group ranged from 31 to 85 days whereas mean healing time in the control group ranged from 42 to 85 days (Pooled weighted mean difference = -10.832856, 95%CI = -22.44 to 0.77, P = 0.0673). No significant procedure related complications were reported in either group. The use of ADSCs in patients with DFU appears to demonstrate improved healing rates. The procedure of ADSC harvest and administration appears to be safe based on the initial reports. Large, randomised trials are needed to establish its role in patients with diabetic foot wounds.","PeriodicalId":49181,"journal":{"name":"International Journal of Lower Extremity Wounds","volume":" ","pages":"542-549"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9501417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Nutrients and Diet Characteristics in the Management of Diabetic Foot Ulcers: A Systematic Review. 营养素和饮食特点在糖尿病足溃疡管理中的作用：系统回顾

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2025-09-01 Epub Date: 2023-02-03 DOI: 10.1177/15347346231153531

Kyriaki Apergi, Charilaos Dimosthenopoulos, Nikolaos Papanas

引用次数: 0

Foot Self-Care Behaviour among People with Type 2 Diabetes mellitus Living in Rural Underserved Area of North India: A Community-Based Cross-Sectional Study. 生活在印度北部农村地区的 2 型糖尿病患者的足部自我护理行为：一项基于社区的横断面研究。

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2025-09-01 Epub Date: 2022-06-26 DOI: 10.1177/15347346221110074

Saurabh Kumar Gupta, Ashu Rastogi, Manmeet Kaur, Sunita Malhotra, P V M Lakshmi

{"title":"Foot Self-Care Behaviour among People with Type 2 Diabetes mellitus Living in Rural Underserved Area of North India: A Community-Based Cross-Sectional Study.","authors":"Saurabh Kumar Gupta, Ashu Rastogi, Manmeet Kaur, Sunita Malhotra, P V M Lakshmi","doi":"10.1177/15347346221110074","DOIUrl":"10.1177/15347346221110074","url":null,"abstract":"The objective of this study was to ascertain the foot self-care behaviour and its associated factors among people with type 2 diabetes mellitus (T2DM) living in the rural resource-constrained health setting of Punjab, North India. A community based cross sectional study was undertaken in the randomly selected underserved rural area of District Fatehgarh Sahib, Punjab, North India. A pre-validated Nottingham Assessment of Functional Footcare (NAFF) scale was administered to assess foot self-care behaviour, and participants were classified based on the percentage of a maximum possible score of 84 on the scale, as poor, if the score was <50%, satisfactory if score 50%-70% and >70% good foot self-care behaviour. A total of 700 participants' responses were recorded. The study results revealed that 84% (588) of the respondents had poor, 16% (112) had satisfactory, and none were following good foot self-care behaviour. An outcome of multivariable logistics regression suggested satisfactory foot self-care behaviour was significantly associated with foot self-care education, with an adjusted odds ratio (aOR) of 2.83 (95%, CI:1.62 - 4.93; p <0.01) among respondents who had received foot self-care education, literate than illiterate (aOR 2.50 95%, CI:1.31- 4.74; p <0.01) and women compared to men (aOR 1.69 95%, CI: 1.06 -2.70; p -0.26). This study revealed that foot self-care behaviours were alarmingly low among people with T2DM living in rural resource-constrained health settings of Punjab, North India, suggesting an urgent need to disseminate foot self-care education to prevent diabetes foot related complications.","PeriodicalId":49181,"journal":{"name":"International Journal of Lower Extremity Wounds","volume":" ","pages":"678-690"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9599795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Response to the Letter to the Editor "Methylene Blue Staining and Ultrasonic Debridement: A Superior Therapeutic Strategy for Pressure Ulcer Debridement". 回复致编辑的信“亚甲蓝染色和超声清创：压疮清创的优越治疗策略”。

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2025-09-01 Epub Date: 2023-06-27 DOI: 10.1177/15347346231176728

Chao Lian, Xiao-Jun Liu, Xue-Lei Li

引用次数: 0

Elevator Speeches (Pitches) and the Pareto Principle. 电梯演讲（推销）和帕累托原则。

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2025-09-01 Epub Date: 2023-08-27 DOI: 10.1177/15347346231197499

Miltos K Lazarides, George S Georgiadis, Nikolaos Papanas

引用次数: 0

Negative Pressure Wound Therapy: Supra-Physiological or Just Physical Effects of Positive Pressure? 负压伤口疗法：正压的超生理效应还是物理效应？

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2025-09-01 Epub Date: 2022-12-07 DOI: 10.1177/15347346221144145

Valdas Macionis

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Denervation Affected Skin Wound Healing in a Modified Rat Model. 去神经支配影响改良大鼠皮肤创面愈合。

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2025-06-01 Epub Date: 2022-03-28 DOI: 10.1177/15347346221090758

Lu Lu, Dandan Liu, Jianghui Ying, Zuochao Yao, Qiang Hou, Hui Wang, Fazhi Qi, Wenjie Luan, Hua Jiang

{"title":"Denervation Affected Skin Wound Healing in a Modified Rat Model.","authors":"Lu Lu, Dandan Liu, Jianghui Ying, Zuochao Yao, Qiang Hou, Hui Wang, Fazhi Qi, Wenjie Luan, Hua Jiang","doi":"10.1177/15347346221090758","DOIUrl":"10.1177/15347346221090758","url":null,"abstract":"Introduction: Lacking of normal innervation increases the chance of chronic wounds and recurrence of ulceration. Various rodent models are designed to reveal nerve-wound relationship but present many limitations to mimic human wound which heals primarily by re-epithelialization rather than contraction in rodents. This article tested a modified rat model of denervated wound healing to better mimic clinical common denervated wounds. Material and Methods: The wounds formed on right hind paws of 18 SD rats served as the experimental (denervated) group and the left side as contra-lateral control (non-denervated). The denervation was achieved through sciatic and femoral nerve co-transection and the control side underwent sham-surgery 3 days prior to a skin punch wound formation on both sides. Wound closure rate was calculated under digital photographing. Loss of innervation and affected healing process was confirmed by histological analyses. Results: Truncation of the sciatic and femur nerve successfully denervated the skin of the hind paw and resulted in a significantly declined healing rate, prolonged inflammation, weakened dermal contraction, hindered macrophage recruitment, retarded re-epithelialization and collagen deposition, decreased angiogenesis and epidermal proliferation, and persisted epidermal apoptosis compared to the innervated contra-lateral control. Conclusion: Wound on denervated dorsal pedis in rats can be used to study denervated skin healing in multiple histological process. We believe that this model will assist in understanding the underlying mechanism of nerve-wound relationship and identifying new treatment strategies that can be more rapidly translated into clinical practice.","PeriodicalId":49181,"journal":{"name":"International Journal of Lower Extremity Wounds","volume":" ","pages":"329-341"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9794732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental Health Status and Quality of Life in Lower-Limb Amputees With Diabetes. 糖尿病下肢截肢者的心理健康状况与生活质量

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2025-03-01 Epub Date: 2023-07-11 DOI: 10.1177/15347346231187185

Annelise Camilleri, Alfred Gatt, Nikolaos Papanas, Cynthia Formosa

{"title":"Mental Health Status and Quality of Life in Lower-Limb Amputees With Diabetes.","authors":"Annelise Camilleri, Alfred Gatt, Nikolaos Papanas, Cynthia Formosa","doi":"10.1177/15347346231187185","DOIUrl":"10.1177/15347346231187185","url":null,"abstract":"Aim: To compare mental health status and quality of life in lower-limb amputees versus nonamputees among participants with diabetes mellitus.Methods: We included 38 participants with prior minor amputation (group 1) and 38 participants without amputation /history of amputation (group 2). These were interviewed twice using 2 questionnaires to screen for mental health status and quality of life (Self Reporting Questionnaire 20-SRQ20 and EQ-5D-5L). Interviews were carried out 1 week and 6 months after amputation.Results: The mean SRQ20 score for group 1 at 1 week postamputation was 8.50 (diagnostic of a mental health disorder), while it was 1.34 for group 2. At 6 months, mean SRQ20 for group 1 decreased to 5.42, indicating a decrease in psychological distress. A significant difference in the mean values for each dimension of the EQ-5D-5L between groups 1 and 2 indicated that amputees had a poorer quality of life at 1 week and at 6 months.Conclusion: Mental health and quality of life are negatively affected at 1 week after minor lower-limb amputation in diabetes. At 6 months, some improvement in mental health distress was seen, indicating that these individuals had adapted to the disability.","PeriodicalId":49181,"journal":{"name":"International Journal of Lower Extremity Wounds","volume":" ","pages":"165-169"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10147557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of Hallux Amputation Versus Partial First Ray Resection in People with Non-Healing Diabetic Foot Ulcers: A Pragmatic Observational Cohort Study. 糖尿病足溃疡不愈合者截肢与部分第一线切除术的疗效：一项务实的观察性队列研究。

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2025-03-01 Epub Date: 2022-09-07 DOI: 10.1177/15347346221122859

Virginie Blanchette, Louis Houde, David G Armstrong, Brian M Schmidt

{"title":"Outcomes of Hallux Amputation Versus Partial First Ray Resection in People with Non-Healing Diabetic Foot Ulcers: A Pragmatic Observational Cohort Study.","authors":"Virginie Blanchette, Louis Houde, David G Armstrong, Brian M Schmidt","doi":"10.1177/15347346221122859","DOIUrl":"10.1177/15347346221122859","url":null,"abstract":"There are few data comparing outcomes after hallux amputation or partial first ray resection after diabetic foot ulcer (DFU). In a similar context, the choice to perform one of these two surgeries is attributable to clinician preference based on experience and characteristics of the patient and the DFU. Therefore, the purpose of this study was to determine the more definitive surgery between hallux amputation and partial first ray resection. We abstracted data from a cohort of 70 patients followed for a 1-year postoperative period to support clinical practice. We also attempted to identify patient characteristics leading to these outcomes. Our results suggested no statistical difference between the type of surgery and outcomes such as recurrence of DFU and amputation at 3, 6, and 12 months or death. However, there was a statistically significantly increased likelihood of re-ulceration for patients with CAD who underwent hallux amputation (p = 0.02). There was also a significantly increased likelihood of re-ulceration for people with depression or a history when the partial ray resection was performed (p = 0.02). Patients with prior amputation showed a higher probability of undergoing another re-amputation with partial ray resection (p = 0.01). Although the trends that emerge from this project are limited to what is observed in this statistical context, where the number of patients included and the number of total observations per outcome were limited, it highlights interesting data for future research to inform clinical decisions to support best practices for the benefit of patients.","PeriodicalId":49181,"journal":{"name":"International Journal of Lower Extremity Wounds","volume":" ","pages":"225-234"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10197922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0