IEEE Pulse最新文献_第9页

Silicon Synapses: The Bold Frontier of Brain-Computer Integration. 硅突触：脑机集成的大胆前沿。

IF 0.3 4区医学

IEEE Pulse Pub Date : 2025-05-01 DOI: 10.1109/MPULS.2025.3572569

Jim Banks

引用次数: 0

Why Consumer Neurofeedback Devices Are More Than Hype for Brain Health. 为什么消费类神经反馈设备不仅仅是对大脑健康的宣传？

IF 0.3 4区医学

IEEE Pulse Pub Date : 2025-05-01 DOI: 10.1109/MPULS.2025.3572577

Mary Bates

引用次数: 0

Restoring the Brain's Rhythm: A Physics-Driven Approach to Treating Alzheimer's Disease. 恢复大脑的节律：治疗阿尔茨海默病的物理驱动方法。

IF 0.3 4区医学

IEEE Pulse Pub Date : 2025-05-01 DOI: 10.1109/MPULS.2025.3572591

Ralph Kern

{"title":"Restoring the Brain's Rhythm: A Physics-Driven Approach to Treating Alzheimer's Disease.","authors":"Ralph Kern","doi":"10.1109/MPULS.2025.3572591","DOIUrl":"https://doi.org/10.1109/MPULS.2025.3572591","url":null,"abstract":"Alzheimer's disease (AD) has traditionally been addressed through biochemical interventions targeting amyloid and tau pathologies. However, these approaches are constrained by high costs, limited accessibility, and suboptimal efficacy. This article introduces a novel, physics-based therapeutic modality: noninvasive neuromodulation via synchronized visual and auditory stimulation to restore gamma frequency brain rhythms. The Spectris AD device, developed by Cognito Therapeutics, leverages principles of signal processing and systems engineering to drive gamma oscillations in patients with mild to moderate AD. Early clinical studies, including the OVERTURE and FLICKER trials, demonstrate promising results, such as a 77% reduction in functional decline [Alzheimer's disease co-operative study ADL (ADCS-ADL)], a 76% slowing of cognitive decline [mini mental-state exam (MMSE)], and structural brain preservation without the safety risks associated with monoclonal antibodies. The ongoing HOPE pivotal trial aims to validate these findings in a diverse U.S. population. Spectris AD exemplifies a shift from molecular to network-level interventions, offering a scalable, home-based solution that reimagines neurodegenerative treatment as a systems-engineering challenge. This article presents the engineering, clinical data, and broader implications of this pioneering approach to neurotherapeutics.","PeriodicalId":49065,"journal":{"name":"IEEE Pulse","volume":"16 3","pages":"56-59"},"PeriodicalIF":0.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Continuous, Real-Time Coagulation State Monitor for ECMO Patients. ECMO患者连续、实时凝血状态监测。

IF 0.3 4区医学

IEEE Pulse Pub Date : 2025-05-01 DOI: 10.1109/MPULS.2025.3572597

Victoria Albanese, Matan Blitz, Nithit Bunchatheravate, Katrina Cao, Parnika Mandewalkar, Mary Mikos

{"title":"A Continuous, Real-Time Coagulation State Monitor for ECMO Patients.","authors":"Victoria Albanese, Matan Blitz, Nithit Bunchatheravate, Katrina Cao, Parnika Mandewalkar, Mary Mikos","doi":"10.1109/MPULS.2025.3572597","DOIUrl":"https://doi.org/10.1109/MPULS.2025.3572597","url":null,"abstract":"For patients undergoing extracorporeal membrane oxygenation (ECMO), clot formation is a critical complication requiring high-risk circuit changes. Blood tests used to assess clotting risk may be drawn only four times a day, potentially missing key information that could inform physician intervention. To mitigate these risks, we designed a device that integrates ultrasound imaging and impedance sensing for continuous, real-time monitoring of blood coagulability (the blood's likelihood to clot). Our design features a tubing adaptor housing two gold probes and an etched region containing a safe concentration of kaolin, a coagulation promoter, which localizes small-scale clot formation in a single detectable region. An ultrasound probe attached to the adaptor captures images at this location for further processing by a computer vision image segmentation algorithm that tracks changes in clot thickness over time. Concurrently, an impedance sensor measures resistive and capacitive changes in the blood during coagulation using the gold probes. The ac voltage input is minimized to prevent electrochemical reactions or shock. The output signal is filtered and analyzed using a lock-in amplifier to extract precise impedance changes that show preliminary correlation with coagulation blood test markers. By integrating these sensors, our system demonstrates preliminary real-time, in-circuit coagulation monitoring, making strides toward overcoming the current limitations of intermittent blood testing with the ultimate goal of improving patient safety in ECMO therapy.","PeriodicalId":49065,"journal":{"name":"IEEE Pulse","volume":"16 3","pages":"68-71"},"PeriodicalIF":0.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking Barriers With Sound: Focused Ultrasound in the Brain. 用声音打破障碍：大脑中的聚焦超声。

IF 0.3 4区医学

IEEE Pulse Pub Date : 2025-05-01 DOI: 10.1109/MPULS.2025.3572600

Tejas Padliya

引用次数: 0

AnchorCat: Intracardiac Echocardiography (ICE) Catheter Fixation Device. 锚猫：心内超声心动图（ICE）导管固定装置。

IF 0.2 4区医学

IEEE Pulse Pub Date : 2025-05-01 DOI: 10.1109/MPULS.2025.3572598

Alexi B Pierre-Louis, Alice Y Tian, Jonathan T Makhoul, Samuel X Wu, Sumin Jeong, Vivian Y Lang

引用次数: 0

Industry Live Q&A With Cala Health's Alex Kent, Senior Director of Research. 与Cala Health的高级研究总监Alex Kent进行行业现场问答。

IF 0.3 4区医学

IEEE Pulse Pub Date : 2025-03-01 DOI: 10.1109/MPULS.2025.3554966

Chad Andresen, Alex Kent

{"title":"Industry Live Q&A With Cala Health's Alex Kent, Senior Director of Research.","authors":"Chad Andresen, Alex Kent","doi":"10.1109/MPULS.2025.3554966","DOIUrl":"https://doi.org/10.1109/MPULS.2025.3554966","url":null,"abstract":"In this exclusive IEEE Pulse interview, Editor in Chief Chad Andresen engages in an in-depth conversation with Alex Kent, Senior Director of Research at Cala Health, to explore the pioneering work that has positioned the company at the forefront of bioelectronic medicine. Cala Health is known for its transformative approach to treating essential tremor through noninvasive, wrist-worn neuromodulation a therapy that merges rigorous neuroscience with intuitive wearable technology. Kent sheds light on the years of intense, multidisciplinary research that underpins Cala's innovation, including the complex challenges of translating neurophysiological insights into practical, patient-ready therapies. From foundational science to FDA clearance, the journey has been one of perseverance, collaboration, and bold thinking. Listeners will gain rare insight into the scientific backbone of Cala Health's success, the commitment to evidence-based development, and the vision for how individualized bioelectronic medicine can reshape the treatment of chronic neurological conditions. This conversation is a tribute to the relentless pursuit of meaningful, scalable impact and to the researchers who make it possible.","PeriodicalId":49065,"journal":{"name":"IEEE Pulse","volume":"16 2","pages":"29-34"},"PeriodicalIF":0.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noninvasive Medical Devices in Low-Income and Complex Settings: Promise, Challenge, and the Path Ahead. 低收入和复杂环境中的非侵入性医疗设备：承诺、挑战和前进的道路。

IF 0.3 4区医学

IEEE Pulse Pub Date : 2025-03-01 DOI: 10.1109/MPULS.2025.3554974

Muhammad Hamid Zaman

引用次数: 0

Waves of Hope: The Heartbreaking Journey Behind Noninvasive Tumor Treating Fields. 希望之波：非侵入性肿瘤治疗领域背后令人心碎的旅程。

IF 0.3 4区医学

IEEE Pulse Pub Date : 2025-03-01 DOI: 10.1109/MPULS.2025.3554958

Janet Rae-Dupree

引用次数: 0

TMS: Unlocking the Brain's Power to Transform Surgery-Free Mental Health. 颅磁刺激：释放大脑的力量，改变无需手术的心理健康。