Considering Sex in Biomedical Research.

Abstract

Until relatively recently, basic biomedical research was almost exclusively conducted with male human, animal, and cell models. It was widely assumed that the research findings and medical treatments developed from these studies could be generalized to the whole population. However, there are sex differences in key biological pathways and processes that can influence a person's disease risk, experience of symptoms, and response to treatment. The lack of female representation in preclinical biomedical research has resulted in gaps in our medical knowledge, with important consequences for women's health. In the past decade, efforts to remedy this historic exclusion have increased, but opportunities remain to make basic biomedical research more equitable, reproducible, and applicable to all people.