Primary Care Diabetes最新文献

筛选
英文 中文
The effects of resistance exercises interventions on quality of life and glycemic control in patients with type 2 diabetes: Systematic review and meta-analysis of randomized controlled trials 阻力运动干预对 2 型糖尿病患者生活质量和血糖控制的影响:随机对照试验的系统回顾和荟萃分析
IF 2.9 4区 医学
Primary Care Diabetes Pub Date : 2024-04-01 DOI: 10.1016/j.pcd.2023.12.006
Jun Jia , Yuping Xue , Yu Chen Zhang , Yue Hu , Siqi Liu
{"title":"The effects of resistance exercises interventions on quality of life and glycemic control in patients with type 2 diabetes: Systematic review and meta-analysis of randomized controlled trials","authors":"Jun Jia ,&nbsp;Yuping Xue ,&nbsp;Yu Chen Zhang ,&nbsp;Yue Hu ,&nbsp;Siqi Liu","doi":"10.1016/j.pcd.2023.12.006","DOIUrl":"10.1016/j.pcd.2023.12.006","url":null,"abstract":"<div><h3>Aims</h3><p>The global burden of diabetes mellitus is escalating rapidly, and the complex comorbidities contribute to a marked decline in patients' quality of life<span>. This review assesses the impact of resistance training on quality of life in type 2 diabetes patients, addressing the ongoing debate over its role in diabetes management and the potential to enhance clinical outcomes.</span></p></div><div><h3>Methods</h3><p>Systematic review<span> and meta-analysis of randomized controlled trials<span><span> regarding assessing effects from resistance training on quality of life among diabetic patients. We systematically searched PubMed, Medline, Web of Science and Embase<span><span> and the register of controlled trials searched to February 2021. All included studies were randomized controlled trials in adults with type 2 diabetes that assessed the effect of a resistance training on glycemic control and change in health-related quality of life (HRQOL). The HRQOL was measured by validated questionnaires, covering physical and mental components scores, and pooled standardized </span>effect sizes were calculated. Glycemic control measured by the level of </span></span>Glycated Hemoglobin (HbA1c), and pooled weighted effect sizes were calculated.</span></span></p></div><div><h3>Result</h3><p>9 randomized controlled trials were eligible for the systematic review and our meta-analysis, with 557 participants completed randomized programs data. With random effects meta-analyses model, there was no significant pooled estimate of the standardized mean difference of PCS of quality of life (0.73, 95%CI: −1.19 to 2.65), while in our sensitivity analysis, resistance training had a marginally significantly positive effect on physical components among diabetic patients (0.21, 95%CI: −0.02 to 0.45). Additionally, resistance exercise was non-significantly related with improvement in mental components scores of HRQOL compared with control group (standardized mean difference, (−0.01 (95%CI: −1.25 to 1.23)). With random effects meta-analyses, constructed resistance training intervention did not significantly change the level of HbA1c compared with the control group (−0.22, 95%CI: −0.98 to 0.54)</p></div><div><h3>Conclusion</h3><p>The resistance/strength training might have the slight positive effect on the PCS of HRQOL among patients with type 2 diabetes, but was non-significantly beneficial for MCS of HRQOL and glycemic control.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 2","pages":"Pages 119-125"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139463842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Board and Aims & Scopes 编辑委员会和目标与范围
IF 2.9 4区 医学
Primary Care Diabetes Pub Date : 2024-04-01 DOI: 10.1016/S1751-9918(24)00046-9
{"title":"Editorial Board and Aims & Scopes","authors":"","doi":"10.1016/S1751-9918(24)00046-9","DOIUrl":"https://doi.org/10.1016/S1751-9918(24)00046-9","url":null,"abstract":"","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 2","pages":"Pages ii-iii"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751991824000469/pdfft?md5=1b4d7a34eafe391763f72b7ba66d84d7&pid=1-s2.0-S1751991824000469-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140536052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perceived stress and progression of cardiometabolic risk factors among South Asians with prediabetes in a lifestyle intervention trial 生活方式干预试验中患有糖尿病前期的南亚人对压力的感知和心脏代谢风险因素的发展。
IF 2.9 4区 医学
Primary Care Diabetes Pub Date : 2024-04-01 DOI: 10.1016/j.pcd.2023.12.002
Nicole D. Fields , K.M. Venkat Narayan , Harish Ranjani , Lisa R. Staimez , Ranjit Mohan Anjana , Shivani A. Patel , Viswanathan Mohan , Mohammed K. Ali , Mary Beth Weber
{"title":"Perceived stress and progression of cardiometabolic risk factors among South Asians with prediabetes in a lifestyle intervention trial","authors":"Nicole D. Fields ,&nbsp;K.M. Venkat Narayan ,&nbsp;Harish Ranjani ,&nbsp;Lisa R. Staimez ,&nbsp;Ranjit Mohan Anjana ,&nbsp;Shivani A. Patel ,&nbsp;Viswanathan Mohan ,&nbsp;Mohammed K. Ali ,&nbsp;Mary Beth Weber","doi":"10.1016/j.pcd.2023.12.002","DOIUrl":"10.1016/j.pcd.2023.12.002","url":null,"abstract":"<div><h3>Aims</h3><p><span>To examine associations between perceived stress and cardiometabolic risk factors in South Asians with </span>prediabetes and assess whether a diabetes prevention program mitigates the impact of stress on cardiometabolic health.</p></div><div><h3>Methods</h3><p>We conducted a secondary analysis of the Diabetes Community Lifestyle Improvement Program, a lifestyle modification trial for diabetes prevention in India (n = 564). Indicators for cardiometabolic health (weight, waist circumference, blood pressure, glucose, HbA1c<span>, and lipids) were measured at each visit while perceived stress was assessed via questionnaire at baseline. Multivariable linear regression assessed associations between stress and cardiometabolic parameters at baseline and 3-year follow up.</span></p></div><div><h3>Results</h3><p><span><span>At baseline, perceived stress was associated with higher weight (b=0.16; 95% CI: 0.04, 0.29) and waist circumference (b=0.11; 95% CI: 0.01, 0.21) but lower 30-minute postload glucose (b=−0.44; 95% CI: −0.76, −0.14) and LDL cholesterol (b=−0.40; 95% CI: −0.76, −0.03). Over the study period, perceived stress was associated with weight gain (b=0.20; 95% CI: 0.07, 0.33) and increased waist circumference (b=0.14; 95% CI: 0.04, 0.24). Additionally, higher perceived stress was associated with lower </span>HDL cholesterol among the control arm (p</span><sub>interaction</sub> = 0.02).</p></div><div><h3>Conclusions</h3><p>Baseline stress was associated with negative cardiometabolic risk factor outcomes over time in those with prediabetes.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 2","pages":"Pages 183-187"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139099385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acanthosis nigricans independently predicts hepatic fibrosis in people with type 2 diabetes in North India 黑棘皮病可独立预测北印度 2 型糖尿病患者的肝纤维化程度
IF 2.9 4区 医学
Primary Care Diabetes Pub Date : 2024-04-01 DOI: 10.1016/j.pcd.2024.01.003
Koel Dutta , Surya Prakash Bhatt , Swati Madan , Irshad Ahmad Ansari , Kanika Tyagi , Shivam Pandey , Anoop Misra
{"title":"Acanthosis nigricans independently predicts hepatic fibrosis in people with type 2 diabetes in North India","authors":"Koel Dutta ,&nbsp;Surya Prakash Bhatt ,&nbsp;Swati Madan ,&nbsp;Irshad Ahmad Ansari ,&nbsp;Kanika Tyagi ,&nbsp;Shivam Pandey ,&nbsp;Anoop Misra","doi":"10.1016/j.pcd.2024.01.003","DOIUrl":"10.1016/j.pcd.2024.01.003","url":null,"abstract":"<div><h3>Background</h3><p><span>Acanthosis nigricans (AN) is a skin condition characterized by </span>hyperpigmentation<span> and thickening, often found in individuals with insulin resistance. Despite this well-established association, the potential link between AN and hepatic fibrosis<span> in people with type 2 diabetes (T2D) has yet to be thoroughly explored.</span></span></p></div><div><h3>Methodology</h3><p><span>We recruited a total of 300 people with T2D, half of whom had AN (n, 150), and the other half without AN (n, 150). We evaluated body composition, biochemistry, and hepatic fat analysis (using the controlled attenuation parameter, CAP), as well as assessments of </span>hepatic stiffness<span> (using the kilopascal, kPa) using Fibroscan<span>. We used multivariable regression analysis to find independent predictors of AN and their relationship to hepatic fibrosis<span>. Furthermore, we developed a prediction equation and AUC<span> for hepatic fibrosis.</span></span></span></span></p></div><div><h3>Results</h3><p>Upon comparison between AN <em>vs.</em><span><span> NAN group, following were significatly higher; weight, BMI, hepatic </span>transaminases<span>, liver span, CAP, and kPa. After adjusting for age, weight, body mass index, diabetes duration, and specific anti-hyperglycaemic drugs (gliclazide, DPP-4 inhibitors, pioglitazone, and Glucagon-like peptide-1 receptor agonists), adjusted OR for AN were, liver span, 1.78 (95% CI: 0.91–3.49, p = 0.09), CAP, 7.55 (95% CI: 0.93–61.1, p = 0.05), and kPa, 2.47 (95% CI: 1.50–4.06, p = 0.001). A ROC analysis of predictive score for hepatic fibrosis showed optimal sensitivity and specificity at a score cut-off of 25.2 (sensitivity 62%, specificity 63%), with an AUC of 0.6452 (95% CI: 0.61235–0.76420).</span></span></p></div><div><h3>Conclusion</h3><p><span>Acanthosis nigricans has the potential to be used as an easy-to-identify clinical marker for risk of hepatic fat and fibrosis in </span>Asian Indians with T2D, allowing for early detection and management strategies.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 2","pages":"Pages 224-229"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139509160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tobacco smoking and diabetes. A comparative survey among diabetologists and smoking cessation specialists 吸烟与糖尿病。一项针对糖尿病专家和戒烟专家的比较调查。
IF 2.9 4区 医学
Primary Care Diabetes Pub Date : 2024-04-01 DOI: 10.1016/j.pcd.2024.01.009
Ivan Berlin , Vincent Durlach , Daniel Thomas , Bruno Vergès , Anne-Laurence Le Faou , on behalf of the Working Group on Smoking and Diabetes
{"title":"Tobacco smoking and diabetes. A comparative survey among diabetologists and smoking cessation specialists","authors":"Ivan Berlin ,&nbsp;Vincent Durlach ,&nbsp;Daniel Thomas ,&nbsp;Bruno Vergès ,&nbsp;Anne-Laurence Le Faou ,&nbsp;on behalf of the Working Group on Smoking and Diabetes","doi":"10.1016/j.pcd.2024.01.009","DOIUrl":"10.1016/j.pcd.2024.01.009","url":null,"abstract":"<div><h3>Aims</h3><p>Because tobacco smoking is a major risk factor of mortality in diabetes and guidelines suggest evaluating smoking behavior among individuals with diabetes and helping smokers quit, we aimed to assess knowledge about the tobacco smoking – diabetes relationship among diabetologists and smoking cessation specialists (SCS).</p></div><div><h3>Methods</h3><p>An online cross sectional survey was conceived by the Working Group on Smoking and Diabetes, France. The questionnaire was tested by the members of the Working Group and deemed to be completed in less than 5 min. Only questions receiving the highest number of approval ratings were kept for the survey. The questionnaire was sent to all members of the French Language Society of Diabetes (Société Francophone du Diabète, SFD), N = 969 and the French Language Society on Tobacco (Société Francophone de Tabacologie, SFT), N = 307. The mailing lists of members were obtained with the previous agreement of the societies’ board.</p></div><div><h3>Results</h3><p>225 diabetologists and 97 SCS (response rate 23.2% and 31.5%, respectively) completed the questionnaire. Over 90% of the diabetologists reported recording smoking status of their patients. Although diabetologists were aware that smoking increases all-cause mortality of individuals with diabetes, only 29.3% were aware that smoking is a risk factor for type 2 diabetes (76.3% among SCS), for poor glycemic control: 32.9% (86.6% among SCS). Significantly less diabetologists (64%) than SCS (76.3%) were aware of smoking being a risk factor for microangiopathy. More diabetologists considered that smoking cessation is more important than optimizing glycemic control among individuals with type 2 (69.3%) than among those with type 1 diabetes (47.1%). Few diabetologists (11.1%) and SCS (14.4%) reported to be trained for smoking cessation among persons with diabetes.</p></div><div><h3>Conclusion</h3><p>Specific knowledge about the negative tobacco smoking – diabetes association seems to be insufficient among French diabetologists. Diabetologists but also other health care professionals should be trained to help individuals with diabetes who smoke to quit smoking.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 2","pages":"Pages 241-245"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S175199182400010X/pdfft?md5=37161c98aaaf0348698337b1dbfc120c&pid=1-s2.0-S175199182400010X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond diagnosis: Investigating factors influencing health-related quality of life in older people with type 2 diabetes in Slovenia 诊断之外:调查影响斯洛文尼亚 2 型糖尿病老年人健康相关生活质量的因素。
IF 2.9 4区 医学
Primary Care Diabetes Pub Date : 2024-04-01 DOI: 10.1016/j.pcd.2024.01.010
Matic Mihevc , Tina Virtič Potočnik , Črt Zavrnik , Marija Petek Šter , Zalika Klemenc-Ketiš , Antonija Poplas Susič
{"title":"Beyond diagnosis: Investigating factors influencing health-related quality of life in older people with type 2 diabetes in Slovenia","authors":"Matic Mihevc ,&nbsp;Tina Virtič Potočnik ,&nbsp;Črt Zavrnik ,&nbsp;Marija Petek Šter ,&nbsp;Zalika Klemenc-Ketiš ,&nbsp;Antonija Poplas Susič","doi":"10.1016/j.pcd.2024.01.010","DOIUrl":"10.1016/j.pcd.2024.01.010","url":null,"abstract":"<div><h3>Aims</h3><p>To examine the present state of health-related quality of life (HRQOL) among elderly individuals with type 2 diabetes (T2D) receiving integrated care and identify risk factors associated with low HRQOL.</p></div><div><h3>Methods</h3><p>A multi-centre cross-sectional survey among elderly individuals with T2D, treated in Slovenian urban and rural primary care settings was performed. HRQOL was investigated using EuroQol 5-dimension (EQ-5D) questionnaire and Appraisal of Diabetes Scale (ADS). Furthermore, socio-demographic, clinical, and laboratory data were collected. Low HRQOL was defined as EQ-5D utility score &lt;10%. Statistical analysis was performed using univariate and multivariate binary logistic regression statistics.</p></div><div><h3>Results</h3><p>Examining 358 people with median age of 72 (range 65–98) years and with a mean EQ-5D utility score of 0.80, the study found that lower HRQOL correlated with older age, higher body mass index (BMI), lower education, elevated depressive symptoms, increased challenges across all EQ-5D dimensions, and less favourable appraisal of diabetes. When considering age, gender, education, and HbA1c, the main predictors of low HRQOL were BMI (OR 1.35, 95% CI 1.04–1.76, p = 0.025) and ADS score (OR 1.63, 95% CI 1.13–2.35, p = 0.009).</p></div><div><h3>Conclusions</h3><p>To improve HRQOL, integrated care models should consider interventions that target mental health, obesity prevention, chronic pain management, diabetes education, self-management, and treatment plan personalisation.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 2","pages":"Pages 157-162"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751991824000111/pdfft?md5=ebcc2f0c82a2f4765703883fbe5d70ff&pid=1-s2.0-S1751991824000111-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139699180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multicausal analysis of mortality due to diabetes mellitus in Spain, 2016-2018 2016-2018年西班牙糖尿病死亡率的多因分析。
IF 2.9 4区 医学
Primary Care Diabetes Pub Date : 2024-04-01 DOI: 10.1016/j.pcd.2024.01.013
Fernando Álvarez-Guisasola , José A. Quesada , Adriana López-Pineda , Rauf Nouni García , Concepción Carratalá-Munuera , Vicente F. Gil-Guillén , Domingo Orozco-Beltrán
{"title":"Multicausal analysis of mortality due to diabetes mellitus in Spain, 2016-2018","authors":"Fernando Álvarez-Guisasola ,&nbsp;José A. Quesada ,&nbsp;Adriana López-Pineda ,&nbsp;Rauf Nouni García ,&nbsp;Concepción Carratalá-Munuera ,&nbsp;Vicente F. Gil-Guillén ,&nbsp;Domingo Orozco-Beltrán","doi":"10.1016/j.pcd.2024.01.013","DOIUrl":"10.1016/j.pcd.2024.01.013","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aimed to assess multicausal mortality due to diabetes from 2016–2018 in Spain. Specific objectives were to quantify the occurrence of diabetes as an underlying cause or as any registered cause on the death certificate.</p></div><div><h3>Materials and methods</h3><p>A cross-sectional descriptive study taking a multicausal approach.</p></div><div><h3>Results</h3><p>Diabetes appears as an underlying cause of 2.3% of total deaths in Spain, and as any cause in 6.2%. In patients in whom Diabetes appears as an underlying cause on the death certificates, the 15 most frequent immediate causes are cardiovascular diseases in men(prevalence ratio 1,59)and women (PR1,31). In men, the causes associated with diabetes as any cause were skin diseases(prevalence ratio 1.33), followed by endocrine diseases(prevalence ratio 1.26)and genitourinary diseases (prevalence ratio1.14). In women, the causes associated with the presence of diabetes as any cause were endocrine (prevalence ratio 1.13)and genitourinary (prevalence ratio 1.04)diseases.</p></div><div><h3>Conclusions</h3><p>In patients in whom diabetes appears as an underlying cause on the death certificates, the 15 most frequent immediate causes are cardiovascular diseases. In men, the causes associated with the presence of diabetes as any cause of death are skin, endocrine and genitourinary diseases. In women, the causes associated with diabetes as any cause are endocrine and genitourinary.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 2","pages":"Pages 138-145"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751991824000251/pdfft?md5=9e29f559c18b12f142ebe6ceb57afe07&pid=1-s2.0-S1751991824000251-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139704310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of GLP-1 receptor agonists on the degree of liver fibrosis and CRP in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: A systematic review and meta-analysis GLP-1 受体激动剂对非酒精性脂肪肝和非酒精性脂肪性肝炎患者肝纤维化程度和 CRP 的影响:系统综述和荟萃分析。
IF 2.9 4区 医学
Primary Care Diabetes Pub Date : 2024-03-30 DOI: 10.1016/j.pcd.2024.03.005
Lixuan Fang , Jine Li , Haixia Zeng , Jianping Liu
{"title":"Effects of GLP-1 receptor agonists on the degree of liver fibrosis and CRP in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: A systematic review and meta-analysis","authors":"Lixuan Fang ,&nbsp;Jine Li ,&nbsp;Haixia Zeng ,&nbsp;Jianping Liu","doi":"10.1016/j.pcd.2024.03.005","DOIUrl":"10.1016/j.pcd.2024.03.005","url":null,"abstract":"<div><h3>Background</h3><p>Based on the rapidly growing global burden of non-alcoholic fatty liver disease (NAFLD) or steatohepatitis (NASH), in order to evaluate the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in the treatment of NAFLD or NASH this paper presents a systematic review and meta-analysis of randomized controlled trials(RCTs).</p></div><div><h3>Methods</h3><p>In this systematic review and meta-analysis, We searched PubMed, Medline, Web of Science and The Cochrane Library databases. All randomized controlled trials involving GLP-1RAs and NAFLD or NASH were collected since the database was established. A meta-analysis of proportions was done with the generalised linear mixed model. Continuous variables were represented by Mean and Standard Deviation (SD), and binary variable were represented by Relative Risk (RR) and 95% Confidence Interval (CI) as effect indicators. The research results were presented by Revman 5.4. This study is registered with PROSPERO (CRD42023390735).</p></div><div><h3>Finding</h3><p>We included 16 placebo-controlled or active drug-controlled randomized controlled trials (involving 2178 patients) that used liraglutide, exenatide, dulaglutide, or semaglutie in the treatment of NAFLD or NASH, as measured by liver biopsy or imaging techniques. This study found that the effect of GLP-1RAs on histologic resolution of NASH with no worsening of liver fibrosis (n=2 RCTs; WMD:4.08, 95%CI 2.54–6.56, p &lt; 0.00001) has statistically significant. At the same time, GLP-1RAs affected CRP (n = 7 RCTs; WMD:−0.41, 95% CI-0.78 to −0.04, p =0.002) and other serological indicators were significantly improved.</p></div><div><h3>Conclusion</h3><p>This study evaluated the efficacy of GLP-1RAs in patients with NAFLD and NASH. These results suggest that GLP-1RAs may be a potential and viable therapeutic approach as a targeted agent to intervene in disease progression of NAFLD and NASH.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 3","pages":"Pages 268-276"},"PeriodicalIF":2.9,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140330467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetes mellitus as a cause of premature death in small areas of Spain by socioeconomic level from 2016 to 2020: A multiple-cause approach 从 2016 年到 2020 年,按社会经济水平划分的糖尿病作为西班牙小地区过早死亡的原因:多原因分析法。
IF 2.9 4区 医学
Primary Care Diabetes Pub Date : 2024-03-21 DOI: 10.1016/j.pcd.2024.03.004
José A. Quesada , Adriana López-Pineda , Domingo Orozco-Beltrán , Concepción Carratalá-Munuera , Xavier Barber-Vallés , Vicente F. Gil-Guillén , Rauf Nouni-García , Álvaro Carbonell- Soliva
{"title":"Diabetes mellitus as a cause of premature death in small areas of Spain by socioeconomic level from 2016 to 2020: A multiple-cause approach","authors":"José A. Quesada ,&nbsp;Adriana López-Pineda ,&nbsp;Domingo Orozco-Beltrán ,&nbsp;Concepción Carratalá-Munuera ,&nbsp;Xavier Barber-Vallés ,&nbsp;Vicente F. Gil-Guillén ,&nbsp;Rauf Nouni-García ,&nbsp;Álvaro Carbonell- Soliva","doi":"10.1016/j.pcd.2024.03.004","DOIUrl":"10.1016/j.pcd.2024.03.004","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to assess premature mortality due to Diabetes in small areas of Spain between 2016 and 2020, and its relationship with socioeconomic level and the immediate cause of death. As a secondary objective, we evaluated the effect of the Covid 19 pandemic.</p></div><div><h3>Methods</h3><p>This was an ecological study of premature mortality due to Diabetes from 2016 to 2020, with a focus on small areas. All deaths in people under 75 years of age due to Diabetes as the underlying cause were included</p></div><div><h3>Results</h3><p>The final sample comprised 7382 premature deaths in 5967 census tracts. Women living in census tracts with an high level of deprivation(RR=2.40) were at a significantly higher risk. Mortality from Diabetes increased with deprivation, especially people aged 0–54(RR=2.40). People with an immediate cause of death related to a circulatory disease, living in census tracts with an high level of deprivation(RR=3.86) was associated with a significantly greater risk of death with underlying Diabetes. When a disease of the circulatory system was recorded as the immediate cause of death, being 65–74 years (RR=71.01) was associated with a significantly higher risk of premature mortality.</p></div><div><h3>Conclusions</h3><p>Living in geographic areas with higher levels of socioeconomic deprivation is associated with a higher risk of premature death from Diabetes in Spain. This relationship has a greater impact on women, people under 54 years, and people at risk of death caused directly by diseases of the circulatory system. Premature mortality due to diabetes saw a modest increase in 2020.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 3","pages":"Pages 356-361"},"PeriodicalIF":2.9,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751991824000640/pdfft?md5=0eada56575c52d5bc9741ac2050692cc&pid=1-s2.0-S1751991824000640-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compliance with eye and foot preventive care in people with self-reported diabetes in Latin America and the Caribbean: Pooled, cross-sectional analysis of nine national surveys 拉丁美洲和加勒比地区自述糖尿病患者对眼部和足部预防护理的依从性:对九个国家调查的汇总横截面分析。
IF 2.9 4区 医学
Primary Care Diabetes Pub Date : 2024-03-19 DOI: 10.1016/j.pcd.2024.03.001
Rodrigo M. Carrillo-Larco , Wilmer Cristobal Guzman-Vilca , Jithin Sam Varghese , Francisco J. Pasquel , Roberta Caixeta , Carmen Antini , Antonio Bernabé-Ortiz
{"title":"Compliance with eye and foot preventive care in people with self-reported diabetes in Latin America and the Caribbean: Pooled, cross-sectional analysis of nine national surveys","authors":"Rodrigo M. Carrillo-Larco ,&nbsp;Wilmer Cristobal Guzman-Vilca ,&nbsp;Jithin Sam Varghese ,&nbsp;Francisco J. Pasquel ,&nbsp;Roberta Caixeta ,&nbsp;Carmen Antini ,&nbsp;Antonio Bernabé-Ortiz","doi":"10.1016/j.pcd.2024.03.001","DOIUrl":"10.1016/j.pcd.2024.03.001","url":null,"abstract":"<div><h3>Aims</h3><p>To estimate the proportion of people with self-reported diabetes receiving eye and foot examinations in Latin America and the Caribbean (LAC).</p></div><div><h3>Methods</h3><p>Cross-sectional analysis of national health surveys in nine countries. Adults aged 25–64 years with self-reported diabetes. We quantified the proportion who reported having an eye examination in the last two years or a foot examination in the last year. We fitted multilevel Poisson regressions to assess socio-demographic (age and sex) and clinical (oral hypoglycemic medication and insulin treatment) variables associated with having had examinations.</p></div><div><h3>Results</h3><p>There were 7435 people with self-reported diabetes included in the analysis. In three countries (Chile [64%; 95% CI: 56%-71%], British Virgin Islands [58%; 95% CI: 51%-65%], and Brazil [54%; 95% CI: 50%-58%]), &gt;50% of people with diabetes reported having had an eye examination in the last two years. Fewer participants (&lt;50% across all countries) reported having had a foot examination in the last year, with Ecuador having the lowest proportion (12%; 95% CI: 8%-17%). Older people, and those taking oral medication or insulin, were more likely to have eye/foot examinations.</p></div><div><h3>Conclusions</h3><p>The proportion of eye and foot examinations in people with self-reported diabetes across nine countries in LAC is low.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 3","pages":"Pages 374-379"},"PeriodicalIF":2.9,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信