1 型糖尿病患者混合人群中心血管自律神经病变的患病率。巴西一项先驱性多中心研究的启示。

IF 2.6 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
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引用次数: 0

摘要

目的:评估巴西 1 型糖尿病(T1D)患者中心血管自主神经病变(CAN)的患病率及其相关因素:这项横断面多中心研究在巴西 10 个城市的 14 家公立诊所进行。在 1760 名患者中,纳入了 1712 人(97.3%):其中 953 人为女性(55.7%),930 人为白种人(54.3%),年龄为(29.9±11.9)岁,糖尿病病程为(15.4±9.2)年。通过心血管自律神经反射测试对 CAN 进行了评估:结果:CAN 的发病率为 23.4%。多变量分层逻辑回归显示,CAN 与年龄、吸烟、较低的社会经济地位、较高的年就诊率、胰岛素治疗方案、较高的 HbA1c、总胆固醇、尿酸、舒张压和心率水平、视网膜病变、糖尿病肾病以及与严重低血糖相关的倾向有关。在单变量分析中还发现,这些患者的健康相关生活质量较低:T1D患者的CAN发病率很高,与其他糖尿病相关慢性并发症以及人口、临床和实验室传统风险因素有关。考虑到缺乏正式政策,我们的数据可用于指导公共卫生方法,以提高巴西T1D患者对CAN的认识,并对其进行筛查、诊断和临床管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of cardiovascular autonomic neuropathy in an admixed population of patients with type 1 diabetes. Lessons from a pioneer multicentre study in Brazil

AIMS

To evaluate the prevalence of cardiovascular autonomic neuropathy (CAN) and its associated factors in Brazilian patients with type 1 diabetes (T1D).

Methods

This cross-sectional, multicentre study was conducted in 14 public clinics in ten Brazilian cities. From 1760 patients, 1712 were included (97.3 %): 953 females (55.7 %), 930 (54.3 %) Caucasians, aged 29.9 ±11.9 years and with diabetes duration of 15.4 ± 9.2 years. CAN was evaluated using cardiovascular autonomic reflex tests.

Results

The prevalence of CAN was 23.4 %. Multivariable hierarchical logistic regression showed CAN associated with age, smoking, lower socioeconomic status, higher yearly medical appointments, insulin therapeutic regimens, higher levels of HbA1c, total cholesterol, uric acid, diastolic blood pressure and heart rate, presence of retinopathy, diabetic kidney disease and a tendency to be associated with severe hypoglycemia. Lower health-related quality of life was also found in univariate analysis in these patients.

Conclusions

Patients with T1D presented an important prevalence of CAN that was associated with other diabetes-related chronic complications, and also with demographic, clinical and laboratorial traditional risk factors. Considering lack of formal policy, our data could be used for guiding public health approach to awareness and CAN’s screening, diagnosis and clinical management in patients with T1D in Brazil.

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来源期刊
Primary Care Diabetes
Primary Care Diabetes ENDOCRINOLOGY & METABOLISM-PRIMARY HEALTH CARE
CiteScore
5.00
自引率
3.40%
发文量
134
审稿时长
47 days
期刊介绍: The journal publishes original research articles and high quality reviews in the fields of clinical care, diabetes education, nutrition, health services, psychosocial research and epidemiology and other areas as far as is relevant for diabetology in a primary-care setting. The purpose of the journal is to encourage interdisciplinary research and discussion between all those who are involved in primary diabetes care on an international level. The Journal also publishes news and articles concerning the policies and activities of Primary Care Diabetes Europe and reflects the society''s aim of improving the care for people with diabetes mellitus within the primary-care setting.
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