Dean T. Eurich , Lisa A. Wozniak , Allison Soprovich , Cerina Lee , Jasjeet K. Minhas-Sandhu , Lynden Crowshoe , Jeffrey A. Johnson , Salim Samanani
{"title":"Effectiveness of RADAR on diabetes processes of care for First Nations communities in Alberta, Canada","authors":"Dean T. Eurich , Lisa A. Wozniak , Allison Soprovich , Cerina Lee , Jasjeet K. Minhas-Sandhu , Lynden Crowshoe , Jeffrey A. Johnson , Salim Samanani","doi":"10.1016/j.pcd.2023.11.004","DOIUrl":"10.1016/j.pcd.2023.11.004","url":null,"abstract":"<div><p>The epidemic of type-2 diabetes in First Nations communities is tragic. Culturally-appropriate approaches addressing multiple components, focusing beyond glycemic control, are urgently needed. Using an intention-to-treat framework, 13 processes of care indicators were assessed to compare proportions of patients who received care at baseline relative to 2-year follow-up. Clinical improvements were demonstrated across major process of care indicators (e.g. screening, education, and vaccination activities). We found RADAR improved reporting for most diabetes processes of care across seven FN communities and was effective in supporting diabetes care for FN communities, in Alberta Canada.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 1","pages":"Pages 104-107"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751991823001845/pdfft?md5=08ee2b223fa9198f264d7a950b26be75&pid=1-s2.0-S1751991823001845-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89721435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nina Al-Saadi , Nichola Beard , Khalid Al-Hashimi , Helen Suttenwood , Michael Wall , Steven Jones , Catherine Merriman
{"title":"The impact of community teaching sessions on onward referral to specialist diabetic foot services","authors":"Nina Al-Saadi , Nichola Beard , Khalid Al-Hashimi , Helen Suttenwood , Michael Wall , Steven Jones , Catherine Merriman","doi":"10.1016/j.pcd.2023.11.008","DOIUrl":"10.1016/j.pcd.2023.11.008","url":null,"abstract":"<div><h3>Introduction</h3><p>Prompt referral of patients with diabetic foot ulceration (DFU) to specialist services can lead to more timely assessment of these patients and subsequent improved rates of limb salvage and patient outcomes. In this study we wanted to determine the impact of education in the primary care setting on onward referrals to our specialist Diabetic Foot multi-disciplinary team (MDT) clinic.</p></div><div><h3>Methods</h3><p>As part of a Diabetic Foot Roadshow, four teaching sessions were delivered in primary care settings across Shropshire by our specialist team from 17th March to the 25th May 2022. Attendees included podiatrists, tissue viability nurses, district nurses and wound care practitioners. Hospital records were used to identify all onward referrals to our Diabetic Foot MDT clinic in the weeks before and after delivery of the roadshow education sessions.</p></div><div><h3>Results</h3><p>184 referrals were made to the diabetic foot clinic from January to July 2022. There were 0.3 referrals per day in the months prior to the commencement of the education sessions, compared to 1.5 referrals per day following the commencement of the teaching sessions. This increase in referrals was statistically significant (p < 0.0001).</p></div><div><h3>Conclusion</h3><p>Teaching sessions delivered to community specialist healthcare professionals significantly increase onward referral of patients to specialist services, facilitating more timely assessment and management of patients with DFUs.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 1","pages":"Pages 79-83"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138465283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hester Lacey , Nityanand Jain , Mai Sugimoto , Masako Shimato , Shi Jia Zhou , Valdis Pirags , Rajani Shakya , Robin Man Karmacharya , Phanindra Prasad Baral
{"title":"Advancing diabetes primary care education and knowledge in Nepal: A scoping review and case study discussion","authors":"Hester Lacey , Nityanand Jain , Mai Sugimoto , Masako Shimato , Shi Jia Zhou , Valdis Pirags , Rajani Shakya , Robin Man Karmacharya , Phanindra Prasad Baral","doi":"10.1016/j.pcd.2023.11.012","DOIUrl":"10.1016/j.pcd.2023.11.012","url":null,"abstract":"<div><h3>Aims</h3><p>Diabetes mellitus (DM) is a chronic disorder of insulin and glucose metabolism. It affects more than 463 million people worldwide and is expected to reach 700 million by 2045. In the Southeast Asian region, the prevalence of DM has tripled to 115 million due to rapid urbanization, unhealthy diet, sedentary lifestyles, and genetic factors. In Nepal, a developing country, DM affects 8.5% of adults, with an alarming increase in recent years. Lack of diabetes education and limited populational adoption of behavioural changes further hamper care.</p></div><div><h3>Methods</h3><p>In the present study, we performed a scoping review to determine the status of awareness, attitudes, and knowledge about diabetes in the Nepalese population with a focus on the educational initiatives that have been implemented. We also conducted a two-week international case study discussion among medical students to brainstorm viable intervention strategies.</p></div><div><h3>Results</h3><p>Our findings indicate that limited data is available on the level of education or initiatives to improve knowledge and practice among healthcare professionals and community members. Targeted studies of people with diabetes also present heterogeneous results due to differences in the sample population, geographic location, education, age, and gender. Accordingly, we propose five interrelated education-based strategies that leverage existing networks to expand community outreach and engagement, improve system resilience, and improve health outcomes.</p></div><div><h3>Conclusions</h3><p>Effective education for healthcare professionals, community, and patients with diabetes is vital in improving diabetes outcomes in Nepal and South Asia. Collaboration, funding, and evaluation are key areas needing reform.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 1","pages":"Pages 25-36"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751991823002176/pdfft?md5=f8946b8578afc2065826195739cb1f9a&pid=1-s2.0-S1751991823002176-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138553218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pedro José Pinés Corrales , Julia Sastre Marcos , Gema López Gallardo , Jesús Moreno Fernández , Sandra Herranz Antolín , Iván Quiroga López , Florentino Del Val Zaballos , Javier González López , José Joaquín Alfaro Martínez , In representation of the DIACAM1 2010–2020 group
{"title":"All-cause mortality and risk factors in patients with type 1 diabetes in Castilla-La Mancha, Spain. DIACAM1 2010–2020 study","authors":"Pedro José Pinés Corrales , Julia Sastre Marcos , Gema López Gallardo , Jesús Moreno Fernández , Sandra Herranz Antolín , Iván Quiroga López , Florentino Del Val Zaballos , Javier González López , José Joaquín Alfaro Martínez , In representation of the DIACAM1 2010–2020 group","doi":"10.1016/j.pcd.2023.11.003","DOIUrl":"10.1016/j.pcd.2023.11.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Despite better treatments and care for patients with type 1 diabetes (T1DM), all-cause and cardiovascular mortality still remains higher compared to the general population. We evaluated mortality and risk factors for mortality in a representative cohort of patients with T1DM.</p></div><div><h3>Methods</h3><p>DIACAM1 was a cross-sectional, multicenter study on adult patients (≥ 16 years old) and diabetes with at least 5 years since diabetes diagnosis conducted between 2009 and 2010. DIACAM1 2010–2020 study was a follow-up study, extension of DIACAM1, where vital status of patients was evaluated between June 2019 and June 2020.</p></div><div><h3>Results</h3><p>4.03% [CI95%, 2.53–5.62) of the 1465 patients with T1DM included in the cohort of the DIACAM1 in 2010 had died. <strong>Survival was lower than in the sex- and age-matched general population in the same region</strong>. 40.7% of deaths were due to cardiovascular disease. HbA1c levels < 7% and triglyceride levels < 150 mg/dL were associated with lower mortality, whereas retinopathy and plasma creatinine were associated with increased mortality.</p></div><div><h3>Conclusions</h3><p>We confirmed a lower survival in people with T1DM, with cardiovascular disease being the main cause of mortality. High HbA1c, high triglycerides, retinopathy, and high creatinine are factors associated with mortality.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 1","pages":"Pages 59-64"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136400905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Point-of-Care testing of HbA1c levels in community settings for people with established diabetes or people at risk of developing diabetes: A systematic review and meta-analysis","authors":"Anna Gourlay , Calum Sutherland , Andrew Radley","doi":"10.1016/j.pcd.2023.10.011","DOIUrl":"10.1016/j.pcd.2023.10.011","url":null,"abstract":"<div><h3>Background</h3><p>Glycated haemoglobin (HbA1c) measurement using Point of Care (POC) testing may be of huge utility, providing convenient testing for early diagnosis and regular monitoring of hard-to-reach patient groups. This systematic review aimed to identify evidence for the successful deployment of these devices to improve patient outcomes in diabetes.</p></div><div><h3>Methods</h3><p>A systematic review and meta-analysis was undertaken in February 2023, to identify all relevant articles: (CINAHL, Cochrane, PubMed, Scopus, and Web of Science). Studies were included if they reported outcomes of community POC testing for HbA1c for people with diabetes or at risk of diabetes. The Prospero database and trial registers were searched. Only English language articles were included.</p><p>Title, abstract screening and full text review was carried out by two reviewers (AG/AR). The Cochrane risk of bias tool for randomised studies and the NIH Quality Assessment tool for observational cohort and cross-sectional studies were used. Publication bias was assessed visually using funnel plot and statistical assessment. We performed a meta-analysis on appropriate studies, applying a fixed effect model. We investigated heterogeneity using visual inspection of forest plots along with evaluative approaches (χ<sup>2</sup>, I<sup>2</sup>). Strength of evidence was assessed using GRADE.</p></div><div><h3>Findings</h3><p>24 studies fulfilled the criteria to be included in the narrative synthesis and 5 could be included in quantitative analysis. 13 studies evaluated HbA1c POC testing in non-diabetic patients, 9 reported results for diabetic patients and 2 included both groups. The narrative synthesis was constructed around 6 key themes: increased test access, diagnosis of people who would otherwise go undiagnosed, intervention/lifestyle change, POC testing effect on HbA1c and glycaemic control, follow-up time and patient satisfaction.</p></div><div><h3>Interpretation</h3><p>The available published data supports the proposed use of POC devices in a community setting, with positive effects on diabetic care with limited evidence that patients can achieve better glycaemic control.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 1","pages":"Pages 7-16"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751991823001778/pdfft?md5=fa7eb722ece84d807c3dd7cc021bf9e1&pid=1-s2.0-S1751991823001778-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71490702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retirement status and physical activity in US adults with type 2 diabetes mellitus: Influence of sex, race/ethnicity and acculturation level","authors":"Ruth Ndjaboue , Joel Desire Diendere , Fadila Bulver , Abigail Djossou , Stella Ruddy , Gerard Ngueta","doi":"10.1016/j.pcd.2023.11.005","DOIUrl":"10.1016/j.pcd.2023.11.005","url":null,"abstract":"<div><h3>Aims</h3><p>We aimed to assess the association between retirement status and recreational physical activity (rPA) in US adults with Type 2 diabetes mellitus (T2DM), while accounting for potential modification effects.</p></div><div><h3>Methods</h3><p>We extracted data from the 2007–2014 National Health and Nutrition Examination Survey. We used logistic regression models to evaluate the association between self-reported retirement status and high rPA (i.e., at least 150 min/week). We reported adjusted odds ratio (aOR) and 95% confidence intervals (95% CI). We estimated the modification effect of sex, race/ethnicity, and acculturation level by including interaction terms into the models.</p></div><div><h3>Results</h3><p>Of the 992 U.S. adults with T2DM, 34.8% was retired. As a whole, retirement was associated with high rPA (aOR=1.87 [95% CI: 1.16–3.00]; <em>P</em> = 0.0110). Retirement was associated with high odds of rPA in females (aOR=2.07 [95% CI, 1.14, 3.73], <em>P</em> = 0.0171), in non-Hispanic whites (aOR=2.57 [95% CI, 1.32, 5.00], <em>P</em> = 0.0062), and in those with high acculturation level (aOR=1.85 [95% CI, 1.07, 3.19], <em>P</em> = 0.0273). We observed no significant statistical interactions.</p></div><div><h3>Conclusions</h3><p>Retirement is associated with a high participation to rPA in US adults with T2DM, and the amplitude varies by sex, race/ethnicity and acculturation level. Intervention for improving rPA in adults with T2DM should collect and consider information on retirement status.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 1","pages":"Pages 52-58"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peter Zeh , Annie Young , Nitin Gholap , Harpal Randeva , Timothy Robbins , Kam Johal , Shweta Patel , J. Paul O’Hare
{"title":"Diabetes specialist intervention in general practices in areas of deprivation and ethnic diversity: A qualitative evaluation (QUAL-ECLIPSE)","authors":"Peter Zeh , Annie Young , Nitin Gholap , Harpal Randeva , Timothy Robbins , Kam Johal , Shweta Patel , J. Paul O’Hare","doi":"10.1016/j.pcd.2023.10.012","DOIUrl":"10.1016/j.pcd.2023.10.012","url":null,"abstract":"<div><h3>Aim</h3><p>To assess patients’ and healthcare professionals’ perspectives of a specialist-led Diabetes Risk-based Assessment Clinic (DIRAC) for people with diabetes at high risk of complications (PWDHRC) in areas of deprivation in Coventry, UK.</p></div><div><h3>Methods</h3><p>A qualitative evaluation of a pilot trial, comprising a specialist team intervention (DIRAC), was undertaken in seven GP practices through observations of weekly virtual or occasional face-to-face patient consultations and monthly interventionists’ meetings. Semi-structured interviews were carried out post-intervention, with PWDHRC, primary care clinicians and diabetes specialists (interventionists). Thematic analyses of observations and interviews were undertaken.</p></div><div><h3>Key findings</h3><p>Over 12 months, 28 DIRAC clinics comprising 154 patient consultations and five interventionists’ meetings, were observed. 19 interviews were undertaken, PWDHRC experienced ‘culturally-sensitive care from a specialist-led clinic intervention encompassing integrated care. This model of care was recommended at GP practice level, all participants (PWDHRC, primary care clinicians and diabetes specialist interventionists) felt upskilled to deal with complex diabetes care. The EMIS and ECLIPSE technologies utilised during the intervention were perceived to positively contribute to diabetes management of PWDHRC despite reservations around cost and database.</p></div><div><h3>Conclusion</h3><p>The specialist-led DIRACs were largely appreciated by study participants. These qualitative data support the trial progressing to a full-service evaluation.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 1","pages":"Pages 37-43"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751991823001808/pdfft?md5=e151418b230a7bbd117a3c1e20113858&pid=1-s2.0-S1751991823001808-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71490701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Aouchiche , D. Bernoux , E. Baechler Sadoul , E. Haine , F. Joubert , S. Epstein , N. Faure Galon , F. Dalla-Vale , J.C. Combe , M. Samper , G. Simonin , S. Castets , E. Marquant , J. Vergier , R. Reynaud
{"title":"Impact of continuous glucose monitoring on everyday life of young children with type 1 diabetes and their parents: An evaluation of 114 families","authors":"K. Aouchiche , D. Bernoux , E. Baechler Sadoul , E. Haine , F. Joubert , S. Epstein , N. Faure Galon , F. Dalla-Vale , J.C. Combe , M. Samper , G. Simonin , S. Castets , E. Marquant , J. Vergier , R. Reynaud","doi":"10.1016/j.pcd.2023.11.002","DOIUrl":"10.1016/j.pcd.2023.11.002","url":null,"abstract":"<div><h3>Introduction</h3><p>The prevalence of type 1 diabetes is increasing worldwide. The advent of new monitoring devices has enabled tighter glycemic control.</p></div><div><h3>Aim</h3><p>To study the impact of glucose monitoring devices on the everyday life of young children with type 1 diabetes (T1D) and their parents.</p></div><div><h3>Methods</h3><p>A questionnaire was addressed to parents of children with T1D under the age of 6 years with an insulin pump treated in one of the hospitals of the ADIM network in France between January and July 2020.</p></div><div><h3>Results</h3><p>Among the 114 families included in the study, 53% of parents (26/49) woke up every night to monitor blood glucose levels when their child had flash glucose monitoring (FGM), compared with 23% (13/56) of those whose child had continuous glucose monitoring (CGM). Overall, 81% of parents (86/108) found that glucose monitoring improved their own sleep and parents whose child had CGM were significantly more likely to report improved sleep (86% vs 73%, <em>p</em> = 0.006). Forty-nine percent of parents (55/113) declared that they (in 87% of cases, the mother only) had reduced their working hours or stopped working following their child’s T1D diagnosis. Maternal unemployment was significantly associated with the presence of siblings (<em>p</em> = 0.001) but not with glycemic control (p = 0,87). Ninety-eight percent of parents (105/107) think that glucose monitoring improves school integration.</p></div><div><h3>Conclusion</h3><p>In these families of children with T1D, new diabetes technologies reduced the burden of care but sleep disruption remained common. Social needs evaluation, particularly of mothers, is important at initial diagnosis of T1D in children.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 1","pages":"Pages 91-96"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138435603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Domingo Orozco-Beltrán , Adriana López Pineda , José Antonio Quesada , Esther Artime , Silvia Díaz-Cerezo , Jennifer Redondo-Antón , Miriam Rubio-de Santos , Erik Spaepen , María Concepción Carratala Munuera
{"title":"Barriers and solutions for the management of severe hypoglycaemia in people with diabetes in Spain: A Delphi survey","authors":"Domingo Orozco-Beltrán , Adriana López Pineda , José Antonio Quesada , Esther Artime , Silvia Díaz-Cerezo , Jennifer Redondo-Antón , Miriam Rubio-de Santos , Erik Spaepen , María Concepción Carratala Munuera","doi":"10.1016/j.pcd.2023.11.007","DOIUrl":"10.1016/j.pcd.2023.11.007","url":null,"abstract":"<div><h3>Background and objective</h3><p>Severe hypoglycaemia (SH) imposes a significant burden for people with diabetes (PwD), their caregivers (CGs), and the healthcare system. The study aimed to identify barriers and solutions in the management of SH in PwD in Spain, gathering consensus from physicians and nurses.</p></div><div><h3>Material and methods</h3><p>Expert opinion from physicians and nurses who manage PwD was collected via a 2-round online Delphi method. Consensus was predefined as ≥ 70% of the panellists agreeing or disagreeing with the statement.</p></div><div><h3>Results</h3><p>Physicians (n = 25) and nurses (n = 17) reached ≥ 90% consensus on the following barriers for the management of SH: absence of symptoms, cost to the health system, lack of implementation of glucose monitoring devices, lack of patient training to identify and manage SH, and the fear of SH in children and CGs. Main solutions, identified with ≥ 70% consensus, included training, education, and psychological support using diabetes nurse educators and the use of new glucose monitoring technologies and applications.</p></div><div><h3>Conclusions</h3><p>This study provides valuable insights on the barriers and solutions in the management of SH in Spain. Structured self-management training, the support of diabetes educators, and the use of insulin delivery devices and glucose monitoring technologies is required for the management of SH.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 1","pages":"Pages 65-73"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751991823001869/pdfft?md5=36db401eb137b0bb24f541d9b7f7a0e7&pid=1-s2.0-S1751991823001869-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}