Revista Espanola De Medicina Nuclear E Imagen Molecular最新文献

{"title":"La linfogammagrafía in vivo de los tumores del seno nasal identifica el ganglio retrofaríngeo y el nivel I como ganglios centinela predominantes","authors":"S. Panda ,&nbsp;A. Nath ,&nbsp;A. Thakar ,&nbsp;R. Kumar ,&nbsp;V. Seenu ,&nbsp;K. Sikka ,&nbsp;C.A. Singh ,&nbsp;R. Kumar","doi":"10.1016/j.remn.2023.06.006","DOIUrl":"10.1016/j.remn.2023.06.006","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate by in vivo lymphoscintigraphy and SPECT-CT imaging, the lymphatic drainage patterns of para-nasal sinus (PNS) tumours. To confirm or refute the belief of the retropharyngeal lymph node (RPLN) being the significant draining lymph node for such tumours.</p></div><div><h3>Methods</h3><p>Prospective cohort study conducted on previously untreated PNS tumours with no clinico-radiological evidence of lymph node metastasis. Lymphoscintigraphy undertaken by nasal endoscopic assisted peritumoral injection of ^99mTc sulphur colloid. Injections were classified as anterior or posterior as per a vertical line along the maxillary sinus ostium.</p></div><div><h3>Results</h3><p>Seventeen patients were included. Lymphoscintigraphy successfully identified 17 sentinel nodes in 15 patients and was unsuccessful (lymphoscintigraphy failure) in 2 patients. Predominant sites of sentinel lymphatic drainage were noted to be the RPLN (<em>n</em> <!-->=<!--> <!-->8; 47%) and level I (<em>n</em> <!-->=<!--> <!-->7; 42%). Occasional drainage was identified at the peri-parotid node (<em>n</em> <!-->=<!--> <!-->1) and at level II (<em>n</em> <!-->=<!--> <!-->1). Contralateral drainage was noted in 2 patients (level I-1 and RPLN-1).</p><p>Anterior injections drained predominantly to level I (6/8) and RPLN (2/8), while posterior injections drained predominantly to the RPLN (6/7). The relative risk of RPLN being identified as the sentinel node was significantly higher for posteriorly placed injections than for anteriorly placed injections (RR: 3.43; 95% CI: 1.0-11.8; <em>P</em>=.05).</p></div><div><h3>Conclusion</h3><p>The RPLN is noted as a frequent draining node for sino-nasal tumours and merits routine attention in all sino-nasal tumours. The radio-colloid SPECT-CT technique described here offers an excellent in vivo technique to further explore and validate the lymphatic drainage pathways of these tumours.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 6","pages":"Pages 374-379"},"PeriodicalIF":1.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49628174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Una perspectiva diferente sobre la radiómica con 18F-FDG-PET en pacientes con cáncer colorrectal; la relación entre el análisis intra y peritumoral y los hallazgos patológicos","authors":"Ö. Vural Topuz ,&nbsp;A. Aksu ,&nbsp;M.B. Yılmaz Özgüven","doi":"10.1016/j.remn.2023.04.002","DOIUrl":"10.1016/j.remn.2023.04.002","url":null,"abstract":"<div><h3>Objective</h3><p>We aimed to determine the value of 18F-fluorodeoxyglucose positron emission tomogra-phy/computed tomography (18F-FDG PET/CT) based primary tumoral and peritumoral radiomics in the prediction of tumor deposits (TDs), tumor budding (TB) and extramural venous invasion (EMVI) of colorectal cancer (CRC).</p></div><div><h3>Methods</h3><p>Our retrospective study included 77 CRC patients who had preoperative¹⁸F-FDG PET/CT between June 2020 and February 2022. A total of 131 radiomic features were extracted from primary tumors and peritumoral areas on PET/CT fusion images. The relationship between TDs, TB, EMVI and T stage in the postoperative pathology of the tumors and radiomic features was investigated. Features with a correlation coefficient (CC) less than 0.8 were analyzed by logistic regression. The area under curve (AUC) obtained from the receiver operating characteristic analysis was used to measure the model performance.</p></div><div><h3>Results</h3><p>A model was developed from primary tumoral and peritumoral radiomics data to predict T stage (AUC 0.931), and also a predictive model was constructed from primary tumor derived radiomics to predict EMVI (AUC 0.739). Radiomic data derived from the primary tumor was obtained as a predictive prognostic factor in predicting TDs and a peritumoral feature was found to be a prognostic factor in predicting TB.</p></div><div><h3>Conclusions</h3><p>Intratumoral and peritumoral radiomics derived from¹⁸F-FDG PET/CT are useful for non-invasive early prediction of pathological features that have important implications in the management of CRC.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 6","pages":"Pages 359-366"},"PeriodicalIF":1.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47357751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variaciones en los parámetros cuantitativos y en la puntuación de la escala de Deauville aplicando diferentes algoritmos de reconstrucción en las imágenes PET/TC con [18F]FDG de pacientes con linfoma","authors":"M. Genc ,&nbsp;N. Yildirim ,&nbsp;N. Coskun ,&nbsp;E. Ozdemir ,&nbsp;S. Turkolmez","doi":"10.1016/j.remn.2023.07.002","DOIUrl":"https://doi.org/10.1016/j.remn.2023.07.002","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><p>18F-FDG PET with the Deauville score (DS) is a unique semiquantitative method for lymphoma. However, type of standard uptake values (max, mean, and peak) reconstruction algorithms could affect DS. We compared the Bayesian Penalized Likelihood reconstruction algorithm (BPL) with Ordered Subsets Expectation Maximization (OSEM) on quantitative parameters and DS in lymphoma. We investigated the effect of the size of the lymph node on quantitative variation.</p></div><div><h3>Patients and Methods</h3><p>Raw PET data of 255 lymphoma patients were reconstructed separately with Q.Clear (GE Healthcare), a BPL, and SharpIR (GE Healthcare), an OSEM algorithm. In both images, each patient's liver, mediastinal blood pool, and SUVs (SUVmax, SUVmean, and SUVpeak) of a total of 487 lesions selected from the patients were performed. DSmax, DSmean, and DSpeak were compared.</p></div><div><h3>Results</h3><p>In our study, DS increased significantly with BPL (p<!--> <!-->&lt;<!--> <!-->0.001), and the DS increased to 4-5 in 30 patients evaluated as 1-2-3 with OSEM. It was found that the quantitative values of the lymph nodes increased statistically with BPL (p<!--> <!-->&lt;<!--> <!-->0.001), and the liver from the reference regions were significantly decreased (p<!--> <!-->&lt;<!--> <!-->0.001). In addition, difference in lymph node was independently associated with size of lesion and was significantly more pronounced in small lesions (p<!--> <!-->&lt;<!--> <!-->0.001). The effects of BPL algorithm were more pronounced in SUVmax than in SUVmean and SUVpeak. DS-mean and DS-peak scores were less changed by BPL than DS-max.</p></div><div><h3>Conclusion</h3><p>Different reconstruction algorithms in FDG PET/CT affect the quantitative evaluation. That variation may affect the change in DS in lymphoma patients, thus affecting patient management.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 6","pages":"Pages 388-392"},"PeriodicalIF":1.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71772968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caracterización metabólica de los cambios pulmonares estructurales en pacientes con hallazgos incidentales sugestivos de neumonía por COVID-19 en estudios 18F-FDG PET/CT. Perspectivas fisiopatológicas de imágenes multimodales obtenidas durante la pandemia","authors":"C.G. Wakfie-Corieh ,&nbsp;F. Ferrando-Castagnetto ,&nbsp;M. García-Esquinas ,&nbsp;M.N. Cabrera-Martín ,&nbsp;C. Rodríguez Rey ,&nbsp;A. Ortega Candil ,&nbsp;R.M. Couto Caro ,&nbsp;J.L. Carreras Delgado","doi":"10.1016/j.remn.2023.07.001","DOIUrl":"https://doi.org/10.1016/j.remn.2023.07.001","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the metabolic uptake of different tomographic signs observed in patients with incidental structural findings suggestive of COVID-19 pneumonia through ¹⁸F-FDG PET/CT.</p></div><div><h3>Material and methods</h3><p>We retrospectively analyzed 596 PET/CT studies performed from February 21, 2020 to April 17, 2020. After excluding 37 scans (non-¹⁸F-FDG PET tracers and brain studies), we analyzed the metabolic activity of several structural changes integrated in the CO-RADS score using the SUVmax of multimodal studies with ¹⁸F-FDG.</p></div><div><h3>Results</h3><p>Forty-three patients with ¹⁸F-FDG PET/CT findings suggestive of COVID-19 pneumonia were included (mean age: 68<!--> <!-->±<!--> <!-->12.3 years, 22 male). SUVmax values were higher in patients with CO-RADS categories 5–6 than in those with lower CO-RADS categories (6.1<!--> <!-->±<!--> <!-->3.0 vs. 3.6<!--> <!-->±<!--> <!-->2.1, <em>p</em> <!-->=<!--> <!-->0.004). In patients with CO-RADS 5–6, ground-glass opacities, bilaterality and consolidations exhibited higher SUVmax values (<em>p</em>-values of 0.01, 0.02 and 0.01, respectively). Patchy distribution and crazy paving pattern were also associated with higher SUVmax (<em>p</em>-values of 0.002 and 0.01). After multivariate analysis, SUVmax was significantly associated with a positive structural diagnosis of COVID-19 pneumonia (odds ratio<!--> <!-->=<!--> <!-->0.63, 95% confidence interval<!--> <!-->=<!--> <!-->0.41–0.90; <em>p</em> <!-->=<!--> <!-->0.02). The ROC curve of the regression model intended to confirm or rule out the structural diagnosis of COVID-19 pneumonia showed an AUC of 0.77 (standard error<!--> <!-->=<!--> <!-->0.072, <em>p</em> <!-->=<!--> <!-->0.003).</p></div><div><h3>Conclusions</h3><p>In those patients referred for standard oncologic and non-oncologic indications (43/559; 7.7%) during pandemic, imaging with ¹⁸F-FDG PET/CT is a useful tool during incidental detection of COVID-19 pneumonia. Several CT findings characteristic of COVID-19 pneumonia, specifically those included in diagnostic CO-RADS scores (5–6), were associated with higher SUVmax values.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 6","pages":"Pages 380-387"},"PeriodicalIF":1.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71773018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarcadores pronósticos en el uso del radio-223 en pacientes con cáncer de próstata metastásico resistente a la castración","authors":"M. Vidal ,&nbsp;R. Cárdenas-Perilla ,&nbsp;A. Delgado ,&nbsp;S. Morón ,&nbsp;J.L. Londoño Blair ,&nbsp;I. Vega ,&nbsp;J.J. Correa Ochoa ,&nbsp;J. Rojas","doi":"10.1016/j.remn.2023.06.004","DOIUrl":"https://doi.org/10.1016/j.remn.2023.06.004","url":null,"abstract":"<div><h3>Objectives</h3><p>Establish basal biomarkers in patients with bone metastatic castration-resistant prostate cancer (mCRPC) treated with Ra-223 that predicted a better overall survival (OS), assess hematology toxicity and treatment response.</p></div><div><h3>Materials and methods</h3><p>Retrospective multicenter study in 151 patients with mCRPC between 2013 and 2020. OS was assessed according to basal hemoglobin (Hb), PSA, alkaline phosphatase (AP), WHO pain scale, Eastern Cooperative Oncology Group (ECOG), number of metastatic lesions on bone scan (BS), use of protective bone agents and received. Hematological toxicities were evaluated. Treatment response was based on changes in FA and pain.</p></div><div><h3>Results</h3><p>Median OS was 24<!--> <!-->months (95%<!--> <!-->CI: 16.5-31). OS in 70% of patients who received complete Ra-223 treatment (5-6 doses) was 34.9<!--> <!-->m vs. 5.8<!--> <!-->m in patients with incomplete treatment (1-4 doses). OS was longer in patients with lower PSA and AP, Hb<!--> <!-->&gt;<!--> <!-->13<!--> <!-->g/dL, lesser bone metastasis on GO and ECOG 0-1. 52/151 patients (34%) died during follow-up. Nearly 70% of patients experienced decrease in pain and 66% reduction on AP. Half of patients had mild hematological adverse effects and only 5% had severe.</p></div><div><h3>Conclusions</h3><p>mCRPC patients treated with Ra-223 who had Hb<!--> <!-->&gt;<!--> <!-->13<!--> <!-->g/mL, ECOG 0-1, low AP, PSA<!--> <!-->&lt;<!--> <!-->20<!--> <!-->ng/ml and lesser bone metastasis on BS shown a better OS with adequate safety profile.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 5","pages":"Pages 310-317"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49837237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linfoma hepatoesplénico raro de células T gamma-delta detectada por18F-FDG PET/TC","authors":"X. Lu,&nbsp;J. Yang","doi":"10.1016/j.remn.2023.01.002","DOIUrl":"https://doi.org/10.1016/j.remn.2023.01.002","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 5","pages":"Pages 334-335"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49837233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cirugía radioguiada de tumores mesenquimales con semilla de 125I","authors":"A.G. Barranquero ,&nbsp;S. Corral Moreno ,&nbsp;A. Martínez Lorca ,&nbsp;L. Hernández-Cosido ,&nbsp;M.E. Rioja Martín ,&nbsp;A. Mena Mateos ,&nbsp;J. Cabañas Montero ,&nbsp;J.M. Fernández-Cebrián","doi":"10.1016/j.remn.2023.04.001","DOIUrl":"10.1016/j.remn.2023.04.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Radioguided surgery uses radioactive substances to identify and remove hard-to-locate lesions. Mesenchymal tumors constitute a heterogeneous group of neoplasms derived from the mesoderm, including benign lesions and malignant sarcomas. The aim of this study was to evaluate the ability of the ¹²⁵I radioactive seed to guide intraoperative localization of mesenchymal tumors, analyzing its complication rates and evaluating the margins of the surgical specimens retrieved.</p></div><div><h3>Methods</h3><p>Retrospective observational study of all consecutive patients undergoing radioguided surgery of a mesenchymal tumor with a ¹²⁵I radioactive seed from January 2012 to January 2020 at a tertiary referral center in Spain. The seed was inserted percutaneously guided by ultrasound or computed tomography on an outpatient setting.</p></div><div><h3>Results</h3><p>Fifteen lesions were removed in 11 surgeries on 11 patients, recovering all marked lesions (100%) with a ¹²⁵I seed. The lesions included areas of benign fibrosis (26.7%), cellular angiofibroma (6.7%), desmoid tumor (20%), solitary fibrous tumor (13.3%), chondrosarcoma (6.7%), and pleomorphic sarcoma (26.7%), with a high rate of recurrent tumors (60%). There was only one complication (6.7%) due to the seed falling within the surgical bed. According to the UICC classification of residual tumor, 80% of the lesions resulted in an R0 resection, 6.7% were an R1 resection, and 13.3% were an R2 resection.</p></div><div><h3>Conclusion</h3><p>Radioguided surgery was a precise technique for the removal of hard-to-locate mesenchymal tumors.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 5","pages":"Pages 296-301"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49241372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribución de la medicina nuclear en la cirugía de precisión en el cáncer de mama","authors":"R.A. Valdés Olmos ,&nbsp;S. Vidal-Sicart","doi":"10.1016/j.remn.2023.06.010","DOIUrl":"https://doi.org/10.1016/j.remn.2023.06.010","url":null,"abstract":"<div><p>Nuclear medicine has significantly contributed to precision surgery in breast cancer in the past decades. Radioguided surgery (RGS) has enabled sentinel node (SN) biopsy in assessing regional nodal involvement modifying the management of patients with early breast cancer. For the axilla the SN procedure has resulted in fewer complications and better quality of life when compared with axillary lymph node dissection. Originally, SN biopsy principally concerned cT1-2 tumors without evidence of axillary lymph node metastases. However, in last years SN biopsy is also being offered to patients with large or multifocal tumors, ductal carcinoma in situ, ipsilateral breast cancer relapse, and to patients receiving neoadjuvant systemic treatment (NST) for breast sparing surgery. Parallel to this evolution various scientific associations are trying to homogenise issues such as radiotracer choice, breast injection site, preoperative imaging standardisation and SN biopsy timing in relation to NST as well as management of non-axillary SN metastasis (e.g. internal mammary chain). Additionally, RGS is currently used to accomplish primary breast tumour excision either by intralesional radiocolloid injection or by radioactive iodine seed implantation which is also employed to target metastatic axillary lymph nodes. This latter procedure contributes to manage the node-positive axilla in combination with ¹⁸F-FDG PET/CT in an effort to tailor systemic and loco regional treatment.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 5","pages":"Pages 343-351"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49837235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18F-DOPA PET/TC: diagnóstico de un tumor neuroendocrino apendicular sincrónico en una paciente con cáncer medular de tiroides","authors":"J. Amaya ,&nbsp;A. Repetto ,&nbsp;S. Rubí ,&nbsp;J. Fuster ,&nbsp;M. Martínez ,&nbsp;A. García-Granero","doi":"10.1016/j.remn.2023.03.001","DOIUrl":"10.1016/j.remn.2023.03.001","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 5","pages":"Pages 338-339"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47529639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actualización en carcinoma diferenciado de tiroides refractario a radioyodo","authors":"E. Abou Jokh Casas ,&nbsp;A. Repetto ,&nbsp;A. Rodríguez Gasén ,&nbsp;J.L. Vercher Conejero ,&nbsp;P. Bello Arques ,&nbsp;T. Cambil Molina ,&nbsp;J.A. Vallejo Casas","doi":"10.1016/j.remn.2023.06.005","DOIUrl":"10.1016/j.remn.2023.06.005","url":null,"abstract":"<div><p>Radioiodine therapy represents a fundamental pillar in the routine adjuvant therapy of patients with high-risk differentiated thyroid carcinoma. However, a non-negligible percentage of these patients will develop iodine refractoriness, showing a worse prognosis, as well a lower survival, which demonstrates a clear need to explore different therapeutic approaches. Iodine refractory patient treatment continues to be a challenge, currently having different novel therapeutic options that should be known by the different specialties related to differentiated thyroid carcinoma (DTC). The aim of this work is to review iodine refractory thyroid carcinoma treatment, focusing especially on the definition of iodine refractoriness, highlighting its importance due to its high mortality, and introducing the different therapeutic options available for these patients.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 5","pages":"Pages 324-333"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48966881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}