Revista Espanola De Medicina Nuclear E Imagen Molecular最新文献

{"title":"Respuesta: Redefiniendo la localización preoperatoria basada en imagen de los adenomas en pacientes con hiperparatiroidismo primario candidatos a cirugía mínimamente invasiva","authors":"P. Aphale, S. Dokania, H. Shekhar","doi":"10.1016/j.remn.2025.500227","DOIUrl":"10.1016/j.remn.2025.500227","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 5","pages":"Article 500227"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148859671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacto terapéutico de la PET/TC con [18F]F-Colina frente a las técnicas de imagen convencionales en la estadificación del cáncer de próstata de alto riesgo","authors":"C. Cases-Pellisé,&nbsp;J.L. Villa Palacios,&nbsp;R.M. Álvarez-Pérez,&nbsp;E.M. Triviño-Ibáñez,&nbsp;L. Brero Sánchez,&nbsp;V. Pachón Garrudo,&nbsp;I. Cejudo Liébana,&nbsp;R. Sánchez Sánchez,&nbsp;J.M. Jiménez-Hoyuela García,&nbsp;J.M. Freire-Macías,&nbsp;A. Rodríguez-Fernández","doi":"10.1016/j.remn.2025.500272","DOIUrl":"10.1016/j.remn.2025.500272","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the impact of [¹⁸F]F-Choline PET/CT findings on therapeutic management compared to conventional imaging techniques in the high-risk prostate cancer (PC) staging.</div></div><div><h3>Materials and methods</h3><div>Observational, longitudinal and retrospective study including patients with high-risk PC who underwent a [¹⁸F]F-choline PET/CT after initial staging with conventional imaging techniques (bone scan and abdomen-pelvis CT) between January 2018 and December 2023. Findings were classified as limited disease (lymph node involvement in pelvis and/or axial skeleton) or extended disease (extrapelvic lymph node involvement, involvement of extra-axial skeleton and/or distant sites). Finally, the impact of the results on therapeutic management and on disease volume reclassification (CHAARTED criteria) was analyzed.</div></div><div><h3>Results</h3><div>119 patients were included (mean age: 68.43<!--> <!-->±<!--> <!-->9.33<!--> <!-->years, diagnostic prostate-specific antigen 64.22<!--> <!-->±<!--> <!-->159.40<!--> <!-->ng/mL). [¹⁸F]F-choline PET/CT was positive in 71.4% of patients (50.4% with limited disease and 21.0% with extended disease) versus 21.2% detected by conventional techniques (<em>P</em> <!-->&lt;<!--> <!-->.001). Based on PET findings, 18% of patients had high-volume disease compared to 5% based on conventional imaging (p<!--> <!-->=<!--> <!-->0.002). [¹⁸F]F-choline PET/CT findings led to a change in therapeutic management in 54 patients (45.4%). Among them, 11 (9.2%) received radiotherapy to the pelvic lymph nodes, 14 patients (11.8%) hormone therapy, 23 patients (19.3%) were candidates for therapy with new antiandrogens, and 6 cases (5%) received systemic chemotherapy.</div></div><div><h3>Conclusion</h3><div>[¹⁸F]F-choline PET/CT is superior to conventional imaging techniques in high-risk prostate cancer staging, detecting 18% of patients with high-volume disease and leading to a change in therapeutic management in 45% of cases.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 5","pages":"Article 500272"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148859674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacto del sincronismo mecánico del ventrículo izquierdo sobre la función sistólica evaluada mediante la gated-SPECT de perfusión miocárdica","authors":"S. Alkan,&nbsp;A.Ö. Karaçalıoğlu","doi":"10.1016/j.remn.2026.500283","DOIUrl":"10.1016/j.remn.2026.500283","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the relationship between left ventricular phase analysis parameters and Peak Emptying Rate (PER) with ejection fraction (EF); to evaluate the role of PER in predicting early systolic dysfunction; and to examine how these parameters are affected by the severity of coronary artery disease (CAD) in patients with ischemia or infarction detected by gated myocardial perfusion scintigraphy (gMPS).</div></div><div><h3>Materials and methods</h3><div>Data from 430 patients who underwent myocardial perfusion scintigraphy for confirmed or suspected CAD were retrospectively analyzed. Based on perfusion defect scores, patients were categorized into three groups: normal (142 patients, SSS<!--> <!-->≤<!--> <!-->3), ischemia (140 patients, SSS<!--> <!-->≥<!--> <!-->4, reversible defect), and infarction (148 patients, SSS<!--> <!-->≥<!--> <!-->4, fixed defect). Systolic and diastolic functional parameters of the left ventricle (EF, EDV, ESV, PER, PFR, TPFR) and synchrony indices (phase standard deviation [SD], histogram bandwidth [HBW]) were measured and compared across groups.</div></div><div><h3>Results</h3><div>EF values (65, 60, and 43%) and PER values (3.15, 2.94, and 2.06 s^–1) progressively decreased from the normal to the ischemia and infarction groups, with statistically significant differences among groups (<em>P</em>&lt;.001). Synchrony indices (SD and HBW) increased markedly, especially in the infarction group (mean HBW: 60.86-75.01-149.31; <em>P</em>&lt;.001). In both ischemia and infarction groups, significant correlations were observed between synchrony (HBW) and systolic (EF, PER) as well as diastolic (PFR, TPFR) parameters, with the strongest associations in the infarction group (<em>P</em>&lt;.001).</div></div><div><h3>Conclusion</h3><div>Progressive coronary artery disease is associated with worsening left ventricular systolic and diastolic function, along with impaired mechanical contraction synchrony. PER may serve as a valuable scintigraphic parameter for improving the diagnostic assessment of left ventricular systolic function.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 5","pages":"Article 500283"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148859678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linfoma MALT bilateral de glándulas lagrimales detectado incidentalmente en PET/TC con 68Ga-DOTATATE: un hallazgo poco frecuente pero relevante","authors":"C. Kucuker,&nbsp;S. Akin,&nbsp;D.P. Baran,&nbsp;E. Gumeler,&nbsp;A. Uner,&nbsp;P. Kiratli","doi":"10.1016/j.remn.2025.500202","DOIUrl":"10.1016/j.remn.2025.500202","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 5","pages":"Article 500202"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148859681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La PET/TC con [18F]FDG revela una metástasis hepática solitaria de adenocarcinoma de uraco que simula una pseudolesión hepática en la TC con contraste","authors":"D. Huang,&nbsp;C. Jiang,&nbsp;Z. He,&nbsp;Y. Chen","doi":"10.1016/j.remn.2025.500259","DOIUrl":"10.1016/j.remn.2025.500259","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 5","pages":"Article 500259"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148859084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET-PSMA como herramienta emergente para la valoración de respuesta en el cáncer de próstata metastásico (CPm): revolución y evolución necesaria","authors":"N. Álvarez Mena,&nbsp;J. Gómez Hidalgo,&nbsp;M.P. Fierro Alanis,&nbsp;P. García-Talavera San Miguel,&nbsp;A. Roteta Unceta Barrenechea,&nbsp;S. Menéndez Sánchez,&nbsp;J.E. Montalvá Pastor,&nbsp;J.A. Badell Martínez,&nbsp;A.C. Peñaherrera Cepeda,&nbsp;D. Carrera Salazar,&nbsp;G. Quincoces Fernández,&nbsp;M. Rodríguez-Fraile,&nbsp;en nombre del Grupo de Oncología de la SEMNIM","doi":"10.1016/j.remn.2026.500285","DOIUrl":"10.1016/j.remn.2026.500285","url":null,"abstract":"<div><div>This article critically reviews the available evidence on the role of PSMA-PET in evaluating therapeutic response in metastatic prostate cancer (mPC), comparing it with conventional criteria —serum PSA levels, Response Evaluation Criteria in Solid Tumours (RECIST 1.1), Prostate Cancer Working Group 3 (PCWG3)— and analyzing its integration into clinical practice. It addresses the biological basis of PSMA and how different treatments —androgen deprivation therapy (ADT), androgen receptor pathway inhibitors (ARPI), taxanes, [¹⁷⁷Lu]Lu-PSMA-617, [²²³Ra], stereotactic body radiotherapy (SBRT)— modulate its expression, which influences image interpretation and phenomena such as flare.</div><div>This work describes specific assessment systems for PSMA-PET, including PSMA PET Progression Criteria (PPP), Response Evaluation Criteria in PSMA (RECIP 1.0), and EAU/EANM criteria, highlighting their superior prognostic value compared to RECIST and PCWG3, especially in metastatic castration-resistant prostate cancer (mCRPC). RECIP 1.0, initially validated for [¹⁷⁷Lu]Lu-PSMA-617, has demonstrated robust correlation with overall survival and interobserver reproducibility, improving risk stratification when combined with PSA. Quantitative parameters such as PSMA-VOL and TLP, key biomarkers for monitoring response and predicting outcomes, are analyzed.</div><div>Furthermore, the evidence is reviewed by therapeutic modality, proposing practical recommendations on the optimal timing for PSMA-PET (baseline, intermediate, or delayed depending on treatment) and the need for standardized reporting (PROMISE, E-PSMA). The article also identifies current limitations: variability among radiopharmaceuticals, a lack of universal criteria, a scarcity of prospective studies, and challenges in multimodal integration with PSA and other biomarkers.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 5","pages":"Article 500285"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148859670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimización de la estadificación axilar en cáncer de mama: eficacia de la biopsia del ganglio centinela y la disección axilar dirigida post-quimioterapia","authors":"A. García-Ruiz,&nbsp;I. Martínez-Rodríguez,&nbsp;N. Martínez-Amador,&nbsp;F.J. Gómez-de la Fuente,&nbsp;A. Sánchez-Salmón,&nbsp;J. Jiménez-Bonilla,&nbsp;M. de Arcocha-Torres,&nbsp;V. Mendi Barcina,&nbsp;F. Rodríguez-Izquierdo,&nbsp;N.V. Carvalho-Duarte,&nbsp;M.P. Botanch-Domingo,&nbsp;L. Cabrera-Portillo,&nbsp;P.D. Andrade-Mejía,&nbsp;A. Clavijo-Umbarila,&nbsp;R. Quirce","doi":"10.1016/j.remn.2025.500134","DOIUrl":"10.1016/j.remn.2025.500134","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the contribution of sentinel node biopsy using lymphoscintigraphy in breast cancer (BC) with clip-marked lymph node involvement and neoadjuvant chemotherapy (NACT) in axillary staging and reduction of potential false negatives from exclusively radiological localization.</div></div><div><h3>Material and methods</h3><div>A retrospective study of 20 women with BC and nodal involvement marked with clip and NACT. Lymphoscintigraphy was complemented with SPECT/CT in 12 patients. The correlation between lymphoscintigraphic sentinel lymph node (SLN) and the clip-marked node was analyzed.</div></div><div><h3>Results</h3><div>Lymphoscintigraphy detected 34 axillary SLNs. SPECT/CT showed uptake in 10 of 16 clip-marked nodes (62.5%). During surgery, 39 nodes were removed; 33 (84.6%) were SLNs: 18 with clip, and 15 without clip. One SLN was not located surgically. Six clip-marked nodes (15.3%) showed no uptake. In 8 of 20 patients (40%), drainage to a single SLN was detected; this corresponded to the clip-marked node in 5 cases (non-metastatic) and non-clip-marked nodes in 3 cases (1<!--> <!-->metastatic). In 12 of 20 patients (60%), lymphoscintigraphy showed drainage to more than one SLN. A total of 26 SLNs were detected: 13 SLNs with clip (5 metastatic) and 13 without clip (4 metastatic). Lymphoscintigraphy detected 5 SLNs in 4 of 20 patients (20%) that did not match the clip-marked node and were metastatic.</div><div>The detection and removal rate of GCL was 97% and false negative rate was 16,67%.</div></div><div><h3>Conclusion</h3><div>Lymphoscintigraphy in BC with positive axilla before NACT detected metastases in a significant percentage of patients not identified with clip, being an essential tool for accurate axillary staging.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 5","pages":"Article 500134"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148859673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacto terapéutico de la PET/RM con 18F-PSMA-1007 en la estadificación de pacientes con riesgo intermedio / alto de cáncer de próstata. Biomarcadores de imagen y análisis radiómico asociados a la agresividad del tumor","authors":"J.R. Garcia,&nbsp;L. Pinilla,&nbsp;A. Compte,&nbsp;N. Garrido,&nbsp;L.L. Mont-Castro,&nbsp;S. Ruiz,&nbsp;J. Garcia Magro,&nbsp;J.M. Santabárbara,&nbsp;D. Tovar,&nbsp;S. Mourelo,&nbsp;M. Soria,&nbsp;E. Riera","doi":"10.1016/j.remn.2026.500309","DOIUrl":"10.1016/j.remn.2026.500309","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the impact of initial staging in prostate cancer patients using ¹⁸F-PSMA PET/MRI and to analyze the prognostic value of pre-treatment PET/MRI imaging biomarkers.</div></div><div><h3>Methods</h3><div>Prospective study of 50 consecutive patients diagnosed with intermediate/high-risk prostate cancer.</div><div>Simultaneous acquisition on PET/MRI (SIGNA® GE) 1 hour after intravenous administration of 370<!--> <!-->±<!--> <!-->10% MBq of ¹⁸F-PSMA-1007:<ul><li><span>•</span><span><div>Prostate (20<!--> <!-->min): PET emission<!--> <!-->+<!--> <!-->mpMRI sequences: DIXON, T1, T2, DWI, DCE.</div></span></li><li><span>•</span><span><div>Whole-body (30<!--> <!-->min): PET emission<!--> <!-->+<!--> <!-->MRI sequences: DIXON, T1, T2, DWI, STIR.</div></span></li></ul></div><div>Consensus between nuclear medicine physician and radiologist for T, nodal, and metastatic staging. Visual interpretation. Treatment selection by multidisciplinary tumor board.</div><div>SUV and ADC values were calculated. Pearson correlation analysis was performed. Radiomic analysis included extraction of 93 features: first-order and texture-based. Significant differentiation was assessed using ANOVA between two prognostic groups: (1) TxN0M0 or TxN1M0; (2) TxN1M1a or M1b.</div></div><div><h3>Results</h3><div>PET/MRI enabled comprehensive staging in a single session, classifying 28% of patients as T3b and detecting extraprostatic disease in 44% (28% oligometastatic, 16% polymetastatic).</div><div>PET/MRI concordance for extracapsular extension and seminal vesicle invasion was high in T3b (85.7%) but markedly lower in T3a (25%).</div><div>SUVmax/ADC correlation was inverse and significant (<em>P</em>&lt;.05). Texture features showed superior discriminative ability compared to conventional parameters, achieving an AUC of 0.79 for differentiating advanced T stages.</div><div>Following PET/MRI, 66% of patients underwent radical prostatectomy (with targeted lymphadenectomy in N1), 18% received image-guided radiotherapy, and 16% systemic therapy, without performing surgery in cases with extracapsular extension or metastatic disease.</div></div><div><h3>Conclusion</h3><div>PET/MRI with [¹⁸F]F-PSMA-1007 is a feasible and effective technique for initial staging of intermediate/high-risk prostate cancer, acting as a comprehensive «one-stop» diagnostic procedure.</div><div>Its high sensitivity for nodal and bone disease, combined with integration of radiomic biomarkers, provides prognostic value and enables optimization of personalized therapeutic decisions.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 5","pages":"Article 500309"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148859680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enfermedad de Castleman intrapulmonar que simula un cáncer de pulmón primario localmente avanzado en la PET/TC con 18F-FDG","authors":"D. Huang,&nbsp;X. Yang,&nbsp;Y. Chen,&nbsp;J. Gong","doi":"10.1016/j.remn.2025.500213","DOIUrl":"10.1016/j.remn.2025.500213","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 5","pages":"Article 500213"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148859682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respuesta a la carta sobre «Redefiniendo la localización preoperatoria basada en imágenes de los adenomas en pacientes con hiperparatiroidismo primario candidato a cirugía mínimamente invasiva»","authors":"S. Casanueva-Eliceiry,&nbsp;K. Quintero-Martinez,&nbsp;D. Fuster-Pelfort","doi":"10.1016/j.remn.2025.500257","DOIUrl":"10.1016/j.remn.2025.500257","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 5","pages":"Article 500257"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148859672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}